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Sarcoidosis - Cleveland Clinic Center for Continuing Education

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What is new in Epidemiology?<br />

• ACCESS study (Baughman et al, AJRCCM 2001)<br />

(a case control etiologic study of sarcoidosis)<br />

-enrolled 736 patients within 6 months of diagnosis at 10 ctrs in the US<br />

-same number of age, sex, race matched controls<br />

-follow-up of first 240 patients <strong>for</strong> 2 years<br />

• Peak age 35-45 yr, one third >55 yr, women older<br />

• Blacks: more extrathoracic, more severe lung disease<br />

• Women: higher incidence <strong>for</strong> EN, ocular, neurological disease<br />

• Occupational and environmental exposure with increased risk:<br />

-musty odors, insecticides, air conditioning, raising birds<br />

-employment in agriculture, teaching, and others<br />

-smoking: strong negative predictor

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