Research Report 2003 - Max-Planck-Institut für molekulare Genetik

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Research Report 2003 Published by the Max Planck Institute for Molecular Genetics (MPIMG), Berlin, Germany, October 2003 Editorial Board Bernhard Herrmann, Hans Lehrach, H.-Hilger Ropers, Martin Vingron Coordination & lay-out: Patricia Béziat Photos: Katrin Ullrich, MPIMG Printing & technical support: Thomas Didier, Meta Data Contact: Max Planck Institute for Molecular Genetics Ihnestr. 63 - 73 D-14195 Berlin Phone: ++49 / 30 / 8413 - 0 Fax: ++49 / 30 / 8413 - 1394 Email: info@molgen.mpg.de For further information about the MPIMG please see our website: http://www.molgen.mpg.de
Table of Contents The Max Planck Institute for Molecular Genetics • Organigram . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 • Mission . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5 • Development of the institute. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5 • Research concept . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Department of Vertebrate Genomics • Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 • Protein Structure Factory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 • Mass Spectrometry Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 • Bioinformatics Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 • Mouse, Medaka & MHC Group. . . . . . . . . . . . . . . . . . . . . . . . . . . 25 • Genetic Variation, Haplotypes & Genetics of Complex Disease Group . . 30 • Oligofingerprinting / Cell Arrays Group . . . . . . . . . . . . . . . . . . . . 32 • Kinetic Modeling Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 • In vitro Ligand Screening Group. . . . . . . . . . . . . . . . . . . . . . . . . . 39 • Neurodegenerative Disorders Group . . . . . . . . . . . . . . . . . . . . . . . 43 • Automation Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 • Evolution & Development Group . . . . . . . . . . . . . . . . . . . . . . . . . 52 • Gene Traps & Microarrays - Molecular Analysis of Heart Failure Group . 56 • Protein Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 • Cardiovascular Genetics Group . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 • Genomic Sequencing & Gene Function in Complex Diseases Group . . . 68 • Chromosome 21 Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 Department of Human Molecular Genetics • Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 • Neurochemistry Group & Mouse Lab . . . . . . . . . . . . . . . . . . . . . . 81 • Clinical Genetics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 • Chromosome Rearrangement & Disease . . . . . . . . . . . . . . . . . . . . 87 • DNA Microarrays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 • Neurobiology Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .94 • Cytology Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 • Biochemistry of Inherited Brain Disorders . . . . . . . . . . . . . . . . . 101 • Familial Mental Retardation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104 Department of Computational Molecular Biology • Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 • Gene Structure & Array Design Group . . . . . . . . . . . . . . . . . . . . 112 • Protein Families & Evolution Group . . . . . . . . . . . . . . . . . . . . . . 115 • Algorithms Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 • Protein Function Analysis Group . . . . . . . . . . . . . . . . . . . . . . . . . 122 • Computational Diagnostics Group . . . . . . . . . . . . . . . . . . . . . . . . 124 • Transcriptional Regulation Group . . . . . . . . . . . . . . . . . . . . . . . . 128 MPI for Molecular Genetics Research Report 2003 1
Page 1: Max-Planck-Institut für molekulare
Page 5 and 6: MPI for Molecular Genetics Research
Page 7 and 8: The Max Planck Institute for Molecu
Page 9 and 10: Department of Vertebrate Genomics I
Page 11 and 12: To generate high resolution express
Page 13 and 14: Competitive position Since a long t
Page 15 and 16: the Protein Structure Factory. Fina
Page 17 and 18: Mass Spectrometry Group Head: Dr. J
Page 19 and 20: different tissues of A. thaliana, w
Page 21 and 22: Bioinformatics Group Heads: Ralf He
Page 23 and 24: a) Evolutionary studies In a recent
Page 25 and 26: Fuchs T, Malecova B, Linhart C, Sha
Page 27 and 28: Mouse, Medaka & MHC Group Head: Dr.
Page 29 and 30: General information Publications 19
Page 31 and 32: Jochen Wittbrodt, EMBL, Heidelberg
Page 35 and 36: THETA - Two Hybrid Transfected-cell
Page 37 and 38: Academical co-operations Andreas Ra
Page 39 and 40: The investigation of signaling path
Page 41 and 42: In vitro Ligand Screening Group Hea
Page 45 and 46: Neurodegenerative Disorders Group H
Page 47 and 48: Automation Group Graduate students:
Page 49 and 50: In addition, novel methods for the
Page 51 and 52: Sittler A, Walter S, Wedemeyer N, H
Page 53 and 54:
Prof. Dr. Joachim Klose, Institut f
Page 55 and 56:
eral years. This ambiguity is partl
Page 57 and 58:
Clark MD, Panopoulou GD, Cahill DJ,
Page 59 and 60:
integrations were passaged to the g
Page 61 and 62:
General information Publications 19
Page 63 and 64:
Protein Group Scientists: Sabine Ba
Page 65 and 66:
Kersten B, Bürkle L, Kuhn EJ, Giav
Page 67 and 68:
Cardiovascular Genetics Group Head:
Page 69 and 70:
protein interaction partners and at
Page 71 and 72:
Page 73 and 74:
Chromosome 21 Group Head: Marie-Lau
Page 75 and 76:
Page 77 and 78:
Department of Human Molecular Genet
Page 79 and 80:
Network (NGFN). Recently, DNA from
Page 81 and 82:
Finally, several of these groups ar
Page 83 and 84:
Neurochemistry Group & Mouse Lab Gr
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studies. Furthermore, these mice wi
Page 87 and 88:
Noonan syndrome and related disorde
Page 89 and 90:
Chromosome Rearrangements & Disease
Page 91 and 92:
General information Selected Public
Page 93 and 94:
DNA Microarrays Scientists: Dr. Fik
Page 95 and 96:
General information Publications He
Page 97 and 98:
that in addition to reduced prolife
Page 99 and 100:
Christoph Redies, Prof. Dr., Instit
Page 101 and 102:
Since my move to the MPIMG in 11/20
Page 103 and 104:
Biochemistry of Inherited Brain Dis
Page 105 and 106:
Schweiger S, Chaoui R, Tennstedt C,
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Until 2002, 13 genes have been impl
Page 109 and 110:
General information Selected public
Page 111 and 112:
Department of Computational Molecul
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EU: The European Molecular Biology
Page 115 and 116:
EST tissue distribution Besides the
Page 117 and 118:
Protein Families & Evolution Group
Page 119 and 120:
Page 121 and 122:
We make use of the well-known HMMer
Page 123 and 124:
Theses Benjamin Georgi: A graph-bas
Page 125 and 126:
wide analysis of tyrosine as well a
Page 127 and 128:
Further projects include multiple t
Page 129 and 130:
Co-operations Identification and fu
Page 131 and 132:
upstream of the translational start
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Department of Developmental Genetic
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2000; see figure 1). So far, we hav
Page 137 and 138:
partners are. We also want to find
Page 139 and 140:
Emeritus Group General Molecular Ge
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Sethmann S, Ceglowski P, Willert J,
Page 143 and 144:
Research Group Development & Diseas
Page 145 and 146:
MPI for Molecular Genetics Research
Page 147 and 148:
Goals An important future goal is t
Page 149 and 150:
Independent Junior Research Groups
Page 151 and 152:
over, daf-9 is tightly regulated by
Page 153 and 154:
European C.elegans Meeting, Blanken
Page 155 and 156:
and at the ribosomal DNA locus. One
Page 157 and 158:
lencer, has so far remained unchara
Page 159 and 160:
Molecular control of skeletal devel
Page 161 and 162:
BMPs, into a common control network
Page 163 and 164:
this end I plan to analyze mouse mu
Page 165 and 166:
Ribosome Group The Ribosome group c
Page 167 and 168:
General information Selected Public
Page 169 and 170:
group during the same period. In ad
Page 171 and 172:
11) Agmon I, Auerbach T, Baram D, B
Page 173 and 174:
Reconstitution & function The ribos
Page 175 and 176:
Wendrich TM, Blaha G, Wilson DN, Ma
Page 177 and 178:
Miscellaneous Research Groups There
Page 179 and 180:
vealed that the extraordinary stabi
Page 181 and 182:
34. Thorsted PB, Macartney DP, Akht
Page 183 and 184:
esis and DNA packaging of this phag
Page 185 and 186:
Other launched projects concern con
Page 187 and 188:
BMBF 01GR0105, Plattform 1.1: NGFN
Page 189 and 190:
DNA synthesis, lipid biosynthesis,
Page 191 and 192:
Administration & Research Support H
Page 193 and 194:
Technical Management and Workshops
Page 195 and 196:
tion based on the simplified GOOD a
Page 197 and 198:
Library Librarians: Dipl.-Fachinf.
Page 199:
How to get to the Institute Max Pla
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