Potency and Tolerance of Calcitonin Stimulation with High Dose ...
Potency and Tolerance of Calcitonin Stimulation with High Dose ...
Potency and Tolerance of Calcitonin Stimulation with High Dose ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
calcium-stimulated hCT levels were strongly correlated (Figure 1C, Spearmans’ rho = 0.758,<br />
P < 0.001). Analysis <strong>of</strong> variance revealed that sex significantly influenced the magnitude <strong>of</strong><br />
the stimulated hCT levels (P =0.008), but age, weight, height, body mass index <strong>and</strong> thyroid<br />
volume did not.<br />
Tolerability <strong>of</strong> stimulation agents<br />
Clinical side effects also are reported in Table 1. Due to a perception <strong>of</strong> more<br />
unpleasant adverse effects <strong>of</strong> pentagastrin than <strong>of</strong> calcium, all subjects receiving both (n = 42)<br />
declared a preference for the latter.<br />
Discussion<br />
Because <strong>of</strong> its relatively large sample size, rigorous exclusion <strong>of</strong> evidence <strong>of</strong> thyroid<br />
abnormality, <strong>and</strong> inclusion <strong>of</strong> calcium stimulation testing, the present study provides the most<br />
reliable <strong>and</strong> clinically relevant reference values for basal <strong>and</strong> stimulated serum hCT<br />
concentrations in healthy adults obtained to date via automated chemiluminescent assay. Our<br />
reference range for basal hCT agrees <strong>with</strong> Leboulleux et al.’s description <strong>of</strong> “normal” adult<br />
circulating hCT levels as
Change language