ISCAGUARD ® Preservatives for Personal Care - ISCA UK Ltd

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3 Iscaguard ® PE Iscaguard ® PE, 2-phenoxy ethanol is a versatile and widely used preservative for personal care products. Often used in conjunction with parabens, it has good activity against gram-positive and gram-negative bacteria and is particularly effective against troublesome Pseudomonas species. Iscaguard ® PE is active over a pH range of 3.0 to 8.5 and is compatible with most personal care ingredients. Typical use levels for Iscaguard ® PE range from 0.4% to 1.0%. Regulatory Status Iscaguard ® PE is permitted for use in personal care products in the US, Europe (up to a maximum of 1.0%) and Japan (up to a maximum of 3.0%). Using Iscaguard ® PE Iscaguard ® PE is soluble in water to approximately 2.4%, significantly higher than typical use concentrations, but warming to 40ºC may be required to speed dissolution in formulations with a very high water content. Table 3 Solubility of Iscaguard ® PE (% w/w @ 25°C) Water Approx. 2.4% Propylene glycol Miscible Butylene glycol Miscible Table 4 Antimicrobial activity of Iscaguard ® PE Micro-organism Minimum inhibitory concentration (%) Pseudomonas aeruginosa 0.55 Escherichia coli 0.55 Proteus vulgaris 0.55 Staphylococcus aureus 0.70 Bacillus cereus 0.65 Enterococcus faecium 0.90 Candida albicans 0.45 Saccharomyces cerevisiae 0.37 Aspergillus niger 0.30 ISCA Iscaguard ® Preservative Blends Iscaguard ® BA Iscaguard ® BA, benzyl alcohol, has broad-spectrum activity against bacteria and fungi and is also particularly effective against troublesome gram-negative Pseudomonas species. Like Iscaguard ® PE, Iscaguard ® BA is effective over a pH range of 3.0 – 8.5 and is compatible with most ingredients found in personal care formulations. Typical use concentrations for Iscaguard ® BA range from 0.4% to 1.0%. Regulatory Status Iscaguard ® BA is permitted in personal care products in the US, Europe (up to a maximum of 1.0%), and Japan (up to a maximum of 3.0%). Using Iscaguard ® BA Iscaguard ® BA is soluble to approximately 4.0% but, like Iscaguard ® PE, warming up to 40ºC may be useful in order to speed up the dissolution in formulations with a high water content. Table 5 Solubility of Iscaguard ® BA (% w/w @ 25°C) Water Approx. 4% Propylene glycol Miscible Butylene glycol Miscible Table 6 Antimicrobial activity of Iscaguard ® BA Micro-organism Minimum inhibitory concentration (%) Pseudomonas aeruginosa 0.35 Escherichia coli 0.55 Proteus vulgaris 0.65 Staphylococcus aureus 0.65 Bacillus cereus 0.75 Enterococcus faecium 0.95 Candida albicans 0.50 Saccharomyces cerevisiae 0.37 Aspergillus niger 0.32
Iscaguard ® Iscaguard ® IU and DU Iscaguard ® IU, imidazolidinyl urea and Iscaguard ® DU, diazolidinyl urea, are both fine white, virtually odourless powders with excellent activity against gram-negative and gram-positive bacteria. Both are extremely soluble in water and do not usually require heating to dissolve. Neither product should be exposed to temperatures greater than 40ºC and should be added during the cooling stage of hot processes. Regulatory Status Iscaguard ® DU is permitted in the US (maximum 0.5%) and Europe (maximum 0.5%) but it is not permitted in Japan. Iscaguard ® IU is permitted in the US (maximum 0.5%) and Europe (maximum 0.5%). It is permitted in Japan for use in rinse-off products only up to a maximum of 0.3%. Table 7 Solubility of Iscaguard ® DU (% w/w @ 25°C) Water 70% Propylene glycol 40% Butylene glycol 0.25% Table 8 Antimicrobial activity of Iscaguard ® DU Microorganism Minimum inhibitory concentration (%) Pseudomonas aeruginosa 0.10 Escherichia coli 0.12 Proteus vulgaris 0.13 Staphylococcus aureus 0.08 Bacillus cereus 0.10 Enterococcus faecium 0.11 Candida albicans 0.70 Saccharomyces cerevisiae 0.20 Aspergillus niger 0.30 Table 9 Solubility of Iscaguard ® IU (% w/w @ 25°C) Water 65% Glycerine 48% Mineral oil < 0.01% ISCA Iscaguard ® Preservative Blends 4 Table 10 Antimicrobial activity of Iscaguard ® IU Microorganism Minimum inhibitory concentration(%) Pseudomonas aeruginosa 0.10 Escherichia coli 0.13 Proteus vulgaris 0.13 Staphylococcus aureus 0.10 Bacillus cereus 0.10 Enterococcus faecium 0.10 Iscaguard ® DMD Iscaguard ® DMD is a 55% solution of dimethyl dimethylol hydantoin(DMDMH) in water. It has excellent broad-spectrum activity and is effective at low use concentrations, from 0.15-0.4%. Using Iscaguard ® DMD Iscaguard ® DMD has excellent solubility in water and should be added during the cooling stage of hot processes. Regulatory Status Iscaguard ® DMD is approved for use in the US, Europe (up to a maximum of 0.6%) and Japan for rinse-off products only, up to a maximum concentration of 0.3%. Table 11 Antimicrobial activity of Iscaguard ® DMD Microorganism Minimum inhibitory concentration(%) Pseudomonas aeruginosa 0.05 Staphylococcus aureus 0.025 Candida albicans 0.1 Aspergillus niger 0.15 Iscaguard ® CMI Iscaguard ® CMI is a 1.5% solution of a blend of chloromethyl and methyl isothiazolinone in a strictly controlled ratio of 3:1. The mixture is stabilised with magnesium chloride and magnesium nitrate. Using Iscaguard CMI ® On a weight/weight basis, this isothiazolinone blend is probably the most effective broad-spectrum preservative available for personal care products and it is particularly useful in detergent-based products, such as shower gels, bath foams and shampoos.
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ISCAGUARD ® Preservatives for Personal Care - ISCA UK Ltd

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