January/February 2012 • Volume 10 • Issue 1 - SKINmed Journal

ONE PRESCRIPTION.
TWO POWERFUL EFFECTS.
The power to calm inflammatory acne
Inflammation is an important aspect in the
pathophysiology of acne 1
Both laboratory and clinical studies document the
anti-inflammatory effects of minocycline 1
TM
CALMING
WIPES
(30 WIPES)
Complementary T 3 Calming Wipes
Soothing and alcohol-free —
part of a complete approach
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The only pelletized form of Minocycline available...
A dual approach to acne care
The power to eradicate P acnes
Significant reduction in P acnes—even up to 3 weeks
after discontinuation 2
A decrease in P acnes can lead to a drop in
pro-inflammatory cytokines and reduced inflammation1 Minimal resistance in an in vitro study
—The majority of tetracycline-resistant P acnes
were cross-resistant to doxycycline—but sensitive
to minocycline* 3
The most common adverse events associated with MINOCIN are nausea, vomiting, and diarrhea. CNS adverse effects may include
dizziness, vertigo, and headache.
Important Information
The most common adverse events associated with MINOCIN are nausea, vomiting, and diarrhea. Central nervous system adverse events including
light-headedness, dizziness, or vertigo have been reported with minocycline therapy, but are generally transient in nature. Other adverse events
include tinnitus, headache, sedation, and skin pigmentation, particularly on the face and mucous membranes. MINOCIN is contraindicated in persons
who have shown hypersensitivity to any of the tetracyclines or to any of the components of the product formulation. WARNING: MINOCIN Pellet-
Filled Capsules, like other tetracycline-class antibiotics, can cause fetal harm when administered to a pregnant woman. The use of drugs of the
tetracycline class during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years) may cause permanent
discoloration of teeth (yellow-gray-brown). Concurrent use of tetracyclines may render oral contraceptives less effective.
References: 1. SapadinAN,Fleischmajer R.Tetracyclines:nonantibiotic properties and their clinical implications.JAmAcad Dermatol. 2006;54(2):258-265. 2. Leyden JJ,McGinley KJ,KligmanAM.Tetracycline and minocycline
treatment.Arch Dermatol. 1982;118(1):19-22. 3. Hubbell CG,Hobbs ER,RistT,White JW Jr.Efficacy of minocycline compared with tetracycline in treatment of acne vulgaris.Arch Dermatol.1982;118(12):989-992.
*In vitro activity does not necessarily correlate to in vivo activity.
©2010 Triax Pharmaceuticals, LLC All rights reserved. Printed in USA. MN-0810-280
For more information, go to www.minocin-kit.com