Tempo biosciences Overview2023
Tempo Bioscience, Inc (Tempo) develops human stem cells (human iPSC technology) based cell models and biosensor enabling technologies for preclinical drug discovery & development, biobanking, in vitro diagnostics, and biomarker development. Our in-house developed proprietary technologies and cell-based products serve as valuable tools for the Biotechnology and Pharmaceutical industry.
Tempo Bioscience, Inc (Tempo) develops human stem cells (human iPSC technology) based cell models
and biosensor enabling technologies for preclinical drug discovery & development, biobanking, in vitro diagnostics, and biomarker development. Our in-house developed proprietary technologies and cell-based products serve as valuable tools for the Biotechnology and Pharmaceutical industry.
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<strong>Tempo</strong> Bioscience ®<br />
...Trust Your Cells<br />
PERICYTES<br />
Fragile X Syndrome<br />
HEPATOCYTES<br />
Angelman's Syndrome<br />
KUPFFER CELLS<br />
Trisomy<br />
Osteogenesis Imperfecta<br />
SCHWANN CELLS<br />
NEURAL<br />
PROGENITORS<br />
Osteoporosis<br />
OLIGODENDROCYTE<br />
PROGENITOR<br />
ASTROCYTES (I & II)<br />
Warfan Syndrome<br />
MOTOR NEURONS<br />
CORTICAL<br />
NEURONS<br />
Alzheimer's Disease<br />
PERICYTES<br />
Schizophrenia and Bipolar<br />
DOPAMINERGIC<br />
NEURONS<br />
Seizure Disorders<br />
MICROGLIA<br />
Huntington's Diseasev<br />
Parkinson's Disorder<br />
Multiple Sclerosis<br />
MELANOCYTES<br />
KERATINOCYTES<br />
CD14+ MONOCYTES<br />
PHAGOCYTES<br />
Freidreich's Ataxia<br />
Spinal Muscular Atrophy<br />
Emery-Dreifuss Muscular Dystrophy<br />
Spinocerebella Ataxia<br />
Von Hippel-Lindau Syndrome<br />
Cancer<br />
RETINAL PIGMENT<br />
EPITHELIAL (RPES)<br />
Cardiomyopathy<br />
MESENCHYMAL<br />
STEM CELLS<br />
Chronic Kidney Diseases<br />
Fabry Disease<br />
LIVER SINUSOIDAL<br />
ENDOTHELIALS<br />
Seizure Disorders (e.g., Epilepsy)<br />
Dunchenne Muscular Dystrophy<br />
OSTEOBLASTS<br />
Charcot Marie Tooth<br />
Paget Diseases of the Bone<br />
BRAIN MICROVASCULAR<br />
ENDOTHELIAL CELLS<br />
CD34+ HEMATOPOIETIC<br />
STEM CELLS<br />
Non-alcoholic steatohepatitis<br />
SENSORY<br />
NEURONS<br />
Frontotemporal Dementia<br />
KIDNEY PROXIMAL<br />
TUBULE CELLS & PODOCYTES<br />
Developing 10,000 Human Disease Models<br />
<strong>Tempo</strong> Bioscience, Inc (<strong>Tempo</strong>) develops human stem cells (human iPSC technology) based cell models<br />
and biosensor enabling technologies for preclinical drug discovery & development, biobanking, in vitro<br />
diagnostics, and biomarker development. Our in-house developed proprietary technologies and cell-based<br />
products serve as valuable tools for the Biotechnology and Pharmaceutical industry.<br />
Human Cell Models<br />
Lead optimization<br />
Preclinical discovery<br />
Investigative toxicology<br />
In-vitro efficacy<br />
Gene therapy dosing<br />
Biosensor Assays<br />
<strong>Tempo</strong>ATP for ATP Metabolism<br />
<strong>Tempo</strong>CAL for Calcium<br />
<strong>Tempo</strong>Mito for Mitochondria<br />
Blood brain barrier (BBB)<br />
Liver organoids models<br />
Kidney 3D spheroids<br />
Physiological barriers<br />
Cytotoxicity evaluations<br />
<strong>Tempo</strong>O2 for Oxygen<br />
Metabolism<br />
<strong>Tempo</strong>VOL for Cationic<br />
Voltage<br />
tempobioscience.com/tempo2023<br />
©2023 <strong>Tempo</strong> Bioscience. All rights reserved.<br />
<strong>Tempo</strong> Services<br />
Custom Cell Based Assays<br />
3D Organoid Assays - CNS and<br />
Liver<br />
LIVE-cell Biosensor Assays<br />
Blood Brain Barrier Assays<br />
Custom disease model<br />
development<br />
Custom 3D/spheroid/organoid<br />
development<br />
Distributed by PELOBIOTECH GmbH<br />
(P) +49 89 517 286 59-0<br />
(F) +49 89 517 286 59-88<br />
Email: info@pelobiotech.com<br />
www.pelobiotech.com
Organoid Engineering Process Timeline<br />
iPSC DERIVATIVE<br />
CELL TYPES<br />
CNS Organoids<br />
Pericytes<br />
CNS Organoid<br />
iCort, iAstro,<br />
iOligo, iMG<br />
6:1<br />
3:1<br />
4:1<br />
Customize Neural : Glia<br />
ratio to 6:1, 3:1, 4:1<br />
10-14 Days Controlled<br />
Assembly of Organoids<br />
with Custom Ratio<br />
Easily Scalable<br />
Hepatocytes<br />
Astrocytes (I and II)<br />
Cardiomyocytes<br />
Liver Organoid<br />
iLSEC, iKupffer,<br />
iHepStellate, iHep3D<br />
Liver Organoids<br />
The <strong>Tempo</strong> Bioscience Advantage<br />
• >25 human iPSC-derivative cell types per donor/patient line. Enable 3D cell<br />
culture<br />
• >25 cell culture media products. Support 3D spheriod/organoid cell culture.<br />
• No vector, no episomes, serum-free, feeder-free reprogramming. In-house<br />
developed<br />
• proprietary reprogramming technologies and patented biosensors (Free of<br />
Yamanaka factors + licensing)<br />
• High purity; donor-matched products; no mixing donors’ cells<br />
• Emerging market with high demand (human iPSC derived cell types)<br />
• Customizable disease modeling using human iPSC based models<br />
• Preclinical in vitro safety and in vitro efficacy<br />
• End-to-end solution provider (Custom projects available.)<br />
• Bespoke assay solution provider (Custom projects available.)<br />
• High quality technical support<br />
30% 70%<br />
60% 40%<br />
Customize ratio of<br />
Hepatocytes to<br />
iLSEC/iKupffer/iHepStellate<br />
60%/40%, 30%/70%<br />
10-14 DAYS Controlled<br />
Organoid with<br />
Custom Ratio<br />
Easily Scalable<br />
Liver Sinusoidal<br />
Endothelials<br />
Cortical Nuerons<br />
Schwann Cells<br />
Brain Microvascular<br />
Endothelial Cells<br />
Motor Neurons<br />
Dopaminergic Neurons<br />
Microglia<br />
Osteoblasts<br />
Sensory Neurons<br />
Hepatic Stellate Cells<br />
Mesenchymal Stem Cells<br />
Melanocytes<br />
Keratinocytes<br />
CD14+ Monocytes<br />
Phagocytes<br />
Retinal Pigment<br />
Epithelials<br />
Neural Progenitors<br />
Kupffer Cells<br />
Kidney Proximal Tubule<br />
Cells & Podocytes<br />
Distributed by PELOBIOTECH GmbH<br />
tempobioscience.com/tempo2023<br />
www.pelobiotech.com
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