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TNI ® Studies
50
Therapy
Diagnostics
200 AMERICANJOURNALOFRESPIRATORYANDCRITICALCAREMEDICINE VOL 176 2007
empiric,streamlinedtherapeuticapproachwithTNIforalarge
proportionofpatientswithsleepapnea.
Insummary,ourstudyprovidesclinicalproofofconceptfor
employingTNIasanoveltreatmentforpatientswithobstructive
sleep apnea–hypopnea syndrome. Because one flow rate and
cannulasizewassufficienttostabilizebreathingpatternsinthe
majority of our subjects, titration may be obviated, thereby
streamliningtheinitiationoftreatment.Moreover,theminimally
intrusivenasalinterfaceofTNImayimprovepatientadherence,
andmayultimatelyprovemoreeffectiveinmanagingthelongterm
morbidity and mortality of sleep apnea. Further studies
willberequiredtoextendthesefindingsandtodeterminethe
ultimateroleofTNIinmanagingobstructivesleepapnea.
ConflictofInterestStatement: B.M.M.doesnothaveafinancialrelationshipwith
acommercialentitythathasaninterestinthesubjectofthismanuscript.S.P.P.
doesnothaveafinancialrelationshipwithacommercialentitythathasaninterest
inthesubjectofthismanuscript.J.P.K.doesnothaveafinancialrelationshipwith
acommercialentitythathasaninterestinthesubjectofthismanuscript.P.L.S.
doesnothaveafinancialrelationshipwithacommercialentitythathasaninterest
inthesubjectofthismanuscript.A.R.S.received$18,000in2006,underaprivate
licensingagreementbetweenDr.SchwartzandSeleonGmbH.Thetermsofthis
arrangementarebeingmanagedbyJohnsHopkinsUniversityinaccordancewith
itsconflictofinterestpolicies.H.S.received$78,000from2003to2006.Under
a private licensing agreement between Dr. Schneider and Seleon GmbH,
Dr.Schneiderreceivesconsultingfees(U.S.$18,000in2006)andisentitledto
royaltypaymentsonthefuturesalesofproductsdescribedinthisarticle.Under
aseparatelicensingagreementbetweenDr.SchneiderandSeleonGmbHand
JohnsHopkinsUniversity,Dr.Schneiderisentitledtoashareofroyaltyreceived
bytheuniversityonsalesofproductsdescribedinthisarticle.Thetermsofthis
arrangementarebeingmanagedbyJohnsHopkinsUniversityinaccordancewith
itsconflictofinterestpolicies.Fundingforthestudydescribedinthisarticlewas
partiallyprovidedbySeleonGmbH.
Acknowledgment : The authors thank Mr. Peter DeRosa and Mr. Christopher
Smithforcontributionstothisstudy,whichincludedtechnicalsupport,data
collection,andhelpinthepreparationoftablesandfigures.
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