ISCAGUARD ® Preservatives for Personal Care - ISCA UK Ltd

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19 ISCA Iscaguard ® Preservative Blends Iscaguard + SAP The preservation of cosmetic products is becoming ever more customer driven partially due to a wider knowledge base and partially due to bad press of chemical based preservatives. Combined with this regulatory standards governing personal care products are becoming more stringent. In the last thirty years we have seen several groups of chemical products either removed through legislation or becoming unpopular. Isca UK Ltd has worked on a solution whereby customers are able to purchase products that whilst they are not preservative chemicals as listed in Annex VI of the Biocidal Products Directive, they do inherently have anti-microbial properties. Iscaguard + SAP is enriched with L(+) amino acids physiologically valuable substances which contribute considerably to antimicrobial effects. Iscaguard + SAP is a 100% natural preservative containing Ecocert certified ingredients. It is a synergistic blend of propandiol with Salix alba extract. The renewablysourced propanediol made using a unique process is more sustainable compared to petroleum-based 1,3-PDO and PG. Benefits include its high purity, lack of skin irritation or sensitization, improved humectancy, excellent aesthetics and environmentally sustainable nature. Iscaguard + SAP is based on compounds that occur in nature and have natural anti-microbial properties. Typical use levels for Iscaguard + SAP range from 0.125% to 1.0% Using Iscaguard + SAP Iscaguard + SAP is soluble in water to approximately 0.35%, the preferred method of use is to pre dissolve into the non-aqueous phase prior to addition. This negates the need to heat Iscaguard + SAP. INCI name: Propandiol & Salix alba. Regulatory Status Not Regulated Antimicrobial activity of Iscaguard + SAP Microorganism Minimum inhibitory concentration(%) Pseudomonas aeruginosa ≤ 0.125 Escherichia coli ≤ 0.125 Staphylococcus aureus ≤ 0.125 Candida albicans 0.5 Aspergillus niger 0.5
Iscaguard MIT Iscaguard is a safe, broad spectrum bactericide for the preservation of leave-on and rinse-off products. Iscaguard MIT is a particularly suitable as replacement for formaldehyde donors in leave-on applications such as skin care formulations and sun care formulations, Zinc pyrithione-based antidandruff shampoos, high pH surfactant systems and high pH liquid cleaners. Iscaguard MIT provides formulators with a non formaldehyde-releasing bactericidal solution which is effective at very low use levels. Iscaguard MIT is also compatible with existing fungicides like parabens and is more stable in difficult to preserve high pH formulations. INCI Name: Methylisothiazolinone Regulatory Status Isacaguard MIT is supported by extensive toxicology studies and global regulatory dossiers and is expected to have global approvals for use in cosmetics at the time of printing. Using Iscaguard MIT Iscaguard MIT preservative should be added as the last ingredient and at the lowest temperature (≤ 45°C if possible). Since the components of personal care formulations vary considerably and may impact on the effect of preservatives, we urge each manufacturer to confirm the efficacy and stability of Iscaguard MIT in use. The recommended use level is 0.05% - 0.1% (48 - 95 ppm of active ingredient) as supplied. At low contamination risk and low detergent or protein content; 0.01-0.05% At medium contamination risk, medium detergent or protein content; 0.05 - 0.1% ISCA Iscaguard ® Preservative Blends 20 Solubility of Iscaguard MIT (%w/w @ 25ºc) Water Miscible Propylene Glycol Miscible Butylene Glycol Miscible Antimicrobial activity of Iscaguard MIT Microorganism Minimum inhibitory concentration(%) Pseudomonas aeruginosa 0.04 Escherichia coli 0.04 Proteus vulgaris 0.02 Staphylococcus aureus 0.03 Bacillus cereus 0.02 Enterococcus faecium 0.04 Candida albicans 0.32 Saccharomyces cerevisiae 0.35 Aspergillus niger 0.16 The MIC-values have been determined in dilution assays: Bacteria: 24-48 h at 37ºC Yeast/Fungi: 48-72 h at 28ºC
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ISCAGUARD ® Preservatives for Personal Care - ISCA UK Ltd

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