2017 HCHB_digital

Topiramate Actavis
Topiramate 25mg, 50mg, 100mg, 200mg
Stop
Migraines
Before
They Start
FULLY FUNDED.
WITH NO SPECIAL AUTHORITY
Consider migraine prevention for patients suffering from frequent headache ≥ 2/
week; migraines that significantly interfere with daily routine, and uncommon
migraine conditions, including hemiplegic migraine, basilar migraine, migraine
with prolonged aura, and migrainous infarction.
Good clinical evidence supports the clinical efficacy of topiramate in the
treatment of migraine prevention. Within one month patients can expect:
Migraine Pain intensity decreased
Frequency of migraines decreased
Quality of life increased (1)
1. Nelles G et al. J Headache Pain 2010; 11:33-44
Topiramate Actavis (topiramate) 25, 50,100 & 200mg Tablets. Prescription Medicine. Indications: Epilepsy-adults and children 2 years plus as monotherapy in patients with newly
diagnosed epilepsy, for conversion to monotherapy in patients with epilepsy, as add-on therapy in partial onset seizures, generalised tonic-clonic seizures or seizures associated with
Lennox-Gastaut syndrome. Migraine: prophylaxis of migraine headache in adults.
Precautions: Adequate hydration required. Suicidal behaviour/ideation/attempt, nephrolithiasis, oligohydrosis, anhidrosis, hyperthermia, acute myopia, glaucoma, metabolic acidosis,
mood disturbances, depression, renal or hepatic impairments, psychiatric-behavioural disturbances, pregnancy, lactation, fetal harm, congenital malformations, oral clefts in infants.
Interactions: Digoxin, CNS depressants, oc, lithium, risperidone, hydrochlorothiazide, metformin, pioglitazone, glibenclamide, phenytoin, carbamazepine, valproic acid, agents
predisposing to nephrolithiasis, propranolol, amitryptyline, haloperidol, diltiazem, flunarizine. Dosage: Migraine: Start with 25mg/day and increase weekly to total daily dose of 100mg/
day re clinical outcome. Epilepsy: Monotherapy: Target dose of 100mg/day to maximum of 500mg/day. Add-on therapy: Target dose of 200-400mg/day with maximum of 1000mg/
day. Adverse Effects: Decreased appetite and weight loss. Consult the full data sheet at www.medsafe.govt.nz before prescribing. Actavis New Zealand Ltd, Auckland. TAPS NA 8622