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Artificial Human vision - KSOS

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428 Kerala Journal of Ophthalmology Vol. XXI, No. 4<br />

stimulator based on multiple microchips have been tried<br />

on animal experiments, another Japanese project based<br />

on supra choroidal –trans retinal stimulation, the<br />

minimal invasive retinal project of Prof Heinrich<br />

Gerding in Switzerland, the Seoul <strong>Artificial</strong> project of<br />

Prof Hum Chung etc.<br />

Conclusion<br />

With ongoing advances in technology, surgical<br />

techniques and treatment options, there has been<br />

significant advancement towards restoring some <strong>vision</strong><br />

to patients suffering from RP.<br />

Although many advances have been made, the field of<br />

artificial <strong>vision</strong> is still young.We hope within another<br />

five years, patients with retinitis pigmentosa will be<br />

able to receive a retinal prosthesis, suitable to their<br />

needs, and possess <strong>vision</strong> allowing them to possibly<br />

perform. The management options of AMD has changed<br />

a lot since the retinal prosthesis started developing in<br />

nineties. In the dawn of anti VEGF era, the number of<br />

patients who needs prosthetic <strong>vision</strong> due to this disease<br />

is expected to fall according to many researchers.<br />

Future research by all AHV groups will need to address<br />

more on the energy needs, its supply, long-term<br />

biocompatibility of microelectronics in the saline<br />

environment of the eye in terms of hermetic packaging<br />

of the micro fabricated electrode arrays, minimization<br />

of the heat generated and dissipated with its use, effect<br />

of chronic electrical stimulation on the retina etc. In<br />

addition to this, significant attention needs to be given<br />

to the manner in which visual images will be encoded<br />

and delivered in patterns of electrical stimulation to<br />

the retina. Plasticity of the visual system in response to<br />

electrical stimulation as well as how the brain interprets<br />

a pattern of stimulation resulting from thousands of,<br />

electrodes has to be understood well and will be crucial<br />

in the evolution of better prosthetic design.<br />

We can thus tell our patients with outer retinal<br />

degenerations that there is progress toward an<br />

electronic retinal prosthesis but fully functional, longlasting<br />

devices are not on the immediate horizon.<br />

References<br />

1. Cornsweet TN. The retinal prosthesis is based on the<br />

fundamental concept of replacing photoreceptor<br />

function with an electronic device. Visual Perception.<br />

Academic Press, NY, USA (1970).<br />

2. Santos A, Humayun MS, de Juan E, Jr., Greenburg RJ,<br />

Marsh MJ, Klock IB, Milam AH (1997) Preservation of<br />

the inner retina in retinitis pigmentosa. A morphometric<br />

analysis. Arch Ophthalmol 115:511–515. 344 Sekirnjak<br />

et al.<br />

3. Humayun MS, Prince M, de Juan E, Jr., Barron Y,<br />

Moskowitz M, Klock IB, Milam AH (1999)<br />

Morphometric analysis of the extramacular retina from<br />

postmortem eyes with retinitis pigmentosa. Invest<br />

Ophthalmol Vis Sci 40:143–148<br />

4. Arturo Santos, MD; Mark S. Humayun, MD, PhD; Eugene<br />

de Juan, Jr, MD; Robert J. Greenburg; Marta J. Marsh,<br />

MS; Ingrid B. Klock; Ann H. Milam, PhD. Arch<br />

Ophthalmol. 1997;115(4):511-515.<br />

5. Dagnelie G. Toward an artificial eye. IEEE Spectrum<br />

22–29 (1996).<br />

6. Normann RA, Maynard EM, Guillory KS, Warren DJ.<br />

Cortical implants for the blind. IEEE Spectrum 33, 54–<br />

59 (1996).<br />

7. Hambercht FT. The history of neural stimulation and<br />

its relevance to future neural prostheses. In: Neural<br />

Prostheses: Fundamental Studies. Agnew WF, McCreery<br />

DB (Eds). Prentice Hall, NJ, USA (1990).<br />

8. Brindley GS, Lewin WS. The sensations produced by<br />

electrical stimulation of the visual cortex. J. Physiol.<br />

196, 479–493 (1968)<br />

9. Dobelle W. <strong>Artificial</strong> <strong>vision</strong> for the blind by connecting<br />

a tele<strong>vision</strong> camera to the brain. ASAIO J. 46, 3–9<br />

(2000).<br />

10. Maynard EM, Nordhausen CT, Normann RA. The Utah<br />

intracortical electrode array: a recording structure for<br />

potential brain- computer interfaces Electroencephalogr.<br />

Clin. Neurophysiol. 102, 228–239 (1997)<br />

11. Naik G, Regalado A. An inventor struggles to restore<br />

sight. In: Wall Street Journal, NY, USA, B1 (2003)<br />

12. Xinyu chai, Liming li, Kaijie wu, Chuanqing zhou,<br />

Pengjia cao, and Qiushi Ren IEEE Engineering in<br />

medicine and biology magazine<br />

13. Weiland JD, Liu W, Humayun MS. Retinal prosthesis.<br />

Annu Rev Biomed Eng 2004.<br />

14. Humayun MS, de Juan E Jr, Dagnelie G, Greenberg RJ,<br />

Propst RH, Phillips DH. Visual perception elicited by<br />

electrical stimulation of retina in blind humans. Arch<br />

Ophthalmol 1996;114:40-6.<br />

15. Humayun MS, de Juan E Jr, Weiland JD, Dagnelie G,<br />

Katona S, Greenberg R. Pattern electrical stimulation<br />

of the human retina. Vision Res 1999;39:2569-76.<br />

16. Humayun MS, Weiland JD, Fujii GY, Greenberg R,<br />

Williamson R, Little J, et al. Visual perception in a blind<br />

subject with a chronic microelectronic retinal prosthesis.<br />

Vision Res 2003;43:2573-81.<br />

17. Feasibility Study of a Retinal Prosthesis: Spatial Vision<br />

With a 16-Electrode Implant A Caspi, JD Dorn, KH<br />

McClure, MS Humayun … - Archives of Ophthalmology,<br />

2009 - Am Med Assoc

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