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2022 Spring/Summer Highlights of Hope

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HIGHLIGHTS OF<br />

HOPE<br />

SPRING/SUMMER ’22 ISSUE<br />

2 VAI welcomes six new scientists 4 New program launched in cancer research<br />

5 Rallying to the grand challenge <strong>of</strong> Parkinson’s<br />

6 VAI scientists have record-breaking year for scientific grants<br />

8 VAI scientists recognized as top <strong>of</strong> their fields 9 Research highlights<br />

10 Newest Grad School cohort illustrates growth<br />

12 A day in the life <strong>of</strong> a VAI grad student 13 Graduate School highlights<br />

14 From Afterschool Cohort to Fulbright Scholar 16 In-person field trips return<br />

17 Education highlights 18 Events 24 Event sponsors<br />

26 VAI Purple Community partners put in the time, effort & talent<br />

28 VAI Marathon Team runners back in action<br />

29 VAI Student Ambassador Program making moves<br />

30 Gifts in action: Funding new equipment to peer into cells 32 Memorials & Tributes


RESEARCH<br />

VAI welcomes six new scientists<br />

and their labs<br />

In the past year, VAI recruited six new faculty — an achievement that expands our scientific capacity and impact in Grand Rapids and<br />

beyond. These exceptional experts, each <strong>of</strong> whom leads their own lab at the Institute, bring with them a wealth <strong>of</strong> expertise at the<br />

forefront <strong>of</strong> scientific innovation and discovery.<br />

Nick Burton, Ph.D., Assistant Pr<strong>of</strong>essor<br />

Department <strong>of</strong> Epigenetics<br />

Joined VAI from University <strong>of</strong> Cambridge<br />

Dr. Nick Burton explores how our environment,<br />

especially microbes, can impact our health and<br />

the health <strong>of</strong> our <strong>of</strong>fspring — even before they<br />

are born. His research has extensive implications<br />

for understanding how epigenetics contributes to<br />

human disease and how the environment we are<br />

exposed to today affects not only our own health,<br />

but also our children’s.<br />

“In the last decade, it has become increasingly<br />

clear that an individual’s environment and their<br />

epigenetics play a major role in determining<br />

whether or not they will go on to develop many<br />

different pathologies, ranging from diabetes to<br />

autism. We are now beginning to understand<br />

the mechanisms underlying many <strong>of</strong> these<br />

observations. At Van Andel Institute, I look<br />

forward to working alongside many world-class<br />

researchers looking to solve these mechanisms<br />

and find new ways to improve human health.”<br />

— Dr. Nick Burton<br />

Yvonne Fondufe-Mittendorf, Ph.D., Pr<strong>of</strong>essor<br />

Department <strong>of</strong> Epigenetics<br />

Joined VAI from University <strong>of</strong> Kentucky<br />

Dr. Yvonne Fondufe-Mittendorf investigates how<br />

environmental factors, such as toxicants, impact our<br />

genetic code and contribute to cancer. Her research<br />

is illuminating powerful new insights that could<br />

influence our understanding <strong>of</strong> health and disease,<br />

providing a path forward for new strategies for<br />

cancer prevention and treatment.<br />

“Our environment has a pr<strong>of</strong>ound impact on our<br />

health, down to the molecular level. My research<br />

addresses some <strong>of</strong> today’s health challenges<br />

by developing a deeper understanding <strong>of</strong><br />

the mechanisms underpinning this critical<br />

relationship. Van Andel Institute is a global<br />

center for leading-edge epigenetics research,<br />

and I am thrilled to be part <strong>of</strong> it.”<br />

— Dr. Yvonne Fondufe-Mittendorf<br />

Stephanie Grainger, Ph.D., Assistant Pr<strong>of</strong>essor<br />

Department <strong>of</strong> Cell Biology<br />

Joined VAI from San Diego State University<br />

Stem cells give rise to every cell type in the human<br />

body and play important roles in health and disease.<br />

Dr. Stephanie Grainger seeks to understand how<br />

these special cells develop, how they are maintained,<br />

and how they can become cancerous, with the goal<br />

<strong>of</strong> developing new strategies for combating cancer.<br />

“Traditional cancer therapies do not target<br />

the rare cells that initiate cancer growth, and<br />

instead take a brute force approach <strong>of</strong> killing<br />

any cells that are growing. This includes the<br />

cells in your intestines, skin and hair and is why<br />

chemotherapy causes side effects like an upset<br />

stomach and hair loss. These rare cells, which<br />

behave similarly to a specialized group <strong>of</strong> cells<br />

in our bodies called stem cells, are <strong>of</strong>ten able to<br />

regrow tumors once therapy is withdrawn. One<br />

<strong>of</strong> the main goals <strong>of</strong> my research group at VAI<br />

is to figure out how these rare cells talk to each<br />

other in normal and cancerous conditions. Once<br />

we figure that out, we can more effectively kill<br />

<strong>of</strong>f these cells that initiate cancer.”<br />

— Dr. Stephanie Grainger<br />

2 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Sara Nowinski, Ph.D., Assistant Pr<strong>of</strong>essor<br />

Department <strong>of</strong> Metabolism and Nutritional<br />

Programming<br />

Joined VAI from University <strong>of</strong> Utah<br />

Dr. Sara Nowinski investigates how cells determine<br />

the amount <strong>of</strong> energy needed for everyday life<br />

and how they adjust to meet those requirements.<br />

Her research has uncovered new insights into the<br />

intricate balance between nutrient availability and<br />

cellular respiration — both critical components for<br />

maintaining health.<br />

“Mitochondria are well known for their role in<br />

energy production as the ‘powerhouses <strong>of</strong> the<br />

cell,’ but there is still so much we don’t know<br />

about how cells control and fine-tune their<br />

activity in different situations. I’m incredibly<br />

excited to join the Department <strong>of</strong> Metabolism<br />

and Nutritional Programming at VAI and<br />

look forward to the discoveries we will make<br />

together.”<br />

— Dr. Sara Nowinski<br />

Evan Worden, Ph.D., Assistant Pr<strong>of</strong>essor<br />

Department <strong>of</strong> Structural Biology<br />

Joined VAI from Johns Hopkins University<br />

Dr. Evan Worden leverages VAI’s powerful suite <strong>of</strong><br />

cryo-electron microscopes to explore the complex<br />

molecular interactions that give rise to cancer. To<br />

date, his research has revealed novel insights into<br />

poorly understood regulatory elements in the genetic<br />

code and illuminated how aberrations in these<br />

processes can transform healthy cells into malignant<br />

ones.<br />

“Our understanding <strong>of</strong> how epigenetics<br />

contributes to cancer has exploded in the last<br />

decade. This opened the door for us to use<br />

structural biology to answer really detailed<br />

questions about how the genetic elements<br />

expressed in cancer are regulated. I’m excited to<br />

continue this work at Van Andel Institute.”<br />

— Dr. Evan Worden<br />

Qiang Zhu, Ph.D., Assistant Pr<strong>of</strong>essor<br />

Department <strong>of</strong> Neurodegenerative Science<br />

Joined VAI from University <strong>of</strong> California, San Diego<br />

Dr. Qiang Zhu investigates the genetic, epigenetic<br />

and cellular factors that lead to neurodegenerative<br />

diseases such as ALS and frontotemporal dementia.<br />

To date, his work has revealed the complex<br />

mechanisms underlying the most common genetic<br />

cause for both <strong>of</strong> these diseases — an insight that<br />

has provided novel targets for the development <strong>of</strong><br />

new therapies.<br />

“The lack <strong>of</strong> therapies that impede progression<br />

<strong>of</strong> ALS and frontotemporal dementia is a major<br />

gap in patient care. I’m heartened that my<br />

research to date has contributed to clinical<br />

exploration <strong>of</strong> potential treatments and am<br />

excited to expand my efforts at VAI. The Institute<br />

has exceptional research facilities and a highly<br />

supportive, collaborative scientific environment.<br />

I look forward to teaming up with my colleagues<br />

to achieve our shared goal — new, more effective<br />

treatments for neurodegenerative diseases.”<br />

— Dr. Qiang Zhu<br />

In 2021, VAI was ranked by Nature Index as no. 24 in the Life Sciences<br />

category out <strong>of</strong> the top 100 nongovernmental/nonpr<strong>of</strong>it organizations<br />

(up from no. 29 in 2020).<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 3


RESEARCH<br />

New program launched to develop<br />

future leaders in cancer research<br />

The scientific leaders <strong>of</strong> tomorrow are the trainees <strong>of</strong> today —<br />

and Van Andel Institute is committed to helping them achieve<br />

success and improve human health, now and in the future.<br />

As part <strong>of</strong> our dedication to this goal, we launched VAI’s Cancer<br />

Epigenetics Training Program for exceptional postdoctoral fellows.<br />

These trainee scientists have completed their Ph.D.s but are<br />

pursuing additional training before starting their own independent<br />

laboratories.<br />

Cancer epigenetics is a growing field with untold potential to impact<br />

human health. Epigenetic abnormalities are universally found<br />

across cancers and serve as major drivers for transforming healthy<br />

cells into sick ones, making epigenetic alterations promising new<br />

targets for the development <strong>of</strong> life-changing cancer treatments.<br />

The Cancer Epigenetics Training Program combines extensive<br />

pr<strong>of</strong>essional development with comprehensive, interdisciplinary<br />

research training by VAI’s internationally recognized cadre <strong>of</strong><br />

experts. Postdoctoral trainees in the program also have access<br />

to the Institute’s state-<strong>of</strong>-the-art shared scientific resources and<br />

technologies as well as opportunities to participate in established<br />

translational research programs and partnerships led by VAI<br />

investigators.<br />

“In the past few years, VAI has become a global destination for<br />

groundbreaking, collaborative cancer epigenetics research,” said<br />

VAI Chief Scientific Officer Dr. Peter A. Jones. “Postdoctoral trainees<br />

will emerge from our Cancer Epigenetics Training Program with<br />

extensive, rigorous training and a solid foundation from which to<br />

launch their independent research careers.”<br />

The program is supported by a five-year, $1.7 million grant from<br />

the National Cancer Institute <strong>of</strong> the National Institutes <strong>of</strong> Health.<br />

Jones and VAI Associate Pr<strong>of</strong>essor Dr. Scott Rothbart will lead the<br />

program in collaboration with Dr. Erica Gobrogge, program director<br />

<strong>of</strong> VAI’s Office <strong>of</strong> Postdoctoral Affairs. The program also benefits<br />

from the guidance <strong>of</strong> its advisory committee, which includes<br />

renowned scientists from across the U.S.<br />

By supporting exceptional trainees today, VAI is helping to ensure a<br />

brighter, healthier future fueled by innovation and discovery.<br />

The Cancer Epigenetics Training program is supported by a National<br />

Cancer Institute T32 training grant (no. T32CA251066). The content is<br />

solely the responsibility <strong>of</strong> VAI and does not necessarily represent the<br />

<strong>of</strong>ficial views <strong>of</strong> the National Institutes <strong>of</strong> Health.<br />

“In the past few<br />

years, VAI has<br />

become a global<br />

destination for<br />

groundbreaking,<br />

collaborative<br />

cancer epigenetics<br />

research.”<br />

— Peter A. Jones,<br />

Ph.D., D.Sc. (hon)<br />

4 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Rallying to the<br />

grand challenge<br />

<strong>of</strong> Parkinson’s<br />

disease<br />

How do a person’s genetics impact their risk for<br />

Parkinson’s disease?<br />

That’s the question more than 500 people from around the<br />

world explored during Van Andel Institute’s annual Grand<br />

Challenges in Parkinson’s Disease scientific symposium and<br />

parallel Rallying to the Challenge meeting for people with<br />

Parkinson’s and care partners, co-hosted with the U.K.’s Cure<br />

Parkinson’s. Held virtually in October 2021, these events tackled<br />

how two specific genes — LRRK2 and GBA1 — contribute to<br />

Parkinson’s disease risk and how they may be leveraged to<br />

develop new and urgently needed treatments. Attendees<br />

heard scientific presentations from leading researchers and<br />

participated in panel discussions with advocates and people<br />

with Parkinson’s.<br />

As part <strong>of</strong> Grand Challenges in Parkinson’s Disease and Rallying to<br />

the Challenge, we recognized two scientists for their exceptional<br />

contributions to the Parkinson’s field and community. VAI<br />

presented the 2021 Jay Van Andel Award for Outstanding<br />

Achievement in Parkinson’s Disease Research to Dr. Ted Dawson,<br />

<strong>of</strong> Johns Hopkins University for his groundbreaking research<br />

into the molecular and genetic mechanisms underlying<br />

Parkinson’s disease — many <strong>of</strong> which have informed the<br />

development <strong>of</strong> potential new medications.<br />

Cure Parkinson’s and VAI presented Dr. Camille Carroll, <strong>of</strong><br />

University <strong>of</strong> Plymouth with the 2021 Tom Isaacs Award, which<br />

honors individuals who have had a significant impact on the<br />

lives <strong>of</strong> people with Parkinson’s and/or involved them in a<br />

participatory way in research. This award recognizes Carroll’s<br />

commitment to engage people with Parkinson’s in research and<br />

to foster collaboration between scientists, physicians and the<br />

Parkinson’s community.<br />

Save the date! The next Grand Challenges in Parkinson’s<br />

Disease and Rallying to the Challenge will be held Sept. 28–29,<br />

<strong>2022</strong>. Visit grandchallengesinpd.org to learn more.<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 5


RESEARCH<br />

VAI scientists have recordbreaking<br />

year for scientific grants<br />

Our scientists surpassed the Institute’s<br />

all-time funding record in 2021, earning<br />

more external grants than ever before.<br />

These important awards do more than<br />

support our groundbreaking research —<br />

they are vital, objective validation <strong>of</strong> this<br />

research.<br />

In 2021, VAI scientists earned 33 new<br />

grants, totaling more than $39 million.<br />

Achieving this milestone would not have<br />

been possible without the exceptional<br />

support from VAI donors, whose generous<br />

gifts <strong>of</strong>ten fuel the early, foundational<br />

research required to attain these highly<br />

competitive grants.<br />

Many <strong>of</strong> this year’s grants will support<br />

projects that harness the collective<br />

expertise <strong>of</strong> VAI scientists and collaborators<br />

across the U.S. Here’s a snapshot.<br />

Specialized Programs <strong>of</strong> Research<br />

Excellence (SPORE) | National Cancer<br />

Institute <strong>of</strong> the National Institutes<br />

<strong>of</strong> Health<br />

This five-year grant, estimated at $12.4 million,<br />

will support nearly 20 scientists as they<br />

work to improve epigenetic therapies for<br />

cancer. The project is co-led by Coriell<br />

Institute for Medical Research’s President<br />

and CEO Dr. Jean-Pierre Issa, Van Andel<br />

Institute’s Chief Scientific Officer<br />

Dr. Peter A. Jones and Johns Hopkins<br />

University and VAI’s Dr. Stephen Baylin. 1<br />

Read more at bit.ly/vaispore<br />

Transformative Research Award | National<br />

Institutes <strong>of</strong> Health Common Fund<br />

VAI’s Dr. J. Andrew Pospisilik and Maine<br />

Medical Center Research Institute’s<br />

Dr. Joseph Nadeau earned a five-year,<br />

$9.6 million Transformative Research Award<br />

from the National Institutes <strong>of</strong> Health<br />

to answer a set <strong>of</strong> questions that could<br />

fundamentally transform our understanding<br />

<strong>of</strong> health and disease: If you were born<br />

multiple times under the exact same<br />

circumstances, would you turn out to be the<br />

same person each time? And if not, what<br />

implications could the differences have for<br />

your health? Although they may sound like<br />

science fiction, the answers could provide<br />

real-world insights into new strategies for<br />

combating cancer, obesity and a host <strong>of</strong><br />

other health concerns and diseases. 2<br />

Read more at bit.ly/vaitransform<br />

6 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE<br />

VAI GRADUATE SCHOOL STUDENT SVETLANA DJIRACKOR


Collaborative Research Network grants |<br />

Aligning Science Across Parkinson’s<br />

Two VAI scientists and their collaborators<br />

were awarded more than $15 million to<br />

advance Parkinson’s disease research<br />

and accelerate the development <strong>of</strong> new<br />

therapies.<br />

This pair <strong>of</strong> awards, called Collaborative<br />

Research Network grants, comes from<br />

Aligning Science Across Parkinson’s, a<br />

coordinated research initiative to accelerate<br />

the pace <strong>of</strong> discovery and inform the<br />

path to a cure for Parkinson’s through<br />

collaboration, research-enabling resources<br />

and data sharing.<br />

VAI’s Dr. Michael Henderson and colleagues<br />

at Yale University and University <strong>of</strong><br />

Pennsylvania were awarded $9 million to<br />

identify areas and cell types in the brain<br />

that may be particularly vulnerable to<br />

Parkinson’s disease. 3<br />

VAI’s Dr. Hong-yuan Chu and colleagues at<br />

Emory University were awarded $6.3 million<br />

to investigate the brain’s motor cortex —<br />

which helps manage movement — and its<br />

role in Parkinson’s. Changes to the cells<br />

that comprise this critical brain region have<br />

long been implicated in the disease. They<br />

also will collaborate with scientists at SUNY<br />

Downstate and Inscopix. 4<br />

Read more at bit.ly/ASAPChu and bit.ly/<br />

ASAPHend<br />

Maximizing Investigators’ Research Award<br />

| National Institute <strong>of</strong> General Medical<br />

Sciences <strong>of</strong> the National Institutes<br />

<strong>of</strong> Health<br />

Maximizing Investigators’ Research Awards<br />

are highly competitive and prestigious fiveyear<br />

grants and, in 2021, one was awarded<br />

to VAI Assistant Pr<strong>of</strong>essor Dr. Stephanie<br />

Grainger. The award is worth nearly<br />

$2.4 million over the life <strong>of</strong> the award.<br />

Grainger’s project will explore a critical<br />

type <strong>of</strong> cellular communication that drives<br />

healthy development and, when disrupted,<br />

can spur cancer, osteoporosis, heart<br />

conditions and other diseases. 5<br />

Research Scholar’s Grant | American<br />

Cancer Society<br />

VAI’s Dr. Scott Rothbart earned a four-year,<br />

$792,000 Research Scholar’s Grant from<br />

the American Cancer Society to investigate<br />

the mechanisms that power a promising<br />

class <strong>of</strong> potent anti-cancer drugs. Called<br />

EZH2 inhibitors, these drugs work by<br />

targeting an enzyme named EZH2 that has<br />

long been <strong>of</strong> interest to cancer researchers<br />

because it interacts with the proteins that<br />

support DNA. As such, EZH2 plays a major<br />

role in switching genes that regulate cell<br />

proliferation “on” or “<strong>of</strong>f” — a process that<br />

can lead to cancer if it goes awry. It<br />

also helps tumors evade attack by the<br />

In 2020, VAI<br />

ranked among<br />

the top five<br />

National<br />

Institutes <strong>of</strong><br />

Health-funded<br />

organizations<br />

in Michigan,<br />

just after the<br />

state’s larger<br />

universities and<br />

health systems.<br />

immune system. 6 VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 7<br />

Source: United for Medical Research.<br />

2020. NIH in Your State: Michigan.<br />

unitedformedicalresearch.org/nih-in-yourstate/<br />

Funding Acknowledgements<br />

Research reported in this publication was supported by the National Institutes <strong>of</strong> Health under award numbers: 1 P50CA254897;<br />

2<br />

1R01HG012444; and 5 R35GM142779. The content is solely the responsibility <strong>of</strong> the authors and does not necessarily<br />

represent the <strong>of</strong>ficial views <strong>of</strong> the National Institutes <strong>of</strong> Health<br />

3<br />

Research reported in this publication was supported by funds from Emory University as part <strong>of</strong> an Aligning Science Across<br />

Parkinson’s Collaborative Research Network award.<br />

4<br />

Research reported in this publication was supported by funds from Yale University as part <strong>of</strong> an Aligning Science Across<br />

Parkinson’s Collaborative Research Network award.<br />

6<br />

Scott B. Rothbart, Ph.D., is supported by a Research Scholar Grant, RSG-21-031-01-DMC, from the American Cancer Society.<br />

The content is solely the responsibility <strong>of</strong> the authors and does not necessarily represent the <strong>of</strong>ficial views <strong>of</strong> the granting<br />

organizations.


RESEARCH<br />

VAI scientists recognized<br />

as top <strong>of</strong> their fields<br />

It’s no secret that VAI<br />

scientists are among the<br />

world’s best. This year,<br />

five <strong>of</strong> our investigators<br />

were honored with<br />

inclusion on the Clarivate<br />

Highly Cited Researchers<br />

List, a distinction marking<br />

them as leaders in<br />

their fields.<br />

The annual list identifies<br />

scientists from around the<br />

world who demonstrate<br />

significant influence in<br />

their area <strong>of</strong> study through<br />

the publication <strong>of</strong> multiple<br />

highly cited papers during<br />

the last decade. Citations,<br />

or references, to a<br />

scientist’s published work<br />

by other researchers is<br />

universally considered to<br />

be a measure <strong>of</strong> influence<br />

and impact in the scientific<br />

community. Only about<br />

1 in 1,000 scientists in the<br />

world make this elite list,<br />

according to Clarivate.<br />

Peter A. Jones, Ph.D., D.Sc. (hon)<br />

Chief Scientific Officer<br />

Director, VAI Cancer Center<br />

Patrik Brundin, M.D., Ph.D.<br />

Deputy Chief Scientific Officer<br />

Director, VAI Parkinson’s Disease Center<br />

Read more online at bit.ly/<br />

vaihrc21<br />

Russell Jones, Ph.D.<br />

Chair, Department <strong>of</strong> Metabolism and Nutritional<br />

Programming<br />

Peter Laird, Ph.D.<br />

Pr<strong>of</strong>essor, Department <strong>of</strong> Epigenetics<br />

X. Edward Zhou, Ph.D.<br />

Senior Research Scientist, Li Lab<br />

Department <strong>of</strong> Structural Biology<br />

8 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Research highlights<br />

Looking for the latest from VAI’s scientists? Here’s a snapshot <strong>of</strong><br />

advances from the Institute’s labs.<br />

Understanding gut inflammation may hold clues to mitigating Parkinson’s onset<br />

Chronic inflammation in the gut may propel processes in the body that give rise<br />

to Parkinson’s disease, according to a study by Dr. Patrik Brundin’s lab at VAI and<br />

colleagues at Roche. The findings add to a growing list that links the gut and the<br />

immune system to Parkinson’s, and track with several large-scale studies that<br />

show an association between Parkinson’s and inflammatory bowel diseases, such<br />

as ulcerative colitis and Crohn’s disease. 1<br />

Read more at bit.ly/vaicolitis<br />

‘Roadmaps’ <strong>of</strong> the brain reveal regions vulnerable to Alzheimer’s disease<br />

Much like a supply truck crossing the countryside, the misfolded proteins<br />

that damage neurons in Alzheimer’s disease travel the “roads” <strong>of</strong> the brain,<br />

sometimes stopping or even re-routing to avoid roadblocks, reports a study by<br />

VAI’s Dr. Michael Henderson and collaborators at University <strong>of</strong> Pennsylvania.<br />

Understanding how and why this happens could clear the way for the<br />

development <strong>of</strong> new therapies to slow or stop disease progression. 2<br />

Read more at bit.ly/vaitau<br />

‘Tasty’ protein may lead to new ways to treat metabolic and immune diseases<br />

The same taste-sensing molecule that helps you enjoy a meal from your favorite<br />

restaurant may one day lead to improved ways to treat diabetes and other<br />

metabolic and immune diseases. TRPM5 is a specialized protein concentrated in<br />

the taste buds, where it helps relay messages to and from cells. It has long been<br />

<strong>of</strong> interest to researchers due to its roles in taste perception and blood sugar<br />

regulation. VAI scientists Dr. Wei Lü and Dr. Juan Du have published the firstever<br />

high-resolution images <strong>of</strong> TRPM5, which reveal two areas that may serve as<br />

targets for new medications for diseases like diabetes. These structures also may<br />

aid in the development <strong>of</strong> low-calorie alternative sweeteners that mimic sugar. 3<br />

Read more at bit.ly/vaitrpm5<br />

Study sheds light on how DNA mutates in<br />

melanoma, a deadly skin cancer<br />

The mutations that give rise to melanoma result<br />

from a chemical change in DNA fueled by sunlight<br />

— not just a DNA copying error as previously<br />

believed, reports a study by VAI’s Dr. Gerd Pfeifer.<br />

The findings upend long-held beliefs about the<br />

mechanisms underlying the disease, reinforce<br />

the importance <strong>of</strong> prevention efforts and <strong>of</strong>fer a<br />

path forward for investigating the origins <strong>of</strong> other<br />

cancer types. 4<br />

Read more at bit.ly/vaimelanoma<br />

An overactive sweet tooth may spell trouble for<br />

our cellular powerplants<br />

Although we’ve long known that eating too much<br />

sugar can contribute to Type 2 diabetes and other<br />

disorders, the exact way this overconsumption<br />

sets the stage for metabolic diseases on a cellular<br />

level has remained elusive. But now, a study led<br />

by VAI’s Dr. Ning Wu has shown that surplus<br />

sugar may cause our cellular powerplants —<br />

called mitochondria — to become less efficient,<br />

reducing their energy output. The findings<br />

highlight the cellular implications <strong>of</strong> excessive<br />

sugar consumption and provide an important<br />

new model to study the initial metabolic events<br />

that may contribute to diabetes development. 5<br />

Read more at bit.ly/vailipids<br />

Funding Acknowledgements<br />

Research reported in this publication was funded by:<br />

1<br />

Van Andel Institute and Roche. Early work on this project was supported in part by the European Research Council.<br />

2<br />

Michael J. Fox Foundation for Parkinson’s Research award no. 16879 (Henderson); the National Institute on Aging <strong>of</strong> the National Institutes <strong>of</strong> Health under awards T32AG000255 (Lee),<br />

P30AG10124 (Trojanowski) and U19AG062418 (Trojanowski);the National Institute <strong>of</strong> Neurological Disorders and Stroke <strong>of</strong> the National Institutes <strong>of</strong> Health under award nos. P50NS053488<br />

(Trojanowski) and R01NS099348 (Bassett); the National Institute <strong>of</strong> Mental Health <strong>of</strong> the National Institutes <strong>of</strong> Health under award no. F30 MH118871-01 (Cornblath); and the National<br />

Science Foundation under award nos. PHY1554488 (Bassett) and BCS1631550 (to Bassett). Bassett also acknowledges support from the John D. and Catherine T. MacArthur Foundation, the ISI<br />

Foundation, the Alfred P. Sloan Foundation, and the Paul G. Allen Foundation.<br />

3<br />

Van Andel Institute; the National Heart, Lung, and Blood Institute <strong>of</strong> the National Institutes <strong>of</strong> Health under award no. R56HL144929 (Lü) and R01HL153219 (Lü); a McKnight Scholar Award (Du);<br />

a Klingenstein-Simons Scholar Award (Du); a Sloan Research Fellowship in neuroscience (Du); and a Pew Scholars in Biomedical Research Award from the Pew Charitable Trusts (Du).<br />

4<br />

Van Andel Institute and the National Cancer Institute <strong>of</strong> the National Institutes <strong>of</strong> Health under award no. R21CA228089 (Pfeifer).<br />

5<br />

Van Andel Institute; the National Institute <strong>of</strong> General Medical Sciences <strong>of</strong> the National Institutes <strong>of</strong> Health under award no. R01GM120129 (Wu); and the National Institute on Aging <strong>of</strong> the<br />

National Institutes <strong>of</strong> Health under award no. RF1AH061872 (Han).<br />

The content is solely the responsibility <strong>of</strong> the authors and does not necessarily represent the <strong>of</strong>ficial views <strong>of</strong> the National Institutes <strong>of</strong> Health or other granting organizations.<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 9


RESEARCH<br />

Newest<br />

cohort<br />

illustrates<br />

growth at<br />

Graduate<br />

School<br />

Van Andel Institute Graduate School<br />

trains the biomedical research leaders<br />

<strong>of</strong> tomorrow, a focus that dovetails with<br />

the Institute’s overarching mission to<br />

transform human health for generations<br />

to come. We move ourselves — and the<br />

world — closer to lasting breakthroughs<br />

by welcoming a diversity <strong>of</strong> experiences,<br />

cultures and thoughts.<br />

Richard Cassidy<br />

Kansas City, Kansas<br />

Svetlana Djirackor<br />

Nairobi, Kenya<br />

In Fall 2021, the Graduate School’s largest<br />

and most diverse cohort arrived —<br />

14 students representing eight countries.<br />

The new cohort bolsters VAI’s growing<br />

reputation as a global destination for<br />

doctoral students.<br />

This array <strong>of</strong> students and perspectives<br />

helps us to better understand the full scope<br />

<strong>of</strong> health threats facing humanity. Every new<br />

cohort that arrives at VAI strengthens our<br />

organization and gives new shape to our<br />

mission; indeed, for the last few years, each<br />

successive cohort has grown larger and<br />

more diverse.<br />

S<strong>of</strong>ia Ievleva<br />

Voronezh, Russia<br />

Yanqing Liu<br />

Shandong Province, China<br />

The 2021 cohort includes students from<br />

The Bahamas, China, India, Iran, Kenya,<br />

Russia, the U.K. and the U.S. Although their<br />

paths were different, they arrived here<br />

united in one goal: to become the leaders<br />

who take us into the bright future where<br />

diseases like cancer and Parkinson’s are met<br />

with life-changing treatment and care.<br />

Kate Thurlow<br />

London, United Kingdom<br />

Xiao Wang<br />

Yunnan Province, China<br />

10 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


James Eapen<br />

Cochin, India<br />

Abigail Godec<br />

Denver, Colorado<br />

Thomas Goralski<br />

Livonia, Michigan<br />

Paige Matusiak<br />

LaGrange Highlands, Illinois<br />

Shantinique Miller<br />

Nassau, The Bahamas<br />

Christina Straham<br />

Flint, Michigan<br />

Riley Wedan<br />

Savage, Minnesota<br />

Mehrshid Faraji Zonooz<br />

Tehran, Iran<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 11


RESEARCH<br />

A day in the life <strong>of</strong> a VAI<br />

Graduate School student<br />

The life <strong>of</strong> a VAI graduate student varies greatly from year to year.<br />

Some years are spent more in the classroom, and others in the lab.<br />

But no matter how a student’s typical day looks, they are all working<br />

toward careers as biomedical research leaders.<br />

Nadia Dehghani is a third-year Ph.D. student in the labs <strong>of</strong> Dr. Rita<br />

Guerreiro and Dr. José Brás. Nadia studies genetic contributors to<br />

dementia. We caught up with her to get a glimpse into the life <strong>of</strong> a<br />

VAI grad student.<br />

What does a typical day with your thesis research look like?<br />

Days can be vastly different from one another, or vastly different<br />

from what was “ideally” planned! My time is generally spread across<br />

ongoing projects at varying milestones — data generation and<br />

troubleshooting, data analysis and write-up, and responding to peer<br />

reviewers who <strong>of</strong>fer feedback on my research.<br />

Additional daily constants include discussing and consolidating<br />

approaches to projects and reading newly published scientific<br />

studies. These can be directly related to my thesis research, or may<br />

<strong>of</strong>fer a new approach for me to consider. Most days, I also engage<br />

with a scientific seminar or a formal class; this semester,<br />

I have enrolled in the fantastic Lab Leadership class organized by<br />

Dr. J. Andrew Pospisilik, chair <strong>of</strong> VAI’s Department <strong>of</strong> Epigenetics.<br />

How has the Graduate School’s unique setup benefited your<br />

studies and research?<br />

We are very fortunate to be led by the vision and philosophy <strong>of</strong><br />

Dean Dr. Steven J. Triezenberg. With our highly dedicated and<br />

supportive Graduate School staff, we’ve cultured a stimulating and<br />

collegial environment where graduate students are seamlessly<br />

integrated within VAI.<br />

Most recently, we moved into new, designated facilities on VAI’s<br />

campus for students’ scholarly and pr<strong>of</strong>essional development — a<br />

result <strong>of</strong> the Graduate School’s exciting growth and recognition. As<br />

students, developments in our research approaches are aided by<br />

perspectives from peers and mentors; the growing diversity within<br />

the Graduate School makes this possible and increasingly practical.<br />

To learn more about VAI Graduate School, visit vaigs.vai.org.<br />

(STARTING AT LEFT, GOING ACROSS) NADIA DEHGHANI<br />

& DR. RITA GUERREIRO; LEENA KARIAPPER PRESENTING AT VAI GRADUATE SCHOOL<br />

12 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Graduate School<br />

highlights<br />

Origins <strong>of</strong> Cancer probes intersection <strong>of</strong> cancer, neuroscience<br />

The 2021 Origins <strong>of</strong> Cancer symposium, held in July, explored the intersection <strong>of</strong> cancer<br />

and neuroscience, an area that holds great promise for better understanding the complex<br />

biological interactions that give rise to disease. Students and scientists joined together<br />

for the virtual conference to discuss how the future <strong>of</strong> cancer research may combine two<br />

discrete areas <strong>of</strong> study by exploring the common threads that unite them. This annual<br />

event, organized and hosted by VAI Graduate School students, serves as a shining example<br />

<strong>of</strong> collaboration — a value that is at the heart <strong>of</strong> VAI’s ethos.<br />

Taylor Boyd joins Graduate School leadership<br />

The Institute’s commitment to training the scientific leaders <strong>of</strong> tomorrow leapt forward in<br />

October 2021 with the hiring <strong>of</strong> Taylor Boyd as director <strong>of</strong> assessment and pr<strong>of</strong>essional<br />

development. Boyd, who previously served in the Office <strong>of</strong> the Provost at Grand Valley<br />

State University, is responsible for assessing the Graduate School’s curriculum and cocurricular<br />

activities. He also assists VAI faculty in enhancing their teaching and mentoring<br />

skills, as well as in monitoring the progress <strong>of</strong> student learning. Boyd will also lead the work<br />

to sustain the Graduate School’s accreditation.<br />

3 quick facts<br />

about VAI<br />

Graduate School<br />

• The Graduate School has<br />

graduated 34 students to date: 30<br />

Ph.D. and four M.S. Of the<br />

30 Ph.D. graduates:<br />

70% have gone to postdoctoral or<br />

research associate positions<br />

20% have taken positions in industry<br />

• As <strong>of</strong> September 2021, 44 students<br />

were enrolled in our Ph.D. program.<br />

The student body includes:<br />

28 women<br />

13 international students<br />

2 students from populations<br />

underrepresented in the biomedical<br />

workforce (by NIH standards)<br />

4 students enrolled in dual-degree<br />

(M.D.-Ph.D.) programs<br />

• In 2020, Graduate School<br />

students and alumni contributed<br />

24 authorships on 17 research<br />

publications, with 12 authorships on<br />

11 papers in 2021.<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 13


EDUCATION<br />

From Afterschool Cohort to<br />

Fulbright Scholar: One student’s<br />

journey with VAI<br />

Van Andel Institute for Education strives to foster a love <strong>of</strong><br />

learning in every student who walks through our doors. Whether<br />

they join us for a field trip or attend one <strong>of</strong> VAI’s Afterschool<br />

Cohorts, our mission is to teach them how to think and act like<br />

a scientist.<br />

Former Afterschool Cohort student Eli Bieri exemplifies the impact<br />

<strong>of</strong> our work. Bieri, a passionate and curious scientist, was recently<br />

awarded a Fulbright Scholarship to pursue work in amphibian<br />

conservation.<br />

“I remember hearing toad calls when I was a little kid, in the<br />

summertime from my backyard, and I was just innately drawn to<br />

that noise,” Bieri said. “From then on, I spent so much free time<br />

just wading through ponds and swamps, looking for frogs and<br />

snakes and turtles.”<br />

“I remember doing this project where I was testing what effect<br />

common pesticides or herbicides would have on African Clawed<br />

Frogs. What I really loved about that project was that I felt like the<br />

instructor really treated me like a scientist,” Bieri said. “He was like,<br />

‘You are scientists! You’re doing science!’ That’s the kind <strong>of</strong> thinking<br />

that translates into a career in science, and I’m really grateful<br />

for that.”<br />

These days, as a Fulbright Scholar, Bieri is participating in a two-year<br />

master’s program at the University <strong>of</strong> New South Wales in Sydney,<br />

Australia. Working with Dr. Jodi Rowley, he studies how aggressive<br />

wildfire suppression may negatively impact the country’s amphibian<br />

population. Bieri and Rowley hope their research will lead to better,<br />

more sustainable practices for both humans and amphibians<br />

alike. Eventually, Bieri would like to work at the intersection <strong>of</strong> land<br />

management and public policy.<br />

“I remember hearing toad calls when I was a little kid,<br />

in the summertime from my backyard, and I was just<br />

innately drawn to that noise. From then on, I spent<br />

so much free time just wading through ponds and<br />

swamps, looking for frogs and snakes and turtles.”<br />

— Eli Bieri<br />

As he grew, Bieri searched for new ways to satisfy his inquisitive<br />

nature. When a family friend received a pamphlet on VAI’s student<br />

programs, she thought <strong>of</strong> Bieri and passed the information on to<br />

his mother. That small decision would ultimately set Bieri on his<br />

trajectory toward a career in science and biology.<br />

While enrolled in Afterschool Cohort, Bieri quickly realized<br />

he’d found a place where his curiosity could be channeled into<br />

something productive and fun. Cohorts are designed around<br />

hands-on investigations where students ask questions and<br />

discover answers using scientific tools and resources. In fact, the<br />

classrooms at VAI for Education are home to many <strong>of</strong> the same<br />

reptiles and amphibians Bieri <strong>of</strong>ten searched for in his backyard.<br />

“VAI had a significant impact on Eli’s natural curiosity,” said his<br />

mother, Gail Greco-Bieri. “It was the spark that lit the fire for him to<br />

validate the ‘whys’ he thought about, and he continues to question<br />

today. VAI taught Eli to think like a scientist, and he’s not stopped<br />

ever since.”<br />

We are grateful to the Rottman Family Charitable Foundation for their<br />

support <strong>of</strong> Afterschool Cohort.<br />

ELI BIERI<br />

14 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 15


EDUCATION<br />

In-person field trips return at<br />

Van Andel Institute for Education<br />

In the early days <strong>of</strong> the pandemic, Van Andel Institute<br />

for Education pivoted to <strong>of</strong>fer our suite <strong>of</strong> student and<br />

teacher programs in a virtual format. We knew that<br />

educators, parents and kids were in uncharted territory,<br />

and we worked swiftly to support them where they needed<br />

us most.<br />

At the start <strong>of</strong> the 2021–22 academic year, the Institute<br />

returned to an in-person format for one <strong>of</strong> our most<br />

popular <strong>of</strong>ferings: field trips. With appropriate safety<br />

protocols and masking in place, we welcomed classrooms<br />

back to our educational labs at 216 Division Ave. As <strong>of</strong><br />

January <strong>2022</strong>, there have been 23 field trips serving more<br />

than 400 students for this academic year.<br />

Our educational philosophy is guided by the principle that<br />

immersive, hands-on scientific investigations are best for<br />

creating classrooms where curiosity, creativity and critical<br />

thinking thrive. Although we successfully <strong>of</strong>fered virtual<br />

field trips for months, and continue to do so upon request,<br />

it was clear that all <strong>of</strong> us missed the benefits <strong>of</strong> in-person<br />

learning.<br />

“We are so happy to have students back in our labs,<br />

doing experiments that get them thinking and acting like<br />

scientists and nurturing a curiosity for the world around<br />

us,” said Terra Tarango, director and chief education <strong>of</strong>ficer<br />

<strong>of</strong> Van Andel Institute for Education. “We will always work<br />

tirelessly to create fun, safe learning environments for<br />

every student who walks through our doors.”<br />

To learn more about our field trip <strong>of</strong>ferings, visit vaei.org.<br />

(STARTING AT TOP RIGHT, GOING CLOCKWISE) STUDENTS FROM<br />

CROSSROADS CHARTER ACADEMY COLLABORATE; TWO CLASSMATES<br />

EXAMINE THE PROPERTIES OF GLITTER; STUDENTS PREPARE TO CONDUCT<br />

AN EXPERIMENT DURING THEIR FIELD TRIP TO VAI FOR EDUCATION;<br />

STUDENTS WORK TOGETHER DURING FIELD TRIPS TO VAI FOR EDUCATION<br />

16 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Education highlights<br />

The pandemic has brought many challenges to the classroom. Our educators worked<br />

hard to make sure that teachers and administrators could support students to the<br />

best <strong>of</strong> their ability with a suite <strong>of</strong> instructions, resources, projects and pr<strong>of</strong>essional<br />

development <strong>of</strong>ferings to help create classrooms where curiosity, creativity and critical<br />

thinking continue to thrive. Resources mentioned here can be found at vaei.org.<br />

Better Together: A Virtual Event for K–12 Administrators<br />

To combat learning loss, VAI hosted several networking events for K–12<br />

administrators to help address concerns related to the pandemic. More than<br />

350 administrators from 20 states and two continents have registered for Better<br />

Together events.<br />

VAI’s Admin Guides<br />

These relevant and comprehensive guides are designed to equip administrators<br />

with strategies for school development. This year featured “Beyond Learning<br />

Loss: Six Ways Schools Can Thrive in the Aftermath <strong>of</strong> the Pandemic” and “7 Tips<br />

for Successful School Improvement Planning.” The Admin Guides have been<br />

downloaded more than 500 times.<br />

Blue Apple Timely Topics<br />

Our expert educators created nine free Blue Apple Timely Topics connecting to<br />

current events, such as “Celebrating Black History Month,” “Respectful Debate”<br />

and “Spooktacular STEAM.” In 2021, these lessons were downloaded more<br />

than 2,800 times and were used throughout the U.S. and more than 25 other<br />

countries.<br />

Flex PD<br />

VAI’s popular Flex PD is a comprehensive, affordable pr<strong>of</strong>essional development<br />

model that promotes tangible shifts in instruction for teachers and<br />

administrators. Our plans are customizable to fit educators’ individual needs and<br />

include immersive workshops, learning sessions and coaching.<br />

NexGen Inquiry Quests<br />

Our new NexGen Inquiry Quests are story-driven video lessons that capture<br />

student interest by introducing them to real-world problems they can solve<br />

with hands-on, scientific investigations. Each Quest includes three inquirybased<br />

investigations that help students exercise critical and creative thinking,<br />

collaboration with peers, and the application <strong>of</strong> solutions that will make the world<br />

a better place. In one Quest, students play the role <strong>of</strong> an electrical engineer who<br />

is troubleshooting a power outage. In another, students learn “crime scene”<br />

forensics to locate a reptile that’s gone “missing” from VAI’s classrooms.<br />

“Once again, thank<br />

you for supporting<br />

our teachers. You<br />

(VAI) have been a<br />

wonderful asset and<br />

support system as<br />

our teachers navigate<br />

implementing projectbased<br />

learning in our<br />

schools.”<br />

— Hilary B.,<br />

Allegan Public Schools<br />

Field Trips<br />

Our field trips immerse students — and their teachers — in learning science<br />

through investigation. Students conduct unique, grade-specific investigations and<br />

participate in hands-on discovery with activities like mock fossil digs, engineering<br />

challenges and robotics coding. After being held virtually for the 2020–21<br />

school year, field trips returned to an in-person format with appropriate safety<br />

precautions in fall 2021.<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 17


EVENTS<br />

VAI Golf Outing<br />

In September, golfers gathered at the majestic Wuskowhan<br />

Players Club in West Olive, Michigan, for the 14th annual<br />

VAI Golf Outing. The 2021 event featured a scramble<br />

tournament, lunch, dinner and a brief award presentation.<br />

For nearly 15 years, the VAI Golf Outing has brought the golf<br />

community <strong>of</strong> West Michigan together in support <strong>of</strong> the<br />

Institute’s biomedical research and educational programs.<br />

Thank you to our Title Sponsor, the Veldheer, Long, Mackay &<br />

Bernecker Group <strong>of</strong> Merrill Lynch.<br />

(STARTING AT TOP RIGHT, GOING CLOCKWISE) CAROL VAN ANDEL; MOLLY KRAUSE, KAREN CUSTER, KELLIE CUSTER & TERRI DEBOER;<br />

DAVID VAN ANDEL KICKS OFF THE DAY; ANN CALLAHAN & SHAWN PREMER; RYAN FORMSMA,<br />

ERIC HELZER, CHRISTOPHER STRALKOWSKI & STAN ELENBAAS<br />

18 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Please note: All events followed health and safety protocols related to the<br />

COVID-19 pandemic in place at the time <strong>of</strong> occurrence.<br />

Couture for a Cure<br />

Back live and in action, Couture for a Cure brought glitz, glam and<br />

generosity together at the Institute for a 16th year. The event<br />

featured a New York-style runway show by Leigh’s and highlighted<br />

the Fall 2021 collection <strong>of</strong> designer Veronica Beard. Co-founders<br />

<strong>of</strong> the eponymous brand — Veronica Miele Beard and Veronica<br />

Swanson Beard — shared a special virtual message with the<br />

evening’s guests, who also enjoyed a seated dinner, table service<br />

and fabulous musical stylings from AB. Guests also learned more<br />

about VAI’s work into ovarian cancer research. New products and<br />

on-trend looks from Artistry appeared on the runway, and all<br />

guests took home swag bags <strong>of</strong> exclusive gifts, treats and Artistry<br />

products.<br />

Thank you to our Presenting Sponsor, Leigh’s, and our<br />

Title Sponsor, Amway.<br />

(STARTING AT TOP RIGHT, GOING CLOCKWISE) SCOTT & REBECCA WIERDA WITH DAVID & CAROL VAN ANDEL; MODEL ON THE RUNWAY; MODEL SHOWING<br />

OFF ONE OF THE NIGHT’S CHIC LOOKS; CAROL VAN ANDEL; CONSUMERS CREDIT UNION’S LYNNE JARMAN-JOHNSON (CENTER, IN BLACK & GOLD)<br />

WITH A GREAT GROUP OF GUESTS AT THE EVENT ENTRANCE; MODEL SHOWS OFF A GLAMOROUS LOOK ON THE RUNWAY<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 19


EVENTS<br />

<strong>Hope</strong> on the Hill Gala<br />

As the culminating event <strong>of</strong> our 25th anniversary, the 21st<br />

annual <strong>Hope</strong> on the Hill Gala marked a quarter century <strong>of</strong><br />

progress at the Institute with a night <strong>of</strong> glamour, mystery<br />

and support <strong>of</strong> VAI’s mission. Guests broke out their best<br />

black-tie attire to celebrate those who, for the past 25 years,<br />

have helped make great strides at the Institute: our donors,<br />

our community, and the scientists and educators they support.<br />

The event included a seated dinner <strong>of</strong> delectable cuisine and<br />

artisan cocktails, live entertainment from AB and world-class<br />

electroviolinist Svet, and presentations from Institute leaders on<br />

VAI’s history, breakthroughs and dreams for the future.<br />

Thank you to our Title Sponsor, Fifth Third Private Bank.<br />

20 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Thank you to all donors and guests who<br />

supported us through our virtual events in<br />

2021, including:<br />

• VAI Forum on Depression & Inflammation<br />

• Carol Van Andel Angel <strong>of</strong> Excellence Virtual Dinner<br />

& Award Presentation<br />

• Grand Rapids Griffins VAI Purple Community Game<br />

• Board <strong>of</strong> Governors Annual Dinner<br />

• Around the World<br />

• VAI Public Lecture Series<br />

• Virtual C<strong>of</strong>fee Connection Events<br />

While we wish we could have seen more <strong>of</strong> you in person<br />

in 2021, we are so happy you were able to join us in some<br />

capacity to celebrate VAI’s research and education efforts<br />

from the last year — and the last quarter century.<br />

(STARTING AT TOP LEFT, GOING CLOCKWISE) SENATOR MARK HUIZENGA<br />

& KRIS HUIZENGA, BILL & MARY JACKSON, RUSTY & JENN MERCHANT &<br />

MAUREEN WATSON-BOLGER & MATT BOLGER (FAR RIGHT);<br />

DAVID & CAROL VAN ANDEL; JAKE KENNARD & KATE ZWIERS &<br />

NICOLE & DAVID ZWIERS; SVET; DAVID VAN ANDEL;<br />

ENTRYWAY TO THE EVENT; DJ AB<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 21


EVENTS<br />

A Conversation About Pancreatic<br />

Cancer — Hosted by<br />

Carol Van Andel<br />

Despite incredible advances in cancer detection and treatment,<br />

pancreatic cancer continues to pose a particular challenge to<br />

physicians and patients because it <strong>of</strong>ten lacks obvious early<br />

symptoms. By the time the disease is found, it is typically quite<br />

advanced, complicating treatment and leading to poorer patient<br />

outcomes.<br />

Thanks to new breakthroughs, there is hope. In November,<br />

guests at A Conversation About Pancreatic Cancer — Hosted by<br />

Carol Van Andel learned about the latest advances in pancreatic<br />

cancer research, with a focus on promising opportunities for<br />

early detection. Speakers included pancreatic cancer experts<br />

Dr. Brian Haab, a VAI pr<strong>of</strong>essor whose lab is at the forefront <strong>of</strong><br />

new diagnostic efforts, and Dr. J. Bradley Morrow, director <strong>of</strong><br />

endoscopy at Mercy Health St. Mary’s. For the past five years,<br />

Drs. Haab and Morrow have collaborated on developing new<br />

diagnostics for pancreatic cancer.<br />

Thank you to our Presenting Sponsor, The Howard Miller Company.<br />

(STARTING AT TOP RIGHT, GOING CLOCKWISE) CAROL VAN ANDEL; GUESTS HEAR FROM DR. BRIAN HAAB;<br />

DR. J. BRADLEY MORROW AND MARANDA; DR. J. BRADLEY MORROW<br />

22 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Gaming for <strong>Hope</strong><br />

In 2021, VAI hosted our inaugural Gaming for <strong>Hope</strong>, a fully<br />

online, 24-hour gaming marathon that blended a passion for<br />

online gaming and streaming with raising funds to support the<br />

Institute’s work. Streamers <strong>of</strong> all ages and experience levels played<br />

numerous games over the course <strong>of</strong> the day, including singleplayer<br />

FIFA 21, Super Smash Bros. Ultimate, League <strong>of</strong> Legends,<br />

and Counter-Strike: Global Offensive. Featured streamers joined in<br />

on the action, and giveaways and prizes were up for grabs for those<br />

who fundraised for the Institute.<br />

Thank you to our Presenting Sponsor, Element Four.<br />

(STARTING AT TOP LEFT, GOING CLOCKWISE) COLIN GRAHAM & DAVENPORT ESPORTS INTERN; MAE LEXI ZURITA;<br />

COLIN GRAHAM; MIKE “POROSAURUS” NAVARRO<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 23


EVENTS<br />

Thank you to our generous<br />

event sponsors<br />

To learn more about sponsoring an event, contact Sarah Rollman at<br />

sarah.rollman@vai.org.<br />

Winterfest Celebration<br />

Rob & Dawn Arnoys<br />

Steven & Amanda Barbour<br />

Bluewater Technologies<br />

Jerry & Suzanne Callahan<br />

Custer Inc.<br />

Mike & Jean Dery<br />

Edge Natural Resources<br />

Ernst & Young<br />

Grand Rapids Christian Schools<br />

HB Wealth Management<br />

Hines Corporation<br />

Dr. Jurgen & Becky Luders<br />

Macatawa Bank<br />

McShane & Bowie PLC<br />

Mercy Health<br />

MMS Education<br />

Mike & Sally Murdock<br />

Owen-Ames-Kimball Co.<br />

P.L. Capital<br />

Pioneer Construction<br />

Red Glasses Movement<br />

Rockford Construction<br />

Sharpe<br />

Warner Norcross + Judd LLP<br />

Ge<strong>of</strong>f & LeeAnne Widlak<br />

Around the World<br />

James & Shirley Balk<br />

Jerry & Suzanne Callahan<br />

Brian DeVries & Barbara Pugh<br />

Caledonia Dental Group<br />

Greenridge Realty, Inc.<br />

Huizenga Group<br />

John Hancock Financial Services<br />

Lake Michigan Credit Union<br />

Leigh’s<br />

The Meijer Foundation<br />

Mike & Rachel Mraz<br />

Lee & Alexandra Perez<br />

Lisa M. Rose & Dr. Ken H<strong>of</strong>fman<br />

West Michigan Woman<br />

This list includes sponsors <strong>of</strong> 2021 signature events.<br />

Design & Discovery<br />

Alpine Events<br />

Autocam Medical<br />

Franco & Alessandra Bianchi<br />

Bluewater Technologies<br />

Robert & Sandra Borsos<br />

The Brooks Family<br />

Byrne Electrical Specialists<br />

Cascade Engineering<br />

Cauley Ferrari <strong>of</strong> Detroit<br />

Cottage Home<br />

The Currie Foundation<br />

Randy Damstra & Julie Duisterh<strong>of</strong><br />

David & Carol Van Andel Family<br />

Foundation<br />

Dominique & Julie DeNooyer<br />

Dunn & Laug Wealth<br />

Mike & Barb Ellis<br />

Ernst & Young<br />

EV Construction<br />

Geerlings Development<br />

Company/Midwest Construction<br />

Group<br />

Jeff & Ann Harten<br />

Matt & Jen Haworth<br />

Heidi Huizenga<br />

The Hilldore Group — Baird<br />

Holland Hospital<br />

Inontime<br />

James Group<br />

Jeffery Roberts Design<br />

Kyle Geenen Group<br />

Al & Linda Lanning<br />

Management at Morgan Stanley<br />

Michigan Homes & Cottages<br />

Mike Schaap Builders, Inc.<br />

Paul & Anne Nemsch<strong>of</strong>f<br />

Nicolai North America<br />

Padnos<br />

Priority Health<br />

Progressive AE<br />

Rowerdink Inc.<br />

Marc & Jeanne Schupan<br />

SeyferthPR<br />

SIBSCO<br />

24 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE<br />

Spectrum Health<br />

Craig & Wendy Spoelh<strong>of</strong><br />

John & Judy Spoelh<strong>of</strong><br />

Scott & Jan Spoelh<strong>of</strong><br />

Kathleen Stewart Ponitz<br />

Kenneth & Nancy Teutsch<br />

Visbeen Architects Inc.<br />

Warner Norcross + Judd LLP<br />

West Michigan Woman<br />

Woodways International<br />

YMCA <strong>of</strong> Greater Grand Rapids<br />

VAI Golf Outing<br />

Applied Imaging<br />

Bluewater Technologies<br />

Bouma Corporation<br />

Consumers Credit Union<br />

Cornerstone University<br />

Custer Inc.<br />

Erhardt Construction<br />

First National Bank<br />

Gallagher Insurance<br />

Grand Rapids Christian Schools<br />

Ben & Molly Hunting<br />

Loomis, Sayles & Company, L.P.<br />

Macatawa Bank<br />

Merrill Lynch — Veldheer, Long,<br />

Mackay & Bernecker Group<br />

Metro Health — University <strong>of</strong><br />

Michigan Health<br />

Midwest Capital Advisors<br />

Northern Jet Management<br />

Owen-Ames-Kimball Co.<br />

Pine Rest<br />

Priority Health<br />

John & Therese Rowerdink<br />

Secrest Wardle<br />

Sharpe<br />

Standard Lumber<br />

Thomas & Mary Stuit<br />

Summit Point Ro<strong>of</strong>ing<br />

US Signal<br />

Brian & Lori Vander Baan<br />

Dave & Beth VanPortfliet<br />

Wells Fargo<br />

West Michigan Woman<br />

Couture for a Cure<br />

Amway<br />

Andy J. Egan Company<br />

Bluewater Technologies<br />

Chuck & Christine Boelkins<br />

Cheeky Strut<br />

Consumers Credit Union<br />

Mimi Cummings<br />

CWD Real Estate Investment<br />

David & Carol Van Andel Family<br />

Foundation<br />

Deloitte<br />

Brian DeVries & Barbara Pugh<br />

Eileen DeVries Family Foundation<br />

Eurest<br />

First National Bank <strong>of</strong> Michigan<br />

Gallagher<br />

Jana Hall<br />

Paul & Sheryl Haverkate<br />

J.C. & Tammy Huizenga<br />

Bill & Starr Humphries<br />

Jandernoa Foundation<br />

Jeffery Roberts Design<br />

Dr. Peter & Veronica Jones<br />

Kool Auto Group<br />

Lake Michigan Credit Union<br />

McAlvey Merchant & Associates<br />

Priority Health<br />

Rockford Construction<br />

The Steve & Amy Van Andel<br />

Foundation<br />

West Michigan Woman<br />

Greg & Meg Willit<br />

Zip Xpress, Inc.<br />

<strong>Hope</strong> on the Hill Gala<br />

Advantage Commercial Real<br />

Estate<br />

Al & Robin Koop Foundation<br />

Amway<br />

Aon<br />

Aquinas College<br />

AssurancePlus<br />

Autocam Medical<br />

John & Ginny Baysore<br />

Jeff & Meg Bennett<br />

Betz Industries


BHS Insurance<br />

Dave & Jill Bielema<br />

Bluewater Technologies<br />

Chuck & Christine Boelkins<br />

Buist Electric<br />

Jerry & Suzanne Callahan<br />

Cancer & Hematology Centers <strong>of</strong><br />

Western Michigan, P.C.<br />

Consumers Credit Union<br />

Ryan & Jessica Cook<br />

Crowe LLP<br />

Tom & Tracy Curran<br />

Custer Inc.<br />

Czech Asset Management<br />

Davenport University<br />

David & Carol Van Andel Family<br />

Foundation<br />

Deloitte<br />

Dick & Betsy DeVos Family<br />

Foundation<br />

The Douglas & Maria DeVos<br />

Foundation<br />

Eenhoorn<br />

Pete & LeAnn Engles<br />

Fifth Third Private Bank<br />

Gallagher Insurance<br />

Grand Valley State University<br />

Martin & Peggy Greydanus<br />

Jana Hall<br />

Kurt & Madelon Hassberger<br />

<strong>Hope</strong> College<br />

Howard Miller<br />

Huizenga Group<br />

ICN Foundation<br />

Jandernoa Foundation<br />

Matt & Sarah Jones<br />

Dr. Peter & Veronica Jones<br />

Craig & Debra Kinney<br />

Blake & Mary Krueger<br />

John & Katie Kuiper<br />

Lake Michigan Credit Union<br />

Ray & Jeannine Lanning<br />

Gary & Vicky Ludema<br />

Macatawa Bank<br />

McAlvey Merchant & Associates<br />

Meijer<br />

The Meijer Foundation<br />

Merrill Lynch — The Veldheer,<br />

Long, Mackay & Bernecker<br />

Group<br />

Michigan State University College<br />

<strong>of</strong> Human Medicine<br />

Bill & Pat Mills<br />

New Holland Brewing Co.<br />

Northern Jet Management<br />

NPF Investment Advisors<br />

Owen-Ames-Kimball Co.<br />

Pageworks<br />

Peter C. & Emajean Cook<br />

Foundation<br />

The Peter F. Secchia Family<br />

Pioneer Construction<br />

Pitsch Companies<br />

Plastic Surgery Associates/Grand<br />

Pearl Spa<br />

Priority Health<br />

Quality Air Service<br />

Rockford Construction<br />

Eve Rogus & Paul Becker<br />

Rowerdink Inc.<br />

Tony & Dawn Semple<br />

Sharpe<br />

Spectrum Health<br />

David & Linda Spencer<br />

Rob & Susan Stafford<br />

Steelcase Inc.<br />

Stephen Klotz Family Foundation<br />

The Steve & Amy Van Andel<br />

Foundation<br />

Taconic<br />

Thomas S. Fox Family<br />

Truscott Rossman<br />

University <strong>of</strong> Michigan Health<br />

West<br />

Mike & Michelle Van Dyke<br />

Dan & Ann Van Eerden<br />

Christian & Kara VerMeulen<br />

Russ & Chris Visner<br />

Warner Norcross + Judd LLP<br />

Wells Fargo<br />

West Michigan Woman<br />

Williams Kitchen & Bath<br />

Wolverine Worldwide<br />

Jim & Jane Zwiers<br />

A Conversation About Pancreatic<br />

Cancer — Hosted by<br />

Carol Van Andel<br />

Autocam Medical<br />

Bluewater Technologies<br />

Gallagher Insurance<br />

Howard Miller<br />

Leigh’s<br />

West Michigan Woman<br />

Dr. Bart & Wendy Williams<br />

Gaming for <strong>Hope</strong><br />

Bluewater Technologies<br />

Element Four<br />

Herman Miller<br />

Mercantile Bank <strong>of</strong> Michigan<br />

NVINT<br />

Service Express<br />

Varnum<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 25


VAI PURPLE COMMUNITY<br />

VAI Purple Community<br />

partners put in the time,<br />

effort and talent<br />

As one <strong>of</strong> Van Andel Institute’s core values, collaboration plays a central role in all<br />

work done at the Institute.<br />

Whether it’s the latest research breakthroughs in cancer and Parkinson’s,<br />

educational innovations for K–12 and graduate students, or well-crafted plans for<br />

signature events, we know the meaning <strong>of</strong> working together for something bigger<br />

than us.<br />

Our incredible community partners hold collaboration in high esteem, too. They<br />

work directly with the grassroots fundraising program VAI Purple Community to<br />

put their time, effort and connections to use in supporting VAI’s work. In 2021, VAI<br />

Purple Community programs raised more than $380,000, which — like all funds<br />

raised through VAI community and signature events — goes directly to the research<br />

and education programs at VAI.<br />

Here are just a few highlights from last year’s VAI Purple Community events:<br />

• West Ottawa Public Schools put on fundraisers all year long in support <strong>of</strong> VAI.<br />

In a typical year, each West Ottawa sports team holds a Purple Game, with the<br />

proceeds going directly to VAI’s work. While 2021 was certainly not a normal year,<br />

the girls’ soccer team was able to hold their Purple Game at the end <strong>of</strong> the 2020–21<br />

school year. The players wore specially made jerseys featuring the names <strong>of</strong> people<br />

dear to them who have been affected by cancer, Parkinson’s or another disease — a<br />

tangible reminder <strong>of</strong> why we do the work we do here at the Institute.<br />

• Otsego Public Schools hold a huge football game in support <strong>of</strong> VAI every other<br />

year, thanks in large part to Holly McCaw, Otsego’s director <strong>of</strong> communications and<br />

a 2020 recipient <strong>of</strong> the Carol Van Andel Angel <strong>of</strong> Excellence Award. In 2021, they had<br />

to postpone their VAI Purple Community event to the spring, which required some<br />

creativity. Out <strong>of</strong> that came the first-ever VAI Purple Community Otsego 5K, featuring<br />

purple shirts, purple dust throws at race checkpoints and more. Organizers hosted<br />

games throughout the week leading up to the race, and a carnival closed out<br />

race day.<br />

• Duncan Lake Middle School has partnered with VAI for many years for its<br />

annual cancer walk. In 2021, the walk was held outside in the spring. Attendees<br />

could donate to dunk a teacher, participate in a silent auction online, or purchase a<br />

variety <strong>of</strong> popsicles, ice cream and other cool treats, with all funds going directly to<br />

cancer research at the Institute.<br />

To learn more about VAI Purple Community and how to start your own event, visit<br />

purplecommunity.org.<br />

(STARTING AT TOP, GOING DOWN) RUNNERS RACE<br />

ACROSS THE FINISH LINE AT VAI PURPLE COMMUNITY<br />

OTSEGO 5K; WHEN NOT RACING, ATTENDEES COULD TRY<br />

TO DUNK A TEACHER; A GOLF CART DECKED OUT FOR<br />

THE OCCASION; RUNNERS WERE COVERED IN PURPLE<br />

POWDER AT RACE CHECKPOINTS<br />

26 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


(STARTING AT TOP LEFT,<br />

GOING CLOCKWISE) WALKERS<br />

DECKED OUT IN PHOTO PROPS<br />

BEFORE THE RACE; ATTENDEE<br />

SHIRTS FEATURED NAMES OF<br />

LOVED ONES HONORED IN<br />

THE WALK; WALKERS TAKE A<br />

BREAK TO HAVE FUN HULA<br />

HOOPING; A GROUP OF<br />

WALKERS MOVES AROUND<br />

THE TRACK; AN ATTENDEE<br />

SHARING WHAT THE CANCER<br />

WALK MEANS TO HER;<br />

WALKERS PARTICIPATING IN<br />

FUN AND GAMES WHEN NOT<br />

ON THE TRACK<br />

(STARTING AT FAR LEFT, GOING<br />

CLOCKWISE) SPECTATORS<br />

CHEER ON THE ATHLETES;<br />

ATTENDEES SHOWING OFF<br />

THEIR VAI PURPLE COMMUNITY<br />

SWAG IN THE STANDS; A WEST<br />

OTTAWA PLAYER LAUNCHES<br />

THE BALL DOWN THE FIELD;<br />

WEST OTTAWA GIRLS’ SOCCER<br />

TEAM CELEBRATING THEIR<br />

SUCCESSFUL FUNDRAISING<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 27


VAI PURPLE COMMUNITY<br />

VAI Marathon Team runners back<br />

in action at four global marathons<br />

With marathons around the world<br />

canceled, postponed or downsized in<br />

2020 and 2021 due to the COVID-19<br />

pandemic, Van Andel Institute Marathon<br />

Team runners also found themselves in<br />

a holding pattern. They were ready and<br />

excited to run a world-class marathon and<br />

raise funds in support <strong>of</strong> VAI’s research and<br />

education efforts, but many had to wait to<br />

put all that energy to good use.<br />

After two years <strong>of</strong> waiting and a smallerthan-usual<br />

number <strong>of</strong> runners in the 2021<br />

races — the number <strong>of</strong> runners allowed in<br />

each race was capped as part <strong>of</strong> health and<br />

safety precautions — the VAI Marathon<br />

Team is coming back strong in <strong>2022</strong>, with<br />

a limited number <strong>of</strong> complimentary entries<br />

to four races for runners fundraising on<br />

behalf <strong>of</strong> the Institute:<br />

• BMW Berlin Marathon: Sept. 25<br />

• TCS London Marathon: Oct. 2<br />

• Bank <strong>of</strong> America Chicago Marathon: Oct. 9<br />

• TCS New York City Marathon: Nov. 6<br />

Each year, dedicated runners train for<br />

these world-renowned races while raising<br />

funds for the Institute. They have each<br />

been touched by the diseases studied by<br />

VAI scientists (including cancer, Parkinson’s,<br />

and Alzheimer’s and related dementias),<br />

whether through a loved one’s diagnosis or<br />

even their own. Each <strong>of</strong> them understands<br />

the incredible value <strong>of</strong> the Institute’s K–12<br />

and graduate education programs that are<br />

training the next generation <strong>of</strong> scientific<br />

leaders. And each <strong>of</strong> them wants to do their<br />

part to make sure our efforts can continue<br />

to improve health and enhance lives for<br />

years to come.<br />

“Running a marathon is tough, and training<br />

for a marathon is grueling,” said former VAI<br />

Marathon Team member McKenzie Hollern<br />

Southerington. “But I ran for VAI because<br />

I knew I’d be helping bring hope to people<br />

who are fighting something much more<br />

difficult.”<br />

Did you know?<br />

In 2021, six athletes ran the<br />

New York City Marathon and<br />

11 ran the Chicago Marathon.<br />

Comparatively, in 2019 — the<br />

last year these races were held<br />

prior to COVID-19 pandemic<br />

restrictions — nearly 40 athletes<br />

ran these two marathons on<br />

behalf <strong>of</strong> VAI. We look forward to<br />

being back at it in full force for<br />

both races (and more) this year!<br />

Entries for the <strong>2022</strong> Berlin Marathon are sold out. To<br />

learn more about the VAI Marathon Team and how<br />

to join, visit vai.org/marathon-team/.<br />

28 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAI Student<br />

Ambassador Program<br />

making moves<br />

Van Andel Institute’s Student<br />

Ambassador Program serves as<br />

a tangible reminder <strong>of</strong> the power<br />

and passion exuded by the younger<br />

generations. Twenty-eight students<br />

came together virtually at the beginning<br />

<strong>of</strong> the 2021–22 school year to form the<br />

program’s third cohort. These bright,<br />

driven students meet once a month<br />

throughout the school year to connect<br />

with Institute scientists, educators and<br />

staff and learn how their efforts make a<br />

concrete difference to VAI’s work. They<br />

also meet with Institute staff to explore<br />

topics such as crafting a communications<br />

plan to support a fundraiser and how to<br />

pursue support from business sponsors.<br />

VAI Student Ambassadors combine<br />

everything they learn in the program<br />

to launch a fundraiser on behalf <strong>of</strong> the<br />

Institute, with 100% <strong>of</strong> proceeds going<br />

directly to our research and education<br />

programs. They also receive exclusive<br />

mentorship from the Institute’s heart and<br />

soul: Carol Van Andel, executive director<br />

<strong>of</strong> The David and Carol Van Andel Family<br />

Foundation and wife <strong>of</strong> VAI Chairman and<br />

CEO David Van Andel.<br />

Our current Student Ambassadors are hard<br />

at work on their culminating fundraiser —<br />

a movie night at Celebration Cinema on<br />

March 5 featuring the highly anticipated film<br />

“The Batman,” with the goal <strong>of</strong> selling out<br />

the 330-seat movie theater.<br />

To learn more about the Student Ambassador<br />

Program, or if you know someone who<br />

may be interested in applying, visit<br />

purplecommunity.org. Applications for the<br />

<strong>2022</strong>–23 school year will open May 1, <strong>2022</strong>.<br />

Upcoming Volunteer<br />

Opportunities<br />

Grand Rapids Griffins Purple Community Game<br />

(March 18)<br />

Volunteer C<strong>of</strong>fee and Catch Up<br />

(May 6 and Nov. 4)<br />

VAI Volunteer Celebration<br />

(Aug. 4)<br />

Weekly Volunteer Team<br />

(Wednesday mornings, 9–11 a.m.)<br />

Volunteer with VAI<br />

Van Andel Institute Purple Community<br />

is our grassroots fundraising program,<br />

bolstered by dedicated volunteers<br />

supporting VAI’s mission to improve<br />

health and enhance the lives <strong>of</strong> current<br />

and future generations.<br />

We have more than 50 active<br />

volunteers who support a variety <strong>of</strong><br />

VAI events each year that raise critical<br />

funds in support <strong>of</strong> the Institute’s<br />

groundbreaking research into diseases<br />

like cancer and Parkinson’s, as well as<br />

our science education programs.<br />

VAI Purple Community volunteers<br />

support the Institute for a multitude<br />

<strong>of</strong> reasons. Some have been<br />

personally impacted by the diseases<br />

our scientists study or have a friend<br />

or family member who has been<br />

affected. Others want to help foster<br />

and encourage the next generation<br />

<strong>of</strong> scientific minds, and Van Andel<br />

Institute for Education and Van Andel<br />

Institute Graduate School do just that!<br />

With an average <strong>of</strong> nearly 40<br />

community-led events per year, there<br />

are plenty <strong>of</strong> ways to get involved with<br />

VAI Purple Community, including:<br />

• Organizing and hosting an event<br />

• Volunteering at a VAI Purple<br />

Community event<br />

• Corporate partnerships<br />

• Becoming a VAI Student Ambassador<br />

To learn more about how you can get<br />

involved, visit purplecommunity.org or<br />

email purplecommunity@vai.org.<br />

Please note: Volunteer opportunities,<br />

especially for in-person events, are<br />

subject to change based on health and<br />

safety recommendations at the time <strong>of</strong><br />

the event.<br />

(AT LEFT) 2019 BANK OF AMERICA CHICAGO MARATHON<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 29


PHILANTHROPY<br />

Gifts in action:<br />

Funding new<br />

equipment to<br />

peer into cells<br />

Each gift to Van Andel Institute helps our scientists move another<br />

step closer to improving health and enhancing lives, especially with<br />

regard to diseases like cancer, Parkinson’s, and Alzheimer’s and related<br />

dementias. When these contributions come together in support <strong>of</strong> VAI’s<br />

work, their potential impact grows larger yet.<br />

In 2021, VAI received an incredible gift from the estate <strong>of</strong> the late Gasper<br />

“Gabe” Amodeo, a long-time supporter <strong>of</strong> our work who passed away in<br />

February 2021. Amodeo was diagnosed with Parkinson’s disease in the<br />

years prior to his passing, and he had a specific interest in supporting<br />

research into this insidious disease.<br />

Paired with a substantial gift from Richard and Paula Nelson — two<br />

dedicated supporters <strong>of</strong> VAI who have been personally touched by<br />

Parkinson’s disease through Richard’s own diagnosis — these funds have<br />

allowed VAI to purchase two ZEISS Axioscan 7 microscope slide scanners<br />

to be housed in the Institute’s Optical Imaging Core. These instruments<br />

will help facilitate the research <strong>of</strong> many VAI scientists and collaborators,<br />

including those focused on understanding the underpinnings <strong>of</strong><br />

Parkinson’s in the hopes <strong>of</strong> guiding the creation <strong>of</strong> new treatments for<br />

this disease and others like it. They are scheduled to be delivered and<br />

installed in March <strong>2022</strong>.<br />

VAI currently has a single ZEISS Axio Scan.Z1 — a previous version <strong>of</strong> the<br />

Axioscan 7 — that is utilized nearly 24 hours a day, seven days a week.<br />

The newest iteration <strong>of</strong> this technology digitizes specimens to create highquality,<br />

virtual microscope slides, and will be <strong>of</strong> great use to researchers<br />

in the Department <strong>of</strong> Neurodegenerative Science and throughout the<br />

Institute.<br />

Whether through new equipment or the support <strong>of</strong> a new study, the<br />

generosity <strong>of</strong> our donors powers research and education initiatives with<br />

the potential to change lives. Pairing gifts together allows VAI to make the<br />

biggest impact possible with donor funds.<br />

Remembering VAI in your estate plans helps ensure the Institute<br />

can continue its work to improve health and enhance lives for<br />

generations to come. For more information on ways to give,<br />

please contact Philanthropy Directors Kate Frillmann (kate.<br />

frillmann@vai.org) or Steve Ozinga (steve.ozinga@vai.org).<br />

30 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


(STARTING AT LEFT)<br />

GASPER “GABE” AMODEO;<br />

RICHARD & PAULA NELSON<br />

High-tech equipment at the Institute —<br />

including tools like the Leica microscope<br />

(pictured here) and the ZEISS Axioscan 7<br />

microscope slide scanners (funded in part by<br />

donor support) — enables VAI scientists to<br />

move their research further toward improving<br />

health and enhancing lives.<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 31


PHILANTHROPY<br />

MEMORIALS<br />

We appreciate your trust in us to fight disease in memory or in honor <strong>of</strong> your family and friends — with hope for a healthier tomorrow.<br />

To make a gift in memory or in honor <strong>of</strong> a loved one, please call 616.234.5392.<br />

Dominic Amante<br />

Scott & Audrey Olth<strong>of</strong><br />

Gasper J. Amodeo<br />

Catherine Amodeo<br />

Cindy Catalano<br />

Joseph & Marianne DiLorenzo<br />

The Grand Rapids Community<br />

Foundation<br />

Inglenook Condominium Association<br />

Patrick Leikert<br />

Daniel Veneklase<br />

William E. Anderson<br />

David & Ardith Robinson<br />

Allan L. Arnoys<br />

Joanne Arnoys<br />

Philip H. Battershall<br />

Martin & Susan Allen<br />

John Barrows<br />

Evie Bowers<br />

Joan Buchanan<br />

Gordon & Janice Bundy<br />

Martha Chalmers<br />

Diane Comfort<br />

David & Judith Devlin<br />

Marilyn Garter<br />

Shane & Ann Hansen<br />

Barnaby Jacob<br />

Jeffrey Koeze<br />

Madelaine Lane<br />

Gordon Lewis<br />

Rodney & Mimi Martin<br />

William & Ruselle Petchauer<br />

Frank & Lynette Spies<br />

Star Truck Rentals, Inc.<br />

Peter & Joan Steketee<br />

Jan Michel & Elisa ter Kuile<br />

David & Garnet Vanderleek<br />

William & Pat Waanders<br />

Warner<br />

Thomas Wisnom<br />

G. Thomas & Doris Worthington<br />

Raymond C. Becker<br />

James & Connie Becker<br />

Robert & Jane Boonstra<br />

Janice Buckley<br />

Roger & Karen Grinwis<br />

Lisa Locatis<br />

Philip & Marcia Mejeur<br />

Robert & Carolyn Walton<br />

Elizabeth Belson<br />

Lenora Lowe<br />

Nicole L. Beuschel<br />

Sue & James Baar<br />

Ernest C. Bevins<br />

David Bevins<br />

George W. Blasen<br />

Robert & Paula Hampson<br />

Thomas & Pamela Palmer<br />

Steven & Elizabeth<br />

Scharphorn<br />

Kathryn Thwaites<br />

Dale J. Bordewyk<br />

Shirley Bordewyk & family<br />

Robert L. Bradford<br />

Marvin & Ruth Bradford<br />

Patsy Jo Brinkert<br />

Kim Maurice<br />

Tom Brownell<br />

Tony Brownell<br />

Peter G. Bylsma<br />

Carol Bylsma<br />

Michael Calvaruso<br />

Jeffrey & Kelli Wynsma<br />

Richard A. Cebelak<br />

Mike & Sue Anderson<br />

Teresa Casey<br />

John & Nancy DeWildt<br />

Krin & Kevin Dreuth<br />

John & Mary Fix<br />

Paul & Carolyn Grady<br />

Pauline Jones<br />

Kellie & Kent Koth<br />

Ron & Kathy Mysliwiec<br />

Frank Palczewski<br />

Linda & Steven Parks<br />

John & Patricia Peters<br />

Marsha Potter<br />

Richard H Brown Foundation<br />

Norma J. Chapman<br />

Norma Chapman<br />

Roger Cook<br />

Roger & Judy Abbott<br />

Marilyn Cramer<br />

Helen & Ronald Van Farowe<br />

Lawrence DeSantis<br />

Kenneth & Arlynn Beimers<br />

Michelle Brainard & Julie O’Brien<br />

Ben & Gwen DeSantis<br />

Jon & Vicki Gardner<br />

Robert & Katie Kluting<br />

Ed & Susan Labanowski<br />

Christine & John Ritzenhein<br />

Kyle Rogers & Jerry Rogers<br />

Rodney Rothley & Mary Jensen<br />

Dave & Kimberly Shelton<br />

Darlene Snyder<br />

Kathleen Sparkman<br />

Anna Steinbrecher<br />

Jennifer Stevens<br />

Nate & Jeni Thomasma<br />

Sandra & Steve Vander Molen<br />

Todd Wawee<br />

Robert C. DuHadway<br />

Bill & Linda Peterson<br />

Ron Dykstra<br />

Christopher Chea<br />

Melissa A. Eden<br />

Keith & Carolyn Murphy<br />

John S. Edison<br />

Edith Vasu<br />

Carla Fail<br />

Andrew Hoeksema<br />

Patsy R. Ferrell<br />

Gretchen & Michael LaBell<br />

Joyce A. Fortier<br />

Jacqueline Kozal<br />

William R. Foster<br />

John Marshall<br />

Susan Freyer<br />

Jonathan & Julie Freyer<br />

Gerald Goeldel<br />

Kim Maurice<br />

Betty & Richard Goodenough<br />

Frieda Jaynes<br />

Marjorie R. Haan<br />

Jacqueline Kozal<br />

Carol A. Haarman<br />

Stephen Haarman<br />

James F. Hass<br />

Richard Hillman & Barbara<br />

Burby Hillman<br />

Olivia Haverkamp<br />

Derek Jacobsen<br />

Billie M. Janer<br />

Andrew & Courtney Kolanowski<br />

32 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Gisela Kah<br />

Greg Northrup & Birgit Klohs<br />

Mark L. Kastner<br />

Brenda Kastner<br />

Nathanael Kastner<br />

John R. Kendall<br />

Carole DuHadway<br />

Min Ja Kim<br />

Dr. Chung Yul Kim<br />

Leah E. Koldenhoven<br />

David & Carol Van Andel<br />

Family Foundation<br />

James M. Kozal<br />

Jacqueline Kozal<br />

Steven Kruith<strong>of</strong>f<br />

Edward & Karen Bezilla<br />

Joann Lehman<br />

Bernie Lehman<br />

MaryKay Lehman<br />

Laura Miersen<br />

Gertrude A. L<strong>of</strong>gren<br />

Kim Maurice<br />

Michelle Marie Lunn<br />

Michelle Lunn <strong>Hope</strong> Foundation<br />

Donald W. Maine<br />

Kenneth & Jill Peirce<br />

William R. McCallister<br />

Kathryn & Richard Hansen<br />

Robert H. McDowell<br />

Richard Hillman & Barbara<br />

Burby Hillman<br />

Sandra McNeil<br />

Joyce Snow<br />

Eleanor Medendorp<br />

Mark & Mary Fletcher<br />

Jack & Marcy Medendorp<br />

Randall L. Meredith<br />

Donna & Ervin Miller<br />

Mary H. Milidonis<br />

Mike Everett<br />

Richard L. Miller<br />

Paul & Mary Jane Jackman<br />

Micheline Jura<br />

Caroline Stacy<br />

Claudette Wandt<br />

Barb & Gary Woodhull<br />

Verne Miller<br />

Jacqueline Kozal<br />

Betty Ann Morin<br />

J. Brooks<br />

Jane Nichols<br />

John Nichols<br />

Robert D. Oberto<br />

Carole DuHadway<br />

Gregory D. Olson<br />

J. Brooks<br />

Angela N. Pasteur<br />

David & Carol Van Andel<br />

Family Foundation<br />

Patty Peck<br />

Theresa Kettlewell<br />

Thomas M. Peck<br />

Susan Van Dellen<br />

Denise Picardat<br />

Brian Picardat<br />

Valerie J. Poppema<br />

Mike & Lieschen Jacobs<br />

Cindy Keson<br />

Richard L. Pullen<br />

Ruth Kemp<br />

Neda L. Raterink<br />

Gary Raterink<br />

Rosie Ridder<br />

Dawn & Shawn Walton<br />

Harvey Ringerwole<br />

Timothy Sanders<br />

Nicole A. Robach<br />

West Michigan Tag & Label, Inc.<br />

Ellen K. Roberts<br />

Florence Benson<br />

Gerald & Betty Hecht<br />

Eileen McKenna<br />

James Kilduff & Shannon<br />

Neumann Kilduff<br />

Mel & Mary Pasch<br />

Robert & Judy Plumer<br />

Lucy Roberts<br />

Douglas & Tina Rudd<br />

Austin & Miriam Zimmerman<br />

Daniel T. Robinson<br />

Anonymous<br />

Richard D. Roetman<br />

David & Sallie Brinks<br />

Ken A. Ross<br />

Margaret Fondren<br />

David L. Rossi<br />

Anne Rossi<br />

Fred R. Rozema<br />

James & Jeri Kett<br />

Roger & Susan Levering<br />

The Rozema Family Fund<br />

James R. Schenden<br />

Pamela Allen<br />

Donald & Marilyn Cory<br />

James & Becki Hansen<br />

Randy & Linda Lincoln<br />

Luce Plumbing, LLC<br />

Joanne Schenden<br />

Kirk & Cindy Warner<br />

James R. Schmalz<br />

Leslie Schmalz<br />

Teri Sivertson<br />

Martha Elias<br />

Robyn R. Sorrell<br />

Kim Maurice<br />

Heather Sturr<br />

Eric Sturr<br />

Randall S. Sullivan<br />

Ryan Bassett<br />

Mark Bryan & Juan Carlos<br />

Carretero<br />

Larry & Edith Young<br />

Susan L. Suwyn<br />

Dale & Susan Prins<br />

Morris W. Symon<br />

Rick & Willow Chapla<br />

Marilyn Van Portfliet<br />

David & Carol Van Andel<br />

Family Foundation<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 33


PHILANTHROPY<br />

MEMORIALS (continued)<br />

Dr. George F. Vande Woude<br />

David & Susan Birdsall<br />

David & Carol Van Andel<br />

Family Foundation<br />

James & Gail Fahner<br />

David Garfinkel & Janet<br />

Westpheling & John Hibbard<br />

Dr. Anthony Hunter<br />

Emily Knowles Kellett<br />

Eun Mi Koo<br />

Michigan State University<br />

College <strong>of</strong> Human Medicine<br />

Michael & Pamela Murray<br />

Ann Schoen<br />

Bill VanDenBerge<br />

Connor & Mallory Millar<br />

Steven R. VandenBrink<br />

Kim Maurice<br />

Elizabeth F. VanderJagt<br />

Grandville Bible Church<br />

Lake Michigan Dental<br />

Lois Mol<br />

Casey Tjalsma<br />

Steven Vanderjagt<br />

William J. VanRegenmorter<br />

William & Rosemary Stevenson<br />

Katherine A. Veldink<br />

Kim Maurice<br />

Nina C. Veneklase<br />

Catherine Amodeo<br />

Rebecca M. Vogelsang<br />

Stephen & Jennifer Czech<br />

Katelyn M. Wallace<br />

Walter & Nina Gorak<br />

Maryrita Weiss<br />

Thomas & Susan Swaney<br />

Eric Westra<br />

Hilary Hoekwater<br />

David Wiersema<br />

Kilwins<br />

Carol L. Winton<br />

Dave & Jody Lockwood<br />

Nicole A. Wyble<br />

Joseph & Sara Robach<br />

Dan Young<br />

Joseph & Kelley Young<br />

William R. Zoller<br />

Mark Miller<br />

Maria Van Til<br />

Bill Zollverein<br />

Merrill Lynch, Pierce, Fenner<br />

& Smith Inc.<br />

Charles Zwiers<br />

David & Carol Van Andel<br />

Family Foundation<br />

TRIBUTES<br />

Darrin Batdorff<br />

Grandville Middle School<br />

Raymond Becker<br />

Priscilla Becker<br />

Liz Sadlowski Burns<br />

Jonathan & Beth Mast<br />

Rachel Ducat<br />

Michelle & Brian Retzler<br />

Pauline Flaga<br />

Cathy & Mike Flaga<br />

Lee W. Formwalt<br />

Sanders Foundation<br />

Tom Halstead<br />

Eugene & Barbara Gutting<br />

David H. Kammeraad<br />

Richard Spruit & Marisa Fahnenstiel<br />

Sandy Kelly<br />

Lesley Goebel<br />

Matthew Kirkwood<br />

Kristen Mahoney<br />

Belinda Klein<br />

Cassandra & Brandon Zeivel<br />

Kathleen P. Maine<br />

Kenneth & Jill Peirce<br />

David M. Munn<br />

Ann & Herbert Alvarado<br />

Olivia Nino<br />

Esperanza Watt<br />

Kenneth & Jill Peirce<br />

M. Rodrick & Kathleen Bolhous<br />

Ronald K. Rutkowski<br />

Nancy & Leonard Fouty<br />

Steve Sanxter<br />

Meghan Sanxter<br />

Ruth Secor<br />

Steve Secor<br />

Nikki Stevenson Serrano<br />

Toni Sadlowski<br />

Louie Stein<br />

Carolyn Stein<br />

Todd Stevens<br />

Kathleen Teunis<br />

David & Carol Van Andel<br />

Mike & Lynette Ellis<br />

James & Gail Fahner<br />

Judy VanEk<br />

Beth Andringa<br />

Char Veenstra<br />

Karen & Brian Meidema<br />

Richard Vokes<br />

Carolyn Stein<br />

Dona Whitehouse<br />

Greg Northrup & Birgit Klohs<br />

Karen Zylstra<br />

Grandville Middle School<br />

Graham Hoekstra<br />

Sara & Scott Pedersen<br />

Ashley K. Owen<br />

Sheldon & Emma Weiss<br />

Brian Toronyi<br />

Susan Toronyi<br />

These lists represent gifts made between Jan. 1, 2021, and Dec. 31, 2021. The accuracy <strong>of</strong> these lists is very important to us. Please contact 616.234.5392 if an error has been made.<br />

34 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 35


Van Andel Institute<br />

represents a family<br />

legacy. Founded by<br />

Join the Jay and Betty Van Andel<br />

Circle <strong>of</strong> <strong>Hope</strong><br />

A significant and growing number <strong>of</strong> individuals and households have<br />

remembered VAI in their estate plans. These planned giving intentions<br />

will greatly benefit the Institute’s research into diseases like cancer,<br />

Parkinson’s, and Alzheimer’s and related dementias, as well as our work<br />

to educate the next generation <strong>of</strong> scientific leaders and foster curiosity,<br />

creativity and critical thinking in K–12 classrooms.<br />

Jay and Betty<br />

Van Andel, that<br />

VAI honors those who have included the Institute in their estate plans<br />

through the Jay and Betty Van Andel Circle <strong>of</strong> <strong>Hope</strong>. When you notify<br />

us <strong>of</strong> your intentions, you are invited to become a member. More<br />

information about the benefits <strong>of</strong> membership can be found at<br />

vai.org/plannedgiving.<br />

legacy is now<br />

carried forward by<br />

Chairman and CEO<br />

David Van Andel<br />

and his wife, Carol.<br />

We welcome a conversation about estate giving that<br />

makes the most sense for you while also supporting<br />

the mission <strong>of</strong> VAI. Additional information about<br />

estate giving can be found at vai.giftlegacy.com.<br />

Please contact:<br />

Kate Frillmann, Philanthropy Director<br />

616.234.5515<br />

Kate.Frillmann@vai.org<br />

Steve Ozinga, Philanthropy Director<br />

616.234.5040<br />

Steve.Ozinga@vai.org<br />

JAY VAN ANDEL<br />

BETTY VAN ANDEL

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