Book of abstracts version 5

MIP synthesis of 4-vinylpyridine
Author
Ilse van Kessel
Academy of Technology for Health and Environment
Avans Hogeschool, Breda
Avans Lectorate
Sonny van Seeters
Abstract
MIP synthesis of 4-vinylpyridine
Taxol is a medicine used against different kinds of cancer. For the production of Taxol mostly used is 10 -DAB (10-
deacetylbaccatin III, this compound can be extracted from the Taxus Baccata L.. To simplify the extraction of 10 -DAB from
the Taxus Baccata L. a MIP (Molecular Imprinted Polymer) can be used. A MIP is an highly selective polymer whereby the
synthesis of a MIP uses a template of the molecule, a monomer and a cross linker. [1] The result is a high cross-linked
polymer because of the new bonds between the template and the cross -linked polymer during the curing process. The
template is removed and the permanent pores stay in the polymer. The polymer is highly selective for the template
molecule (10-DAB). In figure 1 is the schematic representation of the synthesis of the MIP shown.[2] The goal of this study
is the synthesis of a MIP with another functional monomer than used in earlier investigations. This MIP has to be specific
for 10-DAB, the analysis that are used are HPLC, DSC, TGA and FTIR. 4 -VP (4-vinylpyridine) is used as functional monomer.
The expectation of this study is that a MIP with 4-VP can be synthesised. The MIP will also be selective for 10-DAB and has
a recovery higher than 80%.
Keywords: Taxol, 10-DAB, MIP
Table of content
Figure 1: Schematic representation of MIP synthesis.
[1] M. J. M. E.-M. R. D. &. F. A. Fatemeh Azizi Ishkuh, „Synthesis and characterization of paclitaxel-imprinted nanoparticles
for recognition and controlled release of an anticancer drug,” Journal of materials science, vol. 48, nr. 68, pp. 6343-6352,
2014.
[2] B. v. d. Velde, „Synthesis of molecularly imprinted polymers (MIPs) of 10-DAB III particles using a magnetite core-shell
approach,” Breda, 2017.
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