Impaired glucose-induced glucagon suppression after partial ...

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53. Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim HS, Lee IK, Bonner-Weir S 2003 Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 88:2300-2308. 54. Baetens D, Malaisse-Lagae F, Perrelet A, Orci L 1979 Endocrine pancreas: threedimensional reconstruction shows two types of islets of langerhans. Science 206:1323- 1325. 18
Figure legends: Figure 1: Plasma concentrations of glucose (a), insulin (b), glucagon (c), and C-peptide (d) in 36 patients (18 males, 18 females) examined before (filled symbols) and after partial pancreatectomy (open symbols). At t = 0 min, an oral glucose load (75g) was ingested. Data are presented as means ± SEM. P-values Statistics were carried-out using paired repeated measures ANOVA and denote A: Overall differences between the experiments, B: differences over the time course and AB: differences between the experiments over the time course. Asterisks indicate significant (p < 0.05) differences at individual time points versus control subjects (one-way ANOVA). Figure 2: Changes (�) in glucagon concentrations (calculated as mean glucagon concentrations from t = 15 to t = 240 min minus basal glucagon levels) after the oral ingestion of 75 g glucose in 36 patients (18 males, 18 females) examined before (filled symbols) and after partial pancreatectomy (open symbols). Statistics were carried-out using paired t-tests. Figure 3: Linear regression analysis between the changes (�) in glucagon concentrations (calculated as mean glucagon concentrations from t = 15 to t = 240 min minus basal glucagon levels) and the respective changes in insulin (A) and C-peptide concentrations (B) after the oral ingestion of 75 g glucose in 36 patients (18 males, 18 females) examined before (filled symbols) and after partial pancreatectomy (open symbols). Dashed lines indicate the respective upper and lower 95 % confidence intervals. r = correlation coefficient. Figure 4: Plasma glucagon concentrations in 24 patients undergoing pancreatic head resection (A) and 12 patients undergoing pancreatic tail resection (B) examined before (filled symbols) and after surgery (open symbols). At t = 0 min, an oral glucose load (75g) was 19
Page 1 and 2: J Clin Endocrin Metab. First publis
Page 3 and 4: Introduction: In health, glucose ho
Page 5 and 6: Materials and methods Study design
Page 7 and 8: assay (ELISA) from DAKOP Ltd., Camb
Page 9 and 10: However, after pancreatic head rese
Page 11 and 12: cell secretion (34, 35). Consistent
Page 13 and 14: A number of previous studies in rat
Page 15 and 16: References: 1. Meier JJ, Butler PC
Page 17: 36. Robertson RP, Sutherland DE, Se

Impaired glucose-induced glucagon suppression after partial ...

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