SMART Drugs Engineering Nature’s Solution to the Undruggable Target Challenge
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Confirmed Screening Hits Against KRAS<br />
Ternary Complex FormaFon<br />
(Presenter|Ligand|KRAS)<br />
Average: 91.2%<br />
Hits = above 129.7% (3σ)<br />
EC-50 ~ 1.2 uM<br />
% ternary background<br />
Pool<br />
• ~50k CsA-alog compounds<br />
screened <strong>to</strong> date<br />
• Confirmed hit rate for single<strong>to</strong>n ~<br />
0.06%<br />
• Confirmed Hits Identified:<br />
o<br />
o<br />
o<br />
o<br />
Presenter-dependent and targetspecific<br />
binding<br />
EC-50s ≤ 10 uM<br />
Cell penetrant with in cellulo<br />
presenter protein engagement<br />
Fur<strong>the</strong>r Hit validation in progress<br />
WARP DRIVE BIO, INC.<br />
22