16-05-2022 The Asian Independent
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NEWS
16-05-2022 to 31-05-2022
13
Study sheds new light on how
genes contribute to diabetes
Vax for rare, deadly
mosquito-borne viruses
shows promise in trial
Washington : A vaccine for eastern equine encephalitis
virus (EEEV), western equine encephalitis virus (WEEV),
and Venezuelan equine encephalitis virus (VEEV) was found
to be safe, well-tolerated and induced a neutralising antibody
response in adult volunteers, according to newly published
results from a Phase 1 clinical trial.
The vaccine candidate was developed by scientists at the
US National Institute of Allergy and Infectious Diseases
(NIAID) Vaccine Research Center (VRC), part of the
National Institutes of Health.
EEEV, WEEV and VEEV are spread to humans through
the bites of infected mosquitoes.
Infections from these diseases in humans are rare but can
lead to flu-like symptoms and, in some cases, severe neurological
damage or death.
However, under certain laboratory conditions, the viruses
can transmit through the air by aerosol droplets and cause
infection in humans and are therefore classified as priority
pathogens, potential biological agents that pose a risk to
national security and public health.
NIAID Director Anthony Fauci, and team have highlighted
the possible utility of a vaccine for EEEV for people at
high occupational risk of contracting the disease, including
members of the military and laboratory workers.
According to researchers, horses are also susceptible to
infection, but horses cannot transmit the viruses directly to
humans.
The viruses have caused recurrent, small outbreaks in
North, Central and South America, including an EEEV outbreak
in 2019 in the northeastern United States that led to 38
confirmed cases and 15 deaths.
In the study appearing in The Lancet Infectious Diseases,
VRC researchers designed a virus-like particle (VLP) vaccine
candidate (abbreviated WEVEE) that uses proteins from
the outer shells of the EEE, WEE and VEE viruses to prompt
an immune response. VLPs do not contain the genetic material
that the viruses need to replicate inside cells, so VLPs
cannot cause infection.
For the Phase 1 clinical trial, 30 healthy adult volunteers
ages 18 to 50 years received varying doses of the WEVEE
vaccine (6, 30 or 60 micrograms) by intramuscular injection.
Participants then returned to receive the same dose as a
boost eight weeks later. Some participants also received a
formulation of the experimental vaccine that contained an
alum adjuvant added to increase immune responses.
The team reported that the vaccine was safe, well-tolerated
and induced durable immune responses against all three
viruses.
The highest neutralising antibody response was observed
in participants who received the 30-microgram dose with
adjuvant. The authors note that the findings support further
clinical evaluation of the vaccine candidate.
NIAID has approved a commercialisation licence for the
advanced development of the WEVEE vaccine candidate to
the life sciences company Emergent BioSolutions in
Maryland, US.
New Delhi : Healthy adults
who eat a diverse diet, with at
least 8-10 grams of soluble fibre
such as grains, beans, lentils, nuts
and some fruits and vegetables
daily, have fewer antibioticresistant
microbes in their guts,
according to a study.
Microbes that have resistance
to various commonly-used
antibiotics such as tetracycline
and aminoglycoside are a significant
source of risk for people worldwide,
with the widely held expectation
that the problem of antimicrobial resistance
(AMR) - the term that refers to
bacteria, viruses, and fungi that are
resistant to antibiotics - is likely to
worsen throughout the coming decades.
Antimicrobial resistance in people is
largely based in their gut microbiome,
where the microbes are known to carry
genetically encoded strategies to survive
contact with antibiotics.
"And the results lead directly to the
idea that modifying the diet has the
potential to be a new weapon in the
fight against antimicrobial resistance.
And we're not talking about eating
some exotic diet either, but a diverse
Hyderabad : A world-wide study,
which included Indian scientists, of
diverse populations has shed new light
on how genes contribute to Type 2 diabetes.
The study, named DIAMANTE
(DIAbetes Meta-ANalysis of Trans-
Ethnic association studies), co-led by
Prof Andrew Morris of the University of
Manchester, has been published in
Nature Genetics.
The global prevalence of Type 2 diabetes,
a familial disease with severe
morbidity, has increased 4-fold over the
last 3 decades. Asia, especially India and
China, are major hubs of this spurt.
It is thought that Indians are especially
at risk of Type 2 diabetes because they
are centrally obese, or fat around the
abdomen - indicative of fat around their
visceral organs, and are more insulin
resistant right from birth. This is in contrast
to the Europeans who are overall fat
in a generalised manner. Despite this
fact, the largest studies to understand the
genetic basis of Type 2 diabetes have
mostly been conducted on populations
of European ancestry. Dr. Giriraj R
Chandak, Chief Scientist at CSIR -
Centre for Cellular and Molecular
Biology (CSIR - CCMB) and one of the
lead investigators from India, highlighted
this study as a landmark event where
scientists from different parts of the
world put together their minds to understand
similarities and differences in
genetic susceptibility to Type 2 diabetes
in different populations. His group had
earlier provided evidence of greater
genetic heterogeneity in Indians compared
to Europeans, which compromises
the ability to predict Type 2 diabetes risk
in the Indian populations using
European data.
This recent study compared genomic
DNA of 1.8 lakh people with Type 2 diabetes
against 11.6 lakh normal subjects
from five ancestries - Europeans, East
Asians, South Asians, Africans, and
Hispanics, and identified large number
of genetic differences (Single
Nucleotide Polymorphisms or SNPs)
diet, adequate in fibre," said research
molecular biologist Danielle Lemay at
the US Department of Agriculture's
Agricultural Research Service.
In the study, published in the journal
mBio, the researchers found that regularly
eating a diet with higher levels of
fibre and lower levels of protein, especially
from beef and pork, was significantly
correlated with lower levels of
antimicrobial resistance genes (ARG)
among their gut microbes.
Those with the lowest levels of ARG
in their gut microbiomes also had a
greater abundance of strict anaerobic
microbes, which are bacteria that do not
thrive when oxygen is present and are a
hallmark of a healthy gut with low
between patients and the normal subjects.
"The study found population-specific
differences in genetic susceptibility to
Type 2 diabetes. These results pave the
way towards development of ancestryspecific
genetic risk score for risk prediction
in different populations and has
immense implications for Indians, where
every sixth individual is a potential diabetic,"
said Dr. Chandak.
"This study sets up the stage for further
investigating the South Asian population
for genetic susceptibility to Type 2
Diabetes and extends the journey on the
path of precision medicine," CCMB
Director, Dr Vinay Nandicoori, said.
High-fibre rich diet can help
fight antibiotic resistance
inflammation. Bacterial
species in the family
Clostridiaceae were the most
numerous anaerobes found.
But the amount of animal
protein in the diet was not a
top predictor of high levels of
ARG. The strongest evidence
was for the association of
higher amounts of soluble
fibre in the diet with lower levels
of ARGs.
"Surprisingly, the most important
predictor of low levels of ARG, even
more than fibre, was the diversity of the
diet. This suggests that we may want to
eat from diverse sources of foods that
tend to be higher in soluble fibre for
maximum benefit," Lemay added.
On the other hand, those people who
had the highest levels of ARG in their
gut microbiomes were found to have
significantly less diverse gut microbiomes
compared to groups with low and
medium levels of ARG.
"Our diets provide food for gut
microbes. This all suggests that what
we eat might be a solution to reduce
antimicrobial resistance by modifying
the gut microbiome," Lemay said.