SREE CHITHRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES TECHNOLOGY

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UTILITY OF WEEKLY ORALAZITHROMYCIN IN PREVENTION OFGROUP A BETA HEMOLYTICSTREPTOCOCCAL THROATCOLONIZATION, INFECTION ANDRHEUMATIC FEVER.
INTRODUCTIONSecondary prophylaxis with antibiotic against streptococcal infection is a landmark public health intervention evolved in the last century(l ). Injectable long actingpenicillin once in three weeks is the gold standard, 1 but not widely practiced in keralabecause of the fear of anaphylaxis(2). Oral penicillin and erythromycin in a twice-dailydose is at present used as an alternative.Azithromycin is an orally effective antibiotic with a long half life and there arereports highlighting its utility in prevention of streptococcal infection( 17). lienee itsutility in preventing rheumatic recurrence was evaluated against oral penicillin.REVIEW OF LITERATURERheumatic heart disease remains a major cause of cardiovascular morbidity andmortality in our country despite the fact that it has declined in the west except lorresurgence in the 1980's. Rheumatic fever and rheumatic heart disease constitute 35-40'%of admissions to hospitals in India(3). The enigma of how group A Beta hemolyticstreptococci (GAS) cause rheumatic fever is evading us. But, what is obvious is that it iseasily preventable by simple means at a negligible cost. It is more economical to preventrheumatic fever than treat rheumatic heart disease. After a GAS throat infection, 0.3
Page 1 and 2: SREE CHITHRA TIRUNAL INSTITUTE FORM
Page 3: PROJECTSUTILITY OF WEEKLY ORAL AZYT
Page 7 and 8: Secondary prevention has evolved fr
Page 9 and 10: for those who arc not tolerating Pe
Page 11 and 12: AIMTo study the utility of once wee
Page 13 and 14: RESULTIt was an open lubel study.Tr
Page 15 and 16: DATA ON FIRST ATTACK OFRHEUMATIC FE
Page 17 and 18: They were followed up for 4 weeks a
Page 19 and 20: when the study drug was continued,
Page 21 and 22: lntrucellular localizution of antib
Page 23 and 24: REFERENCESI. Gene H Stollcnnan: Cha
Page 25 and 26: 28. Bruna Facinclli cl al The Lance
Page 27 and 28: INTRODUCTIONFamilial hypertrophic c
Page 29 and 30: ( FAM) analysis. The SSCP analysis
Page 31 and 32: Ul:1 01:2 111:3 U1:4111:1 01:2 Hl:3
Page 33 and 34: 11:2 is a 40 year old lady, symptom
Page 35 and 36: Ill: I is the 19 year old daughter
Page 37 and 38: Nl, FAMILYProband (11:8) is a 54 ye
Page 39 and 40: DISCUSSION7/22 patients (77.3%) had
Page 41 and 42: esult from complex inheritance patt
Page 43 and 44: ReferencesI. WATKINS H, SEIDMAN JG,
Page 45: 13-myosin heavy chain gene have a s

SREE CHITHRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES TECHNOLOGY

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