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<strong>HuCAL</strong> <strong>Platinum</strong>:<br />
HCDR3 Length Distribution<br />
Frequency %<br />
Design and composition of Library HCDR3 selected from Library<br />
14,0<br />
12,0<br />
10,0<br />
8,0<br />
6,0<br />
4,0<br />
2,0<br />
0,0<br />
Lenght Distribution HCDR3<br />
4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23<br />
� Composition Library = Design<br />
aa<br />
Planned<br />
Library<br />
� Increased number of long HCDR3<br />
December 2008, San Diego © <strong>MorphoSys</strong> AG<br />
Page 20<br />
Unique binder<br />
50<br />
45<br />
40<br />
35<br />
30<br />
25<br />
20<br />
15<br />
10<br />
5<br />
0<br />
4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23<br />
HCDR3 length (aa)<br />
<strong>HuCAL</strong> Gold (N=100)<br />
<strong>HuCAL</strong> <strong>Platinum</strong> (N=300)<br />
<strong>HuCAL</strong> <strong>Platinum</strong> delivers higher number of sequences with long HCDR3
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