Verzeichnis wissenschaftlicher Arbeiten

Verzeichnis wissenschaftlicher Arbeiten
1.) Marquetant R, Brehm B, Strasser RH. Chronic beta-blockade transregulates inhibitory A1
adenosine and muscarinic M2 receptors of the adenylyl cyclase system. J Mol Cell Cardiol
1992, 24: 535-548
2.) Baumbach A, Brehm B, Sauer W, Döller G, Hoffmeister HM. Spontaneous splenic
rupture complicating acute Q fever. Am J Gastroenterol 1992: 87: 1651-1653
3.) Axel DI, Brehm BR, Wolburg-Buchholz K, Betz EL, Kovecker G, Karsch KR. Induction of
cell-rich and lipid-rich plaques in a transfilter coculture system with human vascular cells. J
Vasc Res 1996, 33: 327-339
4) Brehm BR, Zvizdic M, Karsch KR. Dynamische Regulation �-adrenerger Rezeptoren
mittels Endothelin-1 an vaskulären glatten Muskelzellen. Nieren- und Hochdruckkrankheiten
1996, 26: 173-175
5.) Axel DI, Kunert W, Göggelann C, Oberhoff M, Herdeg C, Kuttner A, Wild A, Brehm BR,
Reissen R, Karsch KR. Paclitaxel inhibits arterial smooth muscle cell proliferation and
migration in vitro and in vivo using local drug delivery. Circulation 1997, 96: 636-64
6.) Brehm BR, Bertsch D, Wolf SC. Nebivolol hemmt die Proliferation sowohl von humanen
koronararteriellen glatten Muskelzellen als auch von Endothelzellen und steigert die NO-
Freisetzung. Perfusion 1998, 11: 475-484
7.) Brehm BR, Meergans M, Karsch KR. Einfluß gering erhöhter LDL-Konzentrationen auf
die �-adrenerge Rezeptordichte und die Adenylylzyklase-Aktivität in Media-Explantaten von
Koronararterien. Perfusion 1998, 11: 185-194
8.) Brehm BR, Büttcher E, Beyer ME, Hoffmeister HM. Comparison of circulating endothelin-
1 and big-endothelin-1 levels in unstable versus stable angina pectoris. J Cardiovasc
Pharmaco1 1998, 31(Suppl. 1): S90-S93
9.) Brehm BR, Zvizdic M, Bernhard R, Hoffmeister HM, Wolf SC, Karsch KR. Dynamic
regulation of �-adrenergic receptors by endothelin-1 in smooth-muscle cells. J Cardiovasc
Pharmacol 1998, 31(Suppl 1): S77-S80
10.) Wolf SC, Smoltczyk H, Brehm BR, Erley CM, Risler T. Endothelin-1 and endothelin-3
levels in different types of glomerulonephritis. J Cardiovasc Pharmacol 1998, 31 (Suppl):
S482-485
11.) Beyer ME, Slesak G, Brehm BR, Hoffmeister HM. Hemodynamic and inotropic effects
of the endothelin A antagonist BQ-610 in vivo. J Cardiovasc Pharmacol 1998, 31 (Suppl):
S258-261

12.) Brehm BR, Meergans M, Axel DI, Pfohl M, Heinle H, Karsch KR. Downregulation of �adrenergic
receptors by low density lipoproteins and its prevention by �-adrenergic receptor
antagonists. Cardiovasc Res 1998, 38: 522-530
13.) Brehm BR, Karsch KR. Characterization of �1- and �2-adrenergic receptors in the media
of porcine coronary arteries. Perfusion 1999, 12: 126-132
14.) Wolf SC, Brehm BR, Gaschler F, Brehm S, Klaussner M, Smykowski J, Amann K,
Osswald H, Erley CM, Risler T. Protective effects of endothelin antagonists in chronic renal
failure. Nephrol Dial Transplant 1999, 99: 1010-1093
15.) Brehm BR, Bertsch D, von Fallois J, Wolf SC. �-blockers of the third generation inhibit
endothelin-1 liberation, mRNA production and proliferation of human coronary smooth
muscle and endothelial cells. J Cardiovasc Pharmacol 2000, 36 (Suppl. 1): S401-S403
16.) Brehm BR, Heinle H, Risler T, Wolf SC. Chronically elevated endothelin-1
concentrations modulate the �-adrenergic receptor system in vitro and in vivo. J Cardiovasc
Pharmacol 2000, 36 (Suppl. 1): S157-S159
17.) Wolf SC, Gaschler F, Brehm S, Klaussner M, Amann K, Risler T, Brehm BR.
Endothelin-receptor antagonists in uremic cardiomyopathy. J Cardiovasc Pharmacol 2000,
36 (Suppl): 348-350
18.) Brehm BR, Bock C, Wesselborg S, Pfeiffer S, Schüler S, Schulze-Osthoff K. Prevention
of human smooth muscle cell proliferation without induction of apoptosis by the
topoisomerase I inhibitor topotecan. Biochem Pharmacol 2001, 61: 119-127
19.) Brehm BR, Wolf SC, Bertsch D, Klaussner M, Wesselborg S, Schüler S, Schulze-
Osthoff K. Effects of nebivolol on proliferation and apoptosis of human coronary artery
smooth muscle and endothelial cells. Cardiovasc Res 2001, 49: 430-439
20.) Hahn U, Konig CW, Miller S, Brehm B, Heuschmid M, Kopp AF, Claussen CD.
Multidetector CT Angiography - is it a valuable screening tool to detect significant renal artery
stenosis. Röfo 2001, 173: 1086-1092
21.) Brehm BR, Wolf SC, Görner S, Buck-Müller N, Risler T. Effect of nebivolol on left
ventricular function in patients with chronic heart failure: a pilot study. Eur J Heart Fail 2002,
4: 757-63
22.) Brehm BR, Klaussner M, Wolf SC. Chronic elevated endothelin-1 concentrations
regulate mitogen-activated protein kinases ERK 1 and ERK 2 in vascular smooth muscle
cells. Clin Sci (Lond) 2002, 103 (Suppl) 48: 137S-140S
23.) Langer P, Bartsch D, Gerdes B, Schwetlick I, Wild A, Brehm B, Erley C, Lamberts R.
Renin producing neuroendocrine pancreatic carcinoma - a case report and review of the
literature. Exp Clin Endocrinol Diabetes 2002, 110: 43-49
24.) Brehm BR, Wolf SC, Freudenberg J, Friedmann F, Heinle H, Schulze-Osthoff K.
Modulation of the beta-adrenergic receptor system of vascular smooth muscle cells in vitro
and in vivo by chronically elevated endothelin-1 levels. Biochem Pharmacol 2002, 63: 1361-
1369

25.) Wolf SC, Amend T, Risler T, Amann K, Brehm BR. Influence of endothelin receptor
antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy.
Clin Sci (Lond) 2002, 103 (Suppl) 48: 276S-279S
26.) Wolf SC, Mayer O, Jürgens S, Vontheim R, Schultze G, Risler T, Brehm BR. Chlamydia
pneumoniae IgA seropositivity is associated with increased risk for atherosclerotic vascular
disease, myocardial infarction and stroke in dialysis patients. Clin Nephrol 2003, 59: 273-279
27.) Kastrup A, Gröschel K, Krapf H, Brehm BR, Dichgans J, Schulz JB. Early outcome of
carotid angioplasty and stenting with and without cerebral protection devices: a systematic
review of the literature. Stoke 2003, 34: 813-819
28.) Wolf SC, Buck-Müller N, Görner S, Risler T, Brehm BR. Influence of the beta-blocker
nebivolol on left ventricular function in patients with chronic heart failure. Med Klin (Munich)
2003, 98: 1-6
29.) Wolf SC, Brehm BR, Mayer O, Jürgens S, Schultze G, Risler T. Infectious risk factors
for atherosclerotic vascular disease in hemodialysis patients - Chlamydia pneumoniae but
not helicobacter pylori or cytomegalovirus is associated with increased C-reactive protein.
Ren Fail 2004, 26: 279-87
30.) Sauter G, Wolf S, Risler T, Brehm B. Influence of endothelin receptor antagonism on
smooth muscle cell proliferation after chronic renal failure. J Cardiovasc Pharmacol 2004, 44
(Suppl): S165-167
31.) Sabine C. Wolf SC, Schultze M, Sauter G, Risler T, Lang F, Brehm BR. Endothelin-1
increases serum-glucose-regulated kinase-1 expression in smooth muscle cells. J
Cardiovasc Pharmacol 2004, 44 (Suppl): S304-306
32.) Wolf SC, Brodbeck C, Sauter G, Risler T, Brehm BR. Endothelin-1 regulates protein
kinase C isoforms differently in smooth muscle cells and in cardiomyocytes. J Cardiovasc
Pharmacol 2004, 44 (Suppl): S301-303
33.) Wolf SC, Sauter G, Rodemann HP, Risler T, Brehm BR. Uremia increases growthfactor-induced
proliferation of vascular smooth muscle cells – effects of endothelin and
angiotensin II receptor antagonism. Nephrol Dial Transplant 2005, 20: 312-318
34.) Wolf SC, Sauter G, Brehm BR. Effects of combined endothelin and angiotensin II
antagonism on growth factor-induced proliferation of vascular smooth muscle cells isolated
from uremic rats. Ren Fail 2005, 27: 465-474
35.) Kempf VA, Lebiedziejewski M, Alitalo K, Walzlein JH, Ehehalt U, Fiebig J, Huber S,
Schutt B, Sander CA, Müller S, Grassl G, Yazdi AS, Brehm B, Autenrieth IB. Activation of
hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible
factor-1 in bacterial infections. Circulation 2005, 111: 1064-62
36.) Sauter G, Kreutzer U, Risler T, Brehm BR, Sabine C. Wolf. Effekte von ß-Rezeptor-
Antagonisten auf die CRP vermittelte Expression von Entzündungsmarkern. Perfusion 2005,
18: 236-240

37.) Wolf SC, Schultze M, Sauter G, Risler T, Lang F, Schulze-Osthoff K, Brehm BR.
Stimulation of serum- and glucocorticoid-regulated kinase-1 transcription by endothelin-1.
Biochem Pharmacol 2006, 71: 1175-83
38.) Wolf SC, Tannapfel A, Petersen P, Risler T, Brehm BR. Secondary syphilis after liver
transplantation: a case report and review of the literature. Clin Transplant 2006, 20: 644-649
39.) Wolf SC, Sauter G, Preyer G, Poerner TC, Kempf VA, Risler T, BR Brehm. Influence of
metoprolol and nebivolol on inflammatory mediators in human coronary endothelial or
smooth muscle cells. Consequences on neointima formation in rat carotid arteries after
balloon denudation. Cell Physiol Biochem 2007, 19: 129-136
40.) Plewnia C, Reimold M, Najib A, Brehm B, Reischl G, Plontke SK, Gerlodd C. Dosedependent
attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive
transcranial magnetic stimulation. Hum Brain Mapp 2007, 244: 238-246
41.) Schäfer R, Kehlbach R, Wiskirchen J, Bantleon R, Pintaske J, Brehm BR, Gerber A,
Wohlburg H, Claussen CD, Northoff H. Transferrin receptor upregulation in vitro labeling of
rat mesenchymal stem cells with supermagnetic iron oxide. Radiology 2007, 244: 514-523
42.) Zürn CS, Brehm BR, Rüb N, Langer H, Klingel K, Kröber S, Kandolf R, Klump B, Miller
S, Gawaz M. Recurrent transient ischemic attacks in a patient with pansinusitis. Internist
(Berl) 2006, 11: 1165-71
43.) Poerner TC, Ferrari M, Brehm B, Figulla HR. Invasive therapeutic strategies in acute
heart failure complicating coronary artery disease: effectiveness and boundaries. Herz 2006,
31: 780-786
44.) Ferrari M, Poerner TC, Brehm BR, Schlosser M, Krizanic F, Schmidt R, Figiulla HR.
First use of a novel plug- and play percutaneous circulatory assist device for high risk
coronary angioplasty. Acute Card Care 2008, 10: 111-115
45.) Wolf SC, Sauter G, Jobst J, Kempf VA, Risler T, Brehm BR. Major differences in gene
expression in human coronary smooth muscle cells after nebivolol or metoprolol treatment.
Int J Cardiol 2008, 125: 4-10
46.) Rupprecht S, Hutschenreuther J, Brehm B, Figulla HR, Witte O, Schwab M. Causality in
the relationship between central sleep apnoe and paroxysmal atrial fibrillation. Sleep Med
2008, 9: 462-464
47.) Franz M, Bahrmann P, Berndt A, Isecke A, Gummert J, Figulla HR, Brehm BR. Surgical
therapy of infective endocarditis. General aspects and therapy. Med Klin (Munich) 2008, 103:
349-355
48.) Jung C, Ferrari M, Gradinger R, Fritzenwanger M, Pfeifer R, Schlosser M, Poerner TC,
Brehm BR, Figulla HR. Evaluation of the microcirculation during extracorporal membraneoxigenation.
Clin Hemorheol Microcirc. 2008; 40:311-4

49.) Jung C, Fischer N, Fritzenwanger M, Pernow J, Brehm BR, Figulla HR. Association of
waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in
adolescents. Pediatr Diabetes. 2009;10:329-35
50.) Jung C, Fischer N, Fritzenwanger M, Thude H, Ferrari M, Fabris M, Brehm BR, Barz D,
Figulla HR. Endothelial progenitor cells in adolescents: impact of overweight, age, smoking,
sport and cytokines in younger age. Clin Res Cardiol. 2009;98:179-88
51.) Pfeil A, Brehm B, Lopatta E, Neumann T, Schmidt P, Wolf G, Kaiser WA, Hansch A.
Acute chest pain, heart failure, and eosinophilia in a woman without coronary disease.
Cardiovasc Intervent Radiol. 2009;32:1272-4
52.) Franz M, Berndt A, Altendorf-Hofmann A, Fiedler N, Richter P, Schumm J,
Fritzenwanger M, Figulla HR, Brehm BR. Serum levels of large tenascin-C variants, matrix
metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus
eccentric left ventricular hypertrophy. Eur J Heart Fail. 2009;11:1057-62
53.) Franz M, Brehm BR, Richter P, Gruen K, Neri D, Kosmehl H, Hekmat K, Renner A,
Gummert J, Figulla HR, Berndt A. Changes in extra cellular matrix remodelling and reexpression
of fibronectin and tenascin-C splicing variants in human myocardial tissue of the
right atrial auricle: implications for a targeted therapy of cardiovascular diseases using
human SIP format antibodies. J Mol Histol. 2010; 41:39-50
54.) Hansch A, Betge S, Pfeil A, Mayer TE, Wolf G, Brehm B. Images in cardiovascular
medicine. Spontaneous rupture of the right coronary artery. Circulation. 2010;121:2692-3
55.) Franz M, Grün K, Richter P, Brehm BR, Fritzenwanger M, Hekmat K, Neri D, Gummert
J, Figulla HR, Kosmehl H, Berndt A, Renner A. Extra cellular matrix remodelling after
heterotopic rat heart transplantation: gene expression profiling and involvement of ED-A+
fibronectin, alpha-smooth muscle actin and B+ tenascin-C in chronic cardiac allograft
rejection. Histochem Cell Biol. 2010;134:503-17
56.) Pfeil A, Drobnik S, Rzanny R, Aboud A, Böttcher J, Schmidt P, Ortmann C, Mall G,
Hekmat K, Brehm B, Reichenbach J, Mayer TE, Wolf G, Hansch A. Compatibility of
temporary pacemaker myocardial pacing leads with magnetic resonance imaging: an ex vivo
tissue study. Int J Cardiovasc Imaging. 2011 Feb
57.) Rupprecht S, Hoyer D, Brehm B, Witte OW, Schwab M. REM sleep related
bradyarrhythmia syndrome: Vagal overactivity or dysfunction of the cardiac conduction
system? Sleep Med. 2011;12:308
58.) Franz M, Berndt A, Grün K, Richter P, Kosmehl H, Neri D, Gummert J, Figulla HR,
Brehm BR, Renner A. Expression of extra domain A containing fibronectin in chronic cardiac
allograft rejection. J Heart Lung Transplant. 2011;30:86-94
59) Hamadanchi A, Finkensieper A, Franz M, Brehm BR, Figulla HR. Congenital left
circumflex artery to left atrial appendage fistula: searching for a 'colorful fountain'.Eur J
Echocardiogr. 2011;12:805.
60) Baldinger A, Brehm BR, Richter P, Bossert T, Gruen K, Hekmat K, Kosmehl H, Neri D,
Figulla HR, Berndt A, Franz M. Comparative analysis of oncofetal fibronectin and tenascin-C
expression in right atrial auricular and left ventricular human cardiac tissue from patients with
coronary artery disease and aortic valve stenosis. Histochem Cell Biol. 2011;135:427-41.
61) Brehm BR, Franz M. Perforation of the left ventricle due to an abscess of a left
ventricular thrombus: survival of the patient with a conservative medical therapy strategy.

BMJ Case Rep. 2011 Apr 13;2011.
62) Schumm J, Luetzkendorf S, Rademacher W, Franz M, Schmidt-Winter C, Kiehntopf M,
Figulla HR, Brehm BR. In patients with aortic stenosis increased flow-mediated dilation is
independently associated with higher peak jet velocity and lower asymmetric
dimethylarginine levels. Am Heart J. 2011 May;161:893-9.
63) Doerr F, Badreldin AM, Bender EM, Heldwein MB, Lehmann T, Bayer O, Brehm BB,
Ferrari M, Hekmat K. Outcome prediction in cardiac surgery: the first logistic scoring model
for cardiac surgical intensive care patients.
Minerva Anestesiol. 2012;78:879-86.
64) Siegel G, Krause P, Wöhrle S, Nowak P, Ayturan M, Kluba T, Brehm BR, Neumeister B,
Köhler D, Rosenberger P, Just L, Northoff H, Schäfer R. Bone Marrow-Derived Human
Mesenchymal Stem Cells Express Cardiomyogenic Proteins But Do Not Exhibit Functional
Cardiomyogenic Differentiation Potential. Stem Cells Dev. 2012
65) Badreldin A, Elsobky S, Lehmann T, Brehm BB, Doenst T, Hekmat K. Daily-Mean-
SOFA, a new derivative to increase accuracy of mortality prediction in cardiac surgical
intensive care units. Thorac Cardiovasc Surg. 2012;60:43-50.
Buchartikel
Vegetatives Nervensystem, in Therapie und Verlauf neurologischer Erkrankungen, 4.
Auflage 2003, Herausgeber: Brandt, Dichgans, Diener. Kohlhammer-Verlag, Stuttgart
Vegetatives Nervensystem, in Therapie und Verlauf neurologischer Erkrankungen, 5.
Auflage 2007, Herausgeber: Brandt, Dichgans, Diener. Kohlhammer-Verlag, Stuttgart
Review-Artikel
Brehm BR, Risler T, Wolf SC. Therapie der Hypertonie im Alter. Nieren- und
Hochdruckkrankheiten 2001
Brehm BR, Ferrari M, Figulla HR. Die vasodilatatorischen Eigenschaften von Testosteron.
Blickpunkt der Mann 2009