Acne and Rosacea Charity Training Manual

Synchrorose
This product contains four synergistic ingredients and is a medically licensed product only available to clinics. A novel ingredient known at a Tryp-2 receptor
antagonist called 4-t-butylcyclohexanol which is the first agent to stop nerve stimulated peptide production irritating the skin by triggering stinging and burning
by activating receptors on skin cells.
4-t-butylcycloheaxanol
Various physiological triggers like food, liquids, temperature change can stimulate nerves which in turn activate receptors on keratinocytes (epidermal skin cells)
which release peptides (protein fragments) which cause a stinging and burning sensation. Rosacea sufferers receptors are much more reactive to these stimuli.
4-t-butylcyclohexanol inhibits the effect of these nerve stimulated peptides thereby calming and soothing rosacea symptoms before they show. Regular use of
these agents can have a profound effect on rosacea symptoms and also other nerve stimulated redness.
Dimethly Sulfone
Also known as methyl sulfonyl methane (MSM) is the second ingredient and works synergistically with the butylcyclohexabol in that it suppresses the activity of
key skin inflammatory agents including the key cytokine interleukin 1 alpha which triggers erythema and swelling. MSM also reduces the activity of vaso
endothelial growth factor and tumour necrosis factor1 alpha. Rosacea sufferers may be hyper-reactive to these skin chemicals which may exacerbate
telangiectasia and phymatous development. In combination these agents have a synergistic effect on rosacea symptoms and development as each is beneficial
to the other.
Polyglutamic Acid
The third ingredient is Polyglutamic Acid which is a long chain of repeating units of glutamic acid, and creates a
physical smooth, elastic, self moisturising and soft film for improved sensory perception and protection of the outer
layer of the skin, a reinforcement of the skin’s support structure, stimulates the production of skin lipids improving skin
sensitivity (less sensitive), stimulates the renewal of the epidermis (also improves sensitivity), raises the tolerance
threshold to rosacea triggers especially external ones (raises TTT (Trigger Tolerance Thresholds)).
Silymarin
A bioflavanoid complex from milk thistle known as Silymarin in the fourth ingredient in Synchrorose and this works in
synergy with MSM to suppress erythema. The retail version of Synchrorose does not contain silymarin, but is the
updated formula and should not be confused with the old MSM/silymarin only formula.