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AcknowledgementsI am indebted to the members of the family of MM, MiR, HH and NP who generouslycooperated in this study.Study was a co-operative project of HCM withMux Plank institute for physiological and clinical research, Department of ExperimentalCardiology,Benekcstr.2,D-6123 Bad Nauheim, Germany.Service de Biochimie B, U 523 INSERM, Institute de Myologic, Batiment Babinski,Hospital de Ia salpetriere, Paris, France.Department of Biochemistry, Center for For Advaned studies in functional Genomics,School of Biological Studies ,Madurai Kamaraj University,Madurai.-695 011, India.Department of cardiology Sree Chitra Tirunal Institute For Medical Sciences AndTechnology. Trivandrum India.41
ReferencesI. WATKINS H, SEIDMAN JG, SEIDMAN CE. Familial hypertrophic cardiomyopathy:u genetic model of cardiac hypertrophy. Hum Mol Genet 1995; 4:1721-1727.2. BLAIR E, REDWOOD C, ASHRAFIAN H, OLIVERIA M, BROXHOLME J, KERRB, SALMON A, OSTMANN-SMITH I, WATKINS H. Mutations in they2 subunit ofAMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence forthe central role of energy compromise in disease pathogenesis. Hum Mol Genet 2001;10(1): 1215-1220. .3. DALLOZ F, OSJNSKA HAND ROBBINS J. Manipulating the contractile apparatus:genetically defined animal models of cardiovascular disease. J Mol Cell Cardiol200 I;33:9-25.4. SAKTHIVEL S, JOSEPH PK, RAJAMANICKAM C, VOSBERG HP. A novelmissense mutation (712Arg-Leu) in the cardiac B-myosin heavy chain gene causinghypertrophic cardiomyopathy in an indian family. Hum Mutat 1999; 15: 298-299.5. NISHI H, KIMURA A, HARADA H, KOGA Y, ADACHI K, MATSUYAMA K,KOYANAGI T, Y ASUNAGA S, IMAIZUMI T, TOSHIMA H, SASAZUKI T. Amyosin missense mutation, not a nuiJ allele, causes familial hypertrophiccurdiomyopathy. Circulation 1995; 91: 2911-2915.6. JESCHKE B, UHL K, WEIST B, SCHRODER D, MEITINGER T, DOHLEMANN C,VOSBERG HP. A high risk ofhypertrophic cardiomyopathy associated with a compound·genotype of two mutated B-myosin heavy chain genes. Hum Genet 1 998; I 02:299-304.7. RICHARD P, ISNARD R, CARRIER L, DUBOURG 0, DONATIEN Y, MATH lEUB, BONNE G, GARY F, CHARRON P, HAGEGE A, KOMAJDA M, SCHWARTZ KAND HAINQUE B. Double heterozygosity for mutations in the B-myosin heavy chainand in the cardiac myosin binding protein-C genes in a family with hypertrophiccardiomyopathy . .I Med Genet 1999: 36: 542-545.8. OR ITA M, IWAHANA H, KANAZA W A H, HAY ASH! K AND SEKJY AT.Detection ofpolymorphisms of human DNA by gel electrophoresis as single-strandconformation polymorphisms. Proc Nat/ A cad Sci USA 1989; 86: 2766-2770.9. VERPY E, BIASOTTO M, MEO T, TOSI M. Efficient detection of point mutations oncolor-coded strands of target DNA. Proc Nat/ A cad Sci USA 1994; 91: 1873-7.I 0. VERPY E, BIASOTTO M, BRAI M, MISIANO G, MEO T, TOSI M. Exhaustivemutation scanning by fluorescence-assisted mismatch analysis discloses new genotypephenotypecorrelations in angiodema [see comments]. Am J Hum Genet 1996; 59: 308-19.42
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Page 15 and 16: DATA ON FIRST ATTACK OFRHEUMATIC FE
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Page 19 and 20: when the study drug was continued,
Page 21 and 22: lntrucellular localizution of antib
Page 23 and 24: REFERENCESI. Gene H Stollcnnan: Cha
Page 25 and 26: 28. Bruna Facinclli cl al The Lance
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SREE CHITHRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES TECHNOLOGY

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