SREE CHITHRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES TECHNOLOGY

5} Cure of GAS infection was defined as negative throat culture at the end of I 0 days.Further evaluation f(x rheumatic fever recurrence was done at 3 weeks.It was planned to cross over between the groups i r secondrecurrence occurred. A third recurrence was supposed be taken as an indication to changeover to B.P. Patients were evaluated at randomization, at one month, 3 months and 6months clinically by ASO and throat swab culture. End points supposed were uhsencc ofstreptococcal colonization, infection or rheumatic fever at the end of 6 months./.AI/ORATORY STUDIESLab personnel were blinded with regard to treatment arms.Throat culture,sL~nsitivity and serology were done by standard methods. Throat swab was obtained usingsterile swab and immediate plating was done in blood agar. Gram stain was done alter 48hr of culture and sub culture was done whenever nescessary. ASO was done using latexugglutination in serial dilutions.11