Acne and Rosacea Charity Training Manual

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Synchrorose This product contains four synergistic ingredients and is a medically licensed product only available to clinics. A novel ingredient known at a Tryp-2 receptor antagonist called 4-t-butylcyclohexanol which is the first agent to stop nerve stimulated peptide production irritating the skin by triggering stinging and burning by activating receptors on skin cells. 4-t-butylcycloheaxanol Various physiological triggers like food, liquids, temperature change can stimulate nerves which in turn activate receptors on keratinocytes (epidermal skin cells) which release peptides (protein fragments) which cause a stinging and burning sensation. Rosacea sufferers receptors are much more reactive to these stimuli. 4-t-butylcyclohexanol inhibits the effect of these nerve stimulated peptides thereby calming and soothing rosacea symptoms before they show. Regular use of these agents can have a profound effect on rosacea symptoms and also other nerve stimulated redness. Dimethly Sulfone Also known as methyl sulfonyl methane (MSM) is the second ingredient and works synergistically with the butylcyclohexabol in that it suppresses the activity of key skin inflammatory agents including the key cytokine interleukin 1 alpha which triggers erythema and swelling. MSM also reduces the activity of vaso endothelial growth factor and tumour necrosis factor1 alpha. Rosacea sufferers may be hyper-reactive to these skin chemicals which may exacerbate telangiectasia and phymatous development. In combination these agents have a synergistic effect on rosacea symptoms and development as each is beneficial to the other. Polyglutamic Acid The third ingredient is Polyglutamic Acid which is a long chain of repeating units of glutamic acid, and creates a physical smooth, elastic, self moisturising and soft film for improved sensory perception and protection of the outer layer of the skin, a reinforcement of the skin’s support structure, stimulates the production of skin lipids improving skin sensitivity (less sensitive), stimulates the renewal of the epidermis (also improves sensitivity), raises the tolerance threshold to rosacea triggers especially external ones (raises TTT (Trigger Tolerance Thresholds)). Silymarin A bioflavanoid complex from milk thistle known as Silymarin in the fourth ingredient in Synchrorose and this works in synergy with MSM to suppress erythema. The retail version of Synchrorose does not contain silymarin, but is the updated formula and should not be confused with the old MSM/silymarin only formula.
Treatment of Type II Rosacea Topical antibiotics Metronidazole - Topical metronidazole Available as 0.75% and 1% gels and creams. Some gels contain cellulose and this leaves a surface film which some patients find unacceptable Topical metronidazole is marketed for the treatment of rosacea and is successful in treating the inflammatory spots in rosacea but will have no effect on flushing or facial redness. Topical erythromycin and clindamycin Topical erythromycin and clindamycin are effective in treating inflammatory rosacea but the alcoholic solutions and gels may be too irritant to be tolerated by the rosacea sufferer. Dalacin T lotion (1% clindamycin) may be better tolerated. Topical pimicrolimus Topical azaleic acid The 15% azaleic acid cream (marketed as Finacea ) is effective in treating inflammatory lesions of rosacea and may have a very mild effect on facial redness. The 20% azaleic acid preparation (marketed as Skinoren) is generally too irritant for the rosacea sufferer. Topical pimicrolimus (marketed as Elidel cream) is a non-steroidal anti-inflammatory agent. One study has shown that it is effective in treating inflammatory lesions of rosacea and gave similar results to topical metronidazole. Neither gave response to flushing or telangiectasia. Topical Ivermectin Topical ivermectin (marketed as Soolantra) has potent anti-inflammatory effects and is very effective in Type 2 rosacea, suppressing the inflammatory lesions but with little effect on the redness. I find that it is more effective than topical metronidazole.
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A R A U K Acne and Rosacea Associat
Page 4 and 5:
Acne - Pathogenesis The pathogenesi
Page 6 and 7:
Follicular Hypercornification The o
Page 8 and 9:
Inflammation The inflammatory respo
Page 10 and 11:
High humidity The comedone is forme
Page 12 and 13:
Psychological impact of acne Acne i
Page 14 and 15:
Module - 2 Acne - Clinical
Page 16 and 17: In some patients, comedones can be
Page 18 and 19: With deeper lesion developing the d
Page 20 and 21: Module - 3 Conventional Treatments
Page 22 and 23: Topical retinoids Retinoids work by
Page 24 and 25: Alternative agents for non-inflamma
Page 26 and 27: Inflammatory acne In mild to modera
Page 28 and 29: Erythromycin Erythromycin is availa
Page 30 and 31: Systemic Antibiotics Tetracyclines
Page 32 and 33: Hormonal therapy in women In women
Page 34 and 35: Oral Isotretinoin Oral isotretinoin
Page 36 and 37: Module - 4 Additional Treatments of
Page 38 and 39: Salicylic Acid Peel (Enerpeel SA) E
Page 40 and 41: Jessners Peel (Enerpeel JR) Jessner
Page 42 and 43: Light and Laser Treatment Sunlight
Page 44 and 45: Lasers 1450 nm Laser with Cooling S
Page 46 and 47: Scientific studies have shown that
Page 48 and 49: Advice for the Acne Sufferer A larg
Page 50 and 51: Module - 7 Acne Scarring
Page 52 and 53: Types of scarring Scarring in acne
Page 54 and 55: Needling Devices (dermal rollers an
Page 56 and 57: Fraxel Laser The Fraxel laser is ef
Page 58 and 59: Rosacea Rosacea is a relatively com
Page 60 and 61: Type III Phytomatous rosacea. This
Page 62 and 63: Module - 9 Treatment of Rosacea
Page 64 and 65: adrenergic blockers (antagonists) T
Page 68 and 69: Systemic antibiotics Tetracyclines
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