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<strong>Book</strong> <strong>of</strong> <strong>abstracts</strong> SPOC 2018<br />
Synthesis <strong>of</strong> a terpyridine ligand used in photodynamic treatment<br />
Author<br />
Harmen Spakman<br />
Academy <strong>of</strong> Technology for Health and Environment<br />
Avans Hogeschool, Breda<br />
University <strong>of</strong> Leiden<br />
terpyridine ligand used in photodynamic treatment<br />
Abstract<br />
This project consists in the synthesis <strong>of</strong> a functional terpyridine derivate that could be part <strong>of</strong> active Ruthenium complex<br />
used in photodynamic treatment for it’s phototoxic activity used in tumor targeting. In which this Ruthenium complex in<br />
the form <strong>of</strong> [Ru(tpy)(bpy)Cl] 2+ will selectively destroy cancerous DNA. The synthesis path follows a reaction path consisting<br />
<strong>of</strong> a Claisen condensation <strong>of</strong> Acetone and Ethylpyridine-2-carboxylate in presence <strong>of</strong> sodium ethoxide as a base followed<br />
by a Krӧnke pyridine synthesis in which a ring closing reaction will occur in the presence <strong>of</strong> Ammonium acetate shown in<br />
figure 1. This path could show an alternative to conventionally used research paths which are widely used [1][2].Goal in<br />
this project will be to record a significant yield in the overall reaction over previous studies conducted at Avans<br />
Hogeschool. Products will be characterized by FTIR, NMR, TLC, Yield and the melting point will be determined. Further<br />
research could be conducted at Leiden University.<br />
Keywords: Synthesis, Claisencondesation, Krӧnke pyridine synthesis, Terpyridine, Terpyridine derivated, PDT<br />
Table <strong>of</strong> content<br />
Figure 1: Reaction scheme <strong>of</strong> followed reactions to complete the synthesis <strong>of</strong> the final terpyridine derivate.<br />
[1] M. C. Thompson, „The synthesis <strong>of</strong> 2,2':6',2"-terpyridine ligands - versatile,” Coordination Chemistry Reviews, School<br />
<strong>of</strong> Chemistry, University <strong>of</strong> Bristol, Cantock s Close, Bristol, BS8 1TS, UK, 1997 .<br />
[2] Synthesis and Adsorption Properties, Toward Some Heavy Metal Ions, <strong>of</strong> a New Polystyrene-Based Terpyridine<br />
Polymer Department <strong>of</strong> Chemistry, The University <strong>of</strong> Jordan, Amman 11942, Jordan2Laboratory <strong>of</strong> Applied Biochemistry,<br />
Department <strong>of</strong> Biology, Faculty <strong>of</strong> Sciences, University Ferhat Abbas, Setif 19000, Algeria<br />
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