Potency and Tolerance of Calcitonin Stimulation with High Dose ...

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high percentage of women (80%) but not men (32%) had very low basal hCT concentrations (
calcium-stimulated hCT levels were strongly correlated (Figure 1C, Spearmans’ rho = 0.758, P < 0.001). Analysis of variance revealed that sex significantly influenced the magnitude of the stimulated hCT levels (P =0.008), but age, weight, height, body mass index and thyroid volume did not. Tolerability of stimulation agents Clinical side effects also are reported in Table 1. Due to a perception of more unpleasant adverse effects of pentagastrin than of calcium, all subjects receiving both (n = 42) declared a preference for the latter. Discussion Because of its relatively large sample size, rigorous exclusion of evidence of thyroid abnormality, and inclusion of calcium stimulation testing, the present study provides the most reliable and clinically relevant reference values for basal and stimulated serum hCT concentrations in healthy adults obtained to date via automated chemiluminescent assay. Our reference range for basal hCT agrees with Leboulleux et al.’s description of “normal” adult circulating hCT levels as
Page 1 and 2: J Clin Endocrin Metab. First publis
Page 3 and 4: Introduction Human calcitonin (hCT)
Page 5: Serum hCT Assay Blood samples were
Page 9 and 10: References 1. Hahm JR, Lee MS, Min
Page 11 and 12: Tables Table 1. Subject characteris
Page 13 and 14: Figure Legends Figure 1. Serum calc
Page 15 and 16: Calcitonin (pg/ml) B) Calcium stimu

Potency and Tolerance of Calcitonin Stimulation with High Dose ...

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