2016 Fall/Winter Highlights of Hope
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RESEARCH<br />
THE BEST OF BOTH WORLDS:<br />
MEET VARI'S PHYSICIAN-SCIENTISTS<br />
What is the best part <strong>of</strong> being a physicianscientist?<br />
Q<br />
Lena Brundin, M.D., Ph.D.<br />
Associate Pr<strong>of</strong>essor, Center for Neurodegenerative Science,<br />
Van Andel Research Institute;<br />
Collaborating Researcher, Pine Rest Christian<br />
Mental Health Services<br />
Patrick Grohar, M.D., Ph.D.<br />
Associate Pr<strong>of</strong>essor, Center for Cancer and Cell Biology,<br />
Van Andel Research Institute;<br />
Pediatric Oncologist, Spectrum Health<br />
Helen DeVos Children’s Hospital<br />
Stefan Jovinge, M.D., Ph.D.<br />
Pr<strong>of</strong>essor, Center for Epigenetics, Van Andel Research Institute;<br />
Director, DeVos Cardiovascular Research Program (a joint effort<br />
between VARI and Spectrum Health);<br />
Medical Director <strong>of</strong> Research, Frederik Meijer Heart &<br />
Vascular Institute, Spectrum Health<br />
Matthew Steensma, M.D.<br />
Assistant Pr<strong>of</strong>essor, Center for Cancer and Cell Biology,<br />
Van Andel Research Institute;<br />
Orthopedic Surgeon, Spectrum Health<br />
MS: There are many wonderful aspects <strong>of</strong> being a<br />
physician-scientist, as well as unique challenges. What<br />
I really like about physician-scientist work is the ability<br />
to see the "entire picture," from bedside to bench<br />
and back. In my opinion, it's the best way to develop a<br />
comprehensive understanding <strong>of</strong> a complex disease<br />
like sarcoma. When you do translational research as<br />
a clinician, you acquire a deep understanding <strong>of</strong> the<br />
genetics or molecular biology <strong>of</strong> disease. It's a great<br />
reminder <strong>of</strong> the invisible battle going on inside <strong>of</strong> a<br />
patient. It can also be incredibly frustrating because it<br />
takes a lot <strong>of</strong> time to implement promising research<br />
findings, or your project simply fails. These frustrations<br />
are inherent to all medical research, but as a physicianscientist<br />
you always want to see the impact <strong>of</strong> your<br />
research. In many ways, our success is defined by how<br />
we improve the lives <strong>of</strong> our patients through research.<br />
The job is very motivating, not only for myself but also for<br />
our lab members, who really appreciate the context <strong>of</strong><br />
their work.<br />
SJ: In my case as a critical care cardiologist, I see very sick<br />
patients, sometimes in a hopeless condition. To be part<br />
<strong>of</strong> the cutting edge to generate new technologies and<br />
treatments gives me a lot <strong>of</strong> inspiration and energy to<br />
move things forward.<br />
LB: The best part is that I am able to do true translational<br />
research. I observe symptoms in patients that generate<br />
ideas and hypotheses that I then can test directly in<br />
my own laboratory. It is very fulfilling to be able to<br />
work like that. It is great to work with the full spectrum<br />
<strong>of</strong> research—to enroll patients in our clinical studies<br />
working directly with several hospitals in Grand Rapids; to<br />
evaluate the patient’s symptoms; collect blood and tissue<br />
samples; and then work on these samples in my own<br />
laboratory, put together the results, and finally interpret<br />
them, <strong>of</strong>ten together with our skilled biostatisticians<br />
at VARI.<br />
PG: Being a physician-scientist is the best <strong>of</strong> both worlds.<br />
I enjoy working directly with patients and making a<br />
2 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE