L.B. Bohle Innovativ 01/2019 EN

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The Bohle Uni Cone BUC ® is a specially slotted air distributor plate with a conical displacement cone. The design allows for completely fluidized particles. Since the fluidized particles or granules move tangentially at relatively low fluidization height, they do not require a high-volume expansion. This reduces the required installation height, saving costs and production space. Another advantage of the tangential design in plants from L.B. Bohle in Thorsten Wesselmann’s opinion is “that granulation, coating and drying can be carried out in a single system without altering the equipment setup.” L.B. Bohle developed the BFS fluid bed system with tangentially mounted spray nozzles and the patented Bohle Uni Cone BUC ® , a specially slotted air distributor plate with a conical displacement cone for batches of 1 to 500 kg. Its pressure shock resistance of up to 12 bar makes the BFS the ideal choice for organic methods. Short product transfer times and efficient cleaning procedures offer additional potential savings in production time and cost. The geometrically similar structure simplifies scaling-up. A newly developed, protected multi-purpose valve directly above the distributor plate facilitates the dustfree suction and draining of the product container. The result for Wesselmann is “clear benefits with regards to ergonomics and cleaning that make the BFS stand out significantly from other fluid bed systems on the market.” Single-Pot Granulation Single-Pot granulation has been used in the pharmaceutical industry for many decades. With the VMA granulator, the mixing, high-shear wet granulation and drying (vacuum drying, carrier-gas drying, or drying by microwave heat) are all carried out in one container. Single-Pot granulators offer the following benefits: • Secure production within a closed container in a vacuum • High mixing and granulation efficiency (even for low doses of active agents at < 1%) • Drying at low temperatures • Small product contact surface for fast, easy cleaning and fast product changeover • Efficient solvent recovery through cooling water • Compact footprint for low space requirements The VMA product range includes classic mixer granulators with agitator and chopper units and a top-drive system. Two stirrers produce a shearing action and loosen the product. This helps to prevent clumping and ensures that the resulting granule is of optimum quality. According to Wesselmann, the GMP-compliant process tank with double jacket is “the heart of the VMA.” The main units are integrated in the granulation pot’s lid (Top-Drive). The process tank is emptied through a cone-shaped sieve (BTS 200) via the floor outlet into a container (IBC). Formula-controlled cleaning is carried out automatically. The VMA produces batch sizes from 20 to 960 litres and can be installed in potentially explosive environments. 6 INNOVATIV 1 | 2019
The Bohle fluid bed system is a multi-purpose system for drying, granulating and coating and offers numerous advantages over systems in the top spray or bottom spray process. INNOVATIV 1 | 2019 7
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L.B. Bohle Innovativ 01/2019 EN

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