5 years ago

MyCells® - Platelet Rich Plasma harvesting kit : from ... -

MyCells® - Platelet Rich Plasma harvesting kit : from ... -

Proangiogenic growth

Proangiogenic growth factors Transforming growth factor, alpha Transforming growth factor, beta 1 Vascular endothelial growth factor A Hypoxia-inducible factor 1, alpha subunit - regulator of VEGF expression Fibroblast growth factor 2 (basic) Cell Adhesion Receptors Integrin, alpha V Integrin, beta 3 Laminin receptor, alpha 5 Endoglin Results Upregulation (x fold) 2.67 2.59 3.04 6.29 13.02 Upregulation (x fold) 3.16 3.17 7.56 4.05 63

Conclusions Our preliminary results indicate that: Exposure of endothelial cells to activated platelets induces enhanced expression of: � TGF –alpha, � TGF- beta, � VEGF (Vascular endothelial GF) � HIF (regulator of VEGF) � basic FGF � Integrin alpha v � Integrin beta 3 � Laminin receptor growth factors involved in regulation of angiogenesis, wound healing and tissue regeneration Factors involved in cell adhesion, survival, migration and regulation of growth factor receptor activity. All these processes play important roles in angiogenesis, tissue regeneration and cell adhesion to the extracellular matrix proteins. 64

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