L.B. Bohle Innovativ 01/2019 EN

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A binding fluid is added to the powdery particles in the high-shear granulator. The agitator blade guarantees effective granulation. High-shear granulation With high-shear granulation a binding fluid is added to the powdery particles in a closed tank that has an agitator blade and chopper. The agitator blade with its high shear and compaction guarantees effective granulation. Dense granules are formed. The chopper prevents excessive granulate growth and distributes the granulation medium throughout the product. The advantages at a glance: • Low fluid consumption • Easy unloading • Closed system • Granulation can be controlled according to the time, quantity or output • Easy to clean and the water is drained completely Twin-screw granulation Twin-screw granulation (TSG) is an established method for continuous wet granulation and is seen as the starting point by companies when it comes to the continuous manufacturing of pharmaceuticals. The powder to be granulated is fed onto two so-called screws, which rotate in the same direction in a cylinder, thereby transporting the material through the process zone and kneading and mixing it at the same time. This TSG design results in several advantages: • Short dwell times for the material in the process (< 1 minute – a few seconds) • Fast and efficient reactions to process and quality deviations • Reduction in the space for the required machines and associated GMP areas • Mixing and granulation in one step and in the shortest time possible • Introduction of instruments for 100% in-line quality control • No more discarding of whole batches necessary as inferior quality products can be selectively ejected • Implementation of experimental test plans in the shortest possible time “Due to the flexibility and simple implementation of the process, the TSG is the perfect, versatile machine for continuous manufacturing processes in research and development and in production,” Thorsten Wesselmann describes the system’s potential. 8 INNOVATIV 1 | 2019
Dry Granulation Continuous dry granulation is an established process in the pharmaceutical industry and is used for more than just moisture or temperature-sensitive products. Compared with wet granulation, no energy-intensive drying processes are required. This reduces the need for large investments in equipment and production facilities and results in a lower cost per batch by reducing the energy costs. Because no drying is required, no solvents need to be stocked, extracted or disposed of. Dry granulators ensure a compacting process with high material throughput. A single machine can produce different products and batch sizes. “L.B. Bohle’s BRC series combines a high level of product capacity with minimum material loss. This system outclasses rival solutions by generating force through purely electromechanical means to ensure consistent ribbon properties,” says Wesselmann, highlighting Bohle’s advantages. The BRC controls the compacting force and ribbon thickness very innovatively. It produces the even compacting of material over a production range of
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L.B. Bohle Innovativ 01/2019 EN

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