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Sarcoidosis - Cleveland Clinic Center for Continuing Education

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Milestones in the Immunology<br />

of <strong>Sarcoidosis</strong><br />

• Boeck 1899 Noncaseating granuloma<br />

• Boeck 1916 Cutaneous anergy to tuberculin<br />

• Kveim 1941 Kveim skin test<br />

• Hirschhorn 1964 Spontaneous lymphoblastic<br />

trans<strong>for</strong>mation of blood cells<br />

• Voisin 1977 BAL lymphocytes increased<br />

• Hunninghake 1980 Spontaneous lymphokine<br />

production by BAL cells<br />

• Adams & Sharma Hypercalcemia caused by<br />

1983 calcitriol production from AM<br />

• Moller 1996 Th1 immune response

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