Extent of Absorption
Extent of Absorption
Extent of Absorption
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<strong>Absorption</strong> and Bioavailability<br />
Irrespective <strong>of</strong> the reason that is responsible for the incomplete<br />
absorption <strong>of</strong> the chemical as the parent compound, it is<br />
essential that there is a parameter which defines the extent <strong>of</strong><br />
transfer <strong>of</strong> the intact chemical from the site <strong>of</strong> administration<br />
into the general circulation. This parameter is the<br />
bioavailability, , which is simply the fraction <strong>of</strong> the dose<br />
administered that reaches the general circulation as the parent<br />
compound. (The term bioavailability is perhaps the most<br />
misused <strong>of</strong> all kinetic parameters and is sometimes used<br />
incorrectly in a general sense as the amount <strong>of</strong> drug available<br />
specifically to the site <strong>of</strong> toxicity.)<br />
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