SMART Drugs Engineering Nature’s Solution to the Undruggable Target Challenge
Warp%20Drive%20Bio_SMART%20Drugs%20Platform_2016
Warp%20Drive%20Bio_SMART%20Drugs%20Platform_2016
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Two-Pronged Proprietary Discovery Platform<br />
Screening Large Diverse <strong>SMART</strong> Libraries<br />
<strong>SMART</strong> Structure-Based Design<br />
Large-scale library of compounds (10 6 ) all capable<br />
of high affinity binding with FKBP but with highly<br />
diversified variable regions<br />
FKBP<br />
HT screening of library<br />
for <strong>Target</strong> binding<br />
Variable Region<br />
…<br />
Millions of<br />
compounds<br />
<strong>Target</strong><br />
FKBP<br />
<strong>Target</strong><br />
<strong>Target</strong><br />
1. Syn<strong>the</strong>Fc Crystallography<br />
<strong>to</strong> solve Presenter-<strong>Target</strong><br />
Interface<br />
2. Structure-Based Drug<br />
Design <strong>to</strong> build Ligand-<br />
<strong>Target</strong> interface<br />
Novel hits and binding ligands <strong>to</strong> enable<br />
hit-<strong>to</strong>-lead medicinal chemistry<br />
WARP DRIVE BIO, INC. 18
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