SMART Drugs Engineering Nature’s Solution to the Undruggable Target Challenge

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Warp Drive’s Mission To build the premiere company advancing transformative medicines that harness the molecules and mechanisms of Nature WARP DRIVE BIO, INC. 2
The Problem of Intractable Targets 80-90% of human proteins cannot be targeted by established modali:es Universe of potential targets Small Molecule-Assisted Receptor TargeCng (SMART) Small Molecules Limited to targets with hydrophobic pockets (10%) Biologics Limited to targets outside the cell (10%) WARP DRIVE BIO, INC. 3
Page 1: SMART Drugs: Engineering Nature’s
Page 5 and 6: How Does Nature Achieve the ‘Impo
Page 7 and 8: Cooperative Binding Mimics Natural
Page 9 and 10: Nature Can Reprogram Target Selecti
Page 11 and 12: Surface of FKBP12 Adapts Itself to
Page 13 and 14: Prolyl Isomerases (e.g., FKBP12) Ar
Page 15 and 16: Key Characteristics of SMART: “Na
Page 17 and 18: Two Presenters, Two Paths for SMART
Page 19 and 20: Two-Pronged Proprietary Discovery P
Page 21 and 22: Primary Screening Assay: TR-FRET Ex
Page 23 and 24: Large-Scale Library Approach (10^6)
Page 25 and 26: Synthetic Crystallography: Concept
Page 27 and 28: Solving the Structure of KRAS-FKBP
Page 29 and 30: FKBP Competes for RAS Effector Bind
Page 31: Summary • Nature has evolved a ge

SMART Drugs Engineering Nature’s Solution to the Undruggable Target Challenge

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