SMART Drugs Engineering Nature’s Solution to the Undruggable Target Challenge
Warp%20Drive%20Bio_SMART%20Drugs%20Platform_2016
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No <strong>Target</strong> is Too Flat<br />
• WDB has discovered mulFple Rapamycin family members w/ novel target selecFvity<br />
• Example: WDB-002 cooperates with FKBP12 <strong>to</strong> bind with sub-nanomolar affinity <strong>to</strong> a<br />
coiled-coil (an archetypal ‘undruggable’ structural moFf)<br />
FKBP12<br />
Kd = 290 pM<br />
CEP250 11.4<br />
WARP DRIVE BIO, INC.<br />
8
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