GANGLIOGLIOMA (WHO I) GANGLIOGLIOMA (WHO I)

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PINEAL PARENCHYMAL TUMORS � Pineocytoma, WHO grade I – Identical to neurocytomas (pineocytic rosettes) � PPT, Int. Differentiation, WHO grades II-III – No rosettes, mitotic activity, NF+ = gr. II? – High MI (Ki-67) and no NF+ = gr. III? � Pineoblastoma, WHO grade IV PINEOCYTOMA, WHO GRADE I PPT, INT. DIFF., WHO GRADE II EMBRYONAL CNS TUMORS MEDULLOBLASTOMA/PNET (WHO IV) � Children/young adults � Aggressive natural history � CSF seeding (“icing” and drop mets) �� 5-year 5 year survival: 60-80% 60 80% with therapy � Radiation may save patient’s life, but is harmful to the developing CNS � Favorable and unfavorable variants � Histogenesis: EGL or SEGM of 4th ventricle � Medulloblastoma – Classic – Desmoplastic – Extensively Nodular – L Large cell/Anaplastic ll/A l ti – Medullo with myogenic differentiation – Medullo with melanotic differentiation � Pineoblastoma � CNS PNET – Neuroblastoma – Ganglioneuroblastoma – Ependymoblastoma – Medulloepithelioma � Atypical teratoid / Rhabdoid tumor
DESMOPLASTIC MEDULLOBLASTOMA Reticulin SYN MIB-1
Page 1 and 2: TUMORS OF THE CENTRAL NERVOUS SYSTE
Page 3 and 4: DESMOPLASTIC INFANTILE GANGLIOGLIOM
Page 5: CENTRAL NEUROCYTOMA, WHO II EXTRAVE
Page 9 and 10: MEDULLOBLASTOMA GENETICS � Geneti
Page 11 and 12: Primitive Neoplasms S-PNET Medullo
Page 13: CD99 PAS PASD EWS-BA EWS-FLI1

GANGLIOGLIOMA (WHO I) GANGLIOGLIOMA (WHO I)

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