Impaired glucose-induced glucagon suppression after partial ...
Impaired glucose-induced glucagon suppression after partial ...
Impaired glucose-induced glucagon suppression after partial ...
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In conclusion, the present study has shown that the <strong>glucose</strong>-<strong>induced</strong> <strong>suppression</strong> in<br />
<strong>glucagon</strong> levels is lost <strong>after</strong> a 50% <strong>partial</strong> pancreatectomy in humans. The changes in post-<br />
challenge <strong>glucagon</strong> levels are closely related to the impairment in insulin concentrations.<br />
These findings suggest that the defects in alpha-cell function typically observed in patients<br />
with type 2 diabetes are likely secondary to the reduction in beta-cell mass. Alterations in<br />
<strong>glucagon</strong> regulation should be considered as potential side effects of <strong>partial</strong> pancreatectomies<br />
in humans.<br />
Acknowledgements: The excellent technical assistance of Birgit Baller, Yvonne Dabrowski,<br />
Kirsten Mros, Heike Achner and Gudrun Müller is gratefully acknowledged.<br />
These studies were supported by grants from the Deutsche Forschungsgemeinschaft (DFG<br />
grant-no. Me2096/5-1 to JJM) and the Ruhr-University of Bochum (FoRUM grants to JJM).<br />
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