Treating Lipid Abnormalities Beyond LDL - Washington Hospital ...
Treating Lipid Abnormalities Beyond LDL - Washington Hospital ...
Treating Lipid Abnormalities Beyond LDL - Washington Hospital ...
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10 mg<br />
30 mg<br />
60 mg<br />
Plasma HDLC and <strong>LDL</strong>C Levels Following<br />
14 days of Treatment with Torcetrapib<br />
120 mg<br />
120 mg bid<br />
60.2 ± 18.6<br />
48.2 ± 5.7<br />
52.5 ± 15.8<br />
48.5 ± 9.2<br />
53.5 ± 10.7<br />
HDL-C<br />
Dose Baseline Treatment<br />
69 ± 18.9<br />
61.3 ± 5.2<br />
83.2 ± 20.7<br />
84.7 ± 21.6<br />
100 ± 18.6<br />
Phase 2<br />
%<br />
Change<br />
16 ± 8<br />
28 ± 13<br />
62 ± 31<br />
73 ± 21<br />
91 ± 42<br />
Clark RW, et al. Arterioscler Thromb Vasc Biol. 2004;24:490<br />
Baseline<br />
103 ± 21<br />
113 ± 31<br />
102 ± 34<br />
119 ± 19<br />
99 ± 23<br />
<strong>LDL</strong>-C<br />
Treatment<br />
110 ± 18<br />
97 ± 26<br />
90 ± 36<br />
95 ± 44<br />
59 ± 21<br />
%<br />
Change<br />
9 ± 17<br />
-14 ± 16<br />
-11 ± 20<br />
-21 ± 33<br />
-42 ± 9<br />
49
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