L.B. Bohle Innovativ 01/2019 EN
The customer magazine of the special maschine builder L.B. Bohle from Ennigerloh/Germany is published twice a year.
The customer magazine of the special maschine builder L.B. Bohle from Ennigerloh/Germany is published twice a year.
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A binding fluid is added to the powdery particles<br />
in the high-shear granulator. The agitator blade<br />
guarantees effective granulation.<br />
High-shear granulation<br />
With high-shear granulation a binding fluid is added to the<br />
powdery particles in a closed tank that has an agitator blade<br />
and chopper. The agitator blade with its high shear and compaction<br />
guarantees effective granulation. Dense granules are<br />
formed. The chopper prevents excessive granulate growth and<br />
distributes the granulation medium throughout the product.<br />
The advantages at a glance:<br />
• Low fluid consumption<br />
• Easy unloading<br />
• Closed system<br />
• Granulation can be controlled according to the time,<br />
quantity or output<br />
• Easy to clean and the water is drained completely<br />
Twin-screw granulation<br />
Twin-screw granulation (TSG) is an established method for<br />
continuous wet granulation and is seen as the starting point<br />
by companies when it comes to the continuous manufacturing<br />
of pharmaceuticals.<br />
The powder to be granulated is fed onto two so-called<br />
screws, which rotate in the same direction in a cylinder, thereby<br />
transporting the material through the process zone and kneading<br />
and mixing it at the same time.<br />
This TSG design results in several advantages:<br />
• Short dwell times for the material in the process (< 1<br />
minute – a few seconds)<br />
• Fast and efficient reactions to process and quality<br />
deviations<br />
• Reduction in the space for the required machines and<br />
associated GMP areas<br />
• Mixing and granulation in one step and in the shortest<br />
time possible<br />
• Introduction of instruments for 100% in-line quality<br />
control<br />
• No more discarding of whole batches necessary as<br />
inferior quality products can be selectively ejected<br />
• Implementation of experimental test plans in the shortest<br />
possible time<br />
“Due to the flexibility and simple implementation of the process,<br />
the TSG is the perfect, versatile machine for continuous manufacturing<br />
processes in research and development and in production,”<br />
Thorsten Wesselmann describes the system’s potential.<br />
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