SMART Drugs Engineering Nature’s Solution to the Undruggable Target Challenge
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How Nature Reprograms <strong>Target</strong> Selectivity<br />
Variable Region: <strong>Target</strong> Binding<br />
Constant Region: FKBP Binding<br />
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FK506 (Calcineurin) Rapamycin (mTor) WDB002 (CEP250)<br />
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Variable Region<br />
Constant Region<br />
v Like Mabs, members of <strong>the</strong> Rapamycin/FK506 family of natural products have a<br />
variable and a constant region<br />
v The variable region confers target specificity; The constant region confers presentation<br />
v Unlike Mabs, <strong>the</strong>se drugs are orally bioavailable and can access intracellular targets<br />
WARP DRIVE BIO, INC.<br />
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