ISCAGUARD ® Preservatives for Personal Care - ISCA UK Ltd

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9 Iscaguard ® LIN Iscaguard ® LIN is a strongly synergistic blend of methyldibromo glutaronitrile, bronopol, phenoxyethanol, butylparaben and isobutylparaben giving the advantages of broad-spectrum antimicrobial protection and ease of liquid handling. The synergistic activity of Iscaguard ® LIN allows very low use concentrations (typically between 0.03 – 0.15%). This activity is similar to that of isothiazolinone-based preservatives. The low concentrations required of Iscaguard ® LIN enhance the safety profile of the product, as much lower concentrations of the individual components are present in the final product compared to normal usage. When using Iscaguard ® LIN, the concentration of bronopol, for example, is reduced by a factor of between 5 – 12. This substantial reduction in bronopol concentrations has critical implications for nitrosamine formation in products containing amines. At normal bronopol use concentrations (200 – 400ppm), there is an increase in the potential for nitrosamine formation when amines are present. Evidence suggests, however, that nitrosamine formation is not detectable in formulations containing both Iscaguard ® LIN and amines such as triethanolamine and stearamidopropyl dimethylamine, even after prolonged storage. Iscaguard ® LIN may, therefore, be used in amine-based formulations, although testing to confirm the absence of nitrosamines is strongly recommended. Iscaguard ® LIN is effective over the range pH 3.0 – 7.5 and is non-irritating to eyes, skin and mucous membranes at the recommended use concentrations. Iscaguard ® LIN retains its activity in the presence of proteins and nonionic emulsifiers. ISCA Iscaguard ® Preservative Blends Regulatory Status Iscaguard ® LIN is permitted for use in rinse-off products in the European Union (maximum 0.77%) and the USA (maximum 0.77%). Iscaguard ® LIN is not permitted for use in Japan. INCI name: phenoxyethanol, methyldibromo glutaronitrile, 2-bromo-2-nitropropane-1,3-diol, butylparaben, isobutylparaben. Using Iscaguard ® LIN Iscaguard ® LIN is soluble in water to approximately 0.4% – significantly greater than the typical use concentrations – but it is preferable to pre-dissolve the product in a non-aqueous component prior to addition. This avoids the need to heat Iscaguard ® LIN, as the product should not be exposed to temperatures above 40°C for prolonged periods. Iscaguard ® LIN may discolour on exposure to UV light and should be stored in the original container. Table 21 Solubility of Iscaguard ® LIN (% w/w @ 25°C) Water Approx. 0.4% Propylene glycol Miscible Butylene glycol Miscible Table 22 Antimicrobial activity of Iscaguard ® LIN Microorganism Minimum inhibitory concentration (%) Pseudomonas aeruginosa 0.035 Escherichia coli 0.025 Proteus vulgaris 0.0175 Staphylococcus aureus 0.03 Bacillus cereus 0.0275 Enterococcus faecium 0.035 Candida albicans 0.0125 Saccharomyces cerevisiae 0.0125 Aspergillus niger 0.04
Iscaguard ® IPT Iscaguard ® IPT is a blend of phenoxyethanol and iodopropynyl butylcarbamate giving the advantages of broad-spectrum antimicrobial protection and the ease of liquid handling. Iscaguard ® IPT is effective at 0.6 – 1.0% in many formulation types, and is compatible with proteins and anionic, cationic and non-ionic emulsifiers. The product should not be used in applications where direct contact with mucous membranes in intended. Iscaguard ® IPT is formaldehyde-free and retains its activity over the pH range 4.0 – 8.0. Regulatory Status Iscaguard ® IPT is permitted for use in personal care products in the European Union and the USA (maximum 1.0%), but may not be used in products intended to come into direct contact with mucous membranes. It is not currently permitted in Japan. INCI name: phenoxyethanol, iodopropynyl butylcarbamate Using Iscaguard ® IPT Iscaguard ® IPT is soluble in water to approximately 0.4%, but may require gentle heating (35 - 40°C) to dissolve completely. It is advisable to pre-dissolve the product in one of the non-aqueous formulation components prior to addition unless the manufacturing process already requires heating. Iscaguard ® IPT may discolour on exposure to UV light and should be stored in the original container. ISCA Iscaguard ® Preservative Blends 10 Table 23 Solubility of Iscaguard ® IPT (% w/w @ 25°C) Water Approx. 0.4% Propylene glycol Miscible Butylene glycol Miscible Table 24 Antimicrobial activity of Iscaguard ® IPT Microorganism Minimum inhibitory concentration (%) Pseudomonas aeruginosa 0.45 Escherichia coli 0.35 Proteus vulgaris 0.40 Staphylococcus aureus 0.40 Bacillus cereus 0.40 Enterococcus faecium 0.50 Candida albicans 0.05 Saccharomyces cerevisiae 0.01 Aspergillus niger 0.005
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ISCAGUARD ® Preservatives for Personal Care - ISCA UK Ltd

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