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CONTACT Curt Bilby, PhD President and CEO ADDRESS 7000 North MoPac Expressway 2nd Floor Austin, TX 78731 TELEPHONE 512 514 6760 FAX 512 287 4241 EMAIL cbilby@terapio.com YEAR FOUNDED 2006 Terapio Corporation www.terapio.com FINANCIAL SUMMARY $6.7M Series A $1M seed capital $3.6M in federal funds Terapio is seeking a lead or syndicate investors to participate with Santé Ventures in Terapio’s Series B financing. Terapio plans at least $10M in Series B financing where Santé Ventures, the Series A lead investor, will participate on a pro rata basis. The use of proceeds for Series B will be primarily used for drug development, preclinical and nonclinical programs, and regulatory activities required to fund the company to the valuation inflection point associated with completing the pivotal nonhuman primate efficacy trial under the FDA Animal Rule. COMPANY PROFILE Launched in 2007 and backed by Santé Ventures, Terapio is a biopharmaceutical company developing clinical applications based on the naturally-occurring RLIP76 protein. RLIP76 is a membrane-associated cellular transport protein that is an integral part of the cell’s normal process of removing toxic metabolites formed by oxidative insults. However, in cases of elevated oxidative stress, such as occurs with exposure to radiation and chemical toxins, the endogenous RLIP76 system can be overwhelmed, leading to cell death. Supplementing cellular levels of RLIP76 through exogenous administration of Terapio’s liposomal formulation of the RLIP76 protein promotes protection by relieving this cellular stress and allows recovery by tissue cells. This mechanism of action has broad applicability to a variety of additional clinical indications, including the treatment of the toxic side effects of therapeutic radiation and chemotherapy in oncology patients and CNS diseases – a key part of Terapio’s commercial pipeline. For biodefense applications, Terapio has accumulated a large body of data demonstrating that the protein is effective in protecting and rescuing animals exposed to otherwise lethal exposures of whole body radiation. Therefore, the company is pursuing the prevention and treatment of Acute Radiation Syndrome (ARS) as a lead indication. No effective countermeasures for ARS exist today, making this a highly unmet need. Terapio has performed multiple 30-day survival studies with the RLIP76 protein in animal models of ARS and demonstrated that administered either before and/or after exposure to lethal doses of radiation results in greater than 90% survival of treated animals, versus 20% survival of controls. MANAGEMENT Curt Bilby, PhD, President and CEO Casey Cunningham, MD, co-founder and Chief Medical Officer Henry Hebel, Vice President of Drug Development Elizabeth Leffel, PhD, MPH, Vice President of Preclinical and Nonclinical Programs t back :: next u WELCOME PHARMA LICENSING GROUPS SPEAKERS PRESENTING COMPANIES SUPPORTING ORGANISATIONS ORGANISERS
CONTACT Eduardo Bravo (speaker) Managing Director and Chief Executive Officer ADDRESS TiGenix NV Haasrode Researchpark 1724 Romeinse straat 12 bus 2 3001 Leuven Belgium TELEPHONE +32 16 396 060 FAX +32 16 397 970 EMAIL eduardo.bravo@tigenix.com YEAR FOUNDED 2000 TiGenix NV www.tigenix.com COMPANY PROFILE TiGenix NV (NYSE Euronext: TIG) is a leading European cell therapy company with a commercial product and an advanced clinical stage pipeline of adult stem cell programs. The company’s lead product, ChondroCelect®, for cartilage repair in the knee, is the first and only approved cell-based product in Europe. The product has received full national reimbursement in Belgium and the Netherlands and is already being commercialized in 5 European countries. TiGenix’s stem cell programs are based on a validated platform of allogeneic expanded adipose-derived stem cells (eASCs) targeting autoimmune and inflammatory diseases. Built on solid pre-clinical and CMC packages, they are being developed in close consultation with the European Medicines Agency. The company has initiated a Phase III clinical trial in complex perianal fistulas in patients with Crohn’s disease, has concluded recruitment in a Phase IIa trial in rheumatoid arthritis, and successfully concluded a Phase I trial to investigate the potential of intra-lymphatic administration of eASCs for autoimmune disorders. TiGenix is based out of Leuven (Belgium), and has operations in Madrid (Spain), and Sittard-Geleen (the Netherlands). MANAGEMENT Eduardo Bravo, Managing Director and Chief Executive Officer (CEO). Gil Beyen BVBA, Managing Director and Chief Business Officer (CBO) Claudia D’Augusta, Chief Financial Officer (CFO) Wilfried Dalemans, Chief Technical Officer (CTO) t back :: next u WELCOME PHARMA LICENSING GROUPS SPEAKERS PRESENTING COMPANIES SUPPORTING ORGANISATIONS ORGANISERS
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