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Sarcoidosis - Cleveland Clinic Center for Continuing Education

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Hypercalcemia in <strong>Sarcoidosis</strong><br />

• 1939 Harrel G: first description<br />

• 1979 Papapoulos SE: increased serum<br />

calcitriol (active Vit D3) is associated<br />

with hypercalcemia<br />

• 1981 Barbour G: site <strong>for</strong> overproduction of<br />

calcitriol must be extrarenal<br />

• 1983 Adams JS & Sharma OP puzzle solved:<br />

cultured AM in sarcoidosis are able to<br />

produce calcitriol

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