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16-05-2022 The Asian Independent

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www.theasianindependent.co.uk

NEWS

16-05-2022 to 31-05-2022

13

Study sheds new light on how

genes contribute to diabetes

Vax for rare, deadly

mosquito-borne viruses

shows promise in trial

Washington : A vaccine for eastern equine encephalitis

virus (EEEV), western equine encephalitis virus (WEEV),

and Venezuelan equine encephalitis virus (VEEV) was found

to be safe, well-tolerated and induced a neutralising antibody

response in adult volunteers, according to newly published

results from a Phase 1 clinical trial.

The vaccine candidate was developed by scientists at the

US National Institute of Allergy and Infectious Diseases

(NIAID) Vaccine Research Center (VRC), part of the

National Institutes of Health.

EEEV, WEEV and VEEV are spread to humans through

the bites of infected mosquitoes.

Infections from these diseases in humans are rare but can

lead to flu-like symptoms and, in some cases, severe neurological

damage or death.

However, under certain laboratory conditions, the viruses

can transmit through the air by aerosol droplets and cause

infection in humans and are therefore classified as priority

pathogens, potential biological agents that pose a risk to

national security and public health.

NIAID Director Anthony Fauci, and team have highlighted

the possible utility of a vaccine for EEEV for people at

high occupational risk of contracting the disease, including

members of the military and laboratory workers.

According to researchers, horses are also susceptible to

infection, but horses cannot transmit the viruses directly to

humans.

The viruses have caused recurrent, small outbreaks in

North, Central and South America, including an EEEV outbreak

in 2019 in the northeastern United States that led to 38

confirmed cases and 15 deaths.

In the study appearing in The Lancet Infectious Diseases,

VRC researchers designed a virus-like particle (VLP) vaccine

candidate (abbreviated WEVEE) that uses proteins from

the outer shells of the EEE, WEE and VEE viruses to prompt

an immune response. VLPs do not contain the genetic material

that the viruses need to replicate inside cells, so VLPs

cannot cause infection.

For the Phase 1 clinical trial, 30 healthy adult volunteers

ages 18 to 50 years received varying doses of the WEVEE

vaccine (6, 30 or 60 micrograms) by intramuscular injection.

Participants then returned to receive the same dose as a

boost eight weeks later. Some participants also received a

formulation of the experimental vaccine that contained an

alum adjuvant added to increase immune responses.

The team reported that the vaccine was safe, well-tolerated

and induced durable immune responses against all three

viruses.

The highest neutralising antibody response was observed

in participants who received the 30-microgram dose with

adjuvant. The authors note that the findings support further

clinical evaluation of the vaccine candidate.

NIAID has approved a commercialisation licence for the

advanced development of the WEVEE vaccine candidate to

the life sciences company Emergent BioSolutions in

Maryland, US.

New Delhi : Healthy adults

who eat a diverse diet, with at

least 8-10 grams of soluble fibre

such as grains, beans, lentils, nuts

and some fruits and vegetables

daily, have fewer antibioticresistant

microbes in their guts,

according to a study.

Microbes that have resistance

to various commonly-used

antibiotics such as tetracycline

and aminoglycoside are a significant

source of risk for people worldwide,

with the widely held expectation

that the problem of antimicrobial resistance

(AMR) - the term that refers to

bacteria, viruses, and fungi that are

resistant to antibiotics - is likely to

worsen throughout the coming decades.

Antimicrobial resistance in people is

largely based in their gut microbiome,

where the microbes are known to carry

genetically encoded strategies to survive

contact with antibiotics.

"And the results lead directly to the

idea that modifying the diet has the

potential to be a new weapon in the

fight against antimicrobial resistance.

And we're not talking about eating

some exotic diet either, but a diverse

Hyderabad : A world-wide study,

which included Indian scientists, of

diverse populations has shed new light

on how genes contribute to Type 2 diabetes.

The study, named DIAMANTE

(DIAbetes Meta-ANalysis of Trans-

Ethnic association studies), co-led by

Prof Andrew Morris of the University of

Manchester, has been published in

Nature Genetics.

The global prevalence of Type 2 diabetes,

a familial disease with severe

morbidity, has increased 4-fold over the

last 3 decades. Asia, especially India and

China, are major hubs of this spurt.

It is thought that Indians are especially

at risk of Type 2 diabetes because they

are centrally obese, or fat around the

abdomen - indicative of fat around their

visceral organs, and are more insulin

resistant right from birth. This is in contrast

to the Europeans who are overall fat

in a generalised manner. Despite this

fact, the largest studies to understand the

genetic basis of Type 2 diabetes have

mostly been conducted on populations

of European ancestry. Dr. Giriraj R

Chandak, Chief Scientist at CSIR -

Centre for Cellular and Molecular

Biology (CSIR - CCMB) and one of the

lead investigators from India, highlighted

this study as a landmark event where

scientists from different parts of the

world put together their minds to understand

similarities and differences in

genetic susceptibility to Type 2 diabetes

in different populations. His group had

earlier provided evidence of greater

genetic heterogeneity in Indians compared

to Europeans, which compromises

the ability to predict Type 2 diabetes risk

in the Indian populations using

European data.

This recent study compared genomic

DNA of 1.8 lakh people with Type 2 diabetes

against 11.6 lakh normal subjects

from five ancestries - Europeans, East

Asians, South Asians, Africans, and

Hispanics, and identified large number

of genetic differences (Single

Nucleotide Polymorphisms or SNPs)

diet, adequate in fibre," said research

molecular biologist Danielle Lemay at

the US Department of Agriculture's

Agricultural Research Service.

In the study, published in the journal

mBio, the researchers found that regularly

eating a diet with higher levels of

fibre and lower levels of protein, especially

from beef and pork, was significantly

correlated with lower levels of

antimicrobial resistance genes (ARG)

among their gut microbes.

Those with the lowest levels of ARG

in their gut microbiomes also had a

greater abundance of strict anaerobic

microbes, which are bacteria that do not

thrive when oxygen is present and are a

hallmark of a healthy gut with low

between patients and the normal subjects.

"The study found population-specific

differences in genetic susceptibility to

Type 2 diabetes. These results pave the

way towards development of ancestryspecific

genetic risk score for risk prediction

in different populations and has

immense implications for Indians, where

every sixth individual is a potential diabetic,"

said Dr. Chandak.

"This study sets up the stage for further

investigating the South Asian population

for genetic susceptibility to Type 2

Diabetes and extends the journey on the

path of precision medicine," CCMB

Director, Dr Vinay Nandicoori, said.

High-fibre rich diet can help

fight antibiotic resistance

inflammation. Bacterial

species in the family

Clostridiaceae were the most

numerous anaerobes found.

But the amount of animal

protein in the diet was not a

top predictor of high levels of

ARG. The strongest evidence

was for the association of

higher amounts of soluble

fibre in the diet with lower levels

of ARGs.

"Surprisingly, the most important

predictor of low levels of ARG, even

more than fibre, was the diversity of the

diet. This suggests that we may want to

eat from diverse sources of foods that

tend to be higher in soluble fibre for

maximum benefit," Lemay added.

On the other hand, those people who

had the highest levels of ARG in their

gut microbiomes were found to have

significantly less diverse gut microbiomes

compared to groups with low and

medium levels of ARG.

"Our diets provide food for gut

microbes. This all suggests that what

we eat might be a solution to reduce

antimicrobial resistance by modifying

the gut microbiome," Lemay said.

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