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WEDNESDAY, 10 SEPTEMBER 50 WAO Congress–XVIII ICACI Final Program WEDNESDAY, 10 SEPTEMBER - continued Free Communication Session 15:45 - 17:15 FC11 - Asthma Mechanisms Room 12, Vancouver Convention & Exhibition Centre CME Credit: 1.5 Co-Chair: Harold Nelson, United States Co-Chair: Anahi Yanez, Argentina Abstract #O-11-1 A key role for neutrophils in nonatopic asthma van Houwelingen AH 1 , Kool M 1 , de Jager SCA 2 , Kraneveld AD 1 , Nijkamp FP 1 1 Utrecht University, Utrecht, Netherlands, 2 Leiden University, Leiden, Netherlands Abstract #O-11-2 Human airway smooth muscle cells express the high affinity receptor for IgE (FcεRI) Soussi Gounni A 1 , Wellemans V 2 , Kamrouz K 1 , Halayko A 1 , Hamid Q 3 , Lamkhioued B 2 1 Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada, 2 CHUM Research Center, University of Montreal, Montreal, Quebec, Canada, 3 Meakins-Christie Labs, McGill University, Montreal, Quebec, Canada Abstract #O-11-3 Exposure of cat-allergic patients to natural cat allergen induces a late asthmatic response in small, but not large, airways Corren J 1 , Goldin J 2 , Zeidler M 2 , Silverman J 3 , Newman KB 4 , Tashkin DP 2 1 Allergy Research Foundation, Inc., Los Angeles, CA, USA, 2 David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 3 USC Keck School of Medicine, Los Angeles, CA, USA, 4 Forest Laboratories, Inc., New York, NY, USA Abstract #O-11-4 Induced sputum in asthma by cockroaches Lluch M 1 , Sastre J 1 , Fernandez-Nieto M 1 , Fernandez-Caldas E 2 , Quirce S 1 1 Fundacion Jimenez Diaz, Madrid, Spain, 2 CBF Leti, Madrid, Spain Abstract #O-11-5 Respiratory viruses and bronchial asthma, HLA-associated markers of susceptibility Khaitov MR 1 , Trofimov DU 1 , Petrova TV 1 , Yakovleva KP 1 , Boldyreva MN 1 , Alexeev LP 1 1 Institute of Immunology, Moscow, Russian Federation Abstract #O-11-6 Mechanism of chitosan IFN-γ gene nanoparticle (CIN) therapy for asthma Mohapatra S 1 , Lockey RF 1 , Kumar M 1 , Kong X 1 , Behera A 1 , Hellerman G 1 , Zhang W 1 1 University of South Florida College of Medicine & VA Hospital, Tampa, FL, USA Presenting authors indicated in bold. SCIENTIFIC PROGRAM Free Communication Session 15:45 - 17:15 FC12 - Atopy: Prediction and Prevention Waterfront Ballroom B, Fairmont Waterfront Hotel CME Credit: 1.5 Co-Chair: Patrick Holt, Australia Co-Chair: Yoichi Kohno, Japan Abstract #O-12-1 Sensitization in a birth cohort of unselected Danish children from birth to 15 years of age Halken S 1 , Hoest A 2 , Jacobsen HP 3 , Mortensen S 2 , Estmann A 4 1 Dept. of Pediatrics, Soenderborg Hospital, Soenderborg, Denmark, 2 Dept. of Pediatrics, Odense University Hospital, Odense, Denmark, 3 Dept. of Pediatrics, Kolding Hospital, Kolding, Denmark, 4 Dept. of Pediatrics, Aarhus University Hospital, Aarhus, Denmark Abstract #O-12-2 Early life viral infection increases ryegrass sensitization: a prospective birth cohort study Kemp AS 1 , Ponsonby AL 2 , Dwyer T 3 , Lim L 2 , Cochrane J 3 , Carmichael A 4 , Couper J 3 1 The Children’s Hospital at Westmead, University of Sydney, Sydney, NSW, Australia, 2 National Centre for Epidemiology and Population Health Australian National University, Canberra, Australia, 3 Menzies Centre for Population Health Research, Hobart, Australia, 4 Department of Pediatrics and Child Health, University of Tasmania, Hobart, Australia Abstract #O-12-3 Maternal breast milk long chain n-3 fatty acids are associated with increased risk of atopy in breast-fed infants Stoney RM 1 , Woods RK 2 , Hosking CS 3 , Hill DJ 3 , Abramson MJ 2 , Thien FCK 4 1 Alfred Hospital, Melbourne, Victoria, Australia, 2 Monash University, Melbourne, Victoria, Australia, 3 Royal Children’s Hospital, Melbourne, Victoria, Australia, 4 Alfred Hospital & Monash University, Melbourne, Victoria, Australia Abstract #O-12-4 Polymorphisms of cytokine genes in atopic dermatitis Sediva A 1 , Sismova K 1 , Vernerova E 1 , Capkova S 2 , Cinek O 3 , Malinova V 4 1 Institute of Immunology, University Hospital Motol, Prague, Czech Republic, 2 Department of Dermatology, University Hospital Motol, Prague, Czech Republic, 3 Second Clinic of Pediatrics, University Hospital Motol, Prague, Czech Republic, 4 Clinic of Pediatrics, First Medical Faculty, Prague, Czech Republic Abstract #O-12-5 Differential response of peripheral blood T and B lymphocytes in adults and children following ex vivo stimulation with bacterial lipopolysaccharide Tulic MK 1 , Zheng H 1 , Mazer BD 1 , Hamid Q 1 1 Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada Abstract #O-12-6 Influence of antiallergic agents on expression of costimulatory molecules in immunized mice Tryka E 1 , Asano K 2 , Suzaki H 3 , Ito J 3 , Hisamitsu T 2 1 Department of Otolaryngology, Medical Academy, Lublin, Poland, 2 Department of Physiology, School of Medicine, Showa University, Tokyo, Shinagawa-ku, Japan, 3 Department of Otolaryngology, School of Medicine, Showa University, Tokyo, Shinagawa-ku, Japan
WAO Congress–XVIII ICACI Final Program WEDNESDAY, 10 SEPTEMBER - continued Free Communication Session 15:45 - 17:15 FC13 -Basic Mechanisms II Waterfront Ballroom A, Fairmont Waterfront Hotel CME Credit: 1.5 Chair: Robyn O’Hehir, Australia Abstract #P-3-1 C57BL/6 and BALB/c do not represent default Th1 and Th2 strains in exogenous antigen-driven immune responses Nashed BF 1 , Marshall A 1 , Thomas W 2 , HayGlass KT 1 1 University of Manitoba, Winnipeg, Manitoba, Canada, 2 University of Western Australia, Perth, Australia Abstract #O-13-2 Diagnostic value of abnormal regulation of arachidonic acid metabolism in leukocytes from aspirin-sensitive asthmatics Kowalski ML 1 , Ptasinska A 1 , Bienkiewicz B 1 , DuBuske L 2 1 Dept. of Clinical Immunology & Allergology, Medical University, Lodz, Poland, 2 The Immunology Research Institute of New England, Fitchburg, MA, USA Abstract #O-13-3 Differences in local eosinophil infiltration for several pollen allergens in seasonal allergic rhinitis Narita S 1 , Shirasaki H 2 , Chin S 1 , Takano Y 1 , Kobayashi K 1 , Itoh J 1 , Himi T 2 1 Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan, 2 Sapporo Medical University, Sapporo, Hokkaido, Japan Abstract #O-13-4 Inhibition of peroxidase release from human eosinophils: role of SNAREs in granule-derived mediator secretion Logan MR 1 , Odemuyiwa SO 1 , Lacy P 1 , Moqbel R 1 1 University of Alberta, Edmonton, Alberta, Canada Abstract #O-13-5 Potential role of human eosinophils in the regulation of T-cell function through induction of indoleamine 2,3-dioxygenase Odemuyiwa SO 1 , Ghahary AD 1 , Li Y 1 , Ghahary AG 1 , Moqbel R 1 1 University of Alberta, Edmonton, Alberta, Canada Abstract #O-13-6 Chromosomal mapping and candidate gene sequencing of a hyper IgE mouse mutant generated by genome wide mutagenesis reveals a novel mutation in ZAP70 Jakob T 1 , Hrabe de Angelis M 2 , Behrendt H 1 , Ring J 1 , Wolf E 3 , Flaswinkel H 3 1 Division of Environmental Dermatology and Allergy GSF/TUM, Munich, Germany, 2 Institute for Experimental Genetics, GSF, Munich, Germany, 3 Institute of Molecular Animal Breeding, Gene Center, LMU, Munich, Germany Presenting authors indicated in bold. SCIENTIFIC PROGRAM Free Communication Session 15:45 - 17:15 FC14 -Immunotherapy Waterfront Ballroom C, Fairmont Waterfront Hotel CME Credit: 1.5 Co-Chair: Kurt Blaser, Switzerland Co-Chair: Linda Cox, United States Abstract #O-14-1 Double blind placebo controlled study of specific immunotherapy (SIT) with Alutard SQ grass pollen for seasonal allergic rhinoconjunctivitis Calderon M 1 , Durham SR 1 , Frew AJ 2 1 National Heart and Lung Institute, London, UK, 2 Southampton General Hospital, Southampton, UK Abstract #O-14-3 Biodegradable microparticles for few-shot treatment of type I allergy Schöll I 1 , Weissenböck A 2 , Förster-Waldl E 3 , Untersmayr E 1 , Gabor F 2 , Jensen-Jarolim E 1 , Walter F 1 , Willheim M 1 , Boltz-Nitulescu G 1 , Scheiner O 1 1 Inst. of Pathophysiology, Vienna, Austria, 2 Inst. of Pharmaceutical Technology and Biopharmaceutics, Vienna, Austria, 3 Dept. of Pediatrics and Juvenile Medicine, Vienna, Austria Abstract #O-14-4 Nasal immunization of proteosome adjuvanted birch pollen extract inhibits the allergic skin reaction in sensitized mice Rioux CR1 , Gelinas AM1 , Diamantakis H1 , Bellerose N1 , Poirier D1 , Vachon D1 , Lowell GH1 , Burt DS1 1ID Biomedical Corporation of Quebec, Ville St-Laurent, Quebec, Canada Abstract #O-14-5 Non-specific plasma proteins during sublingual immunotherapy Reich M 1 , Zwacka G 2 , Markert UR 1 1 Depts. of Dermatology and Obstetrics, Friedrich Schiller University, Jena, Germany, 2 Robert Koch Hospital, Apolda, Germany Abstract #P-15-20 Cat allergen Fel d 1 coupled to carbohydrate-based particles: interaction with human monocyte-derived dendritic cells Gafvelin G 1 , Grönlund H 1 , Neimert-Andersson T 1 , Buentke E 2 , Jacobsson-Ekman G 2 , van Hage-Hamsten M 1 , Scheynius A 2 1 Karolinska Institutet/Dept. of Medicine, Clin. Immunol. & Allergy, Stockholm, Sweden, 2 Karolinska Institutet/Dept. of Medicine, Clin. Allergy Research, Stockholm, Sweden 51 Abstract #O-14-2 Successful grass pollen immunotherapy inhibits eosinophil accumulation in the nasal mucosa: role of adhesion molecules and apoptosis Watanabe H1 , Nouri-Aria KT1 , Jacobson MR1 , Wilson DR1 , Durham SR1 1Imperial College London at the National Heart & Lung Institute, London, UK WEDNESDAY, 10 SEPTEMBER
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