Research Report 2003 - Max-Planck-Institut für molekulare Genetik

More documents

Recommendations

Info

6 General Information Vingron) exploits the generated data to better understanding of biological and disease processes. The newly established Dept. of Developmental Genetics (Dept. Herrmann) uses the systematic functional analysis for understanding developmental mechanisms. The institute pursues a number of large scale projects. Probably the most prominent national project is the German National Genome Network (NGFN), where all departments of the institute participate and collaborate with each other. Other prominent projects include a number of EU projects, participation in several projects of the German Ministry of Science as well DFG “Sonderforschungsbereiche”. With this involvement in national and international research projects as well as by virtue of the research output of the institute, the MPIMG is perceived internationally as a stronghold of genome and genetics research in Germany. The publications coming from the institute document the international competitiveness of the institute. Maintaining this status in the future will require continuing technological innovation, close co-operation with the universities and, in particular, their medical schools, and ongoing integration between genome research and genetics, as well as between experimental and computational biological research. These are the means by which research excellence shall be maintained and further strengthened in the future. Bernhard Herrmann, Director Hans Lehrach, Director H.-Hilger Ropers, Director Martin Vingron, Director
Department of Vertebrate Genomics Introduction Since the foundation of the department “Vertebrate Genomics” in 1994, we have focused our work on structural and functional genomics of man and a number of model organisms, a systematic analysis of structure and function of most or all genes of an organism by high throughput, automated procedures. Since we expect that many biological processes will only become understandable by such systematic, genome-wide analyses, we consider such genome-wide analyses our best chance to understand many processes in biology, particularly many of the common, complex diseases (heart diseases, cancer, neurological diseases) which affect a large fraction of the population. Since much of the funding for biological and medical science (including much of that for the MPG) has always been justified by the argument, that a more detailed understanding of biological processes will ultimately help the population (which, after all, funds science through their taxes) we see a major commitment to this type of research also as essential for the Max Planck Society. Scientific overview Head: Prof. Dr. Hans Lehrach Phone: +49 (0)30-8413 1220 Fax: +49 (0)30-8413 1380 Email: lehrach@molgen.mpg.de Scientific Management: Dr. Claudia Falter Phone: +49 (0)30-8413 1411 Fax: +49 (0)30-8413 1380 Email: falter@molgen.mpg.de Secretary: Johanna Belart Phone: +49 (0)30-8413 1221 Fax: +49 (0)30-8413 1380 Email: belart@molgen.mpg.de We consider life essentially as computational process: the organism computes its phenotype from the DNA sequence of its genome, modulated by the environment. This ‘computation’ is carried out by a complex network of molecular (and cellular) processes, involving most or all genes and gene products of the organism. It is therefore highly likely, that progress in many essential areas, for example to understand and ultimately to be able to treat many of the common diseases, will depend on understanding these networks. We therefore had to develop techniques, able to generate the same types of information, which had previously been generated by hand on selected ‘interesting’ genes on essentially all genes of many different organisms and to use these techniques to analyze the structure and evolution and function of the genes of man and model organisms. This effort has been complemented by the analysis of a number of medical problems (Huntington chorea, Apeced, Downs syndrome, heart disease, obesity, stroke, cancer, infection, arthritis, inflammatory bowel disease, autoimmunity etc.) MPI for Molecular Genetics Research Report 2003 7
Page 1 and 2: Max-Planck-Institut für molekulare
Page 3 and 4: Table of Contents The Max Planck In
Page 5 and 6: MPI for Molecular Genetics Research
Page 7: The Max Planck Institute for Molecu
Page 11 and 12: To generate high resolution express
Page 13 and 14: Competitive position Since a long t
Page 15 and 16: the Protein Structure Factory. Fina
Page 17 and 18: Mass Spectrometry Group Head: Dr. J
Page 19 and 20: different tissues of A. thaliana, w
Page 21 and 22: Bioinformatics Group Heads: Ralf He
Page 23 and 24: a) Evolutionary studies In a recent
Page 25 and 26: Fuchs T, Malecova B, Linhart C, Sha
Page 27 and 28: Mouse, Medaka & MHC Group Head: Dr.
Page 29 and 30: General information Publications 19
Page 31 and 32: Jochen Wittbrodt, EMBL, Heidelberg
Page 35 and 36: THETA - Two Hybrid Transfected-cell
Page 37 and 38: Academical co-operations Andreas Ra
Page 39 and 40: The investigation of signaling path
Page 41 and 42: In vitro Ligand Screening Group Hea
Page 45 and 46: Neurodegenerative Disorders Group H
Page 47 and 48: Automation Group Graduate students:
Page 49 and 50: In addition, novel methods for the
Page 51 and 52: Sittler A, Walter S, Wedemeyer N, H
Page 53 and 54: Prof. Dr. Joachim Klose, Institut f
Page 55 and 56: eral years. This ambiguity is partl
Page 57 and 58: Clark MD, Panopoulou GD, Cahill DJ,
Page 59 and 60:
integrations were passaged to the g
Page 61 and 62:
General information Publications 19
Page 63 and 64:
Protein Group Scientists: Sabine Ba
Page 65 and 66:
Kersten B, Bürkle L, Kuhn EJ, Giav
Page 67 and 68:
Cardiovascular Genetics Group Head:
Page 69 and 70:
protein interaction partners and at
Page 71 and 72:
Page 73 and 74:
Chromosome 21 Group Head: Marie-Lau
Page 75 and 76:
Page 77 and 78:
Department of Human Molecular Genet
Page 79 and 80:
Network (NGFN). Recently, DNA from
Page 81 and 82:
Finally, several of these groups ar
Page 83 and 84:
Neurochemistry Group & Mouse Lab Gr
Page 85 and 86:
studies. Furthermore, these mice wi
Page 87 and 88:
Noonan syndrome and related disorde
Page 89 and 90:
Chromosome Rearrangements & Disease
Page 91 and 92:
General information Selected Public
Page 93 and 94:
DNA Microarrays Scientists: Dr. Fik
Page 95 and 96:
General information Publications He
Page 97 and 98:
that in addition to reduced prolife
Page 99 and 100:
Christoph Redies, Prof. Dr., Instit
Page 101 and 102:
Since my move to the MPIMG in 11/20
Page 103 and 104:
Biochemistry of Inherited Brain Dis
Page 105 and 106:
Schweiger S, Chaoui R, Tennstedt C,
Page 107 and 108:
Until 2002, 13 genes have been impl
Page 109 and 110:
General information Selected public
Page 111 and 112:
Department of Computational Molecul
Page 113 and 114:
EU: The European Molecular Biology
Page 115 and 116:
EST tissue distribution Besides the
Page 117 and 118:
Protein Families & Evolution Group
Page 119 and 120:
Page 121 and 122:
We make use of the well-known HMMer
Page 123 and 124:
Theses Benjamin Georgi: A graph-bas
Page 125 and 126:
wide analysis of tyrosine as well a
Page 127 and 128:
Further projects include multiple t
Page 129 and 130:
Co-operations Identification and fu
Page 131 and 132:
upstream of the translational start
Page 133 and 134:
Department of Developmental Genetic
Page 135 and 136:
2000; see figure 1). So far, we hav
Page 137 and 138:
partners are. We also want to find
Page 139 and 140:
Emeritus Group General Molecular Ge
Page 141 and 142:
Sethmann S, Ceglowski P, Willert J,
Page 143 and 144:
Research Group Development & Diseas
Page 145 and 146:
MPI for Molecular Genetics Research
Page 147 and 148:
Goals An important future goal is t
Page 149 and 150:
Independent Junior Research Groups
Page 151 and 152:
over, daf-9 is tightly regulated by
Page 153 and 154:
European C.elegans Meeting, Blanken
Page 155 and 156:
and at the ribosomal DNA locus. One
Page 157 and 158:
lencer, has so far remained unchara
Page 159 and 160:
Molecular control of skeletal devel
Page 161 and 162:
BMPs, into a common control network
Page 163 and 164:
this end I plan to analyze mouse mu
Page 165 and 166:
Ribosome Group The Ribosome group c
Page 167 and 168:
General information Selected Public
Page 169 and 170:
group during the same period. In ad
Page 171 and 172:
11) Agmon I, Auerbach T, Baram D, B
Page 173 and 174:
Reconstitution & function The ribos
Page 175 and 176:
Wendrich TM, Blaha G, Wilson DN, Ma
Page 177 and 178:
Miscellaneous Research Groups There
Page 179 and 180:
vealed that the extraordinary stabi
Page 181 and 182:
34. Thorsted PB, Macartney DP, Akht
Page 183 and 184:
esis and DNA packaging of this phag
Page 185 and 186:
Other launched projects concern con
Page 187 and 188:
BMBF 01GR0105, Plattform 1.1: NGFN
Page 189 and 190:
DNA synthesis, lipid biosynthesis,
Page 191 and 192:
Administration & Research Support H
Page 193 and 194:
Technical Management and Workshops
Page 195 and 196:
tion based on the simplified GOOD a
Page 197 and 198:
Library Librarians: Dipl.-Fachinf.
Page 199:
How to get to the Institute Max Pla
show all

Research Report 2003 - Max-Planck-Institut für molekulare Genetik

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?