Extent of Absorption
Extent of Absorption
Extent of Absorption
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Factors affecting distribution<br />
1. Blood flow<br />
Drugs are readily distributed to highly perfused tissue<br />
like brain, liver, and kidneys<br />
2. Permeability limitations<br />
Many drugs do not readily enter the brain due to the<br />
blood brain barrier<br />
3. Protein binding<br />
Acidic drugs are bound to the most abundant plasma<br />
protein (albumin); while basic drugs bind to -1-<br />
acid glycoprotein.<br />
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