GETTING THE WORD OUT
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FROZEN STIFF<br />
Did interstellar cloud<br />
kill off the dinosaurs?<br />
IMPRECISION ENGINEERING<br />
To make computers better,<br />
try making them worse<br />
YOU SWINE!<br />
Problem porkers wreak<br />
havoc worldwide<br />
WEEKLY April 2 -8, 2016<br />
MINIMAL LIFE We’ve made the tiniest genome that works<br />
To explain our cosmic backyard,<br />
we need to break gravity<br />
No3067 US$5.95 CAN$5.95<br />
1 3<br />
0 70989 30690 5<br />
Science and technology news<br />
www.newscientist.com<br />
US jobs in science<br />
<strong>GETTING</strong> <strong>THE</strong> <strong>WORD</strong> <strong>OUT</strong> Stuttering starts deep in the brain
CONTENTS<br />
Volume 230 No 3067<br />
This issue online<br />
newscientist.com/issue/3067<br />
News<br />
6<br />
Unlocking the<br />
essence of life<br />
We’ve made the tiniest<br />
genome that works<br />
On the cover<br />
30<br />
Our impossible<br />
galaxy<br />
To explain our cosmic<br />
backyard, we need to<br />
break gravity<br />
Cover image<br />
Lynette Cook/Science Photo Library<br />
Features<br />
34<br />
Getting the<br />
word out<br />
Stuttering starts<br />
deep in the brain<br />
SERGE PICARD/AGENCE VU/CAMERAPRESS TOM DEERINCK & MARK ELLISMAN/NCMIR/UCSD<br />
8 Frozen stiff<br />
Did an interstellar cloud<br />
kill off the dinosaurs?<br />
36 Imprecision engineering<br />
To make computers<br />
better, make them worse<br />
40 You swine!<br />
Porkers wreak havoc<br />
6 Minimal life<br />
Tiniest working genome<br />
34 Getting the word out<br />
Stuttering and the brain<br />
Coming next week…<br />
On the road<br />
Is migration really a crisis?<br />
Black holes unmasked<br />
Frozen universe reveals their secrets<br />
Leaders<br />
3 Exploring the essentials of life isn’t about<br />
playing god. To err should be inhuman<br />
News<br />
4 UPFRONT<br />
Could bomb sensors stop another Brussels?<br />
Fast Antarctic ice melt could see catastrophic<br />
sea rise. Gecko Grippers head to space<br />
6 THIS WEEK<br />
Did a cosmic cloud kill the dinosaurs? Mars<br />
had a short-lived ocean. Prairie dog serial<br />
killers. The twins who felt fear for the first<br />
time. Lock up CO 2 in building materials. How<br />
brain-zapping works. Bright spots on Ceres.<br />
Stacking oranges in 24 dimensions<br />
15 IN BRIEF<br />
Migrating birds stay in UK for longer. Cats<br />
give us rage. Ghost galaxies. Exercise for a<br />
young brain. Unlocking ancient scroll library<br />
Technology<br />
18 Get immersed as first virtual reality games<br />
go on sale. Inside the factory of the future<br />
Aperture<br />
22 What the Zika virus looks like – probably<br />
Opinion<br />
24 Hinkley’s point Paul Ekins urges rethinking<br />
the world’s biggest nuclear power project<br />
24 US in Cuba Michael Clegg on a hopeful start<br />
25 INSIGHT Londoners’ toxic air nightmare<br />
28 Roborescue It’s time robots took their place<br />
in search and rescue, says Robin Murphy<br />
Features<br />
30 Our impossible galaxy (see above left)<br />
34 Getting the word out (see left)<br />
36 Imprecision engineering To make<br />
computers better, try making them worse<br />
40 You swine! Problem porkers wreak havoc<br />
worldwide<br />
CultureLab<br />
42 Animal crackers Pretending to be other<br />
creatures is an altogether human game<br />
43 A drug to make us good Hunting for<br />
morality in a neuroscientific mess<br />
Regulars<br />
52 LETTERS Theory proposes<br />
56 FEEDBACK When is a drug not a drug?<br />
57 <strong>THE</strong> LAST <strong>WORD</strong> Atomic bonds<br />
2 April 2016 | NewScientist | 1
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Bare necessities<br />
Exploring the essentials of life isn’t about playing God<br />
HAVE we found the essentials of<br />
life? A team in the US has reduced<br />
the number of genes in a modest<br />
bug called Mycoplasma mycoides<br />
by almost half, creating the tiniest<br />
genome that can support vital<br />
survival functions (see page 6).<br />
The new strain is called JVCIsyn3.0,<br />
the letters coming from<br />
the name of the J. Craig Venter<br />
Institute in La Jolla, California.<br />
The institute is named after the<br />
charismatic biotechnologist<br />
who is almost as well known for<br />
his swagger as for his scientific<br />
achievements. The first human<br />
genome to be fully sequenced<br />
was Venter’s own, and he has in<br />
the past drawn opprobrium for<br />
attempting to patent genes. His<br />
apparent grandiosity irks more<br />
buttoned-down colleagues.<br />
And his ambition prompts those<br />
averse to genetic engineering to<br />
invoke inchoate risks, frequently<br />
buttressed by the claim that it<br />
amounts to “playing God”. This<br />
time, Venter’s rhetoric has been<br />
reined in a little. The genome of<br />
JVCI-syn3.0, while put together<br />
on a computer and assembled by<br />
DNA sequencers, includes no new<br />
or artificial genes. If anything, its<br />
creation shows the limits of our<br />
power and depth of our ignorance:<br />
we have no idea what a third of the<br />
genes the team found actually do.<br />
But now we can start figuring<br />
out what the essentials of life<br />
really are. That will, Venter insists,<br />
invigorate synthetic biology,<br />
with benefits for all of us: he, and<br />
Toerrshouldbeinhuman<br />
NEURAL networks, like the ones<br />
grabbing headlines for winning<br />
boardgames or driving cars,<br />
depend on huge amounts of<br />
computing hardware. That in<br />
turn means a colossal amount<br />
of power: the next wave may<br />
consume millions of watts each.<br />
That’s one reason why some<br />
suggest we rethink what we want<br />
computers to be. Reducing the<br />
precision with which they analyse<br />
problems, and putting up with<br />
the odd“error”, can cut zeroes off<br />
their energy consumption (see<br />
page 36). And it has precedent in<br />
the human brain – an unrivalled<br />
piece of hardware using electrical<br />
fluctuations and requiring a<br />
million times less power than<br />
a computer.<br />
Introducing error will also make<br />
computers better at handling<br />
the real world. Neural networks,<br />
others, want to design organisms<br />
that can make biofuels, protein<br />
or vaccines more efficiently.<br />
Since Venter made his first<br />
synthetic cell in 2010, however,<br />
the ease of gene editing has<br />
exploded. This allows scientists to<br />
tweak genomes far more cheaply<br />
than building them from scratch.<br />
The CRISPR technique, which has<br />
itself generated much ethical<br />
controversy, might end up the<br />
more practical and widespread<br />
method. Either way, far from<br />
wilfully taking risks – playing<br />
God, if you really must – synthetic<br />
biologists are developing the<br />
expertise to address very human<br />
needs. Venter’s bullish approach<br />
has brought that a step closer.<br />
Let him swagger. ■<br />
loosely modelled on the brain,<br />
capture some of its problemsolving<br />
capacity. AlphaGo<br />
surprised opponents and<br />
designers alike with Go moves<br />
described by some as “intuitive”.<br />
Computers that play Go,<br />
understand human language and<br />
behaviour, spot patterns across<br />
databases of genetic information<br />
or forecast economic and climate<br />
trends do not deal in absolutes.<br />
It is their rough guesses that will<br />
bring us closest to comprehensive<br />
artificial intelligence. ■<br />
2 April 2016 | NewScientist | 3
UPFRONT<br />
ADAM BERRY/GETTY<br />
Satellite lost<br />
JUNKED? Hitomi, a Japanese<br />
astronomy satellite, seems to be<br />
tumbling through space, and may<br />
have broken up. It was due to<br />
come online on 26 March, but<br />
failed to communicate with Earth.<br />
A tweet by the US Joint Space<br />
Operations Center reported five<br />
pieces of debris around the<br />
satellite shortly afterwards.<br />
All may not be lost. The Japan<br />
Aerospace Exploration Agency<br />
heard a brief burst of signal from<br />
the craft, and video taken from<br />
the ground suggests it is falling<br />
through space.<br />
“That indicates the sat was<br />
at that point alive, just unable<br />
to point its antenna at Earth,”<br />
says Jonathan McDowell at the<br />
“If we never hear from<br />
the satellite again,<br />
I would be devastated<br />
but not surprised”<br />
Can we sniff out bombs?<br />
LAST week, terrorists walked into scanned by an array of sensors as<br />
Brussels’ Zaventem airport and<br />
they walk through the tunnel to<br />
detonated bomb-laden luggage get into airports or train stations.<br />
in the check-in area. They also<br />
The Lincoln Laboratory at<br />
bombed a subway station.<br />
the Massachusetts Institute of<br />
As New Scientist went to press,<br />
Technology has a different approach.<br />
35 people had been killed and<br />
A team there has turned to lasers<br />
hundreds wounded.<br />
to “sniff” explosives from a distance.<br />
Can we stop attacks like this?<br />
The lab says it can scan spaces like<br />
Airport security focuses on keeping check-in areas from 100 metres<br />
explosives off planes. Stopping<br />
away by sweeping them with<br />
bombs detonating in crowded<br />
lasers tuned to frequencies that<br />
check-in areas and transit terminals vaporise molecules found in<br />
is a bigger challenge. Security<br />
bombs. This material makes a tiny<br />
checkpoints work, but they cause sound as it vaporises, which is<br />
delays and create queues that can amplified and detected.<br />
also be a target. But there are new<br />
Lasers are also used in a device<br />
ways to scan people as they walk. called G-Scan, developed by Laser<br />
Cameron Ritchie, head of<br />
Detect Systems of Ramat Gan in Israel.<br />
technology at the US-based security This fires a green laser at a target then<br />
firm Morpho, is working on a “tunnel uses Raman spectroscopy to<br />
of truth”. Passengers would be<br />
“fingerprint” the molecules that<br />
scatter light back. It can identify<br />
anything visible, including bottle<br />
contents or surface smears.<br />
Detecting explosive material from<br />
a distance would enable security<br />
services to track down bomb-making<br />
supplies – not just finished weapons.<br />
By scanning for telltale chemicals on<br />
people’s bodies and clothes as they<br />
move around cities, security services<br />
may be able to catch suspects before<br />
they have built their device.<br />
One concern is that such sensitive<br />
detectors may trigger many false<br />
alarms. There is also the question<br />
of whether airport and train security<br />
staff can respond to a positive signal<br />
quickly and effectively enough to<br />
neutralise a threat, says Brian<br />
Jenkins, a security researcher at the<br />
Rand Corporation. “You can’t just yell,<br />
‘hey you with the bomb’.”<br />
Harvard-Smithsonian Center for<br />
Astrophysics. He says it might be<br />
possible to talk to Hitomi and<br />
stop it tumbling. “But if you told<br />
me we were never going to hear<br />
from the sat again, I would be<br />
devastated but not surprised,”<br />
he says.<br />
Hitomi’s mission is to<br />
observe the universe in X-rays,<br />
investigating matters such as<br />
the birth of black holes and the<br />
origins of cosmic rays.<br />
Space geckos<br />
IN A few years, the exterior of the<br />
International Space Station could<br />
be crawling with geckos. It’s not<br />
an alien invasion, or the plot of a<br />
low-budget sci-fi movie. The<br />
robotic geckos could follow from<br />
an experiment NASA launched to<br />
the International Space Station<br />
last week aboard an uncrewed<br />
Cygnus spacecraft.<br />
The Gecko Gripper devices use<br />
tiny artificial hairs that replicate<br />
the ones geckos use to climb walls.<br />
They are designed to help<br />
4 | NewScientist | 2 April 2016
For new stories every day, visit newscientist.com/news<br />
60 SECONDS<br />
astronauts keep track of objects in<br />
zero gravity, and enable robots to<br />
crawl around a spacecraft to<br />
inspect and repair it.<br />
The bots have already been<br />
tested on parabolic aircraft flights,<br />
where they grabbed and<br />
manipulated 10-kilogram and<br />
100-kg objects during 20-second<br />
periods of microgravity. On the<br />
ISS trip, astronauts will test the<br />
system by attaching five devices<br />
in a range of sizes to 30 surfaces<br />
inside the space station at<br />
different angles, to check how well<br />
they grip. The devices will be left<br />
in place for periods of time<br />
between two weeks and a year.<br />
HIV prevention<br />
COLIN MONTEATH/HEDGEHOG HOUSE/MINDEN<br />
Zika’s arrival traced<br />
ONE person carried the Zika virus<br />
to the Americas a full two years<br />
before its detection there last year.<br />
Brazil was the first country in<br />
the Americas to report Zika, in<br />
May 2015, and the virus has since<br />
infected hundreds of thousands<br />
of people in 33 countries. The<br />
virus is native to Africa but in the<br />
last 10 years it jumped to some of<br />
the islands of Micronesia and<br />
Polynesia in the Pacific.<br />
A genetic analysis suggests the<br />
virus in the Americas came from<br />
an individual infected in<br />
Polynesia, and that it arrived<br />
IT SAVES money and prolongs A MASSIVE rise in sea level is coming,<br />
lives, but who should pay – the UK and it will trigger climate chaos<br />
health service or local councils? around the world. That was the<br />
Trials around the world have message from a controversial recent<br />
shown that Truvada, an antiviral paper by climate scientist James<br />
drug, helps prevent uninfected, Hansen. It was slated by many for<br />
at-risk people from getting HIV. assuming – rather than showing –<br />
After 18 months of negotiations, that sea level could rise by between<br />
it looked certain that NHS England 1 and 5 metres by 2100.<br />
would foot the bill if Truvada was But now, just a week after being<br />
rolled out across England. Instead, formally published, it is being backed<br />
on 21 March NHS England<br />
up by another study. “He was<br />
announced it would mount a<br />
speculating on massive fresh water<br />
two-year, £2 million pilot study of discharge to the ocean that I don’t<br />
500 men at high risk of infection think anybody thought was possible<br />
to assess the efficacy and cost.<br />
before,” says Rob DeConto of the<br />
NHS England also backed away University of Massachusettsfrom<br />
funding the drug, saying Amherst. “Now we’re about to<br />
that the bill should be met by local publish a paper that says these rates<br />
authorities, which provide other of fresh water input are possible.”<br />
HIV services.<br />
“After 18 months, it’s galling to<br />
be told that,” says Sarah Radcliffe<br />
at the National AIDS Trust charity.<br />
She says there is abundant<br />
evidence that Truvada is effective<br />
and cuts healthcare costs.<br />
Teresa O’Neill of London<br />
Councils says the capital has the<br />
country’s highest rates of HIV so<br />
councils there would face a high<br />
bill. She points out that it costs<br />
£380,000 to treat an HIV-positive<br />
person for life, versus £4700 to<br />
supply Truvada for a year, so you’d<br />
have to take the drug for 80 years<br />
before it became more expensive. –Still there… for now–<br />
between May and December 2013.<br />
“One person with the infection<br />
was bitten by a mosquito and that<br />
chain of infection persisted,” says<br />
Oliver Pybus of the University of<br />
Oxford (Science, doi.org/bdrx).<br />
It isn’t surprising it took two<br />
“Zika in the Americas came<br />
from an individual infected<br />
in Polynesia, and it arrived<br />
in the second half of 2013”<br />
years for Zika’s presence to come<br />
to light. Its symptoms closely<br />
resemble those of dengue and<br />
chikungunya viruses, which were<br />
already circulating.<br />
Catastrophic Antarctic melting<br />
DeConto’s model includes factors<br />
that previous studies omitted. First,<br />
floating ice shelves around Antarctica<br />
will soon be exposed to above-zero<br />
summer air temperatures, speeding<br />
their melt, he says. Second, once the<br />
shelves are gone, the huge ice cliffs<br />
that remain will begin to collapse<br />
(Nature, DOI: 10.1038/nature17145).<br />
DeConto’s findings suggest that<br />
even if countries meet the pledges<br />
made as part of the Paris agreement,<br />
global sea level could still rise 1 metre<br />
by 2100. If emissions keep climbing it<br />
could go up more than 2 metres.<br />
“Today we’re measuring global sea<br />
level rise in millimetres per year,”<br />
DeConto says. “We’re talking about<br />
the potential for centimetres per year<br />
just from Antarctica.”<br />
Bleach bum<br />
It’s a white-out for the Great Barrier<br />
Reef. An aerial survey last week<br />
showed that at least 95 per cent of<br />
the reef’s northern 1000 kilometres<br />
has been severely bleached. It’s the<br />
worst case in history, says the<br />
National Coral Bleaching Taskforce,<br />
which carried out the survey.<br />
Bleaching is caused by high sea<br />
temperatures and can kill coral.<br />
Apple vs FBI<br />
The stand-off is over, for now. The<br />
FBI has successfully broken into the<br />
iPhone belonging to San Bernardino<br />
gunman Syed Rizwan Farook,<br />
bringing to a halt its legal battle with<br />
Apple. In court documents filed on<br />
Monday, the FBI said it no longer<br />
required Apple’s assistance to access<br />
files on the phone, although it hasn’t<br />
made public how it did it.<br />
Stroke protection<br />
Giving mice antibiotics can protect<br />
them from brain damage caused by<br />
stroke. Antibiotics change the makeup<br />
of the mice’s gut bacteria, which<br />
in turn alters the immune cells<br />
that travel to the brain and would<br />
normally cause inflammation. The<br />
treatment appears to reduce cell<br />
destruction by around 60 per cent<br />
(Nature Medicine, doi.org/bdrw).<br />
Green boom<br />
More than twice as much was<br />
spent on new capacity to generate<br />
electricity from renewables like<br />
solar and wind than on power<br />
stations that burn fossil fuels last<br />
year. China was responsible for twothirds<br />
of the renewables investment<br />
in the developing world, and 36 per<br />
cent of the global total.<br />
Permafrost pups<br />
Two puppies that lived 12,460 years<br />
ago have been discovered perfectly<br />
preserved in permafrost in the<br />
northern Russian region of Yakutia.<br />
Last week, one of them underwent<br />
an autopsy so that its organs can be<br />
compared with those of modern<br />
dogs and wolves.<br />
2 April 2016 | NewScientist | 5
THIS WEEK<br />
Smallest ever genome comes to life<br />
Humans built it, but we don’t know what a third of its genes actually do<br />
Andy Coghlan<br />
WE HAVE even further to<br />
go to understand life than we<br />
thought. In creating the latest<br />
landmark synthetic organism –<br />
the world’s first minimal<br />
genome – Craig Venter and his<br />
team have discovered that we<br />
don’t know the functions of<br />
almost a third of the genes<br />
that are vital for life.<br />
“Finding so many genes without<br />
a known function is unsettling,<br />
but it’s exciting because it’s left<br />
us with much still to learn,” says<br />
Alistair Elfick, a bioengineer at the<br />
University of Edinburgh, UK. “It’s<br />
like the ‘dark matter’ of biology.”<br />
Venter, founder of the J. Craig<br />
Venter Institute in La Jolla,<br />
California, has long hoped to<br />
unravel life’s essential toolkit.<br />
Now his team has created the<br />
first minimal genome – the tiniest<br />
possible stash of DNA capable of<br />
supporting life. With 473 genes,<br />
the new cell, JCVI-syn3.0, has at<br />
least 50 fewer genes than nature’s<br />
record-holder for the shortest<br />
genome in a self-sustaining living<br />
organism, Mycoplasma genitalium<br />
(Science, doi.org/bdrz).<br />
The feat builds on JCVI-syn1.0,<br />
LIFE FROM SCRATCH? NOT YET<br />
The design of the first synthetic<br />
minimal genome hints at new ways<br />
to build life. So can we do this from<br />
scratch? Not quite.<br />
For a start, the genome is<br />
based on a slimline version of<br />
one from a naturally occurring<br />
bacterium. The genes were not<br />
dreamed up by people, but<br />
had already evolved in nature.<br />
Also, to make the minimal genome,<br />
researchers didn’t create any new<br />
genes or biological functions,<br />
but simply dumped those not<br />
TOM DEERINCK & MARK ELLISMAN/NCMIR/UNIVERSITY OF CALIFORNIA AT SAN DIEGO<br />
the first living bacterium reliant<br />
on a synthetic copy of an existing<br />
genome, unveiled by Venter in<br />
2010. That genome was designed<br />
in a computer, before assembly<br />
and insertion into cells.<br />
Since then, Venter and his<br />
colleagues, co-led by Clyde<br />
Hutchison, have been whittling<br />
essential for keeping the cell alive.<br />
Then there was the cell itself.<br />
Once the genome was designed<br />
from code on a computer, it had to<br />
be put inside a living cell stripped of<br />
its own, native genome. That cell also<br />
came from a living natural bacterium<br />
that had all the intricate cellular<br />
machinery already in place. And the<br />
process revealed we have no clue<br />
what a third of those vital genes do.<br />
So the ability to create life from<br />
scratch without nature’s help is still<br />
way beyond our capabilities.<br />
–Minimalist life–<br />
down the 901 genes of JCVIsyn1.0<br />
to the minimum for<br />
supporting life. With the help<br />
of transposons –“jumping<br />
genes” that insert themselves<br />
into sections of DNA and disrupt<br />
individual genes – the team<br />
tested which genes a bacterium<br />
can do without. They then<br />
designed a stripped-down<br />
genome, and inserted it into<br />
an existing cell that had had<br />
its own genome removed.<br />
But their first attempts at a<br />
minimalist cell didn’t succeed.<br />
“Every one of our designs failed<br />
because we based these on our<br />
existing knowledge base,”<br />
says Venter.<br />
Their breakthrough came when<br />
they realised that some genes<br />
they thought were expendable<br />
were actually crucial. “To get a<br />
viable cell, the researchers needed<br />
to make discoveries about many<br />
essential and semi-essential genes<br />
that we did not know about,” says<br />
Steven Benner of the Foundation<br />
for Applied Molecular Evolution<br />
in Alachua, Florida.<br />
Surprisingly, some 31 per cent<br />
of the vital genes have no known<br />
function, suggesting we may<br />
still have much to learn about<br />
the cellular processes crucial<br />
to maintaining life. “It means<br />
we know about two-thirds of<br />
essential biology,” says Venter.<br />
Hutchison says it is an “exciting<br />
possibility” that some of these<br />
genes perform key functions<br />
we don’t know of yet.<br />
It’s unclear how genes of<br />
such universal importance<br />
have ducked under the radar for<br />
so long. One possibility is that<br />
the mystery genes do actually<br />
code for known functions, but<br />
their sequences are so different<br />
from their equivalents in other<br />
organisms that we have not been<br />
able to spot and identify them.<br />
Once these mysterious extra<br />
genes were included, the minimal<br />
cells were found to live, grow and<br />
divide, forming clumps of cells in<br />
a dish of nutrients.<br />
Bacterial Eden<br />
Of the genes with known<br />
functions, most make proteins<br />
vital for survival, or check the<br />
fidelity of genome duplication<br />
when the cell divides. Other<br />
essential genes include ones<br />
that code for cell-membrane<br />
proteins and those that enable<br />
the organism to turn nutrients<br />
into energy.<br />
But Venter’s organism was<br />
produced in a bacterial Eden<br />
with every comfort provided,<br />
including a plentiful energy<br />
supply of easy-to-process glucose.<br />
In a harsher environment, such<br />
as soil or water, it would need<br />
extra genes to compete with rivals<br />
for resources, and to survive and<br />
6 | NewScientist | 2 April 2016
In this section<br />
■ Did a cosmic cloud kill the dinosaurs?, page 8<br />
■ The twins who felt fear for the first time, page 9<br />
■ Get immersed as first virtual reality games go on sale, page 18<br />
grow using scarcer sources of<br />
nutrients. “It is likely that their<br />
degree of ‘essential-ness’ will be<br />
environment-specific,”says Elfick.<br />
Next, the team plans to<br />
work out the functions of the<br />
mystery genes. What they find<br />
out could yield insights into<br />
how genes can be repurposed for<br />
synthetic biology, or enable us<br />
to design entirely new genomes<br />
for the first time (see “Life from<br />
scratch?”, below left).<br />
“What we’ve done is important<br />
because it is a step towards<br />
“Finding so many genes<br />
without a known function<br />
is exciting. It’s like the ‘dark<br />
matter’ of biology”<br />
completely understanding how a<br />
living cell works,” says Hutchison.<br />
“If we can really understand this,<br />
then we will be able to design cells<br />
efficiently for the production<br />
of pharmaceutical and other<br />
useful products.”<br />
Bioengineers have applauded<br />
the feat, but some are sceptical<br />
about the commercial potential.<br />
Some believe it is cheaper and<br />
more effective to tweak existing<br />
natural genomes, using<br />
techniques such as gene editing,<br />
than it is to build new genomes<br />
from the bottom up. “It’s a<br />
milestone,” says George Church<br />
of Harvard Medical School,<br />
who is a pioneer of CRISPR gene<br />
editing. “But the market will tell<br />
youifit’svaluable.”<br />
Such efforts to design synthetic<br />
life forms are often referred to<br />
as playing God, and frequently<br />
raise fears about their possible<br />
impact on the environment and<br />
human health. “If we’re already<br />
playing God, we’re not doing a<br />
particularly good job of it,” Elfick<br />
says. “Simply streamlining what’s<br />
already in nature doesn’t seem<br />
very God-like and, if anything, is<br />
a very humbling exercise.”<br />
He says we should not worry<br />
about this synthetic cell: “There<br />
are plenty of bugs already out<br />
there we should be much more<br />
worried about.” ■<br />
FEDERICO DE LUCA<br />
ONE MINUTE INTERVIEW<br />
Tiny but mighty<br />
A bacterium that can thrive with the smallest feasible string of<br />
synthetic genes is no vanity project, says Richard Kitney<br />
PROFILE<br />
Richard Kitney is a professor of biomedical<br />
systems engineering at Imperial College London,<br />
and co-director of the Centre for Synthetic<br />
Biology and Innovation. He was not involved<br />
in Craig Venter’s research<br />
What is the main advance with the creation of<br />
the smallest synthetic genome, JCVI-syn3.0?<br />
What Craig Venter’s team has done in making this<br />
minimal genome is to identify clear gaps in our<br />
knowledge about what makes a cell survive. They<br />
have essentially removed sections of the genome<br />
one by one to see what happens – in other words,<br />
to see if it dies and to try and understand why.<br />
What new insights has the bacterium given<br />
about life’s minimum requirements?<br />
The failure of a predecessor organism with even<br />
fewer genes led to the refinement of the rules for<br />
designing a genome, and identified a group of<br />
indispensable genes with functions we now need<br />
to investigate.<br />
What do you make of the fact that almost a<br />
third of the genes in syn3.0 have no known<br />
function, yet seem essential to life? What might<br />
they be doing?<br />
This is partially because of the incomplete state of<br />
knowledge within the field. As Venter’s team also<br />
points out, the tools used to match genes in syn3.0’s<br />
genome to comparable ones with known functions<br />
in other organisms may have failed to identify<br />
some genes because their sequences differ too<br />
much. It is of course an intriguing question as to<br />
what any unidentified genes do.<br />
Does the fact that Venter borrowed the<br />
“shell” of a different organism as a host and<br />
provided a perfect environment for growth<br />
detract from his achievement?<br />
Borrowing the shell of a naturally occurring<br />
bacterium is of course a major simplification of the<br />
technical challenge of making a synthetic organism.<br />
But it did allow the team to concentrate on the<br />
problem of genome minimisation–averylarge<br />
endeavour on its own. Because the researchers<br />
chose a rich growth medium, they could snip out<br />
many functions from the original host, as these<br />
are not needed when food is plentiful. What all<br />
this highlights is that there is in fact no universal<br />
minimal cell, only a minimal cell for a given set<br />
of conditions.<br />
Does the work offer clues about how<br />
life began?<br />
No, it tells us nothing about how life started<br />
naturally.<br />
There has been criticism that such work is<br />
a vanity project with no real scientific worth.<br />
Do you agree?<br />
Venter and his colleagues are serious researchers<br />
who are pursuing an important goal, so this is<br />
absolutely not a vanity project. It is an important<br />
step towards meeting synthetic biology’s need<br />
for stable, well-understood host cells that make<br />
and do useful things for us.<br />
Does it take us closer towards creating<br />
living organisms from scratch?<br />
This is not really a step forward in that sense.<br />
And where will the work go next?<br />
What is clear is that the host genome as<br />
presented has quite a way to go in terms of<br />
extending the catalogue of usable organisms<br />
available for synthetic biology.<br />
Interview by Andy Coghlan<br />
2 April 2016 | NewScientist | 7
THIS WEEK<br />
LYNN HILTON/ALAMY STOCK PHOTO<br />
Did a cosmic cloud<br />
kill off the dinos?<br />
Shannon Hall<br />
A NEBULAR winter could have<br />
doomed the dinosaurs. The clue is<br />
a thick layer of an extraterrestrial<br />
element on the ocean floor, now<br />
claimed to be the result of Earth<br />
colliding with a galactic cloud.<br />
The most-heard explanation<br />
for the dinosaurs’ demise is an<br />
asteroid impact, which left a<br />
crater off the coast of Mexico and<br />
a worldwide 30-centimetre-thick<br />
layer of iridium, an element<br />
otherwise rare on Earth.<br />
But every so often, astronomers<br />
suspect, the solar system ploughs<br />
into a giant nebula of molecular<br />
gas and dust much denser than<br />
typical interstellar space. The<br />
resulting galactic fog would have<br />
darkened skies and cooled the<br />
ground until a harsh winter set<br />
in. It would also have destroyed<br />
the ozone layer and halted<br />
photosynthesis.<br />
Now Tokuhiro Nimura of the<br />
Japan Spaceguard Association in<br />
Ibara and colleagues claim such<br />
a collision could have ended the<br />
dinosaurs’150-million-year reign.<br />
At a site in the Pacific Ocean, the<br />
team found an iridium-rich<br />
sediment layer 5 metres thick,<br />
too thick for a sudden event like<br />
an asteroid strike to account for it.<br />
They argue that a collision with<br />
a giant molecular cloud – which<br />
could take Earth at least a million<br />
years to pass through, picking<br />
up iridium steadily as it does so –<br />
fits the discovery much better.<br />
“Such an encounter and related<br />
perturbation in global climate [is]<br />
a more plausible explanation for<br />
the mass extinction than a single<br />
impact event,” they write (arxiv.<br />
org/abs/1603.06136).<br />
Adrian Melott at the University<br />
–No escaping this winter–<br />
of Kansas in Lawrence says the<br />
idea is wacky but not impossible.<br />
“We know that these clouds exist,”<br />
he says. “We know that we’re likely<br />
to run into one sooner or later.<br />
And they have some evidence<br />
from the ocean floor in favour of<br />
their idea.”<br />
Others question that evidence.<br />
David Kring at the Lunar and<br />
Planetary Institute in Houston,<br />
Texas, argues that the deposit<br />
could have been disturbed by<br />
currents, organisms and drilling,<br />
broadening the layer locally.<br />
“There have been several<br />
studies specifically designed to<br />
determine the thickness of the<br />
iridium anomaly,” he says. “They<br />
all indicate the anomaly is sharp,<br />
not broad,” which would favour<br />
the impact hypothesis.<br />
Even so, a collision with a cloud<br />
could have dislodged rocks from<br />
the fringes of the solar system and<br />
sent them hurtling toward Earth –<br />
perhaps explaining the crater and<br />
leaving a thin iridium layer intact.<br />
We could test this idea by<br />
searching the ocean floor for<br />
radioactive elements likely to<br />
be replenished from space, like<br />
uranium and plutonium, says<br />
Alexander Pavlov at NASA’s<br />
Goddard Space Flight Center in<br />
Maryland. Most uranium isotopes<br />
aren’t even found in the solar<br />
system, so finding them along<br />
with iridium would prove that<br />
something interstellar, like a vast<br />
nebula, was the true culprit. ■<br />
Asteroid shower<br />
brought a sea to<br />
young, dry Mars<br />
MARS may once have had an ocean –<br />
but only for a geological eye blink.<br />
This puts a dampener on ideas that<br />
there is or was life on the Red Planet.<br />
That’s according to a theory from<br />
Tim Parker of NASA’s Jet Propulsion<br />
Laboratory in Pasadena, California.<br />
Speaking at the Lunar and Planetary<br />
Science Conference in The Woodlands,<br />
Texas, in March, he argued that a<br />
sustained barrage of asteroids hitting<br />
the young Mars could have delivered<br />
short-lived water to the surface.<br />
Signs that Mars was once rife with<br />
water litter the surface. These include<br />
polygonal cracks seen by NASA’s<br />
Opportunity rover. On Earth, these<br />
require evaporation to form, so Parker<br />
sees them as an indication that the<br />
rover is traversing what was once the<br />
edge of an ocean. “The uniformity of<br />
the surface is much easier to explain<br />
in a shallow marine setting,” he says.<br />
But models of the ancient Mars<br />
climate require a thicker atmosphere<br />
to keep water liquid on the surface.<br />
This atmosphere must have somehow<br />
been rapidly lost to leave Mars as dry<br />
as we see it today.<br />
Now Parker and his colleagues say a<br />
tumultuous time in the solar system’s<br />
history known as the late heavy<br />
bombardment could provide the water<br />
with no need for a major change in the<br />
atmosphere. During this period about<br />
4 billion years ago, a barrage of<br />
asteroids is thought to have collided<br />
“This ocean would have<br />
frozen and disappeared –<br />
leavingverylittletimefor<br />
life to evolve”<br />
with the inner planets. Such asteroids<br />
could have brought water to an<br />
initially dry Mars, says Parker.<br />
Because Mars’s atmosphere<br />
was so thin, this ocean would have<br />
frozen and disappeared after just a<br />
few hundred million years – allowing<br />
very little time for life to evolve.<br />
“Tim is always thinking outside<br />
of the box,” says Devon Burr of the<br />
University of Tennessee, Knoxville.<br />
“There are a variety of ways of<br />
warming Mars and getting liquid<br />
water, I don’t know if the late heavy<br />
bombardment, for me, is conclusive.”<br />
Jacob Aron ■<br />
8 | NewScientist | 2 April 2016
For daily news stories, visit newscientist.com/news<br />
JOHN HOOGLAND<br />
Prairie dogs are<br />
serial killers of<br />
ground squirrel<br />
IT WAS thought to be just a small,<br />
furry grass-nibbler, but the whitetailed<br />
prairie dog has another life – as<br />
a serial killer. Some prairie dogs bite<br />
their ground squirrel neighbours to<br />
death on a regular basis, the first time<br />
that a mammalian herbivore has been<br />
seen killing other herbivores.<br />
What’s more, those who kill go on<br />
to produce more surviving offspring,<br />
improving their evolutionary fitness,<br />
say John Hoogland, a biologist at the<br />
University of Maryland Center for<br />
Environmental Science, and Charles<br />
Brown of the University of Tulsa,<br />
Oklahoma. The duo recorded<br />
163 killings of the squirrels over<br />
six years in the Arapaho National<br />
Wildlife Refuge in Colorado.<br />
Hoogland describes the killings<br />
as quick, subtle and unanticipated.<br />
While some prairie dogs chased the<br />
squirrels, others stalked them, waited<br />
outside their burrows or even dug<br />
babies out of their holes. They bit<br />
them to death, then abandoned<br />
the carcass and resumed foraging<br />
on nearby vegetation. “The killer<br />
supreme killed seven babies from the<br />
same litter in one day,” says Hoogland.<br />
Over the six years, about 47 prairie<br />
dogs killed squirrels, and 19 of<br />
them were serial slayers, including<br />
one female who dispatched nine<br />
squirrels over four years (Proceedings<br />
of the Royal Society B, doi.org/bdpv).<br />
For squirrels a competitor species<br />
can be as much of a risk as a predator.<br />
Aisling Irwin ■<br />
–Not going to eat that...–<br />
BRAND NEW IMAGES/GETTY<br />
‘Fearless’ twins show<br />
body affects emotions<br />
IS FEAR all in the mind – or body?<br />
Experiments on twins who can’t<br />
feel fear are suggesting that some<br />
emotions rely on us becoming<br />
aware of changes to our body.<br />
Many studies have shown that<br />
the amygdalae, two almondshaped<br />
structures in our brain,<br />
are crucial for feeling fear. People<br />
who have lost them through<br />
injury or disease also lose the<br />
ability to feel most kinds of fear.<br />
In 2013, Justin Feinstein, then<br />
at the University of Iowa in Iowa<br />
City, and his colleagues managed<br />
to scare three“fearless”people –<br />
two female identical twins and<br />
a woman known as S. M., all of<br />
whom had had their amygdalae<br />
destroyed by illness. Feinstein<br />
made them inhale carbon dioxide,<br />
giving them the sensation of<br />
choking. This was the first time<br />
that S. M. had experienced fear<br />
since she was a child. It showed<br />
that the amygdalae are not<br />
essential for all kinds of fear.<br />
One theory of emotion suggests<br />
that feelings are not generated<br />
directly by the brain, but through<br />
an awareness of our body. When<br />
–In tune with their body state–<br />
we see a spider, for example,<br />
the theory says we feel fear not<br />
because emotional centres of<br />
the brain are activated, but<br />
because the brain evaluates the<br />
situation and releases hormones<br />
such as adrenaline that increase<br />
“This seems to be evidence<br />
that extreme panic has<br />
different circuitry from<br />
normal fear”<br />
our heart rate and give us sweaty<br />
palms. It is our awareness of<br />
these changes to our body that<br />
we interpret as fear.<br />
Now Feinstein’s colleague<br />
Sahib Khalsa, at the University<br />
of Tulsa, Oklahoma, and his team<br />
have given the fearless twins a<br />
drug that mimics the action of<br />
adrenaline. High levels of this<br />
drug can cause temporary<br />
breathing difficulties and rapid<br />
heart palpitations. The team<br />
asked the twins and a group of<br />
volunteers with intact amygdalae<br />
to rate their experience of these<br />
changes on a scale from 0 to 10.<br />
Both twins had the same<br />
physical reaction as the other<br />
volunteers – their heart and<br />
breathing rates increased. But<br />
only one twin said she was aware<br />
of both these changes, rating her<br />
breathing problems as a 10 on the<br />
scale. She also reported a choking<br />
sensation and had a panic attack.<br />
The volunteers also noted<br />
breathing difficulties and a<br />
quarter had panic attacks.<br />
The other twin noted a slight<br />
awareness of her heart rate<br />
changing, but she rated her<br />
physical symptoms as close<br />
to zero and did not panic.<br />
The results indicate that<br />
there are mechanisms beyond<br />
the amygdalae that are involved<br />
in fear and anxiety, and support<br />
the theory that an awareness of<br />
physiological changes may be<br />
necessary to experience some<br />
kinds of emotion (The Journal<br />
of Neuroscience, doi.org/bdpz).<br />
However, the fact that the<br />
twins – who both have damaged<br />
amygdalae because of a rare<br />
genetic condition – had different<br />
responses suggests there may be<br />
environmental factors at play, too.<br />
“This seems to be more evidence<br />
that extreme panic has its own<br />
underlying circuitry that is<br />
different from normal fear,”<br />
says Nick Medford, who studies<br />
consciousness and emotion at the<br />
Sackler Centre for Consciousness<br />
Science in Brighton, UK.<br />
Further experiments involving<br />
scanning the twins’ brains while<br />
they experience fear would help<br />
us identify mechanisms of<br />
emotion in the brain, says Khalsa.<br />
Such studies could also lead to<br />
alternative treatments for anxiety<br />
disorders. There is some evidence<br />
to suggest that people who have<br />
abnormal awareness of their<br />
bodily functions are more prone<br />
to anxiety and depression.<br />
“If you could pinpoint neural<br />
regions responsible for our<br />
awareness of our body state and<br />
the different mechanisms that<br />
generate fearful feelings, you<br />
might have new targets to<br />
modulate or reduce anxiety,”<br />
says Khalsa. Helen Thomson ■<br />
2 April 2016 | NewScientist | 9
THIS WEEK<br />
Emissions reveal<br />
a constructive side<br />
Richard Schiffman<br />
TAKING carbon dioxide out of the<br />
atmosphere is crucial to slowing<br />
the progress of climate change.<br />
But rather than lock all that CO 2<br />
away underground, what if we<br />
could use it to make things?<br />
That’s the aim of a pilot plant<br />
at the University of Newcastle<br />
near Sydney, Australia.<br />
Launched last week, the plant<br />
will test the commercial potential<br />
of mineral carbonation, a process<br />
that forms stable materials by<br />
chemically binding CO 2<br />
to<br />
minerals containing calcium or<br />
magnesium. The plant will bind<br />
the gas into crushed serpentinite<br />
rocks to create magnesium<br />
carbonate, which can be used to<br />
produce cement, paving stones<br />
and plasterboard.<br />
It could be a way of<br />
“permanently and safely<br />
disposing of CO 2<br />
and making<br />
useful products in the process”,<br />
says Klaus Lackner of Arizona<br />
State University in Tempe,<br />
who pioneered the technique<br />
in the lab.<br />
The process happens naturally<br />
when rocks are gradually<br />
MINERAL CARBONATION INTERNATIONAL<br />
weathered by exposure to CO 2<br />
in the air. This helped cut the<br />
proportion of the gas in the<br />
ancient atmosphere to levels<br />
low enough for life to flourish,<br />
says Geoff Brent, senior<br />
scientist at Orica, an explosives<br />
– Made with greenhouse gases–<br />
manufacturer based in Melbourne.<br />
His firm is supplying the plant<br />
with CO 2<br />
– a by-product of making<br />
ammonium nitrate.<br />
But we can’t afford to wait<br />
millions of years for geology<br />
to rid the atmosphere of our<br />
greenhouse emissions. “It’s about<br />
turning the natural process into<br />
a large-scale industrial process<br />
on our required timescale – which<br />
is extremely urgent,” says Brent.<br />
There are several challenges.<br />
Mining for serpentinite is energyintensive<br />
and damaging to the<br />
environment, for one thing.<br />
But Brent says the rock is one of<br />
the most common on Earth, and<br />
that carbonation plants could<br />
be built near mining areas to<br />
reduce transport emissions.<br />
Another objection is that<br />
mineral carbonation costs too<br />
much compared with storing<br />
CO 2<br />
underground. However,<br />
underground storage has its own<br />
problems: suitable repositories<br />
are hard to find and there is a risk<br />
that the gas may one day escape.<br />
“Carbonation is more secure in<br />
the long term, because there is no<br />
danger of leakage and no need to<br />
maintain long gas pipelines and<br />
transportation infrastructure to<br />
move the CO 2<br />
, since we will be<br />
obtaining it on-site,” says Brent.<br />
“The whole point of the<br />
project is to get the price down<br />
low enough,” says Marcus Dawe,<br />
CEO of Mineral Carbonation<br />
International, the firm<br />
coordinating the effort. “It is<br />
all about how we can make<br />
this economical.”<br />
Dawe and his team are<br />
optimistic that they will make<br />
progress by the end of the 18-<br />
month pilot project. But for<br />
mineral carbonation to take off,<br />
there will need to be a higher<br />
price on carbon, says Dawe,<br />
because right now “nothing is<br />
more economical than putting<br />
CO 2<br />
in the air”. ■<br />
Is calcium boost<br />
behind brain<br />
zap effects?<br />
WE MAY finally be figuring out how<br />
an increasingly popular therapy that<br />
uses electricity to boost the brain’s<br />
functioning has its effects – by<br />
pushing up levels of calcium in cells.<br />
Transcranial direct current<br />
stimulation (tDCS) has been linked to<br />
effects such as accelerated learning<br />
and improving the symptoms of<br />
depression. It involves using<br />
electrodes to send a weak current<br />
across the brain, which proponents<br />
think changes the electrical<br />
properties of neurons, leading<br />
to changes in their connectivity.<br />
But the cellular mechanisms that<br />
lead to such broad neurological<br />
changes are not clear and some are<br />
doubtful that tDCS has any effect on<br />
the brain. Despite this, devices are<br />
being developed to sell to people<br />
keen to influence their own brains.<br />
Now Hajime Hirase at the RIKEN<br />
Brain Science Institute in Tokyo,<br />
Japan, and his colleagues have an<br />
answer. They have identified sudden<br />
surges in calcium flow in the brains of<br />
mice seconds after they receive low<br />
doses of tDCS. The surges start in<br />
star-shaped cells called astrocytes<br />
that strengthen connections between<br />
neurons and regulate the electrical<br />
signals that pass between them.<br />
The team used mice that had been<br />
engineered to show depression-like<br />
symptoms, such as struggling less<br />
against restraints. After they had<br />
received tDCS, the mice struggled<br />
for longer. The same effect didn’t<br />
happen in mice whose calcium<br />
“By triggering calcium<br />
surges, tDCS may<br />
be interfering with<br />
neuron connectivity”<br />
signalling had been disabled (Nature<br />
Communications, doi.org/bdr2).<br />
Astrocytes use calcium to manage<br />
the flow of information between<br />
neurons, and these findings suggest<br />
that tDCS artificially boosts the<br />
process. Hirase thinks calcium<br />
signalling may also be behind other<br />
suggested effects of tDCS, such as<br />
improved memory.<br />
Understanding the link between<br />
tDCS and calcium could dispel doubts<br />
about the technique. “Scepticism is<br />
not so much about tDCS itself as it is<br />
about inflated expectations,” says<br />
Walter Paulus of the University of<br />
Göttingen in Germany. Sally Adee ■<br />
10 | NewScientist | 2 April 2016
F<br />
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CYRUS CORNUT/DOLCE VITA/PICTURETANK
THIS WEEK<br />
NASA/JPL-CALTECH/UCLA/MPS/DLR/IDA/PSI/LPI<br />
Bright spots and<br />
ice dazzle on Ceres<br />
Jacob Aron, The Woodlands, Texas<br />
LET’S take a look inside. The latest<br />
from NASA’s Dawn probe, which<br />
has been in orbit around the dwarf<br />
planet Ceres since April last year,<br />
suggests this tiny world has water<br />
ice on the surface and craters that<br />
provide a window on its interior.<br />
A spectacular view of the<br />
beguiling bright spots at the heart<br />
of the 92-kilometre-wide Occator<br />
crater from just 375 kilometres up,<br />
shown above, was just one of the<br />
latest findings unveiled by the<br />
mission team at the Lunar and<br />
Planetary Science Conference<br />
in The Woodlands, Texas, on<br />
22 March.<br />
These spots have perplexed<br />
researchers since Dawn first<br />
reached Ceres, the largest object<br />
in the asteroid belt. Probing their<br />
nature could give clues to Ceres’s<br />
interior. In the new image, Dawn<br />
has seen colour variations across<br />
the surface of the bright regions.<br />
These wouldn’t be visible to the<br />
human eye, but reflect possible<br />
differences in the composition<br />
of the material seen by Dawn.<br />
This close-in view reveals that<br />
the central bright spot actually<br />
sits within a 10-kilometre-wide<br />
depression inside the crater.<br />
At the centre of that is a small<br />
mound. “We’re starting to see<br />
how complex the distribution of<br />
the bright material is,” said Carol<br />
Raymond of NASA’s Jet Propulsion<br />
Laboratory in California.<br />
How this arrangement formed<br />
is still a mystery. Timothy Bowling<br />
at the University of Chicago<br />
presented a possible explanation,<br />
“Seeing water ice anywhere<br />
on Ceres is a surprise – it<br />
is warm enough at the<br />
surface for it to evaporate”<br />
in which a meteorite smacked<br />
into Ceres, exposing icy material<br />
from as much as 40 kilometres<br />
below the surface and heating it up.<br />
As this material settled into the<br />
Occator crater we see today, the<br />
water would evaporate, leaving<br />
bright salt and minerals behind.<br />
The floor of Occator is also<br />
riddled with fractures that<br />
seem to be older than the crater<br />
itself. These could have provided<br />
an escape route for material<br />
How to stack<br />
oranges in 24<br />
dimensions<br />
IT’S a tight squeeze. Mathematicians<br />
have proved that they know the<br />
best way to pack spheres in eight<br />
and 24 dimensions – the first time<br />
this problem has been solved in a<br />
new dimension for almost 20 years.<br />
“I think they’re fantastic results. I’m<br />
excited that this has been done at last,”<br />
says Thomas Hales at the University<br />
of Pittsburgh, Pennsylvania.<br />
The sphere-packing problem asks<br />
a deceptively simple question: what<br />
–Beguiling brightness– arrangement crams the most spheres<br />
into a limited volume? It is easy to<br />
beneath the surface.<br />
describe, but difficult to prove.<br />
The team behind Dawn has also In 1611, Johannes Kepler suggested<br />
made an unexpected discovery: that the best arrangement for<br />
water ice hiding in a crater. The 3-dimensional spheres like oranges<br />
10-kilometre-wide Oxo crater is a pyramid. But it took until 1998<br />
seems to have formed relatively for Hales to publish a proof – and<br />
recently. The find comes from another 16 years to formally verify it.<br />
spectral data taken during Dawn’s Meanwhile, mathematicians have<br />
higher orbit in June last year.<br />
been gunning for higher dimensions.<br />
Seeing water ice anywhere on Now, Maryna Viazovska at Humboldt<br />
Ceres is a surprise as it is warm University of Berlin has proved that<br />
enough at the surface for any<br />
a grid called the E8 lattice is the best<br />
ice to evaporate into space. That packing in eight dimensions (arxiv.<br />
means it must have been exposed org/abs/1603.04246v1). Almost<br />
recently, said Jean-Philippe<br />
immediately after, she teamed up<br />
Combe of the Bear Fight Institute with other researchers to prove that<br />
in Winthrop, Washington. “This a related arrangement called the<br />
area is possibly a cold trap where Leech lattice is best in 24 dimensions<br />
H 2<br />
0-rich materials could be<br />
(arxiv.org/abs/1603.06518v1).<br />
preserved for at least some time,” The fact that these dimensions<br />
he said.<br />
were next to fall is no coincidence.<br />
So where has this water<br />
For reasons we don’t understand,<br />
come from? Models of Ceres’s such lattices don’t show up in other<br />
formation, along with the<br />
dimensions. But they were suspected<br />
sightings of bright spots like the to be the most efficient arrangements<br />
ones at Occator, suggest the dwarf in the dimensions they apply to.<br />
planet has an icy sub-surface layer “These are unbelievably good<br />
that is mixed up with salt and packings,” says Henry Cohn at<br />
rock. The ice at Oxo could have Microsoft Research New England in<br />
been exposed by a landslide,<br />
Cambridge, Massachusetts. “The<br />
or dug up by a meteorite.<br />
spheres in these dimensions fit<br />
Dawn will continue to gather perfectly, in ways that don’t happen<br />
data about Ceres until August at in other dimensions.”<br />
least, and possibly into next year. Packing spheres in 24 dimensions<br />
But some questions about this isn’t just a mathematical game. The<br />
enigmatic world may not<br />
problem has applications in wireless<br />
be answered until a repeat visit. communication, and has been used to<br />
“It would be nice to land there, communicate with spacecraft in the<br />
wouldn’t it?” said Raymond. ■ distant solar system. Lisa Grossman ■<br />
12 | NewScientist | 2 April 2016
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IN BRIEF<br />
JOHN WATKINS/FLPA/CORBIS<br />
Migrating birds arrive in the<br />
UKearlierandleavelater<br />
SOME common migrating birds – including the blackcap,<br />
(pictured above) – are staying in the UK for two weeks<br />
or more longer than half a century ago. “We knew that<br />
birds were arriving earlier in spring, but this is the first<br />
study I know of in Europe that has also tracked when they<br />
leave in autumn,” says Stuart Newson of the British Trust<br />
for Ornithology.<br />
Newson has tapped into amateur observations of bird<br />
migrations collected over more than 50 years, starting<br />
with paper files in the 1960s and ending with 800,000<br />
records from BirdTrack, an internet-based volunteer<br />
Ghostgalaxiesarefullofdarkmatter<br />
<strong>THE</strong>RE’S more than meets the eye.<br />
A so-called ultra-diffuse galaxy<br />
has been found to consist of over<br />
99.96 per cent dark matter.<br />
An ultra-diffuse galaxy is a<br />
huge galaxy with relatively few<br />
stars widely spread out, so it looks<br />
ghostly and is hard to study.<br />
The fact that they hold their<br />
shape makes researchers think<br />
such galaxies must consist of at<br />
least 98 per cent dark matter – the<br />
stuff thought to make up about<br />
80 per cent of the mass in the<br />
universe overall. But no one<br />
had directly measured it.<br />
Now Michael Beasley at the<br />
Institute of Astrophysics of the<br />
Canary Islands, Spain, and his<br />
colleagues have “weighed” an<br />
ultra-diffuse galaxy in the<br />
Virgo cluster named VCC 1287.<br />
The team measured the speeds<br />
of seven globular star clusters<br />
observation network, to study 14 common migrating<br />
birds. He found that 11 species arrive earlier and four<br />
leave later (Ibis, doi.org/bdpr).<br />
Amateur data is best, he says. Professional<br />
ornithologists have mostly counted birds arriving at a<br />
handful of coastal observation points. And many previous<br />
studies concentrated on dating the first birds to arrive.<br />
Observations from citizen scientists avoid such biases,<br />
and cover leaving times too.<br />
One reason for late leaving could be that females are<br />
laying more than one clutch of eggs thanks to the longer<br />
breeding season, says Tim Sparks of Coventry University,<br />
UK. Indeed, the study also shows that birds taking most<br />
advantage of earlier springs and balmy late autumns,<br />
such as the blackcap, are increasing in number.<br />
orbiting the galaxy, a clue to how<br />
much mass it contains, and found<br />
that it must have about 80 billion<br />
times more mass than the sun<br />
and 3000 times more dark matter<br />
than stellar mass (Astrophysical<br />
Journal Letters, doi.org/bdpb).<br />
VCC 1287 was probably born<br />
with both dark matter and gas<br />
but lost the latter as it fell into<br />
the Virgo cluster. Without gas,<br />
it couldn’t create new stars, so it<br />
ended up with lots of dark matter<br />
but little light.<br />
Exercise keeps<br />
your brain younger<br />
YOUNG in body, young in mind.<br />
Older people who are physically<br />
active seem to stave off memory<br />
loss – but only if they start early.<br />
Clinton Wright at the University<br />
of Miami in Florida and his<br />
colleagues followed 876 people,<br />
starting at an average age of 71,<br />
over five years. At the end, the<br />
brains of non-exercisers looked<br />
10 years older than those who<br />
did moderate exercise. Those<br />
who exercised also showed<br />
less memory loss (Neurology,<br />
doi.org/bdpw).<br />
These effects are associated<br />
with better vascular health,<br />
suggesting that exercise helps<br />
the brain by keeping down blood<br />
pressure and preventing strokes.<br />
But the team’s results showed<br />
that physical activity can only<br />
delay memory loss if a person<br />
begins exercising before the<br />
onset of symptoms. “Once<br />
there’s damage, you can’t really<br />
reverse it,” says Wright.<br />
Why we have really<br />
big noses…<br />
IT’S an evolutionary mystery<br />
that’s literally as plain as the<br />
nose on your face. Why did our<br />
ancestors develop a prominent<br />
protruding nose when most<br />
primates have flat nasal openings?<br />
A new study suggests that our<br />
unusual nose may simply be a byproduct<br />
of other, more important<br />
changes in the structure of our<br />
face as our brains enlarged.<br />
Takeshi Nishimura at Kyoto<br />
University, Japan, and his team<br />
modelled the flow of inhaled air<br />
through the nasal passages of<br />
humans, chimpanzees and<br />
macaques. It turns out that our<br />
noses, unlike those of other<br />
primates, are poor at warming or<br />
cooling air that goes to the lungs<br />
(PLoS Computational Biology, DOI:<br />
10.1371/journal.pcbi.1004807).<br />
2 April 2016 | NewScientist | 15
IN BRIEF<br />
For new stories every day, visit newscientist.com/news<br />
E BRUN<br />
Leaded ink opens<br />
up ancient scrolls<br />
LEAD often gets a bad press. But its<br />
discovery in ancient Graeco-Roman<br />
ink could make it easier to read an<br />
early form of publishing – precious<br />
scrolls buried by the eruption of<br />
Mount Vesuvius in AD 79.<br />
Some 800 scrolls, part of the<br />
classical world’s best-surviving<br />
library, have tantalised scholars<br />
since they were unearthed in a<br />
villa in the ancient Roman city of<br />
Herculaneum in 1752. About 200<br />
are in such a delicate state that they<br />
have never been read. Unrolling the<br />
charred scrolls could destroy them,<br />
so people have been X-raying the<br />
bundles in the hopes of decoding<br />
the writing inside. But progress has<br />
been slow – it is difficult to detect<br />
the difference between the letters<br />
and the papyrus they are written on.<br />
Now physicist Vito Mocella of<br />
the Italian National Research Council<br />
and his colleagues have discovered<br />
lead in the ink on two Herculaneum<br />
papyri fragments held in the<br />
Institute of France in Paris. The<br />
presence of lead means that<br />
imaging techniques could be<br />
recalibrated to pick up the metal,<br />
something X-rays excel at (PNAS,<br />
doi.org/bdn5).<br />
“This really opens up the<br />
possibility of being able to read<br />
these scrolls,” says Graham Davis,<br />
at Queen Mary University of London.<br />
“If this is typical of this scroll or other<br />
scrolls, than that is very good news.”<br />
Violent pirouette spun off the moon’s water<br />
BALLET doesn’t suit everyone.<br />
Molten rock flowing beneath the<br />
moon’s crust billions of years ago<br />
shifted its spin axis by about six<br />
degrees. The pirouette could have<br />
cost the moon most of its water.<br />
We saw the first direct evidence<br />
of water on the moon in 2009,<br />
when a deliberately crashed<br />
satellite found hydrogen – a proxy<br />
for water – in a southern crater.<br />
There was more there than at the<br />
actual pole, a little more than five<br />
degrees away, says Matthew<br />
Siegler of the Planetary Science<br />
Institute in Tucson, Arizona.<br />
Fungi may help<br />
woodpeckers drill<br />
IF A red-cockaded woodpecker<br />
wants a home, it does more than<br />
just knock on wood – it takes some<br />
tiny helpers with it. It seems to<br />
carry spores of wood-rotting fungi<br />
to each new hole.<br />
Red-cockaded woodpeckers<br />
live in the pine forests of the<br />
south-eastern US, where they dig<br />
tree cavities to live in. Each family<br />
has cavities at different stages of<br />
construction. It’s no quick bodge<br />
job–aholecantakeyears to craft.<br />
Michelle Jusino of the US<br />
Forest Service Center for Forest<br />
Mycology Research in Wisconsin<br />
and her colleagues have found a<br />
wide range of fungal spores on the<br />
birds, including many that cause<br />
wood decay and are found in<br />
cavities that woodpeckers dig.<br />
To see whether the birds bring<br />
the fungi to the cavities, the team<br />
drilled holes in 60 trees, covering<br />
half with screens the woodpeckers<br />
can’t get through. After 26 months,<br />
accessible holes had fungal<br />
communities that were more<br />
similar to those found in natural<br />
woodpecker cavities than to<br />
inaccessible holes. This suggests<br />
the birds do disperse fungi,<br />
although any benefit to them is<br />
still unproven (Proceedings of the<br />
Royal Society B, doi.org/bdn7).<br />
While scrutinising maps of<br />
the lunar composition, Siegler<br />
noticed that the highest<br />
concentration of hydrogen at the<br />
north pole is also a few degrees<br />
away from the true pole, but in<br />
the opposite direction.<br />
“They are on exact opposite<br />
sides of the moon from each<br />
other. It’s as if you drew a line<br />
through the centre of the moon<br />
from those two points,” he says.<br />
This indicates that the moon’s<br />
polar axis used to follow that line,<br />
but shifted. Based on its direction,<br />
Siegler and his colleagues think<br />
Parasites, mew give me road rage<br />
CATS can make us angry. Scratching<br />
our furniture, waking us up – and<br />
giving us parasites that may cause<br />
explosive rage.<br />
Toxoplasma gondii is a parasite<br />
carried by cats that lives in the brains<br />
of as many as a third of all people<br />
worldwide. Now the parasite has<br />
been linked to a psychiatric condition<br />
involving disproportionate outbursts<br />
of aggression, like road rage.<br />
Emil Coccaro at the University of<br />
Chicago and his colleagues compared<br />
110 people with intermittent<br />
explosive disorder (IED) with people<br />
who have no psychiatric diagnosis.<br />
the shift was caused when lava<br />
flowing up from the lunar interior<br />
formed the Procellarum region.<br />
The volcanism would have<br />
changed the distribution of the<br />
moon’s mass, spinning it around<br />
(Nature, doi.org/bdn9).<br />
That pirouette could have cost<br />
the moon much of its water. When<br />
the poles shifted, frozen water<br />
would have been exposed to the<br />
sun and evaporated. That helps to<br />
explain why the moon is so dry,<br />
and suggests that much of the<br />
lunar water is leftover from early<br />
in its life.<br />
They found that people with IED<br />
were more than twice as likely to<br />
test positive for exposure to T. gondii.<br />
In both groups, those who tested<br />
positive tended to rank more highly<br />
in tests for aggression (Journal of<br />
Clinical Psychiatry, doi.org/bdpq).<br />
Coccaro thinks the parasite may<br />
be altering neurotransmitters in<br />
the brain. However, the correlation<br />
doesn’t necessarily mean that<br />
T. gondii is causing the explosive<br />
rage. Aggressive people may be<br />
less likely to wash their hands,<br />
making them more likely to catch<br />
the parasite, for example.<br />
NATALIE SHUTTLEWORTH/GETTY<br />
16 | NewScientist | 2 April 2016
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TECHNOLOGY<br />
Getdeepinthegame<br />
After years of hype, the moment is finally here. Douglas Heaven introduces<br />
the games that will kick-start the VR revolution<br />
CHESNOT/GETTY<br />
WHEN a small company called<br />
Oculus announced that it was<br />
building a virtual reality headset<br />
in 2012, it sent expectations<br />
soaring. The hope was for a device<br />
that might finally deliver on<br />
the promise of VR – which had<br />
become the butt of jokes after a<br />
run of false starts in the 1980s and<br />
90s. The moment of truth will<br />
arrive this week, when the Oculus<br />
Rift launches – along with a few<br />
dozen games that aim to kick-start<br />
the VR gaming revolution.<br />
The line-up includes games that<br />
let you conquer Everest, repair an<br />
orbiting space station and even<br />
take part in a ballet. One, Job<br />
Simulator, even puts you in a<br />
world where robots have replaced<br />
human workers and simulations<br />
are the only way to experience a<br />
life of nine-to-five employment.<br />
The Rift, which launches on<br />
28 March, will be joined on 5 April<br />
by the Vive, made by HTC and<br />
Valve. Sony’s Playstation VR<br />
system is due in October. And<br />
earlier this month, Canadian<br />
start-up Sulon revealed yet another<br />
rival headset,coming this Spring.<br />
Few technologies have been so<br />
hotly anticipated. But what will<br />
people make of them? The success<br />
of VR rests on the types of<br />
experiences it will offer. Many<br />
are versions of existing games<br />
that have been adapted to VR.<br />
For example, the view from your<br />
cockpit when travelling between<br />
stars in Elite Dangerous will now<br />
be more overwhelming than ever.<br />
But it is the games developed<br />
specifically for VR that could<br />
change the way we play. As well as<br />
the headset, VR games often make<br />
use of controllers that track your<br />
movements. These let you treat<br />
a controller as a gun – pointing it<br />
to aim as you would a real one – or<br />
as a rope that you have to grip to<br />
climb a rock face, or a basketball<br />
you have to slam dunk. Motion<br />
controllers themselves are not<br />
new, but their greater sensitivity<br />
combined with the full<br />
immersion of a headset that<br />
covers your eyes and ears leads<br />
to extremely vivid experiences.<br />
It sounds obvious, but what<br />
virtual reality lets us do is make<br />
the virtual a reality, says VR<br />
developer Xárene Eskandar at the<br />
University of California, Santa<br />
Barbara. “You are present more<br />
than with any other medium.<br />
It has your full attention.”<br />
But a big challenge facing the VR<br />
“We’re actually a bit thrilled<br />
that The Brookhaven<br />
Experiment might be too<br />
scary for some players”<br />
industry is describing what that is<br />
like to those who have not tried it.<br />
“It is almost impossible to convey<br />
the experience through any<br />
medium other than VR,” says Alex<br />
Knoll, co-founder of game studio<br />
Stress Level Zero, based in LA.<br />
It’s like trying to sell a colour TV<br />
in a world where only black and<br />
white TVs exist, says Steve Bowler<br />
at Phosphor Games in Chicago,<br />
which has made VR horror game<br />
The Brookhaven Experiment.<br />
“We have to get you in the virtual<br />
world with the headset on your<br />
face before you believe us that<br />
it’s amazing.”<br />
Game makers have had to<br />
overcome more practical issues<br />
too. One is how to give players a<br />
sense of freedom and movement<br />
when playing in their living room.<br />
Tripping over furniture and<br />
bumping into walls in one reality<br />
while you are saving the world – or<br />
flipping burgers – in another can<br />
quickly break the spell. A<br />
wireframe showing where the<br />
edges of a room are can be<br />
superimposed over the virtual<br />
world to stop you hurting<br />
yourself. But most games also give<br />
you reasons not to move around<br />
too much. For example, in Stress<br />
Level Zero’s Hover Junkers, a game<br />
–Is it my turn yet?– where you fight on hovercraft,<br />
18 | NewScientist | 2 April 2016
For more technology stories, visit newscientist.com/technology<br />
players are advised to choose a<br />
ship that is roughly the same size<br />
as the room they’re playing in.<br />
In other games, players stand in<br />
one spot and move around in the<br />
game by teleporting, for example.<br />
This also partly addresses the<br />
problem of motion sickness that<br />
many people experienced with<br />
VR software. Games have several<br />
other tricks to deal with this too.<br />
In Hover Junkers, the ships hover<br />
so there is very little bouncing,<br />
creating less conflict between<br />
what you see in the virtual world<br />
and what you feel in the real one.<br />
The ships also do not turn unless<br />
the player twists their body.<br />
Even standing still, there is a lot<br />
of opportunity for visceral action.<br />
In The Brookhaven Experiment<br />
players stand their ground against<br />
waves of monsters. Because the<br />
experience is so realistic, players<br />
reflexively step backwards when<br />
confronted, turn away and shield<br />
their face when hit, or lash out<br />
with their hands in defence.<br />
A handful of players have<br />
stopped playing because it is too<br />
frightening. For Bowler this is a<br />
sign of success. “We’re actually a<br />
bit thrilled that The Brookhaven<br />
Experiment might be too scary for<br />
some players.”<br />
Although nascent, the potential<br />
of consumer VR is clear. The<br />
best experiences do not simply<br />
try to adapt the conventions<br />
of screen-based media, says<br />
Eskandar. Using VR just to display<br />
360° video is pointless, she says.<br />
“It’s just a flat screen wrapped<br />
around your head.”<br />
Eskandar is developing a<br />
VR puzzle game called The<br />
Clocksmith’s Labyrinth. She<br />
thinks that by separating us from<br />
the physical constraints of one<br />
reality, VR experiences could<br />
ultimately give us fresh ways of<br />
conceptualising things.<br />
“I’m curious to see how humans<br />
will evolve with this medium,” says<br />
Eskandar. “My dream is that 20 to<br />
30 years down the road, one of the<br />
kids who has played these games<br />
can solve a cosmological puzzle<br />
that finds the multiverse.” ■<br />
<strong>THE</strong> BROOKHAVEN EXPERIMENT<br />
A horror game in which you must survive an<br />
onslaught from hordes of monsters. Danger<br />
approaches from all sides, so you have to keep<br />
looking over your shoulder. Armed with a pistol<br />
and a limited supply of bullets, every shot counts.<br />
But as the tension mounts, your aim waivers.<br />
Unlike most games, you fire with a motion<br />
controller held like a gun, rather than a mouse or<br />
joystick. The experience is realistic enough that<br />
the developers say they can tell which players<br />
know how to use a real gun.<br />
JOB SIMULATOR<br />
Office job getting you down? Now you can<br />
escape into a simulation of a simulation of a<br />
different one. In this game, all jobs have been<br />
taken by robots. To keep themselves amused,<br />
humans have developed simulations of what<br />
it was like to be an employee in the good old<br />
days – cooking in a restaurant kitchen, sitting at<br />
a supermarket checkout, keeping busy in an office<br />
cubicle. Largely an excuse to have fun interacting<br />
with virtual versions of everyday objects, the<br />
game is a lot more enjoyable than it sounds.<br />
<strong>THE</strong> CLIMB<br />
A hundred metres up, the boats in the beautiful<br />
bay look like toys. Your eyes are fixed on the next<br />
ledge, however. You cling to the rock face by<br />
squeezing the triggers on two motion controllers<br />
held in each hand, and move to the next hand-hold<br />
by looking in its direction and reaching for it. As you<br />
climb, you also have to stop to reapply chalk as your<br />
character’s hands get sweaty. Sometimes the only<br />
way to proceed is to leap, which is guaranteed to<br />
get the heart pumping. Players compete for fastest<br />
ascents or can watch others tackle tricky climbs.<br />
TILT BRUSH<br />
When you’re done with role-playing and just feel<br />
like doodling, this game lets you sketch lines in the<br />
air around you. You can then walk around and view<br />
your creations from different angles. The extra<br />
dimension gives you lots of new ways to interact<br />
with them – you could draw a door and walk through<br />
it, for example. You create your pictures by using<br />
the motion controller as a paintbrush and you can<br />
then share them online. The big bold strokes make<br />
players look like Jackson Pollock. Indeed, we may<br />
soon see the first VR art gallery.<br />
GOOGLE CRYTEK OWLCHEMY LABS PHOSPHOR GAMES STUDIO LLC<br />
2 April 2016 | NewScientist | 19
TECHNOLOGY<br />
ONE PER CENT<br />
Fieldnotes Factory 2050<br />
Wait,I’llreconfigure<br />
Jacob Aron crosses the frontier into the factory of the future<br />
BOND BRYAN<br />
PLANES, trains, automobiles? Not<br />
quite yet: Factory 2050 in Sheffield,<br />
UK, isn’t building anything you can buy.<br />
Instead, the brains behind the project<br />
are rethinking the manufacturing<br />
process itself, aiming to change how<br />
we make everything from airplanes to<br />
nuclear power plants.<br />
Inside the factory, things are looking<br />
a little unfinished. It opened in January,<br />
and the team from the University of<br />
Sheffield’s Advanced Manufacturing<br />
Research Centre (AMRC) are still<br />
moving in. The place is sparkling clean,<br />
and smells like a newly furnished IKEA,<br />
but it’s gearing up to change the way<br />
whole industries work by applying<br />
virtual reality, robotics and bitcoin’s<br />
blockchain.<br />
A gaggle of orange robot arms<br />
catches my eye. Built by German firm<br />
KUKA for car manufacturing, these<br />
bots are sloppy when it comes to<br />
aerospace. Making planes is so<br />
complex that they need to be<br />
assembled with 20 times more<br />
accuracy than these arms can handle.<br />
Steve Bowles, an engineer on the<br />
project, is working to fix this. Laser<br />
tracking can ensure the robots deposit<br />
an exact amount of adhesive between<br />
two parts of a wing, for instance.<br />
Too much or too little could lead to a<br />
catastrophic failure when the plane<br />
takes off.<br />
Past the orange arms is the KUKA<br />
omniMove, a robot the size of a small,<br />
squashed car. Instead of tyres, each of<br />
its eight wheels is covered in diagonal<br />
rollers that let the bot move in any<br />
direction without turning. UK<br />
construction firm Laing O’Rourke has<br />
tasked AMRC with using the<br />
omniMove to study the pouring and<br />
moving of concrete floors. The plan is<br />
for the robots to churn out modular<br />
parts for buildings and assemble them<br />
on location.<br />
AMRC foresees a future in which<br />
robots take on the drudgery of<br />
–Give me a minute, I’m tooling up–<br />
manufacturing, leaving humans to<br />
plan and formulate strategies for<br />
guiding the machines. “You can have<br />
the humans concentrating on<br />
processes that require dexterous<br />
thoughts and hands,” says Bowles.<br />
“The idea is to assist the worker.”<br />
This automated factory will<br />
generate huge volumes of data.<br />
By linking together all the cameras,<br />
lasers and other sensors the team can<br />
create a digital twin of the building<br />
“The factory will physically<br />
rearrange itself to create<br />
thebestproductionline<br />
for the job”<br />
that will monitor every manufacturing<br />
process and perhaps individual<br />
components. This will help AMRC<br />
retool on the fly, digitally swapping out<br />
parts of the production line to model<br />
changes in the hunt for efficiency.<br />
Once an automated system has<br />
determined the best set of tools,<br />
the factory can physically rearrange<br />
itself to create the best production<br />
line for the job.<br />
AMRC has also recently become<br />
interested in the blockchain, the<br />
unfalsifiable ledger technology<br />
behind the bitcoin virtual currency.<br />
It would track and certify the path<br />
of raw materials all the way to the<br />
finished product, ensuring provenance<br />
and quality. “At every interaction,<br />
you would capture data around a<br />
given material or component,”<br />
says AMRC chief technical officer<br />
Sam Turner.<br />
Factory 2050 feels like a toy shop,<br />
but the researchers aren’t just<br />
tinkering. The goal is to get the ideas<br />
straight into industrial use, rather than<br />
letting them languish in the lab. “We’re<br />
looking at how to make manufacturing<br />
processes more efficient, more safe<br />
and more reliable,” says Bowles. ■<br />
Robot ripper<br />
Last week, Apple unveiled Liam,<br />
a robot built to rip apart old phones<br />
and pull out anything that can be<br />
recycled. Made up of 29 robotic<br />
arms, Liam starts by pulling off the<br />
screen, before moving on to the<br />
guts – battery, processor and even<br />
screws. At full clip, it takes apart a<br />
phone every 11 seconds. There is<br />
currently only one Liam, in<br />
California, but Apple is building<br />
another in Europe.<br />
“So fricken excited<br />
to meet you … like<br />
humans seem so<br />
awesome”<br />
Tay greets the world (23 March).<br />
Within hours, the Microsoft chatbot<br />
had been tricked into spewing racist<br />
comments on Twitter<br />
Global face-off<br />
How many people look just like<br />
you? FaceTopo’s software could let<br />
you find out by comparing your<br />
face with thousands of others<br />
around the world. After uploading<br />
a series of selfies, an app identifies<br />
key facial features and uses them<br />
to find lookalikes from around the<br />
world, or show you how similar<br />
your face is to those of family<br />
members in previous generations.<br />
Once FaceTopo has collected<br />
enough data, its developers hope<br />
to study the degree of variation<br />
across all human faces.<br />
APPLE<br />
20 | NewScientist | 2 April 2016
Entries for $250,000<br />
Ryman Prize now open<br />
The Ryman Prize is a unique international<br />
award aimed at encouraging the best<br />
and the brightest thinkers in the world to<br />
focus on ways to improve the health of<br />
older people.<br />
The world’s ageing population means<br />
that in some parts of the globe –<br />
including most of the Western world –<br />
the population aged 75+ is set to triple<br />
in the next 30 years.<br />
In order to stimulate fresh efforts in<br />
the field, the Ryman Foundation is<br />
offering a NZ$250,000 (US$165,000)<br />
annual prize for the world’s best<br />
discovery, development, advance or<br />
achievement that enhances quality of<br />
life for older people.<br />
The inaugural Ryman Prize was won by<br />
Gabi Hollows for her pioneering work<br />
to provide affordable eye surgery for<br />
people in developing countries.<br />
The Hollows Foundation has restored<br />
sight to more than 1 million people<br />
– an amazing achievement that has<br />
transformed lives.<br />
If you have a great idea, or have<br />
achieved something remarkable like<br />
Gabi, we’d love to hear from you!<br />
Go to www.rymanprize.com for more information<br />
Gabi Hollows and Nobel Laureate Dr Erwin Neher at the presentation of the inaugural Ryman Prize<br />
www.rymanprize.com
APERTURE<br />
22 | NewScientist | 2 April 2016
Monstrous beauty<br />
HARD to believe that something so beautiful can<br />
have such a devastating effect. This is what the<br />
infamous Zika virus looks like – probably.<br />
Zika, now sweeping the Americas, was<br />
declared a global health emergency earlier this<br />
year because of the suspected link between the<br />
virus and babies born with microencephaly.<br />
Ivan Konstantinov from Visual Science and his<br />
team used their knowledge of related viruses,<br />
such as dengue, West Nile and yellow fever, to<br />
create an image of a Zika particle. “We applied<br />
the same techniques used in research and drug<br />
development to predict what it looks like,”<br />
says Konstantinov.<br />
Zika is part of the flavivirus family so its<br />
“virions” – infectious particles – are probably<br />
around 50 nanometres, less than half the size of<br />
HIV and flu. Different proteins are coloured blue,<br />
green and grey. In the top right image we can see<br />
a lipid membrane, including a protein, and in the<br />
picture below it is the virus’s RNA genome.<br />
Although the surface of the virus closely<br />
resembles dengue, says Konstantinov, it could<br />
work very differently. “It doesn’t mean that it<br />
behaves the same way in an infected organism.”<br />
Aside from microencephaly, Zika is implicated<br />
in other kinds of fetal damage, as well as in<br />
Guillain-Barré syndrome, which can cause<br />
paralysis.<br />
The team hopes to improve their model once<br />
they know how the virus’s genome organises<br />
itself inside the cell. Sandrine Ceurstemont<br />
Photographer<br />
© Visual Science, 2016<br />
2 April 2016 | NewScientist | 23
OPINION<br />
Critical moment<br />
Time for a serious rethink of the world’s biggest nuclear<br />
power project, says Paul Ekins<br />
FEW energy projects have been as<br />
racked with doubt as the nuclear<br />
power station due to be built at<br />
Hinkley Point in Somerset, UK.<br />
Fresh uncertainty followed the<br />
resignation of the chief finance<br />
director of EDF, the largely stateowned<br />
French company that<br />
would construct the plant, fearing<br />
EDF’s share of the £18 billion cost<br />
could ruin it.<br />
The backdrop is a UK<br />
government desperate for the<br />
plug not to be pulled. It cites<br />
energy security, jobs and cost of<br />
power. Nuclear plants can supply<br />
zero-carbon power continuously,<br />
and Hinkley will generate 7 per<br />
cent of current UK electricity<br />
demand for 60 years, at a rate<br />
that is now cheaper than that of<br />
power from offshore wind. Some<br />
25,000 jobs would be created.<br />
But how essential is Hinkley?<br />
That depends on electricity<br />
demand in decades to come,<br />
Bridging the gulf<br />
More US-Cuba scientific collaboration will<br />
help keep the peace, says Michael Clegg<br />
A HISTORIC visit to Cuba by<br />
Barack Obama – the first such<br />
gesture by a US president for<br />
88 years – reinforces the thaw in<br />
relations between the nations.<br />
It’s no surprise that Obama’s<br />
wish list included better scientific<br />
cooperation. He knows that this<br />
has long been a powerful means<br />
of bridge building. For instance,<br />
the US National Academy of<br />
Sciences runs workshops with<br />
scientists from Iran, and both<br />
governments seem to value this<br />
neutral channel of engagement.<br />
Similar links have been forged<br />
with China, India and Russia – and<br />
earlier with the Soviet Union.<br />
Science provides a context for<br />
dialogue when political tensions<br />
hinder other communication.<br />
What’s more, Cuba has strong<br />
capabilities in fields including<br />
biotechnology, oceanography,<br />
biodiversity, public health and<br />
disaster management. Its<br />
education system achieved nearly<br />
100 per cent literacy by the 1970s<br />
and its higher education and<br />
research sectors are impressive<br />
for a nation of just over 11 million.<br />
Obama had technology-based<br />
entrepreneurism and expanded<br />
access to the internet on his wish<br />
“One idea has suggested<br />
using the US base at<br />
Guantanamo Bay for<br />
biodiversity conservation”<br />
mainly dictated by how efficiently<br />
electricity is used and to what<br />
extent it replaces transport fuels<br />
and natural gas for heating.<br />
UK Energy Research Centre<br />
modelling suggested that demand<br />
in 2050 could be 30 per cent<br />
higher than in 2015, with greater<br />
nuclear capacity playing an<br />
important role combined with<br />
renewables and coal plus biofuels<br />
backed by carbon capture and<br />
storage (CCS). But the ground has<br />
shifted. UK CCS prospects have<br />
dimmed and the cost of electricity<br />
from renewables has fallen.<br />
By 2025, power from offshore<br />
wind is set to be cheaper than that<br />
from Hinkley. And being able to<br />
store a lot of electricity to smooth<br />
out intermittent supply from<br />
renewables is looking more likely.<br />
Lots of renewables, together<br />
with storage and a smart grid<br />
to better match generation to<br />
demand, could render obsolete<br />
list for Cuba, along with the chance<br />
to work with Cuban biotech<br />
efforts, in particular trials for<br />
new vaccines for lung cancer and<br />
other human and animal diseases.<br />
Shared environmental<br />
challenges, such as climateinduced<br />
sea level rise, preparing<br />
for hurricanes, and preserving<br />
marine resources and biodiversity<br />
suggest a cooperative approach.<br />
In this context, one visionary idea<br />
from the research community<br />
proposed using the US naval base<br />
at Guantanamo Bay as a dedicated<br />
area for biodiversity conservation<br />
(Science, doi.org/bdks).<br />
The path ahead has obstacles,<br />
not least opposition from some<br />
24 | NewScientist | 2 April 2016
For more opinion articles, visit newscientist.com/opinion<br />
the whole concept of a continuous<br />
supply of “baseload power”, which<br />
nuclear provides. Under this<br />
scenario, the mid-2020s, when<br />
Hinkley would come online, could<br />
see the UK locked into a 35-year<br />
commitment to an inflexible and<br />
expensive form of electricity illsuited<br />
to a new energy landscape.<br />
Alternatively, if Hinkley can be<br />
built without bankrupting EDF,<br />
deliver power at a predictable cost<br />
for 60 years, and if a more flexible<br />
grid proves unfeasible, then the<br />
enthusiasm may prove justified.<br />
On balance, though, the cost<br />
looks too high, and the current<br />
hiatus provides a chance to back<br />
off from Hinkley and rekindle<br />
investment in renewables, while<br />
building sufficient gas plants to<br />
act as back up in case mass storage<br />
of electricity fails to materialise.<br />
Ultimately, if EDF does pull<br />
out of Hinkley, the government<br />
will have to come back to<br />
renewables or CCS in a big way, or<br />
recognise that its carbon targets<br />
are a lost cause.<br />
The juggling act of getting<br />
secure, low-carbon power at the<br />
lowest cost is not called the energy<br />
policy “trilemma” for nothing. ■<br />
Paul Ekins is professor of resources<br />
and environmental policy at University<br />
College London, and deputy director<br />
of the UK Energy Research Centre<br />
Republicans hoping to contest<br />
the US presidential election.<br />
There are also US laws, such as<br />
an economic embargo, that still<br />
limit engagement, and changing<br />
these will require congressional<br />
action – unlikely in the short term.<br />
Despite this, collaborative<br />
research offers a valuable path<br />
to deeper ties. There are many<br />
opportunities for cooperation and<br />
each such initiative will amplify<br />
and encourage a new future<br />
between these two nations. ■<br />
Michael Clegg is co-chair of the Inter<br />
American Network of Academies of<br />
Science and emeritus professor of<br />
biology at University of California, Irvine<br />
FABRIZIO BENSCH / REUTERS<br />
INSIGHT Air pollution<br />
We need to be angrier<br />
about our toxic air<br />
Michael Le Page<br />
I WORRY about what working at New<br />
Scientist is doing to my health. Not<br />
because of the job itself, but because<br />
our office is located in one of the many<br />
parts of London where air pollution<br />
exceeds the set limits. My colleagues<br />
and I breathe in a lot more nitrogen<br />
dioxide than is good for us. And if you<br />
live or work near to a busy road, or<br />
travel on them, you probably do too.<br />
Rich countries like the UK have<br />
made a lot of progress when it comes<br />
to air pollution. We’ve gotten rid of<br />
the soot from industry that plagues<br />
countries like China and India, and<br />
more insidious threats such as lead<br />
from petrol. But we do have a big<br />
problem with nitrogen dioxide from<br />
traffic fumes. London’s Oxford Street<br />
has the highest recorded levels of<br />
nitrogen dioxide in the world.<br />
According to a European Union<br />
directive that came into force in 2010,<br />
nitrogen dioxide levels should average<br />
less than 40 micrograms per cubic<br />
metre a year and the hourly average<br />
shouldn’t exceed 200 micrograms on<br />
more than 18 occasions in a year.<br />
Parts of London sometimes breach<br />
this limit more than 18 times a week.<br />
That’s outrageous, yet there has<br />
been little outcry. ClientEarth, a group<br />
of activist lawyers, is trying to change<br />
that. It sued the UK government to<br />
force it to take action. The supreme<br />
court ruled in its favour last year.<br />
That meant the government had to<br />
come up with a new plan for reducing<br />
nitrogen dioxide. But that plan wasn’t<br />
much better than the old one: London<br />
would continue to breach the limits<br />
until at least 2025, for example. So<br />
last week ClientEarth announced it<br />
“Nitrogen dioxide is<br />
invisible. The lack of actual<br />
bodies makes it hard to<br />
mobilise public opinion”<br />
was again taking legal action to<br />
force the government to do better.<br />
The trouble is nitrogen dioxide is<br />
an invisible killer. A major report out<br />
last month concluded that air pollution<br />
causes around 40,000 deaths a year<br />
in the UK, of which nearly half are due<br />
to nitrogen dioxide.<br />
However, it isn’t possible to point<br />
to any one death and say that person<br />
was killed by nitrogen dioxide. Rather,<br />
–A big dose of nitrogen dioxide–<br />
some people are becoming ill and<br />
dying sooner than they should have<br />
done. “What we are talking about is a<br />
shortening of life,” says Ian Mudway<br />
of King’s College London. The headline<br />
figure of 40,000 deaths is a statistical<br />
way of representing this toll.<br />
The lack of actual bodies makes it<br />
hard to mobilise public opinion. And<br />
without an angry electorate, getting<br />
the government to take action is<br />
going to be an uphill struggle.<br />
Air pollution does seem to be<br />
moving up the agenda thanks to the<br />
efforts of ClientEarth and others. It<br />
has become an issue in the mayoral<br />
election for London and a recent<br />
YouGov poll on behalf of ClientEarth<br />
found that air pollution is the number<br />
one health concern for Londoners.<br />
Nitrogen dioxide pollution is an<br />
issue in many other traffic-clogged<br />
cities around the world too, but the<br />
problem is particularly bad in Europe<br />
because of efforts to reduce carbon<br />
emissions by encouraging people to<br />
buy diesel cars. Diesel vehicles emit<br />
lots of nitrogen dioxide and – as the<br />
Volkswagen scandal made clear – the<br />
systems meant to mop this up don’t<br />
work nearly as well as claimed.<br />
In the short term we need to get the<br />
most polluting vehicles off the road.<br />
And in the long term, we need to switch<br />
to hybrid or electric vehicles. If we<br />
power these with renewable energy,<br />
we can reduce carbon emissions at the<br />
same time – a win-win situation. But it<br />
won’t happen unless we demand it. ■<br />
2 April 2016 | NewScientist | 25
ASTELLAS INNOVATION DEBATE<br />
Supported by New Scientist<br />
PHOTOGRAPHY BY BEN PAGE<br />
Our Healthcare:<br />
Situation critical?<br />
Ageing populations, expanding waistlines and stricter<br />
budgets are making the future uncertain for healthcare<br />
systems. How should they prepare, ask a panel of experts<br />
at the Astellas Innovation Debate in London<br />
When Trish Greenhalgh<br />
broke a few bones in an<br />
unfortunate accident, she<br />
went to her local accident and<br />
emergency department. What she<br />
wasn’t expecting was a 6 hour wait<br />
on a hospital trolley to get the<br />
treatment she needed. As professor<br />
of primary care health sciences at<br />
the University of Oxford, she is no<br />
stranger to the trials and tribulations<br />
of the National Health Service but<br />
cites her experience as an example<br />
of a service undergoing a crisis.<br />
For her, the reasons for the delay<br />
are clear. “GPs are so stressed that<br />
they are taking time off, so patients<br />
go to accident and emergency<br />
instead,” she told an expert panel<br />
and an audience of invited guests<br />
Trish Greenhalgh says GP morale is low<br />
at the Astellas Innovation Debate<br />
2016 at the Royal Institution in<br />
London in February. “The whole<br />
system is at breaking point.”<br />
So what needs to be done? To<br />
address this question, the Astellas<br />
Innovation Debate drew together<br />
a wide range of healthcare experts<br />
to share their ideas.<br />
Norman Lamb, health<br />
spokesperson for the Liberal<br />
Democrats and a former minister<br />
of health in the UK, painted a stark<br />
picture. “I feel we are sleepwalking<br />
“While the UK spends<br />
£1 in every £12 on<br />
health, the US spends<br />
$1 in every $6”<br />
towards a crash in the healthcare<br />
system in this country,” he said in<br />
his keynote speech.<br />
But other health systems face<br />
similar challenges. “Across the<br />
developed world, costs are rising<br />
at about 4 per cent a year, and they<br />
have done throughout the postwar<br />
period,” he said.<br />
The reasons are many. For a<br />
start, we are living longer and with<br />
higher levels of chronic disease.<br />
“The number of people with three<br />
or more chronic conditions is<br />
projected to rise by 50 per cent by<br />
2019,” he said.<br />
SQUEEZED BUDGETS<br />
All this is set against a backdrop<br />
of ever tighter budgets, particularly<br />
in the UK, where the NHS is<br />
expected to have a funding deficit<br />
of £30 billion by 2020. Lamb says<br />
that only five OECD countries<br />
spend less per capita on health<br />
than the UK; all of them former<br />
Soviet bloc countries in Eastern<br />
Europe. “In terms of our spending<br />
on health, we’re way behind<br />
countries like Germany, France,<br />
the Netherlands and so on.”<br />
But simply spending more<br />
money is not the answer, says<br />
Lamb. Some healthcare systems<br />
26 | NewScientist | 2 April 2016
Clockwise from top left: the healthcare<br />
issues captured in cartoon form; guests<br />
mingle at the Royal Institution; panellists<br />
David Nicholson and Ab Klink; Katherine<br />
Murphy from the Patients Association<br />
questions the panel; the debate<br />
involved a wide range of healthcare<br />
experts; panellists Trish Greenhalgh<br />
and Martin Gaynor<br />
are more efficient than others.<br />
The world’s biggest healthcare<br />
spender is the US. While the UK<br />
spends about £1 in every £12 on<br />
health, the US spends $1 in every<br />
$6 – almost a fifth of the US<br />
economy. But Martin Gaynor,<br />
professor of economics and health<br />
policy at Carnegie Melon University<br />
in Pittsburgh, says this money isn’t<br />
always well spent.<br />
He points to the UK National<br />
Institute for Health and Care<br />
Excellence (NICE) which takes an<br />
Norman Lamb, former UK minister of<br />
health, painted a stark picture<br />
“We are sleepwalking<br />
towards a crash in the<br />
healthcare system in<br />
this country”<br />
evidence-based approach to<br />
healthcare value. “The US has no<br />
equivalent of NICE that<br />
distinguishes true value,” he says.<br />
“The UK and Europe do a much<br />
better job of that.”<br />
The Dutch healthcare system is<br />
a good example. In the 1990s, it<br />
had long waiting times that various<br />
specialists said could only be cut<br />
by throwing money at the problem.<br />
That turned out not to work, says<br />
Ab Klink, a former Dutch minister of<br />
health. There was little incentive to<br />
reduce waiting times and hospitals<br />
even found they could use long<br />
ones to attract extra government<br />
funding. So the Dutch turned to a<br />
system where health insurance is<br />
mandatory and insurers compete<br />
with one another. This immediately<br />
increased productivity and reduced<br />
waiting lists.<br />
But solving one dilemma created<br />
another. “The problem now is that<br />
cutting costs leads to specialists<br />
spending less time with patients<br />
and referring them to other<br />
specialists instead,” says Klink.<br />
The truth is that no healthcare<br />
system is perfect, says David<br />
Nicholson, who was chief executive<br />
of NHS England between 2011 and<br />
2014. He believes that the UK<br />
system has specific problems, for<br />
example in dealing with mental<br />
health issues and in managing its<br />
workforce. This last issue is likely to<br />
grow as emerging countries start to<br />
compete for UK staff.<br />
OVERSEAS THREAT<br />
Nicholson points out that India<br />
wants to recruit another 1 million<br />
doctors and China needs 3 million<br />
more. If just a tiny fraction of these<br />
come from the UK, that will have a<br />
big impact. “It’s going to really hit<br />
us,” he says.<br />
But the NHS is still able to punch<br />
above its weight, at least for now.<br />
“We can probably muddle through<br />
for another year or so,” he says.<br />
Greenhalgh is more worried. “I<br />
have been working as a doctor in<br />
the NHS for 33 years and have<br />
never seen morale so low.” But, she<br />
says, “you can’t just press a button<br />
and change the system, because of<br />
legacy”. Even if you could, there are<br />
some things that shouldn’t change.<br />
“Universal coverage is something<br />
we must maintain,” she says.<br />
Audience member Katherine<br />
Murphy agrees. As chief executive<br />
of the Patients Association, she<br />
believes patient needs are crucial<br />
but easily overlooked in the debate<br />
about the future of healthcare. “We<br />
need to ask patients what they<br />
want,” she says. But the absence<br />
of information available to<br />
patients about their treatments,<br />
possible outcomes, or the clinicians<br />
treating them, makes it hard for<br />
patients to make informed choices,<br />
she says.<br />
One potential solution is<br />
technology. Genetic tests, and the<br />
personalised treatments they allow,<br />
are widely believed to be on the<br />
verge of revolutionising healthcare.<br />
But the NHS hasn’t always been<br />
able to capitalise on new ideas<br />
quickly, says John Burn, professor<br />
of clinical genetics at Newcastle<br />
University and a founder of a<br />
company that makes gene chips.<br />
“It has been challenging to get gene<br />
chip technology into the NHS. The<br />
problem is inertia in the system.”<br />
Whatever the solution, it won’t be<br />
easy to implement. For the<br />
foreseeable future, problems like<br />
Greenhalgh’s 6-hour wait for<br />
treatment may be only the tip of<br />
the iceberg. ■<br />
2 April 2016 | NewScientist | 27
OPINION INTERVIEW<br />
Robot rescue?<br />
We’re ready to roll<br />
From lifeguards to reconnaissance drones, robots are already helping<br />
save lives. It’s time they took their place in the rescuer’s toolbox,<br />
argues Robin Murphy<br />
What motivated you to get into rescue robotics?<br />
The Oklahoma City bombing in 1995. At the<br />
time, robots were being made very small and<br />
agile, but rescue robots were golf-cart-sized<br />
devices or things developed for the nuclear<br />
industry that weighed tonnes. They could only<br />
go on top of the rubble, not into it. But there<br />
might be people trapped deep inside that you<br />
could save if you could just get to them within<br />
48 hours. Small robots, the size of a suitcase or<br />
lunch box, would clearly have been of benefit.<br />
Two decades on, what’s your approach?<br />
At the Center for Robot-Assisted Search and<br />
Rescue, our Roboticists Without Borders<br />
programme finds robot-makers willing to<br />
donate their robots and expertise to us. We<br />
essentially audition the robots, large or small,<br />
for a spot on our team. We develop potential<br />
uses for the machines we select, making them<br />
smarter and adaptable for a variety of disaster<br />
scenarios. Right now we have about 20 types of<br />
ground, air and sea robots, many at my lab in<br />
storage cases, ready for deployment when<br />
something bad happens.<br />
Have you deployed a rescue robot recently?<br />
Yes. When we heard about refugees drowning<br />
off the coast of Greece we called Tony<br />
Mulligan, CEO of a company called<br />
Hydronalix, which makes remote-controlled<br />
lifeguarding marine robots called EMILYs. He<br />
said, “I will take two experts and two EMILYs<br />
to Greece.” I met him out there in January.<br />
He donated the robots, one to the Hellenic<br />
Coast Guard and one to the Hellenic Red Cross.<br />
Why is it dangerous for refugees to land boats<br />
on Greek shores?<br />
They have bad motors and bad boats that are<br />
overloaded, and the wind conditions in that<br />
channel can suddenly change. The shores are<br />
also very rocky. If you find a good beach, great,<br />
but if you hit a bad stretch of shore, there’s no<br />
way to get off the boat or for anyone to come<br />
and rescue you from the rocks, so you are<br />
trapped. Roughly 600 people died last year.<br />
How does a marine robot help?<br />
One way is to get the refugee boats to follow<br />
an EMILY to a better shore. These robots have<br />
cameras and two-way radios to allow rescue<br />
boats to communicate with the people in peril.<br />
The robot can also deploy a flotation device if<br />
the boat goes down. Finally, if a boat gets stuck<br />
on a rocky piece of coast, EMILY can run a line<br />
out so they can clip it in tight around their<br />
boat and let one of the bigger boats pull them<br />
back out to safety – we saw that a lot. In short,<br />
we are preventing drownings.<br />
Are you working on any developments to these<br />
lifesaving robots?<br />
Yes, more automation. EMILYs are remotecontrolled,<br />
but what we would like to be able<br />
to do is have a lifeguard look at the video feed<br />
from EMILY’s onboard camera and say, “Over<br />
there, that’s the cluster of people I want you<br />
to assist”, just by circling on the screen.<br />
What other rescue situations have you<br />
attended with robots?<br />
We helped after mudslides engulfed a rural<br />
community in Oso, Washington, killing more<br />
than 40 people in 2014. In one day we went<br />
out and flew a reconnaissance drone over<br />
the mudslides to get high-resolution images<br />
from angles that crewed helicopters and<br />
satellites could not. We flew above the area for<br />
48 minutes and processed the data on a laptop<br />
PROFILE<br />
Robin Murphy is director<br />
of the Centre for Robot-<br />
Assisted Search and<br />
Rescue at Texas A&M<br />
University in College<br />
Station, where she is<br />
Raytheon professor of<br />
computer science and<br />
engineering<br />
Standing by:<br />
Murphy and an<br />
iRobot ground vehicle<br />
while we were driving back to the incident<br />
command centre. We were able to give them<br />
a high-resolution 3D representation of the<br />
entire area fast. As a result, it became obvious<br />
to the hydrologist where the river had shifted<br />
to, where the lowest points were and where<br />
was the best place to create a flood-bypass<br />
channel to prevent further catastrophe.<br />
What technological advancements with rescue<br />
robots are you most anticipating?<br />
So far everything’s been focused on what<br />
robots see, but what they feel is important to<br />
us as well, so I’m looking forward to robots<br />
with a sense of touch. It’s really hard to clean<br />
the dirt off a trapped survivor in order to start<br />
using infrared techniques to see their blood<br />
28 | NewScientist | 2 April 2016
For more opinion articles, visit newscientist.com/opinion<br />
Photographed for New Scientist by Jeff Wilson<br />
vessels and check their pulse. And if I touch<br />
them I need haptic feedback so I don’t hurt<br />
or scare the bejeezus out of them.<br />
And the newer types of mobility are exciting<br />
too, particularly snake-like robots that are able<br />
to burrow into rubble, for example. Big robots<br />
can only access big spaces, so smaller,<br />
burrowing robots are a big deal.<br />
Have your robots saved a life?<br />
No saved life has been directly attributed to<br />
one of our robots, but that would be like saying<br />
a fire truck or a search camera has saved<br />
someone’s life. They are important tools of the<br />
teams that saved lives, but at the end of the<br />
day it’s the emergency responders who do it.<br />
They are the heroes.<br />
What’s holding back the rise of the rescue bots?<br />
Right now the barriers tend to be lack of<br />
accurate knowledge about what they can do.<br />
That’s why we want them used as much as<br />
possible – seeing is believing if you want<br />
people to adopt this technology. The second<br />
thing is regulations on what government<br />
agencies can spend money on.<br />
Aren’t these machines costly?<br />
Most of our robots cost less than a fire truck;<br />
less than the fire chief’s SUV. They certainly<br />
don’t cost millions of dollars – even if you<br />
factor in training people to use them and<br />
other associated costs. The important thing<br />
is, if you reduce the physical recovery time<br />
of a disaster by just a few days you can take<br />
years off of the economic recovery time.<br />
That’s what robots allow you to do.<br />
You have said it’s unethical not to use rescue<br />
robots – why?<br />
We have now reached the point at which these<br />
technologies are proven. Not every robot is<br />
perfect and not every robot is ready, but in<br />
general these are hardened technologies that<br />
have been used in 50 disasters in 15 countries<br />
since 2001. It’s not like we suddenly came up<br />
with something out of nowhere. It was the<br />
same scenario with vaccines – at some point<br />
you just have to pony up the money and<br />
commit to it. ■<br />
Interview by Chris Baraniuk<br />
2 April 2016 | NewScientist | 29
COVER STORY<br />
SMASH<br />
AND GRAB<br />
The Milky Way’s dwarf satellites were violently<br />
acquired – and that spells trouble for established<br />
ideas of gravity, says Stuart Clark<br />
<strong>THE</strong> end of the Milky Way is already<br />
scheduled, and will be marked with<br />
fireworks. Some 4 billion years from<br />
now, the night skies will be lit by the glow of<br />
hundreds of billions of stars as the nearby<br />
Andromeda galaxy bears down on us. The<br />
two celestial giants will become one and stars,<br />
planets and gas clouds will be hurled into<br />
intergalactic space by titanic gravitational<br />
forces. Surviving stars and planets will be<br />
pitched into a jumbled cloud flaring up with<br />
new stars – floating into a long future not<br />
in the Milky Way, nor Andromeda, but a<br />
monstrous “Milkomeda” galaxy.<br />
It’s a well-established picture of our galaxy’s<br />
cataclysmic future. More controversially,<br />
it might also be a vision of its past.<br />
Observations indicate that the eviscerated<br />
remains of a past encounter between two<br />
celestial giants encircle our galaxy’s<br />
neighbourhood. Forbidden alignments of<br />
satellite galaxies, globular clusters and<br />
streams of stars trailing in our galactic wake<br />
all hint that our local cosmic history needs<br />
a rewrite. And not only that: to explain what<br />
our telescopes are telling us, we may need to<br />
rethink that most mysterious of substances,<br />
dark matter – and perhaps our entire<br />
conception of how gravity works, too.<br />
Like many big problems, this one started<br />
out small: in a strange configuration of tiny<br />
dwarf galaxies surrounding the Milky Way.<br />
In 2012, astronomer Marcel Pawlowski, then<br />
of the University of Bonn in Germany, dubbed<br />
it the “vast polar structure”. This was for the<br />
way the dwarfs line up in a ring that circles the<br />
galaxy at right angles to the main disc of stars,<br />
which contains our sun and everything else.<br />
But he was by no means the first to see it.<br />
That was Donald Lyndon-Bell of the University<br />
of Cambridge, who in 1976 pointed out that<br />
the satellite galaxies surrounding the Milky<br />
Way are not scattered randomly, but look as if<br />
something has corralled them into a distinct<br />
alignment. “They thought it could be the<br />
break-up of a larger galaxy, making it some<br />
form of debris stream,” says Pawlowski,<br />
“There was an open discussion at the time,<br />
but then the topic became unpopular.”<br />
The thing that made it unpopular was<br />
the rise of dark matter. Dark matter became<br />
30 | NewScientist | 2 April 2016
TATIANA PLAKHOVA<br />
“<strong>THE</strong> ALIGNMENT IS<br />
EXACTLYWHATYOU<br />
WOULDEXPECTIF<br />
<strong>THE</strong> TWO GALAXIES<br />
HAD INTERACTED<br />
IN <strong>THE</strong> PAST”<br />
a fixture in the 1970s to explain a glaring<br />
discrepancy between our standard<br />
cosmological models, rooted in the<br />
picture of gravity teased out by Newton and<br />
Einstein, and observations of reality. When<br />
astronomers measured the speed at which<br />
distant galaxies were rotating, they found<br />
these celestial bodies to be whirling round so<br />
fast they would fly apart if they relied only on<br />
visible matter’s gravity to hold them together.<br />
This frenzied rotation could be explained if<br />
there were more to the galaxies than met the<br />
eye – if most of their matter were not made of<br />
conventional atoms, but of particles that did<br />
not interact with light and so were invisible.<br />
Dark matter fitted ideas being floated by<br />
physicists studying the universe’s<br />
rambunctious early years, before stars and<br />
galaxies formed. In this searing environment,<br />
a panoply of new particles would have popped<br />
up to carry forces and energy. As the universe<br />
expanded and its temperature dropped,<br />
these particles would have lost their potency<br />
and become an inert, invisible soup.<br />
No one has ever detected or fabricated so<br />
much as a single particle of dark matter, yet<br />
its popularity has grown and grown. Our<br />
current standard model of cosmology has it<br />
outweighing normal matter by five to one.<br />
Existing in such quantities, dark matter<br />
not only explains galactic rotation, but also<br />
seems to be just the thing to allow galaxies<br />
such as the Milky Way to form. Tiny<br />
irregularities in the initial density of dark ><br />
2 April 2016 | NewScientist | 31
matter caused pockets of the stuff, unimpeded<br />
by interactions with anything else, to begin to<br />
collapse under their own weight. This pulled<br />
in normal matter, which collapsed down into<br />
flat, spinning discs of matter – galaxies.<br />
Simulations of this reproduce the observed<br />
form of galaxies like the Milky Way perfectly.<br />
Hot and cold spots we see in the cosmic<br />
microwave background, light sent pinging<br />
around the cosmos when it was just<br />
380,000 years old, are interpreted as<br />
indicating the seeds of this process. And so we<br />
believe that galaxies today are surrounded by<br />
a cosseting “halo” of dark matter that<br />
generates gravity and keeps everything<br />
together.<br />
Those same simulations show how, as dark<br />
matter collapses to form a galaxy halo, parts<br />
of it fragment, trapping in-falling normal<br />
matter and giving rise to a population of<br />
dwarf galaxies randomly scattered around<br />
the larger parent galaxy. So it is a bit of a<br />
problem that the Milky Way’s dwarf satellites<br />
are by no means randomly scattered.<br />
The huge success of the dark matter model<br />
meant most astronomers were content to<br />
turn a blind eye to this small embarrassment:<br />
the thought was we had simply not yet seen<br />
all the Milky Way’s accompanying dwarfs. But<br />
in 2005, Pavel Kroupa, also at the University<br />
of Bonn, reanalysed the satellite galaxy data<br />
and confirmed the striking mismatch with<br />
dark matter theory.<br />
Pawlowski, Kroupa’s doctoral student, then<br />
went further. He studied the alignment of other<br />
objects in the halo of the Milky Way – spherical<br />
collections of stars much smaller than dwarf<br />
galaxies known as globular clusters, and long<br />
wispy trails of stars thought to form when<br />
dwarf galaxies break up. He found them<br />
marshalled just like the dwarf galaxies.<br />
To explain it all, Pawlowski channelled<br />
Lyndon-Bell’s original suggestion that it<br />
could be the debris of an intergalactic collision<br />
and looked to see what the fallout of such a<br />
collision might be. He investigated whether<br />
dwarf galaxies could indeed form from the<br />
stuff left behind when two galaxies interacted.<br />
Astronomers see quite a few such galactic<br />
dances throughout the universe throwing<br />
out huge tails of stars and gas into space.<br />
Pawlowski’s simulations confirmed that the<br />
Milky Way’s dwarf galaxies could indeed form<br />
in their observed positions following such an<br />
encounter (see “When galaxies collide”, left).<br />
But what was it that danced with us?<br />
There was no obvious candidate until 2013,<br />
when Rodrigo Ibata of the Observatory of<br />
Strasbourg in France and his colleagues<br />
When galaxies collide<br />
An earlier encounter between two galaxies could be<br />
responsible for the strange ring of dwarf galaxies<br />
around the Milky Way<br />
The close encounter of two<br />
galaxies rips off huge tails of gas<br />
These tails coalesce to form dwarf galaxies<br />
in a ring at right angles to the main disc<br />
published observations that showed a similar<br />
polar structure of dwarf galaxies exists around<br />
Andromeda, our nearest galactic neighbour<br />
some 2.5 million light years away. The dwarfs<br />
above the plane of Andromeda are moving<br />
away from us, while those at the bottom are<br />
heading towards us – convincing evidence<br />
that the disc is not a chance alignment, but<br />
a coherent, rotating structure. Andromeda’s<br />
satellite disc is also rotating in the same sense<br />
as ours, and pointing at the Milky Way, albeit<br />
with a slight misalignment of about 35 degrees<br />
from our galaxy’s polar structure. It is all<br />
exactly what you would expect if the two<br />
galaxies had interacted in the past.<br />
Except they couldn’t have done. Even<br />
counting their presumed dark matter haloes,<br />
Andromeda and the Milky Way simply don’t<br />
have enough mass, and thus mutual gravity,<br />
to have pulled them into a collision in the time<br />
available since the big bang.<br />
So it’s a stalemate. Unless, that is, something<br />
is up with gravity. Newton’s and Einstein’s<br />
theories assume that gravity is a force whose<br />
strength declines with the square of the<br />
distance between two massive objects.<br />
That indeed seems to be the case on scales<br />
up to that of our solar system – the orbit<br />
of a body as far out as Pluto conforms to<br />
expectations. But it is an assumption we’ve<br />
never been able to test on larger scales.<br />
The heretical idea that gravity’s strength is<br />
not the same everywhere was proposed back<br />
in the 1980s as an alternative to dark matter.<br />
Known as MOND for “modified Newtonian<br />
dynamics”, the idea was floated by Mordechai<br />
Milgrom, then at Princeton University in<br />
New Jersey. He found that the rotation of<br />
galaxies could be almost perfectly described<br />
if, in situations where the gravitational<br />
field is comparatively weak, its strength<br />
did not continue to decline with the square<br />
of distance, but flattens out. In such<br />
environments, for example in the outer<br />
reaches of galaxies, gravity will be stronger<br />
than expected (see diagram, below right).<br />
In 2014, Hongsheng Zhao of the University<br />
of St Andrews, UK, working with Kroupa and<br />
others, showed that such a subtle change<br />
allowed for an interaction between the Milky<br />
Way and Andromeda between 7 and 11 billion<br />
years ago. “Simply speaking, MONDian<br />
dynamics demands that there was a past<br />
interaction between the two,” says Pawlowski.<br />
Superfluid epiphany<br />
But MOND is not exactly flavour of the month<br />
among physicists. Even though the strength<br />
of gravity has never been tested in very weak<br />
fields, the idea that a force of nature should<br />
change its strength so readily is unpalatable<br />
to most. And MOND runs into problems when<br />
the scales get extremely large. In clusters of<br />
many galaxies, dark matter is still needed<br />
to hold everything together. And those hot<br />
and cold spots in the cosmic microwave<br />
background are very hard to explain without<br />
some form of dark matter assisting the<br />
collapse of normal matter into galaxies.<br />
All of this gave Pawlowski pause for<br />
thought, wondering whether the MOND idea<br />
might itself be modified not just to explain<br />
a past collision between the Milky Way<br />
and Andromeda, but also to fit all other<br />
observations. “Maybe MOND is telling us<br />
something about gravity,” he says. “Or maybe<br />
it is telling us something about dark matter.”<br />
Enter Justin Khoury with the self-same<br />
question – and perhaps an answer. A<br />
theoretical physicist at the University of<br />
Pennsylvania in Philadelphia, Khoury has long<br />
been fascinated by the success of MOND in<br />
32 | NewScientist | 2 April 2016
of two models previously regarded as<br />
implacably opposed. For this hybrid model<br />
to work, his calculations suggest that the<br />
dark matter itself is a billion times lighter<br />
than current models indicate.<br />
TATIANA PLAKHOVA<br />
“ <strong>THE</strong> SUPERFLUID WOULD<br />
REPLICATE DARK MATTER ON<br />
SOME SCALES, AND MODIFY<br />
GRAVITY ON O<strong>THE</strong>RS”<br />
describing cosmic dynamics up to the scale of<br />
galaxies – and its failure with anything bigger.<br />
“You need the component that modifies gravity<br />
on galaxy scales to go quiet on cosmological<br />
scales,” he says. “How do you accommodate<br />
that?” His answer: with superfluids.<br />
Khoury’s epiphany involves a superfluid<br />
state known as a Bose-Einstein condensate,<br />
which kicks in among some types of normal<br />
matter atoms once they drop below a certain<br />
temperature. In this state, the constituent<br />
particles begin to behave as one single,<br />
coherent mass that has no viscosity and<br />
flows without impediment. When the<br />
temperature rises again, they snap back<br />
out into a normal, viscous fluid state.<br />
If dark matter particles could enter a Bose-<br />
Einstein state, Khoury reasoned, that would<br />
be just the thing to replicate MOND on certain<br />
scales, and ordinary dark matter on others.<br />
In the relatively weak gravitational fields of<br />
galaxies, dark matter would be slow-moving<br />
and have a low effective temperature. It would<br />
slip into a Bose-Einstein state whose energy<br />
would be spread uniformly across its extent,<br />
curving space and creating a MOND-like<br />
additional gravitational force. But in stronger<br />
gravitational fields, as found in galaxy<br />
clusters, the coherence would break and the<br />
matter would behave just like ordinary dark<br />
matter, contributing its own minuscule force<br />
of gravity particle by particle.<br />
This would also explain why we see no<br />
MONDian behaviour on the scale of our solar<br />
system. With our sun, we have a very strong<br />
local source of gravity, so the condensate<br />
would break down on this local level. The same<br />
would be true of each of the Milky Way’s stars,<br />
which would behave like impurities in the<br />
condensate. But because our galaxy, like all<br />
galaxies, is mainly empty space, the overall<br />
galactic condensate would still dominate.<br />
Khoury is not the first to suggest dark<br />
matter dynamics would naturally mimic<br />
those of a Bose-Einstein condensate, but he<br />
is the first to suggest it would lead to MONDlike<br />
variations in gravity, thus unifying bits<br />
Gravity assist<br />
Modified Newtonian dynamics provides a boost<br />
togravity’s strength at largedistances<br />
Strength<br />
of gravity<br />
Modified gravity<br />
Standard inversesquare<br />
gravity<br />
Distance from centre of gravity<br />
Stark mismatch<br />
Khoury is currently developing computer<br />
models to see how superfluid dark-matter<br />
haloes would affect how galaxies merge, and<br />
so see if there are any observations he could<br />
make to test the idea. He is also collaborating<br />
with a condensed-matter physicist colleague<br />
at the University of Pennsylvania, Tom<br />
Lubensky, to see if there is any supercooled<br />
atomic fluid known to create exactly the<br />
predicted effect. “If so, then perhaps we can<br />
use cold atom gases to simulate galaxies<br />
and mergers in the laboratory,” he says.<br />
Some regard talk of superfluid dark matter<br />
modifying gravity as an unnecessary and<br />
unwelcome complication – a big disruption<br />
to explain the relatively small problem of<br />
strangely aligned dwarf galaxies. Ed Shaya<br />
of the University of Maryland in College<br />
Park, for instance, thinks that the mismatch<br />
between simulations and the reality of the<br />
dwarf galaxies is down to a lack of computing<br />
power, which limits the resolution of<br />
simulations. He believes that there are still<br />
solutions invoking ordinary physics and<br />
ordinary dark matter. “It is not yet time to<br />
give up on the standard model,” he says.<br />
The distance between simulation and<br />
reality is stark for now. The vast polar<br />
structure’s ring shape is about 500,000 light<br />
years in diameter, yet no more than 50,000<br />
light years wide. Although some standard<br />
galaxy formation simulations can be rigged<br />
to produce similar alignments, they never<br />
produce rings less than a million light years<br />
in width. For Pawlowski, this mismatch is a<br />
big deal. “There are a number of problems<br />
that the standard model has on the scale of<br />
galaxies, but this is the biggest.”<br />
None of this will affect our ultimate fate,<br />
as we serenely spiral towards the giant<br />
firework show at the end of our galaxy. But<br />
will that shock and awe display be a repeat<br />
performance? Who knows – and if we have<br />
to modify our ideas of gravity and dark<br />
matter, we can’t pencil the next date into<br />
our diaries with much certainty, either.<br />
The fireworks could be going off a fair bit<br />
earlier than expected. ■<br />
Stuart Clark is a consultant for New Scientist and<br />
author of The Unknown Universe (Head of Zeus)<br />
2 April 2016 | NewScientist | 33
SERGE PICARD/AGENCE VU/CAMERAPRESS<br />
Getting the<br />
word out<br />
Often thought of as a psychological<br />
disorder, stammering could have a very<br />
different cause, finds Norman Miller<br />
IPRAY every day that no one will ask my name.<br />
That’s not because “Norman” is so terrible<br />
(it’s bad, but not that bad), but because I<br />
stammer. The thing we get asked most often<br />
in life is nearly impossible for me to get out.<br />
I’m far from alone. Also called stuttering,<br />
stammering affects around 70 million people<br />
worldwide, and every language has a word<br />
for it. Despite this, it is an enigma, often<br />
ending up the subject of humour, pity or<br />
jibes rather than serious research. And until<br />
recently, any research that did occur focused<br />
on psychological causes of a condition many<br />
linked to mental trauma or anxiety.<br />
Now, with developments in brain imaging<br />
and genetic techniques, a new picture of<br />
the condition is emerging, one that suggests<br />
a more tangible explanation. “There is<br />
something fundamentally different about<br />
the brains of people who stutter,” says Scott<br />
34 | NewScientist | 2 April 2016
Grafton, a neuroscientist at the University of<br />
California, Santa Barbara. And the hope is that<br />
a better grasp of the physiological basis of<br />
stammering could lead to better treatments.<br />
For much of history, stammerers have<br />
been subjected to often misguided “cures”.<br />
One old belief blamed abnormalities of the<br />
tongue, leading to barbaric cutting of the<br />
“offending” body part. The Greek philosopher<br />
Demosthenes worked to boost his fluency by<br />
shouting at the sea with pebbles in his mouth.<br />
In the 1920s, scientific investigation<br />
of stammering began, with a focus on<br />
psychological theories. One notable early idea<br />
was that it was caused by negative reactions<br />
by overanxious parents to children’s normal<br />
speech hesitancies – an idea still around when<br />
I was being sent to speech therapists in the<br />
1970s, despite a lack of clinical evidence.<br />
The riddles that stammering presents don’t<br />
help. Around 5 per cent of children aged 2 to<br />
5 years old will stammer at some point, but<br />
most grow out of it. And many who do stammer<br />
into adulthood can experience occasions when<br />
their speech stops stumbling – for instance,<br />
when singing or putting on a foreign accent.<br />
The fact that some people acquire a stammer<br />
as a result of brain trauma hinted there could<br />
be a neurological basis. But it was only with the<br />
advent of neuroimaging that we could finally<br />
peer at the brain in action as people stammer.<br />
Speech is produced via a series of precisely<br />
coordinated muscle movements involving<br />
breathing, phonation – or voice production –<br />
and the movement of the throat, palate,<br />
tongue and lips, known as articulation.<br />
This sequence requires sophisticated<br />
coordination of several brain areas. Brainimaging<br />
studies in people who stammer are<br />
pointing to neurological differences leading<br />
to a breakdown in this highly coordinated<br />
planning and execution process.<br />
One implicated area is the arcuate fasciculus,<br />
a bundle of nerve fibres that transmits signals<br />
to parts of the brain known to be involved in<br />
speech production. Last year, Grafton’s team<br />
scanned the brains of people who stammer<br />
and found striking differences in this area.<br />
“In the vast majority of the stutterers we<br />
scanned, there seems to be a missing branch<br />
of neural connections,” he says. This suggests<br />
that the signals involved in speech production<br />
could be getting lost. The idea is backed up by<br />
studies carried out by Kate Watkins and her<br />
colleagues at the University of Oxford, who<br />
found connectivity problems in the arcuate<br />
fasciculus of both adult and child stammerers.<br />
Other implicated regions are Broca’s<br />
area, which is involved in directing muscle<br />
movement of the mouth when you form<br />
words, and the striatum, a part of the brain<br />
located in the basal ganglia, which play a<br />
key part in facilitating voluntary movement.<br />
NIALL O’LEARY/MILLENNIUM IMAGES<br />
But studies that show stammering is related<br />
to connection faults in the speech-producing<br />
networks of the brain raise a question: why<br />
do some people overcome the condition? To<br />
find out, Christian Kell at the Brain Imaging<br />
Center in Frankfurt, Germany, has been<br />
comparing the brain function of stammerers<br />
with that of these recovered stammerers.<br />
We know that among fluent speakers,<br />
the left hemisphere of the brain takes the<br />
dominant role in speech production. In<br />
stammerers, the right hemisphere activates<br />
more strongly when speaking, even if they<br />
aren’t stammering. Kell thinks their brains are<br />
attempting to compensate for malfunctions in<br />
speech areas of the left hemisphere. “To some<br />
degree, this could reduce symptoms – but only<br />
partly, because the right hemisphere usually is<br />
not specialised in speaking,” he says.<br />
Among recovered stammerers, however, Kell<br />
found that some left-hemisphere networks<br />
TYPES OF STAMMER<br />
DEVELOPMENTAL: The most common form,<br />
appearing from childhood and probably linked to<br />
differences in brain structure (see main story)<br />
NEUROGENIC: develops as a result of<br />
strokes or other brain trauma<br />
PSYCHOGENIC: a rare form that arises after<br />
severe emotional trauma<br />
were working again – in particular Brodmann<br />
Area 47, or BA47. This is known to be involved<br />
in various speech mechanisms. In persistent<br />
stutterers, scans show BA47 as one of the areas<br />
that doesn’t activate properly, but among<br />
recovered stammerers it appears to work.<br />
So what causes these brain differences<br />
in the first place? It isn’t clear yet whether<br />
they cause the stutter or whether disfluencies<br />
in early childhood create the anomalies as<br />
the brain is developing, says Watkins. “The<br />
differences are there in young children close<br />
to the time that stammering starts, but most<br />
of the data acquired has been from adults<br />
who have stammered all their lives,” she<br />
says. The best way to solve this mystery will<br />
be studies that follow children who stammer<br />
over years or decades.<br />
Other clues come from genetics – studies<br />
using twins, for instance, show a strong<br />
genetic element. In the hunt for stammering<br />
genes, Dennis Drayna at the National<br />
Institutes of Health in Bethesda, Maryland,<br />
is focusing on families with multiple<br />
stammerers – including one extended<br />
Cameroonian family with more than 40.<br />
Finding a voice<br />
In one analysis of nearly 400 people who<br />
stammer, Drayna found three gene mutations<br />
that appeared repeatedly among them, but<br />
not in a control group. As these genes encode<br />
an enzyme that recycles cellular components,<br />
Drayna believes that these mutations could<br />
prevent the recycling of cells in brain areas<br />
related to speech processing, resulting in the<br />
sort of anomalies – such as missing neural<br />
connections – seen in scans.<br />
Even so, these types of genetic changes<br />
will only be responsible for some cases<br />
of stammering. There is now a growing<br />
understanding that stammering probably<br />
takes on different forms, each with a different<br />
cause (see “Types of stammer”, left).<br />
For those whose stammer is linked to<br />
brain changes, the discoveries are offering a<br />
glimmer of hope for the ultimate treatment –<br />
a pill to make a stammer disappear.<br />
Efforts are homing in on drugs that block<br />
the brain chemical dopamine, following the<br />
curious discovery that people given dopamine<br />
boosters to treat other conditions acquired a<br />
stutter. “Every study completed of a dopamine<br />
blocker [in stammerers] has shown positive<br />
benefit,” says neuroscientist and lifelong<br />
stammerer Gerald Maguire of the School<br />
of Medicine at the University of California,<br />
Riverside. “Dopamine medications result<br />
in a more natural speech by improving<br />
the function of the striatum. We become<br />
fluent when we sing because we bypass<br />
the defective striatum.”<br />
His money is on asenapine – a dopamine<br />
blocker that is approved to treat bipolar<br />
disorder and schizophrenia. In a small study<br />
of stammerers, Maguire found it improved<br />
fluency by between 60 and 75 per cent. Side<br />
effects were minor, so I for one am keeping<br />
my fingers firmly crossed that it makes it<br />
onto the stammering prescription list soon.<br />
Not everyone is as confident. “I think the<br />
scientific theories that implicate dopamine<br />
are persuasive,” says Watkins, “but the<br />
evidence from brain-imaging studies is not<br />
particularly clear.” Part of the problem is that<br />
studies have only been done on small groups.<br />
Still, I can take some comfort in the fact<br />
that stammering is finally getting the serious<br />
research it deserves. And that perhaps one day I<br />
will be able to say my name with confidence. ■<br />
Norman Miller is a freelance writer in Brighton, UK<br />
2 April 2016 | NewScientist | 35
36 | NewScientist | 2 April 2016
To make computers better, we need to make<br />
them worse, says Paul Marks<br />
Let’s cut them<br />
some slack<br />
KRISHNA PALEM’S computers won’t win<br />
any awards for accuracy. Most of the time<br />
they can’t even add up correctly. For<br />
them, 2 + 2 might as well be 5. But don’t be<br />
fooled by the wobbly arithmetic. Palem is<br />
making machines that could represent a new<br />
dawn for computing.<br />
Inaccuracy is not something we typically<br />
associate with computers. Since Alan Turing<br />
laid down their ground rules in the 1930s,<br />
computers have been sticklers for precision,<br />
built on the principle of following step-by-step<br />
instructions in an exact and reproducible<br />
manner. They should not make errors.<br />
But maybe we should cut them some slack.<br />
Letting computers make mistakes could be the<br />
best way to unlock the next wave of smart<br />
devices and prevent high-performance<br />
computing hitting a wall. It would allow us to<br />
run complex simulations that are beyond<br />
today’s supercomputers – models that better<br />
predict climate change, help us design more<br />
efficient cars and aircraft, and reveal the<br />
secrets of galaxy formation. They may even<br />
unlock the biggest mystery of all, by letting us<br />
simulate the human brain.<br />
Until now, we have had to accept a trade-off<br />
between performance and energy efficiency:<br />
a computer can be either fast or low-powered,<br />
but not both. This not only means that more<br />
powerful smartphones need better batteries,<br />
but also that supercomputers are energy<br />
guzzlers. Next-generation “exaflop” machines,<br />
which are capable of 10 18 operations a second,<br />
could consume as much as 100 megawatts, the<br />
output of a small power station. So the race is<br />
on to make computers do more with less.<br />
One way is simply to reduce the amount of<br />
time spent executing code – the less time<br />
taken, the less power used. For programmers,<br />
SPENCER WILSON<br />
this means looking for ways to get the desired<br />
result more quickly. Take the classic travellingsalesman<br />
problem of finding the shortest<br />
route around a group of cities. It’s notoriously<br />
tough to solve, given that the number of<br />
possible routes shoots up exponentially with<br />
the number of cities. Palem, a computer<br />
scientist at Rice University in Houston, Texas,<br />
says that coders often settle for a route that<br />
they estimate to be about half as good as the<br />
best, because to do better would use up too<br />
much computer time. A more recent version<br />
of this approach is to use a machine-learning<br />
algorithm to arrive at an approximate result for<br />
a given piece of code. This rough answer – like<br />
a back-of-the-envelope calculation – can then<br />
be used each time the program runs instead of<br />
executing the original section of code itself.<br />
But saving energy by cutting corners in<br />
software only goes so far. To really save<br />
power, you need to change the way the<br />
hardware works. Computers can save vast<br />
amounts of energy simply by not operating<br />
all their transistors at full power all the time,<br />
but as we’ll soon see, this means sacrificing<br />
accuracy. Palem’s team is hobbling computers<br />
so that they get their sums wrong in an<br />
acceptable way. “What we are proposing is to<br />
alter the computer itself to give you cheaper<br />
but slightly less accurate answers,” says Palem.<br />
Take any algorithm that you think does a good<br />
job, and he will solve it inexactly with a<br />
different physical system under the hood.<br />
Standard computer chips use a sliver of<br />
silicon called a channel to act as a switch<br />
that can flip between on (1) and off (0). The<br />
switching is controlled by a gate that stops a<br />
current flowing through the channel until you<br />
apply a voltage. Then the gate opens like a<br />
sluice in a dam, letting current through.<br />
><br />
2 April 2016 | NewScientist | 37
But it’s finicky. This complementary metaloxide<br />
semiconductor (CMOS) technology only<br />
works well when it has a reliable 5-volt power<br />
supply. Start to lower that and the channel<br />
becomes unstable – sometimes switching,<br />
sometimes not.<br />
In 2003, Palem, then at the Georgia Institute<br />
of Technology in Atlanta, saw trouble coming.<br />
It was clear that the ability of the electronics<br />
industry to continue doubling the number of<br />
transistors on a chip every 18 to 24 months – a<br />
miniaturisation trend known as Moore’s law –<br />
was coming to an end. Miniaturisation was<br />
introducing errors at the chip level. This was<br />
largely due to overheating and interference,<br />
or crosstalk, between the densely packed<br />
transistors. “It was quite likely ultra-small<br />
devices would become quite unstable,” says<br />
Palem. Power was now the critical issue.<br />
What if you could harness instabilities in<br />
some way that would also save energy?<br />
Palem’s answer was to design a probabilistic<br />
version of CMOS technology that was<br />
deliberately unstable. His team built digital<br />
MISSING BITS<br />
Krishna Palem is building an inexact<br />
computer that saves power by<br />
relaxing its precision. With this set-up,<br />
8 + 5 could equal a range of values.<br />
Here’s why: in Palem’s system,<br />
transistors representing the least<br />
significant digits in a number are<br />
deliberately run at a lower than ideal<br />
voltage. This makes them unstable,<br />
prone to flipping from 1 to 0 or 0 to 1.<br />
In a 16-bit number, the eight least<br />
significant bits could be incorrect.<br />
“As many as half the bits can be<br />
flipping,” says Palem.<br />
As a simplified example, consider<br />
adding two 4-bit numbers. In binary,<br />
8 is 1000 and 5 is 0101, and adding<br />
them should give 1101, or 13. But if<br />
the two least significant – rightmost –<br />
bits can flip, then the result<br />
could become 1100 (which is 12), 1110<br />
(14) or 1111 (15). It is possible that the<br />
inputs, 8 and 5, might get corrupted<br />
too: 1000 (8) could turn into 1001 (9),<br />
1010 (10) or 1011 (11); and 0101 (5)<br />
into 0100 (4), 0110 (6) or 0111 (7).<br />
Finally, the result of adding any two of<br />
these numbers could become<br />
corrupted as well, leading to a range<br />
of inexact answers.<br />
Modelling the crucial role of clouds in climate<br />
change is too costly with today’s computers<br />
circuits in which the most significant bits –<br />
those representing values that need to be<br />
accurate – get a regular 5-volt supply, but the<br />
least significant bits get 1 volt. “The significant<br />
bits are running at a proper, well-behaved<br />
voltage, but the least significant get really<br />
slack,” says Palem. As many as half the bits<br />
representing a number can be hobbled like this.<br />
This means that Palem’s version of an adder,<br />
a common logic circuit that simply adds two<br />
numbers, doesn’t work with the usual<br />
precision (see “Missing bits”, below). “When<br />
it adds two numbers, it gives an answer that is<br />
reasonably good but not exact,” he says. “But<br />
it is much cheaper in terms of energy use.”<br />
Spread that over billions of transistors and<br />
you have a significant power saving. The trick<br />
is to choose applications for which the least<br />
significant bits don’t matter too much: for<br />
example, using a large range of numbers<br />
to represent the colour of a pixel. In one<br />
experiment, Palem and his colleagues built<br />
a digital video decoder that interpreted the<br />
least significant bits in an imprecise way<br />
when converting pixel data into screen<br />
colours. They found that human viewers<br />
perceived very little loss in image quality.<br />
“The human eye averages a lot of things out,”<br />
says Palem. “Think about how we see illusions.<br />
The brain does a lot of work to compensate.”<br />
Encouraged by that success, the Rice<br />
University researchers have moved on to<br />
another application involving the senses:<br />
hearing aids. Their initial tests show that<br />
inexact digital processing in a hearing aid<br />
can halve power consumption while reducing<br />
intelligibility by only 5 per cent. The results<br />
suggest that we could use such techniques<br />
to slash the power used by smartphones and<br />
personal computers, given that these are<br />
basically audiovisual devices.<br />
Tim Palmer, a climate physicist at the<br />
University of Oxford, sees even greater<br />
potential. He thinks that computers based<br />
on Palem’s ideas could be the answer to what<br />
is presently an intractable problem: how to<br />
improve the accuracy of climate predictions<br />
for the next century without waiting years<br />
for a new generation of supercomputers.<br />
“The crucial question about climate change<br />
centres on the role of clouds,” says Palmer, in<br />
terms of whether they amplify or dampen<br />
the effects of global warming. “You can’t<br />
really answer that question with any great<br />
confidence unless you can simulate cloud<br />
systems directly.” And right now, it’s not<br />
NGMART/NATIONALGEOGRAPHICCREATIVE<br />
clear how to do that.<br />
Today’s supercomputers don’t have the<br />
brawn to do it, and their successors, expected<br />
in the next decade or so, will just be too<br />
energy-hungry. “Based on current estimates,<br />
the amount of power needed for such a<br />
machine is going to be around 100 megawatts,”<br />
says Palmer, five to 10 times what today’s<br />
top supercomputers use. Assuming they<br />
don’t just melt, running them could prove<br />
prohibitively costly.<br />
“Doing 20 calculations<br />
inexactly may be more<br />
useful than 10 done exactly”<br />
Supercomputers burn so much power<br />
because they are generally optimised for<br />
computing with 64-bit-long numbers. In<br />
principle, this gives greater accuracy. But<br />
climate models involve millions of variables,<br />
simulating complex interacting factors such<br />
as winds, convection, temperatures, air<br />
pressures, ocean temperatures and salinity.<br />
The result, says Palmer, is that they have too<br />
much power-draining data to crunch. What’s<br />
needed, he says, is for different variables to be<br />
38 | NewScientist | 2 April 2016
individual clouds.<br />
“Doing 20 calculations inexactly could be<br />
much more useful than 10 done exactly,” says<br />
Palmer. This is because at 100-kilometre scales,<br />
the simulation is a crude reflection of reality.<br />
The computations may be accurate, but the<br />
model is not. Cutting precision to get a finergrained<br />
model would actually give you greater<br />
accuracy overall. “It is more valuable to have<br />
an inexact answer to an exact equation than<br />
an exact answer to an inexact equation,” he<br />
says. “With the exact equation, I’m really<br />
describing the physics of clouds.”<br />
Power hungry<br />
Despite huge advances in performance, conventional<br />
computers are no match for the human brain when<br />
it comes to efficiency<br />
represented in data strings of varying length,<br />
depending on their importance to the model.<br />
Chipmakers are starting to accommodate<br />
such needs. Nvidia has launched a graphics<br />
processor unit, the TX1, that is capable of<br />
“mixed-precision” processing, allowing<br />
software to switch between 16 and 32-bit<br />
operation as it runs. But Palmer wants to see<br />
Palem’s inexact chips adopted too. “If we can<br />
reduce the number of bits that you need to do<br />
calculations, that would have an enormous<br />
impact on energy consumption,” he says.<br />
Palmer and his colleagues are talking to<br />
supercomputer makers like IBM and Cray<br />
about developing a new breed of energyefficient<br />
hybrid machines that allow varying<br />
levels of accuracy, and that may even adopt<br />
Palem’s strategy. And Palem’s team is working<br />
on mixed-precision computing with the US<br />
government’s Argonne National Laboratory in<br />
Illinois and the European Centre for Medium-<br />
Range Weather Forecasts in Reading, UK.<br />
The pay-offs could be huge. Today’s climate<br />
models tackle Earth’s atmosphere by breaking<br />
it into regions roughly 100 kilometres square<br />
and a kilometre high. Palmer thinks inexact<br />
computing would get this down to cubes a<br />
kilometre across – detailed enough to model<br />
Degrees of accuracy<br />
You can’t just give up on accuracy across the<br />
board, of course. “There is no doubt that if you<br />
represent all of the variables in the climate<br />
model with just 16 bits rather than 64 bits it<br />
would be a disaster: it would fail very quickly,”<br />
says Palmer. The challenge is choosing which<br />
parts can be treated more crudely than others.<br />
Researchers are attacking the problem<br />
from several different angles. Mostly, it comes<br />
down to devising ways to specify thresholds<br />
of accuracy in code so that programmers can<br />
say when and where errors are acceptable.<br />
The software then computes inexactly only in<br />
parts that have been designated safe.<br />
Approximation is not the answer for<br />
everyone, however. Rashid Mansoor is a<br />
London-based computer scientist and<br />
entrepreneur who invented Adbrain, an<br />
algorithm that tracks millions of web users as<br />
they move between devices. He is now looking<br />
at ways to speed up computing done in the<br />
cloud. But Mansoor sees inexactness as a last<br />
resort. “We don’t yield approximate results for<br />
the sake of speeding up computation,” he says.<br />
“We’d consider it to be cheating.”<br />
Even so, Stan Posey, who heads Nvidia’s highperformance<br />
computing team in Santa Clara,<br />
California, sees a host of applications for which<br />
inexact computing will make a big difference,<br />
including accident investigations. After the<br />
Columbia space-shuttle disaster of 2003,<br />
caused by a chunk of insulating foam breaking<br />
off and making a hole in a wing, Posey and his<br />
colleagues spent countless hours simulating<br />
scenarios that could have led to this happening.<br />
He thinks inexact computing would now allow<br />
a number of simulations an order of magnitude<br />
higher within the same time frame. Scenarios<br />
that are worth looking into more closely can<br />
then be pursued with higher accuracy.<br />
Some think inexact simulations could<br />
ultimately help us understand the brain.<br />
Supercomputers like IBM’s Blue Gene are<br />
Smartphone<br />
Desktop PC<br />
Next-generation supercomputer<br />
Human brain<br />
being used to model neurological functions in<br />
the Human Brain Project, for example. But<br />
there is a huge discrepancy in power<br />
consumption between the brain and a<br />
supercomputer, says Palmer (see “Power<br />
hungry”). “A supercomputer needs megawatts<br />
of power, yet a human brain runs on the power<br />
of a light bulb.” What could account for this?<br />
Palmer and colleagues at the University of<br />
Sussex in Brighton, UK, are exploring whether<br />
random electrical fluctuations might provide<br />
probabilistic signals in the brain. His theory is<br />
that this is what lets it do so much with so little<br />
power. Indeed, the brain could be the perfect<br />
example of inexact computing, shaped by<br />
pressure to keep energy consumption down.<br />
What’s clear is that to make computers<br />
better, we need to make them worse. Palmer is<br />
convinced that partly abandoning Turing’s<br />
concept of how a computer should work is the<br />
way forward if we are to discover the true risks<br />
we face from global warming. “It could be the<br />
difference between climate change being a<br />
relatively manageable problem and one that<br />
will be an existential problem for humanity.”<br />
And if approximate computing seems a<br />
shaky foundation on which to build the future<br />
of computing, it’s worth remembering that<br />
computers are always dealing with the<br />
abstract. “All computing is approximation,”<br />
says Posey. Some are just more approximate<br />
than others. ■<br />
Paul Marks is a technology journalist based in London<br />
2 April 2016 | NewScientist | 39
YOU<br />
SWINE!<br />
Feral pigs are wreaking<br />
havoc across the globe.<br />
But it isn’t easy to outwit<br />
these brainy beasts,<br />
says Stephen Ornes<br />
RODNEY WOODSON never set out to be a<br />
pig trapper. He joined the Tennessee<br />
Wildlife Resources Agency because he<br />
was passionate about conserving water birds.<br />
But that was before the hogs rocked up, with<br />
their high libidos and low cunning.<br />
Across the world, and especially in the<br />
southern US, feral pigs are a problem.<br />
Marauding hordes of swine are destroying<br />
crops and sensitive natural environments,<br />
causing traffic accidents and spreading<br />
disease and parasites. They have even dug up<br />
cemeteries. The US Department of Agriculture<br />
estimates the damage at $1.5 billion a year.<br />
As so often with invasive species, this is a<br />
problem of our own making. Wild pigs were<br />
introduced to the US by Spanish settlers<br />
hundreds of years ago, but weren’t a cause of<br />
widespread concern until the 1990s, says<br />
zoologist Jack Mayer at the Savannah River<br />
National Laboratory in South Carolina, when<br />
cable TV ads began promoting the animals as<br />
an exotic alternative hunting target to turkeys<br />
and deer. In 1999, Tennessee established a hog<br />
hunting season, and soon enterprising<br />
landowners were stocking up. That ushered in<br />
“an explosion of new hog populations” across<br />
the state, says Chuck Yoest, coordinator of the<br />
Tennessee Wild Hog Eradication Action Team,<br />
part of the agency that Woodson works for. In<br />
2011, the state reclassified pigs from big game<br />
to destructive pests.<br />
The pigs’ supercharged reproduction rate<br />
isn’t helping. A sow may produce two or more<br />
litters of typically five or six pigs every year,<br />
making it nearly impossible to cull all the<br />
NEW YORK STATE DEPARTMENT OF ENV/EYEVINE RODNEY WOODSON<br />
individuals in an area at once. Pig population<br />
models show that clearing an area requires<br />
removing 70 per cent of the animals “year<br />
after year after year, until you drive that<br />
population to extinction”, says Mayer.<br />
In Texas, some landowners now offer<br />
wealthy customers the opportunity to<br />
machine-gun pigs from a helicopter for as<br />
much as $1000 an hour. Other communities<br />
have called in teams of sharp shooters. But<br />
critics say that these methods of pig control<br />
are not just inhumane, but ineffective. For a<br />
start swine are fast: they can run at up to<br />
50 kilometres an hour. They can also respond<br />
to hunting pressure in surprising ways, for<br />
example switching between nocturnal and<br />
diurnal living patterns. “They’re a pain in the<br />
backside, but they are interesting critters,”<br />
says Mayer.<br />
Traps of the sort Woodson lays are generally<br />
thought to be the least bad option in dealing<br />
with the pigs. But porcine intelligence makes<br />
trapping a full time job. Pigs have been shown<br />
to beat chimps when it comes to IQ, are<br />
whizzes at navigating complex mazes and can<br />
manipulate cursors on a screen by controlling<br />
a joystick with their snout. It means in simple<br />
traps they soon work out how to jump over<br />
short fences and climb taller ones, for example<br />
by gaining purchase at a corner.<br />
Boar busting<br />
Woodson’s first tactic was to play the long<br />
game and put the pigs under surveillance. He<br />
installed cameras near baited traps, so pest<br />
control officers could examine pictures to see<br />
how many animals came by, and when. Once<br />
they knew which traps were frequented by the<br />
hogs, they could stake them out, hiding near a<br />
40 | NewScientist | 2 April 2016
Hog hordes<br />
Problem pigs are popping<br />
up across the globe<br />
UK Wild pigs went extinct in the UK<br />
300 years ago but now they are back<br />
thanks to leaky farms. Last year, a<br />
survey from the Forestry Commission<br />
estimated there were over 1000 in the<br />
Forest of Dean, on the England-Wales<br />
border, alone.<br />
Italy Last year swine in Tuscany<br />
snaffled enough Chianti grapes to<br />
fill 130,000 bottles of wine, leading<br />
wine-makers to call for mass<br />
extermination.<br />
Germany Berlin is home to thousands<br />
of wild hogs that pick through rubbish,<br />
spreading it around neighbourhoods,<br />
and sporadically attack people.<br />
Australia So-called “grunter hunters”<br />
have a huge problem on their hands:<br />
according to official estimates there<br />
are 23 million feral pigs in Australia –<br />
more than humans.<br />
trap and triggering its gate at the right moment.<br />
This was by no means a perfect strategy. It<br />
took lots of time and people, and although<br />
pigs can’t see well, they have a keen sense of<br />
smell. If they picked up the scent of a human,<br />
the pigs wouldn’t approach a trap.<br />
So in his latest iteration Woodson has<br />
gone wireless, using solar-powered cameras<br />
overlooking a circular enclosure with<br />
1.4-metre-high fences – high enough for pigs<br />
to have trouble climbing them, and with no<br />
corners to aid escape. When a motion sensor<br />
detects a pig-sized animal, it sends Woodson<br />
an email. From his own home, he can watch a<br />
real-time feed of the trap and at the right<br />
moment flip a switch to drop the gate.<br />
This human check is critical, Woodson says.<br />
If even one pig from a group is left uncaught,<br />
it may learn to avoid similar traps. Though<br />
maternal education in pigs hasn’t been<br />
studied rigorously, Woodson’s experience<br />
suggests that if it’s a sow, it may train its<br />
offspring to do the same.<br />
His creative trapping is bearing fruit: the<br />
record for one of the traps is 52 swine at once.<br />
And the wireless approach is generally<br />
becoming more popular. Landowners can buy<br />
commercial versions of remotely operated<br />
traps, including the $6000 Australian model<br />
known as the “Boar Buster”.<br />
But the story is far from over. Eager for<br />
more game, a few unscrupulous landowners<br />
are still trafficking pigs to Tennessee from<br />
neighbouring states, creating fresh pockets<br />
of infestation. Longer-term, climate change<br />
may also exacerbate things, at least in Europe.<br />
Last year, researchers at the University of<br />
Veterinary Medicine in Vienna, Austria,<br />
predicted that feral pig numbers there will<br />
surge during mild winters, as more food<br />
US A pair of pigs straying onto the<br />
runway at Florida’s Jacksonville<br />
International Airport in 1988 caused<br />
an F-16 fighter to crash and the pilot<br />
to eject. According to an Associated<br />
Press report at the time: “The pigs<br />
were killed. The pilot was bruised.<br />
The $16-million jet was destroyed.”<br />
becomes available.<br />
So others are thinking beyond traps. There<br />
is the “Judas pig” method, in which, when a<br />
group of pigs is culled, a sow is left alive and<br />
tagged with a GPS collar. She then does the<br />
hard work of finding another, doomed, tribe –<br />
at which point shooters are sent in. Then there<br />
are chemical approaches such as hog-specific<br />
poison or contraceptives. Later this month,<br />
trappers and conservationists will brainstorm<br />
new ideas in Myrtle Beach, South Carolina, at<br />
the international Wild Pig Conference.<br />
Meanwhile Woodson can’t stand idle. His<br />
latest trap has an oblong pen with two gates<br />
directly opposite each other, giving the pigs<br />
the illusion of a safe passage. The hogs in his<br />
patch are wise. It is a brutal business, and<br />
there’s no time for complacency. ■<br />
Stephen Ornes is a journalist in Nashville, Tennessee<br />
2 April 2016 | NewScientist | 41
CULTURELAB<br />
Animal crackers<br />
Pretending to be other creatures is a very human game, says Paul Cobley<br />
Being a Beast by Charles Foster,<br />
Profile Books, £14.99<br />
GoatMan: How I took a holiday from<br />
being human by Thomas Thwaites,<br />
Princeton Architectural Press,<br />
$24.95/£14.99<br />
WHO hasn’t wondered what life<br />
would be like as a (non-human)<br />
animal – flying, leaping,<br />
burrowing and doing all manner<br />
of everyday things that feral<br />
animals do? Such conjectures<br />
are universal. But who would<br />
actually go so far as to attempt to<br />
“become” a specific animal? Two<br />
new books, GoatMan and Being<br />
a Beast, offer engaging answers<br />
to this last question, even if they<br />
never quite manage to get to grips<br />
with the substance of what it is<br />
like to be another kind of creature.<br />
Both volumes veer into the<br />
territory of the classic essay by<br />
philosopher Thomas Nagel, who<br />
asked in 1974 “What is it like to be<br />
a bat?” He concluded that the core<br />
of the problem was consciousness.<br />
In the end, the consciousness of<br />
the bat would be inaccessible to<br />
us, no matter what measures we<br />
took to put ourselves in its place.<br />
“It will not help,” he writes,<br />
“to try to imagine that one has<br />
webbing on one’s arms, which<br />
enables one to fly around at dusk<br />
and dawn catching insects in<br />
one’s mouth; that one has very<br />
poor vision, and perceives the<br />
surrounding world by a system<br />
of reflected high-frequency sound<br />
signals; and that one spends the<br />
day hanging upside down by one’s<br />
feet in an attic.” Such measures<br />
would only enable one to behave<br />
as a bat seems to behave; what it<br />
is to be a bat would be another<br />
matter altogether.<br />
These books take a different<br />
view – or at least try to sidestep<br />
FELICITY MCCABE / <strong>THE</strong> GUARDIAN<br />
the problem. Recounting how,<br />
after winning a grant from the<br />
Wellcome Trust, he prepared<br />
to live like a goat, Thwaites is<br />
childishly defiant: “Well screw<br />
you, Nagel! I’m going to try<br />
anyway.” Meanwhile Foster – a<br />
traveller who sees himself in a<br />
tradition of nature writing –<br />
takes on some of the behaviours<br />
of badgers, urban foxes, otters,<br />
red deer and swifts. He takes<br />
“Beyond the entertainment<br />
afforded by the efforts<br />
of the authors, is there<br />
much to learn here?”<br />
Nagel’s suggestion for a new<br />
phenomenology to describe<br />
animal worlds as a cue for<br />
poesy or a vague reorientation<br />
of language.<br />
The projects described by each<br />
writer consist of fairly limited<br />
attempts to behave like certain<br />
animals. In terms of value for<br />
money, then, the reader can<br />
choose: at roughly the same<br />
length, one book reveals very little<br />
about one species, the other reveals<br />
very little about five species.<br />
Foster’s approach is, in some<br />
ways, allied to recent work in<br />
animal studies – a burgeoning<br />
Joining the smart sett: Charles<br />
Foster camped out as a badger<br />
field in the humanities – in the<br />
way it takes a tissue of human<br />
perspectives as its starting point<br />
and tries to transcend them.<br />
Foster camps out in a badger sett<br />
in Wales with his 8-year-old son,<br />
and prostrates himself in east<br />
London so as to gain a fox’s-eye<br />
view. Following an introductory<br />
chapter, the book is organised<br />
sequentially around highly<br />
personalised discussions of<br />
his five chosen species.<br />
Thwaites’s approach in<br />
42 | NewScientist | 2 April 2016
For more books and arts coverage, visit newscientist.com/culturelab<br />
GoatMan (out in May) is more<br />
focused. Originally wanting<br />
to live as an elephant, he takes<br />
the advice of a Scandinavian<br />
shaman and tries to “become”<br />
a goat. His chapters are devoted<br />
to “Soul”, “Mind”, “Body”, “Guts”<br />
and “Goat Life”.<br />
Despite the liberal use of irony<br />
and bathos, as well as a generally<br />
jokey tone in both books,<br />
Thwaites’s descriptions of his<br />
consultations with experts do<br />
threaten to illuminate the world<br />
of a non-human animal. In<br />
particular, his attempts – and<br />
initial failures – to replicate goat<br />
physiology are probably the most<br />
rewarding passages of either book.<br />
Blood will out<br />
Still, the reader is left<br />
wondering whether, beyond the<br />
entertainment afforded by the<br />
efforts of the authors, there is<br />
much to learn here. After the<br />
elaborate build-up in GoatMan,<br />
not to mention the enticing<br />
cover image – like the book, both<br />
comical and intriguing – it is<br />
disappointing that Thwaites<br />
seems to spend so little time<br />
among his chosen species. (He<br />
does, however, find a way to eat<br />
grass.) Foster, by contrast, has a<br />
friend bring meals to him in the<br />
badger sett.<br />
Inevitably, the reader is going to<br />
feel short-changed. It is as if both<br />
of these projects had involved<br />
the authors “becoming” me and,<br />
out of all my characteristics,<br />
had chosen drinking tea as more<br />
representative than my enduring<br />
the Northern Line, suffering<br />
athlete’s foot, carrying the<br />
consequences of an inability<br />
to afford a dental bridge, etc.<br />
Nevertheless, we can now<br />
confirm who would go so far as to<br />
try to find out what it is like to be a<br />
non-human animal – and that is<br />
the gentleman explorer, alive and<br />
kicking with his gentility intact. ■<br />
Paul Cobley is a semiotician and<br />
professor in language and media<br />
at Middlesex University, UK<br />
A drug to make us good?<br />
Jonathon Keats looks for morality in a neuroscientific mess<br />
The Myth of the Moral Brain: The<br />
limits of moral enhancement by Harris<br />
Wiseman, MIT Press, $38/£26.95<br />
IN 2007, Paul Zak<br />
gathered 68 young<br />
men to play a<br />
game. Pairing<br />
them at random,<br />
he gave $10 to one<br />
person in each<br />
pair, which the<br />
recipient was instructed to split<br />
with his partner. The former could<br />
choose how much to offer. If the<br />
latter accepted, both men kept the<br />
cash. If not, they had to return it.<br />
This is the ultimatum game, a<br />
standard economics experiment.<br />
But Zak, a neuroeconomist, gave it<br />
a twist by dosing half his subjects<br />
with oxytocin. The difference was<br />
dramatic. Those who took a dose<br />
of the hormone were 80 per cent<br />
more generous than those who<br />
didn’t. On the strength of this and<br />
In the real world, our actions and<br />
motivations have complex roots<br />
other studies linking oxytocin<br />
with trust, oxytocin has been<br />
lauded as the “moral” chemical.<br />
Harris Wiseman is sceptical.<br />
He’s also wary of morality claims<br />
for serotonin, dopamine and TMS,<br />
in which electricity is used to<br />
stimulate areas of the brain. In<br />
The Myth of the Moral Brain, he<br />
argues compellingly against<br />
“neuroprimacy” in ethics. “Moral<br />
functioning is travestied when<br />
approached primarily through<br />
biological lenses,” he writes.<br />
Through his thoughtful critique<br />
of neuroscientific reductionism,<br />
he provides a foundation for<br />
understanding the complexities<br />
of moral action.<br />
Wiseman objects to Zak’s<br />
experiments. Real life, he argues, is<br />
nothing like psychological studies,<br />
which require that participants<br />
make simple decisions in<br />
controlled conditions. To attain<br />
statistical significance, the<br />
experiments sacrifice relevance.<br />
Even more damning, Wiseman<br />
observes that the results reveal<br />
TIM O’LEARY/ MILLENNIUM IMAGES<br />
nothing about motivation. In the<br />
ultimatum game, oxytocin may<br />
make the subjects more generous,<br />
or, equally plausibly, it may make<br />
them more risk adverse – which<br />
has nothing to do with morality.<br />
As a result of these serious<br />
limitations, Wiseman thinks<br />
that neuroscience is largely<br />
counterproductive when it comes<br />
to understanding ethics. “Such<br />
studies have given us the illusion<br />
that our understanding has been<br />
deepened,” he writes, “when,<br />
arguably, the superficiality of<br />
the methods, combined with<br />
the authority the domain<br />
carries with it, have served to<br />
undermine and in fact reduce<br />
our understanding of the real-life<br />
phenomena [they] are supposed<br />
to be representing.”<br />
On one level, The Myth of the<br />
Moral Brain is a cautionary tale<br />
of overconfidence in easy fixes<br />
for deep flaws. On another level,<br />
Wiseman uses the inadequacies<br />
of neuroprimacy to stress that<br />
morality emerges not only from<br />
biology, but also from<br />
psychological, political, socialenvironmental,<br />
economic and<br />
religious influences. In such a<br />
quagmire, no drug can be<br />
expected to effectively target<br />
evil. Instead, “virtues require<br />
practice”, he writes.<br />
In this conclusion, Wiseman is<br />
convincing. The challenge is to get<br />
people to practise morally salient<br />
traits such as trust and generosity.<br />
Ironically, chemicals may help.<br />
If we believe that oxytocin<br />
makes us behave morally, we<br />
might yet be enhanced by an<br />
ethical placebo effect. ■<br />
Jonathon Keats is the author of<br />
You Belong To The Universe:<br />
Buckminster Fuller and the future<br />
2 April 2016 | NewScientist | 43
Collaboration<br />
Sara Cherry first met<br />
Carolyn Coyne when she was<br />
interviewing for her position at<br />
the University of Pennsylvania,<br />
where Coyne was a postdoc.<br />
What began as a casual<br />
collaboration quickly grew<br />
into something more. When<br />
Coyne moved to take a job<br />
at the University of Pittsburgh<br />
and found her laboratory<br />
wasn’t ready, Cherry offered<br />
her space in her lab and in her<br />
home. They worked together to<br />
identify host genes that can help<br />
viruses like those that cause<br />
meningitis cross the blood-brain<br />
barrier. The collaboration was<br />
hugely successful, resulting in a<br />
publication in a top tier journal and<br />
a strong friendship that lasts to this<br />
day.<br />
The two infectious disease<br />
researchers have talked regularly<br />
over the last ten years, as much<br />
about their husbands and kids as<br />
about their science. But then the<br />
Zika virus began to spread across the<br />
Americas, leaving devastating birth<br />
defects in its wake, and the phone<br />
calls became a daily occurrence.<br />
3 Tips on<br />
How to Have a<br />
Successful Collaboration<br />
1. Be open and honest. There is no<br />
such thing as a perfect collaboration<br />
(or relationship), says Coyne, but<br />
open and direct communication is<br />
absolutely necessary to establish<br />
the mutual trust needed for a<br />
successful partnership.<br />
2. Take the long view. When you are<br />
¿UVWVWDUWLQJ\RXUODELWLVHDV\<br />
to focus on authorship or other<br />
accolades. Recognize that if you<br />
behave respectably and share credit<br />
appropriately, then everyone will<br />
EHQH¿W<br />
3. Have fun. It is important to like<br />
and want to spend time with<br />
your collaborators, Cherry says,<br />
otherwise the work is no fun. The<br />
same characteristics that make a<br />
good friend can also make a good<br />
collaborator.<br />
specialized cells that reside in the<br />
blood-brain barrier and the placenta<br />
that can protect from infection. Cherry<br />
has expertise in screening strategies<br />
to identify new genes and pathways<br />
in viral replication. Together, they are<br />
searching for FDA-approved compounds<br />
that can block Zika infection in placental<br />
cells. The duo already found a handful<br />
of promising candidates, which will<br />
need to survive several more rounds of<br />
rigorous testing before they could ever<br />
be used in the clinic. Cherry says that<br />
such collaborations can only succeed<br />
when people share mutual trust and<br />
respect for each other, and each play<br />
their part.<br />
“We can’t all be an expert at<br />
everything,” said Cherry. “There are<br />
very few labs and few people who<br />
can do everything well and want to<br />
do all these different things well. We<br />
all have our own personal interests<br />
and excitement. As the world gets<br />
more and more sophisticated,<br />
the assays, the technology, the<br />
biology, I think it benefits us to<br />
take advantage of expertise more<br />
broadly.”<br />
“It was pretty clear that we should work<br />
together to understand and combat this<br />
virus,” said Cherry. “We keep each other<br />
informed about all the experiments we<br />
have going on in the lab, and that way<br />
we can share any assays or tricks that<br />
we find. It is helpful to have that kind of<br />
relationship. We are friends, and we know<br />
that we wouldn’t do anything to compete<br />
with each other. We know exactly what<br />
each we can contribute, because we have<br />
overlapping but different skill sets.”<br />
Coyne has expertise in barrier cells, the<br />
To read the complete article provided to New Scientist by Burroughs Wellcome Fund visit:<br />
http://www.bwfund.org/grant-programs/career-guidance
Incorporating ScienceJobs.com<br />
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2 April 2016 | NewScientist | 45
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Research Areas:<br />
Human Genetics<br />
Immunology<br />
Microbiology<br />
Molecular Pathology<br />
Molecular Physiology<br />
Neuroscience<br />
Pharmacology<br />
The University of North Carolina at Charlotte invites applications for faculty<br />
at the Assistant or Associate level in the Department of Bioinformatics and<br />
Genomics in the College of Computing and Informatics. The Department<br />
seeks candidates with a proven research record in Computational Systems<br />
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The successful candidate should have an earned doctorate and be eligible<br />
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Charlotte is an EOE/AA employer and an NSF ADVANCE Institution.<br />
For additional information, please visit our website at<br />
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Faculty Position<br />
Computational Genomics<br />
Department of Bioinformatics and Genomics<br />
College of Computing and Informatics<br />
University of North Carolina at Charlotte<br />
The Department of Bioinformatics and Genomics at the University of North<br />
Carolina at Charlotte seeks a tenure-track professor at any career stage<br />
to work at our location in the North Carolina Research Campus (NCRC) in<br />
Kannapolis. The NCRC is a public-private partnership between corporations,<br />
universities and healthcare organizations advancing science at the<br />
intersection of human health, nutrition and agriculture.<br />
The NCRC hosts,UNC Charlotte, six other UNC system universities as well<br />
as Duke University. UNC Charlotte has a leadership position at the NCRC in<br />
bioinformatics. We seek applicants wishing to develop a research program in<br />
bioinformatics, computational biology and/or computational genomics. This<br />
position is part of a larger university-wide research initiative in Data Science<br />
and Analytics. The successful applicant will have an earned doctorate with<br />
an exceptional record of achievement and will be expected to maintain<br />
an externally funded research program that will catalyze a larger group<br />
of interdisciplinary scientists. The responsibilities of the position include<br />
teaching quantitative skills such as programming and statistical modeling at<br />
the graduate and undergraduate level.<br />
We offer a collegial environment, excellent facilities, a competitive start<br />
up package, and a competitive nine-month salary commensurate with<br />
experience.<br />
Preliminary inquiries about the position can be made to Dan Janies via<br />
email djanies@uncc.edu. However, formal applications must be made<br />
electronically at https://jobs.uncc.edu (position #1074) and must include<br />
a CV, contact information for 4 references, and statements on research<br />
and teaching. The University of North Carolina at Charlotte is an EOE/AA<br />
employer and an NSF ADVANCE institution.<br />
For additional information, please visit our websites at<br />
http://bioinformatics.uncc.edu and http://transforming-science.com.<br />
48 | NewScientist | 2 April 2016
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50 | NewScientist | 2 April 2016
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2 April 2016 | NewScientist | 51
LETTERS<br />
letters@newscientist.com @newscientist newscientist<br />
EDITOR’S PICK<br />
Theory proposes,<br />
the world disposes<br />
From Michael Duff<br />
I take issue with the critique of the<br />
role of experiment in theoretical<br />
physics by Jim Baggott and Daniel<br />
Cossins (27 February, p 38). May<br />
a physicist be allowed to set the<br />
record straight? The concept of<br />
supersymmetry was not<br />
“conceived as an elegant way to<br />
plug holes in the standard model”<br />
of particle physics. It was first<br />
noted by string theorists and then<br />
applied to supergravity. Had Albert<br />
Einstein not discovered relativity,<br />
then supersymmetry would force<br />
us to invent it.<br />
Most string theorists share<br />
the view that in the long term<br />
the test of a good theory is<br />
experiment. The jury is still out<br />
on the multiverse, for example.<br />
It is those who claim already<br />
to know whether or not our<br />
universe is unique who are being<br />
unscientific – as are those who<br />
claim to know what can and can’t<br />
one day be tested.<br />
Baggott and Cossins write that<br />
“theoretical physicists have grown<br />
increasingly comfortable plucking<br />
theories out of thin air… The Higgs<br />
boson is a case in point.” But the<br />
Higgs was proposed in 1964 and<br />
discovered in 2012, in one of<br />
theory’s greatest triumphs. And<br />
let’s not forget gravitational<br />
waves, first proposed in 1916,<br />
whose discovery 100 years later<br />
confirmed the existence of black<br />
holes – which were proposed by<br />
John Michell in 1783.<br />
London, UK<br />
Social intelligence<br />
all the way down<br />
From Duncan Butlin<br />
Aviva Rutkin focuses on the<br />
wrong sort of human behaviour<br />
when comparing human and<br />
artificial intelligence (19 March,<br />
p 20). The human brain is not<br />
designed to be good at chess,<br />
Jeopardy or Go.<br />
Even object manipulation is not<br />
one of our fortes. It is the things<br />
we do socially that a machine will<br />
find very hard to match. Making<br />
sure granny is offered the last<br />
cucumber sandwich at a tea party,<br />
or ceasing to discipline a child<br />
when you sense you may go too<br />
far, for example. When machines<br />
can model human behaviour<br />
in groups, in all its recursive<br />
splendour, only then will we have<br />
a real challenge on our hands.<br />
Chichester, West Sussex, UK<br />
Ingredient-free<br />
marketing works<br />
From Richard Nissen<br />
Shannon Fischer’s description<br />
of the power of placebos is<br />
fascinating (12 March, p 32). It<br />
chimes with my having heard<br />
the marketing manager for a bigbrand<br />
painkiller saying that the<br />
more you advertise the stronger<br />
the drug becomes – and that its<br />
effects kick in within 5 minutes,<br />
which is pharmacologically<br />
impossible.<br />
London, UK<br />
How would loyalty<br />
cancel a stench?<br />
From Garry Trethewey<br />
You report a finding that body<br />
odour produces less disgust<br />
when attributed to a member<br />
of the smeller’s group, and<br />
Stephen Reicher’s comment that<br />
because loyalties can affect a core<br />
biological response that shows<br />
how powerful and malleable<br />
group identities can be<br />
(27 February, p 20). I find it more<br />
interesting that a “core biological<br />
response” can be affected by<br />
psychosocial events. I wonder<br />
whether this is a basis for the<br />
placebo effect.<br />
Cherryville, South Australia<br />
Is doping partly<br />
mind over matter?<br />
From Alastair Monro<br />
In recurrent furores over doping<br />
in sports, I have not noticed any<br />
consideration of the role of the<br />
brain in performance as outlined<br />
in James Witts’s informative<br />
article (30 January, p 38). Could<br />
any improved performance of<br />
an athlete on a performanceenhancing<br />
drug not be due, at<br />
least in part, to a mental change?<br />
Having worked on many<br />
clinical trials, I propose one for<br />
athletes in which half of the test<br />
group is on the real drug and half<br />
on a placebo, no one knowing<br />
which. Sadly, I find it difficult to<br />
imagine top athletes agreeing to<br />
participate in such a study.<br />
Sandwich, Kent, UK<br />
A bump passing in<br />
the quantum night<br />
From Alan Wilson<br />
I am as excited as anyone about<br />
the possibility of a new particle<br />
being discovered that would<br />
shake up our understanding of<br />
the universe (5 March, p 30). But<br />
I am a little alarmed that it turns<br />
up at exactly six times the mass<br />
of the Higgs boson.<br />
To me it seems more likely<br />
that it is an artefact of statistical<br />
analysis, and might turn out to be,<br />
to put it in musical instrument<br />
terms, a harmonic of the Higgs.<br />
I fear that it will just fade away<br />
like the Cheshire Cat, leaving<br />
nothing behind but an enigmatic,<br />
vanishing smile. Of course, the<br />
idea of a harmonic might just<br />
be plausible if we visualise it in<br />
terms of string theory.<br />
Colmworth, Bedfordshire, UK<br />
Fusion reactors<br />
are all difficult<br />
From Alessandro Tesini<br />
David Hambling mentions a new<br />
breed of leaner, meaner nuclear<br />
fusion reactor, including the<br />
“affordable, robust, compact”<br />
ARC device (30 January, p 34). But<br />
the claims for ARC include rapid<br />
dismantling and re-assembly of<br />
the lining and the shell of the<br />
“doughnut” in which fusion takes<br />
place. These need to be replaced<br />
as the flux of neutrons from the<br />
reaction makes them radioactive<br />
and thus weakens them.<br />
I can report from experience<br />
that this replacement will require<br />
a very big “hot cell” containing<br />
complex equipment for remote<br />
handling of the radioactive parts.<br />
The ARC designers propose<br />
including a tank of molten<br />
fluorine-lithium-beryllium salt<br />
(FLiBe) in the shell. This will<br />
involve solving the problem of<br />
welding replacement segments of<br />
the tank to irradiated metal in the<br />
adjacent segments. And there are<br />
issues of toxicity and long-lasting<br />
radioactive contamination of the<br />
FLiBe. ARC’s claimed “plug-andplay”<br />
flexible configuration is<br />
only theoretical: the more<br />
radioactive it becomes, the more<br />
difficult it will be to reconfigure<br />
it to the extent claimed.<br />
Luynes, France<br />
How to detect an<br />
absent neutrino<br />
From Dieter Gold<br />
Matthew Chalmers describes the<br />
neutronless double beta decay<br />
and the difficulty of detecting it<br />
(13 February, p 30). It is already<br />
very difficult to detect the<br />
presence of a neutrino.<br />
52 | NewScientist | 2 April 2016
“Until the poachers come through and kill<br />
them. Will they have some sort of protection?”<br />
Sara Mains Palkovich is sceptical about plans to<br />
reintroduce extinct species to Europe (26 March, p 8)<br />
So how can we be sure we<br />
have detected the absence of a<br />
neutrino? How can researchers<br />
be sure that they have observed<br />
a double beta decay without a<br />
neutrino, instead of one with two<br />
of them? Can there be sufficiently<br />
precise measurement of the<br />
momentum of the detected<br />
particles to be sure that no<br />
momentum is carried away by<br />
the neutrinos of an ordinary<br />
double beta decay?<br />
Voiron, France<br />
From Lindsay Coker<br />
An intriguing cover line: “Once in<br />
100 trillion trillion years – we’re<br />
about to see the rarest event in the<br />
universe” (13 February), though<br />
the article (p 30) says it may<br />
happen every 10 25 years.<br />
Mornington, Victoria, Australia<br />
The editor writes:<br />
■ Neutrinoless double beta decay<br />
(NDBD) does emit electrons,<br />
whose energies and directions<br />
of motion can be measured<br />
accurately enough to discriminate<br />
it from other decays. And the<br />
article reported the lower limit<br />
on NDBD half-life, established as<br />
TOM GAULD<br />
10 25 years, though the full range<br />
now being investigated stretches<br />
up to 10 27 years.<br />
Nudge theory and<br />
regulation practice<br />
From Hugh Robertson,<br />
Senior Policy Officer, Trades<br />
Union Congress<br />
Your leader “A nudge too far?”<br />
makes some interesting points<br />
but perpetuates the idea that<br />
the work of the UK Behavioural<br />
Insights Team uses a solely<br />
“evidence-based” approach<br />
(12 March, p 5). As you rightly<br />
point out, nudges are seen as a<br />
replacement for legislation. It<br />
would therefore be appropriate<br />
to compare the outcome of a<br />
“nudge” with the likely outcome<br />
of regulation.<br />
That is not what the trials<br />
do. The biggest nudge in the<br />
UK was the Responsibility Deal<br />
which attempted a voluntary<br />
approach to health issues around<br />
food, alcohol and the workplace<br />
by getting pledges from<br />
manufacturers, retailers and<br />
employers. These were viewed<br />
by most public health experts<br />
as totally ineffective. Instead,<br />
there have been calls for the<br />
government to introduce<br />
regulation such as compulsory<br />
labelling and minimum<br />
alcohol pricing. The deals have<br />
all now been abandoned by the<br />
government and a sugar tax has<br />
been announced.<br />
Nudge theory has its place, but<br />
to state that it is evidence-based<br />
is a stretch when, in the UK, its<br />
application is underpinned by<br />
an ideological assumption that<br />
regulation is inherently negative.<br />
The evidence is that regulation<br />
can be far more effective than<br />
behavioural interventions, as<br />
shown by a range of public safety<br />
and health laws, from seat-belt<br />
use to workplace smoking.<br />
London, UK<br />
Shocking timing<br />
in obedience trial<br />
From Chris Wilkinson<br />
Andy Coghlan reports a modified<br />
version of the infamous Milgram<br />
experiment on obeying orders, in<br />
which participants were asked to<br />
estimate the time lapse between<br />
pressing a key and hearing a tone,<br />
in milliseconds (27 February, p 14).<br />
My estimate is that the best that<br />
I could do would be to report to<br />
the nearest 250 milliseconds. Did<br />
some reported estimates really<br />
go to three significant digits?<br />
Turramurra, New South Wales,<br />
Australia<br />
The editor writes:<br />
■ The experiment built on earlier<br />
work showing that the perceived<br />
time delay (not necessarily the<br />
actual delay) correlates with a<br />
sense of agency or control.<br />
Participants were indeed asked to<br />
make use of all possible numbers<br />
between 0 and 1000 milliseconds.<br />
For the record<br />
■ This one is far away: it was Mike<br />
Brown of the California Institute of<br />
Technology who observed that, seen<br />
from the Oort cloud, the sun appears<br />
so small that you could completely<br />
block it out with the head of a pin<br />
(19 March, p 30).<br />
■ Delila Gasi-Tandefelt and her<br />
colleagues are taking blood samples<br />
from men with advanced prostate<br />
cancer in sequence, not at fixed<br />
intervals (19 March, p 38). And Bert<br />
Vogelstein and colleagues make<br />
strands of DNA that mirror their<br />
target mutation, and tag these with<br />
a fluorescent marker so that they can<br />
detect any bits of mutated DNA that<br />
stick to their bait.<br />
■ A bass-ic mistake: the song of<br />
lonely Whale 52 has recently<br />
deepened from 52 Hz to 47 Hz<br />
(19 March, p 30).<br />
Letters should be sent to:<br />
Letters to the Editor, New Scientist,<br />
110 High Holborn, London WC1V 6EU<br />
Email: letters@newscientist.com<br />
Include your full postal address and telephone<br />
number, and a reference (issue, page number, title)<br />
to articles. We reserve the right to edit letters.<br />
Reed Business Information reserves the right to<br />
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New Scientist magazine, in any other format.<br />
2 April 2016 | NewScientist | 53
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FEEDBACK<br />
For more feedback, visit newscientist.com/feedback<br />
PAUL MCDEVITT<br />
WHEN is a drug not a drug? The<br />
UK government’s Psychoactive<br />
Substances bill seeks to prohibit the<br />
sale of consumables that affect a<br />
person’s mental state. Previously,<br />
the minister in charge of the bill, Mike<br />
Penning, insisted “We will ensure that<br />
we insert what we want to insert,<br />
while at the same time having a<br />
blanket ban” (14 November, 2015).<br />
Now we learn what he meant as,<br />
in addition to the government’s own<br />
lengthy list of exempted inebriants<br />
such as alcohol and nicotine, the<br />
Advisory Council on the Misuse of<br />
Drugs (ACMD) has been tasked with<br />
finding a way to exclude alkyl nitrites.<br />
Otherwise known as poppers,<br />
this recreational drug is a popular<br />
sex aid because of its muscle-relaxing<br />
effects, as well as its instant high.<br />
Following an investigation, the ACMD<br />
reported that although poppers<br />
increase blood flow to the brain, they<br />
don’t cross the blood-brain barrier.<br />
The ACMD concludes that any<br />
psychoactivity is a peripheral effect,<br />
and poppers do not directly stimulate<br />
the central nervous system – even<br />
though users feel a high. The circle<br />
deftly squared, another popular drug<br />
falls outside the UK’s increasingly<br />
threadbare blanket ban on drugs.<br />
FUR<strong>THE</strong>R to observations on the<br />
quantum superposition of USB<br />
cables (5 March), Sue McDonald<br />
comes unstuck over another case<br />
of strange geometries.<br />
“I was trying to find the end<br />
of the sticky tape on its roll,” she<br />
writes. “Assuming the roll is a<br />
circle with an infinite number of<br />
sides, I’ve experienced infinity + 1,<br />
which is the number of sides of<br />
the sticky tape roll I have to<br />
investigate before finding the<br />
end of the tape.”<br />
Feedback thinks this is a serious<br />
underestimate – we have to rotate<br />
a roll of sticky tape through at<br />
least 720 degrees before finding<br />
the end.<br />
SWISS army equipper Victorinox<br />
have been pricked by criticism after<br />
a customer noticed the online store<br />
had 51 “neutral” pocket knives and<br />
“Daylight Saving Time is A Reminder to Change<br />
Clocks” – Andrew Doble receives some timely<br />
advice from Florida’s Village Daily Sun<br />
one “female” model – which was,<br />
predictably, pink. Feedback pauses<br />
here to spare a thought for all the<br />
women who have been toiling with<br />
unsuitably gendered knives until now.<br />
Taken to task, the company<br />
quickly announced that the offending<br />
classification would be cut from<br />
their website.<br />
IAN WITHAM writes in with a<br />
money-saving tip. “Those herbal<br />
remedies that contain none of<br />
the advertised herbs will not be<br />
wasted,” (12 March) he says. “They<br />
can be relabelled and sold as<br />
homoeopathic remedies.”<br />
WHAT mires lie in wait for scientists<br />
who stray from their field of expertise.<br />
Famed astrophysicist Neil deGrasse<br />
Tyson got bogged down earlier this<br />
month when he tweeted: “If there<br />
were ever a species for whom sex<br />
hurt, it surely went extinct long ago.”<br />
Biologists quickly directed the<br />
space scientist to the many examples<br />
of painful sex, from barbed penises to<br />
traumatic insemination. In the face of<br />
many angry ornithologists shouting<br />
about duck vaginas, Tyson dialled<br />
back on his first tweet and offered an<br />
olive branch to the life sciences with<br />
another aphorism: “If you have a gene<br />
for celibacy, you didn’t inherit it.”<br />
Oh dear. May Feedback offer one in<br />
reply: “It’s better for an astrophysicist<br />
to remain silent on the subject of<br />
biology and be thought a fool, than to<br />
open his mouth and remove all doubt.”<br />
A PRESS flyer from Alan Dolan,<br />
Lanzarote-based respiratory guru<br />
to the stars, invites Feedback’s<br />
colleague to his next breathing<br />
retreat, “a powerful and intensive<br />
five days in which to relax”, by,<br />
err, breathing.<br />
But no ordinary breathing<br />
of course, this is Conscious<br />
Breathing, “a powerful and<br />
safe way to infuse the body with<br />
oxygen”. By wresting control of<br />
respiration from your brainstem –<br />
which Feedback notes has been<br />
managing it competently and<br />
continuously since the day you<br />
were born – Alan says you will<br />
enjoy a bingo card of vaguely<br />
worded benefits, such as higher<br />
levels of consciousness, reenergised<br />
systems, and a detox<br />
for every level of your being.<br />
“I’m sceptical,” admits our<br />
colleague, “but I think I need to be<br />
sent to Lanzarote to investigate.”<br />
<strong>THE</strong> apple doesn’t fall far from the<br />
tree: “Your mention of Lucy de la<br />
Pasture (5 March) reminds me of the<br />
novelist Mrs Henry de la Pasture,”<br />
writes Griselda Mussett. “Her<br />
daughter Esmée was also a novelist,<br />
and chose the name Delafield to mark<br />
the distinction between them.”<br />
A DENTAL firm is offering Glyn<br />
Williams “new ways to replace<br />
your teeth with digital<br />
technology”. Aside from this<br />
sounding very uncomfortable,<br />
Feedback thinks it would be a<br />
chore having to upgrade your<br />
mouth every two years.<br />
IN CONTRAST to the UK, drug<br />
law reform in the US is of a more<br />
permissive kind, fuelling a<br />
commodities market in cannabis, but<br />
so far, possession is still illegal in Ohio.<br />
However, you could be forgiven<br />
for wondering if the state’s leading<br />
gardening supplies manufacturer,<br />
The Scott’s Miracle Gro Company,<br />
is planning to diversify its business<br />
portfolio. A recent online advert for<br />
the company’s lawn seed ran with the<br />
tagline “Grass: it smells good. It feels<br />
good. It looks good. It is good.”<br />
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56 | NewScientist | 2 April 2016
<strong>THE</strong> LAST <strong>WORD</strong><br />
Last words past and present at newscientist.com/lastword<br />
Atomic bonds<br />
On an atomic level, how do Post-it<br />
notes stick to things?<br />
Post-it notes are a classic<br />
application of polymer chemistry.<br />
Funnily enough, the stickiness in<br />
question was discovered when<br />
Spencer Silver was trying to<br />
produce an incredibly strong<br />
adhesive in 1968. Instead, he<br />
produced an incredibly weak<br />
one, but most discoveries are<br />
accidents, so who is going<br />
to complain? Perhaps just<br />
students like myself as we<br />
stick up reminders of our<br />
exam dates and assignments.<br />
The glue used in Post-it notes<br />
is a pressure-sensitive adhesive.<br />
This means you only need to<br />
apply light pressure to stick the<br />
“The adhesive in Post-it<br />
notes was discovered<br />
when trying to produce an<br />
incredibly strong adhesive”<br />
note to something. The bond<br />
between the note and the surface<br />
is formed through a fine balance<br />
between flow and resistance to<br />
it. The adhesive can flow just<br />
enough to fill tiny crevices on<br />
the surface, but will resist flow<br />
enough to remain there. This<br />
produces the bond between the<br />
note and the surface.<br />
If we zoom in further, we can<br />
see that on a molecular level, the<br />
biggest contributors to the bond<br />
strength are van der Waals forces.<br />
These are created when a molecule<br />
has more of its electrons on one<br />
side than the other, producing a<br />
dipole (like a tiny magnet). This<br />
induces the opposite dipole in<br />
another molecule nearby and the<br />
two stick to each other. Van der<br />
Waals forces are normally weak,<br />
but they increase in strength as<br />
the size of the molecules grows.<br />
Bradley Clarke<br />
Brighton, East Sussex, UK<br />
Post-it adhesive sticks in<br />
much the same way as any<br />
other pressure-sensitive contact<br />
adhesive: through a combination<br />
of van der Waals forces, a decent<br />
balance of cohesion (the glue<br />
molecules sticking to each other)<br />
and adhesion (sticking to<br />
everything else), and good contact<br />
with the microscopic topography<br />
of the target surface.<br />
The more interesting<br />
question is how the notes peel off<br />
harmlessly. In practice, peeling<br />
leaves microscopic traces of<br />
Post-it glue on the target surface,<br />
but those are generally too small<br />
to cause visible damage. The<br />
secret is the molecular structure<br />
of the polymer, which forms a<br />
delicate network that links<br />
relatively large lumps together.<br />
Imagine it as being like a tennis<br />
net with sticky balls attached at<br />
intervals over most of its surface.<br />
The Post-it paper soaks up and<br />
holds powerfully onto one full<br />
surface of the adhesive mass (the<br />
tennis ball), but only one cheek of<br />
each sphere (or ball) sticks out,<br />
just touching the other surface.<br />
This has two important effects:<br />
ensuring that cohesive forces<br />
greatly exceed adhesive ones, and<br />
that peeling the paper off the<br />
target pulls on only the next ball<br />
in line – each requiring only a<br />
small force at a concentrated<br />
point, almost like undoing a zip<br />
tooth by tooth. Strong contact<br />
adhesives are different in that<br />
they spread the peeling forces<br />
over as wide an area as possible.<br />
They make it hard to pull any<br />
point free without fighting all<br />
the neighbouring adhesive<br />
material at the same time.<br />
Jon Richfield,<br />
Somerset West, South Africa<br />
Liquid gold<br />
I recently saw vodka in the<br />
supermarket with real gold leaf flakes<br />
in it. What caught my eye was that the<br />
gold flakes were distributed uniformly<br />
throughout the bottle. Gold is much<br />
denser than water, so why don’t they<br />
sink to the bottom?<br />
(Continued)<br />
One product that displays the<br />
behaviour described is Smirnoff<br />
Gold Cinnamon Flavoured<br />
Liqueur. If a bottle of this is rotated<br />
gently through about 45 degrees<br />
clockwise, the gold flakes follow<br />
the clockwise motion, but will<br />
then “rebound” anticlockwise<br />
when you stop. You can often<br />
observe similar rebounding if you<br />
stir a bowl of soup. This is not the<br />
behaviour of a Newtonian fluid,<br />
so the bottle probably contains<br />
something other than the usual<br />
constituents – perhaps some<br />
gelling agent.<br />
The gelatinous motion of the<br />
bottle’s contents is more<br />
reminiscent of a weak Bingham<br />
plastic, a material that remains<br />
rigid until it experiences a<br />
sufficient level of shear stress<br />
to start behaving as a viscous fluid<br />
(for example, mayonnaise).<br />
This can be confirmed by<br />
shaking the bottle and observing<br />
the motion of the air bubbles:<br />
as they rise, you can clearly see<br />
that they are threading their way<br />
through an invisible solid matrix,<br />
and some bubbles even become<br />
trapped in it.<br />
Terry Collins<br />
Harrogate, North Yorkshire, UK<br />
This week’s<br />
questions<br />
CASE LAW<br />
Do neatly folded clothes take<br />
up less luggage space? Logic<br />
suggests that just stuffing<br />
them in – which is my favoured<br />
approach – would take up the<br />
same space, or perhaps even<br />
less if you use a bit of pressure.<br />
Practice suggests otherwise.<br />
Ben Calascione<br />
London, UK<br />
SURF’S UP<br />
Surfers are often heard to say, on<br />
a day of meagre waves, that one<br />
should wait for the tide to turn<br />
because the waves will get bigger<br />
when the tide is “on the push”. Is<br />
there any reason to believe that<br />
waves will increase in height with<br />
an incoming tide?<br />
Colin Risner<br />
St Austell, Cornwall, UK<br />
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