Báo cáo khoa học: Hydrogels as Drug Delivery Systems (Hệ dẫn truyền thuốc Hydogels)
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III. THE SYSTHESIS OF HYDROGELS, THE WAYS TO LOAD DRUGS INTO<br />
HYDROGELS AND THE RELEASE OF DRUGS FROM HYDROGELS<br />
3.1. Preparations of hydrogels<br />
3.1.1. Physical cross-linking<br />
- H-bonded hydrogel can be obtained by lowering the pH of<br />
aqueous solution of polymers carrying carboxyl groups.<br />
- Examples of such hydrogel is a hydrogen-bound CMC<br />
(carboxymethyl cellulose) network formed by dispersing CMC<br />
into 0.1M HCl.<br />
- The mechanism involves replacing the sodium in CMC with<br />
hydrogen in the acid solution to promote hydrogen bonding.<br />
- The hydrogenbonds induce a decre<strong>as</strong>e of CMC solubility in<br />
water and result in the formation of an el<strong>as</strong>tic hydrogel.<br />
- Transactions of the Materials Research Society of Japan, Vol 32, No 332, 713-716<br />
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