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Treating Lipid Abnormalities Beyond LDL - Washington Hospital ...

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Potential Mechanisms Involved in<br />

the Generation of Dysfunctional HDL<br />

Dysfunctional<br />

Lyso<br />

PC<br />

Dysfunctional HDL<br />

Ox. PL<br />

HDL<br />

Oxidation<br />

sPLA 2<br />

HDL<br />

Glycation in<br />

Diabetes<br />

Myeloperoxidase<br />

Foger B, et al. J Biol Chem. 1999;274(52):36912-36920.<br />

Ansell BL, et al. Curr Opin <strong>Lipid</strong>ol. 2007;18(4):427-434.<br />

Nicolls SJ , et al. Trends Cardiovasc Med. 2005;15(6):212-221.<br />

Shao B, et al. Curr Opin Mol Ther 2006;8(3):198-205.<br />

N0 2<br />

Dysfunctional HDL<br />

Cl<br />

Dysfunctional HDL

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