with Judy Wyatt

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Biopsy based treatment Slide 08 Moderate to severe hepatitis C defined as histological evidence of significant scarring (fibrosis) and/or significant necrotic inflammation. First NICE guidance October 2000 Reviewed January 2004 – retain biopsy based treatment; may revise when results of mild hepatitis C studies are available August 2006 – treatment of mild chronic hepatitis C
Biopsy to determine severity of disease not an exact science What will the biopsy result depend on? • Time of biopsy – LFTs fluctuate • Biopsy site variation between biopsies • Biopsy length >25mm* • Biopsy width >1mm** Smaller biopsies underestimate severity Need >10 portal tracts** 1998 1.3mm wide 2005 0.56mm wide Which Pathologist? Inter-observer variation * Bedossa et al Hepatology 2003;38;1449-1457 ** Colloredo et al J Hepatol 2003;39;239-244
Page 1 and 2: Hepatitis C with Judy Wyatt
Page 3: What do we mean by “liver fibrosi
Page 7 and 8: Histopathological features of chron
Page 9 and 10: Introduction: x10 5
Page 11 and 12: Who are you and where did you come
Page 13 and 14: How do you get in? Four receptors o
Page 15: Your host is not immunocompromised,
Page 18 and 19: Well let’s get to something that
Page 20 and 21: How do you do it? Two ways of causi
Page 22 and 23: Genotype 1 BMI 25 Male Age Alcohol
Page 24 and 25: Association between omental adipose
Page 26 and 27: HCV and coronary artery disease 82,
Page 28 and 29: RNA virus, so how can it cause canc
Page 30: Summary - hepatitis C - virus of ou

with Judy Wyatt

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