GANGLIOGLIOMA (WHO I) GANGLIOGLIOMA (WHO I)

PINEAL PARENCHYMAL TUMORS
� Pineocytoma, WHO grade I
– Identical to neurocytomas (pineocytic rosettes)
� PPT, Int. Differentiation, WHO grades II-III
– No rosettes, mitotic activity, NF+ = gr. II?
– High MI (Ki-67) and no NF+ = gr. III?
� Pineoblastoma, WHO grade IV
PINEOCYTOMA, WHO GRADE I
PPT, INT. DIFF., WHO GRADE II EMBRYONAL CNS TUMORS
MEDULLOBLASTOMA/PNET (WHO IV)
� Children/young adults
� Aggressive natural history
� CSF seeding (“icing” and drop mets)
�� 5-year 5 year survival: 60-80% 60 80% with therapy
� Radiation may save patient’s life, but is harmful
to the developing CNS
� Favorable and unfavorable variants
� Histogenesis: EGL or SEGM of 4th ventricle
� Medulloblastoma
– Classic
– Desmoplastic
– Extensively Nodular
– L Large cell/Anaplastic
ll/A l ti
– Medullo with myogenic
differentiation
– Medullo with melanotic
differentiation
� Pineoblastoma
� CNS PNET
– Neuroblastoma
– Ganglioneuroblastoma
– Ependymoblastoma
– Medulloepithelioma
� Atypical teratoid /
Rhabdoid tumor