Chromatography Data Software 2008 Product Plan - Waters

©2011 Waters Corporation 

Empower 3 

Control of Instruments 

3rd Party Control 

Mogens Hallas 

Nordic User Training 2011 

Långvik, September 6 th to 9th 

1


2

Empower 3 

Obsoleted support of detectors 

The following instrumentation is reaching its end 

of life, is on limited support status and will no 

longer be supported in Empower 3: 

- 410 RI Detector 

- 486 TUV Detector 

- 996 PDA Detector 

- 474 Fluorescence Detector 

Support for the A5890S and 7673S under serial 

control (Using LAN Serial Control) 

But not serial busLAC/E control, will remain in 

Empower 3. 


3

Equinox Serial 8-Port Card 

Equinox Serial Card is only supported on Windows XP 

32-bit – Not in Windows 7. 

Current serial instrument support using the Equinox 

8-port card is: 

- Agilent 5890 GC (5890S) 

- Agilent 7673 GC autosampler (7673S) 

- Agilent 6890 GC (all models, including 6890N) 

- Agilent 6850 GC (serial number

Prior to Empower 3 

Previously discontinued instrumenys 

As a reminder, support for the following instruments 

has been previously been discontinued: 

Not supported as of Empower 2 

- Integrity TMD 

- ISA BusLAC/E card 

- GPC 2000 

- 5890 GC (under busLAC/E control) 

- 7673 (under busLAC/E control) 

Not supported as of Empower build 1154 

- 700, 710, and 712 Injectors 

- 715 Autosampler 

- LC Module 1 

Not supported as of Millennium32 v4.0 

- Waters 490 Variable UV 


5

Instrument Control 

� Provide a comprehensive, reliable and robust feature set for 

each instrument we support. 

— Waters works closely with its customers to ensure the 

instruments supported with Empower Software provided scientist 

the capabilities to realize the most value from their instrument 

investment. 

� Instrument Driver Approach - Open Instrument Portal (OIP) 

— Similar to the Microsoft Printer driver approach 

— Allows creation of software plug-ins to add hardware control 

capabilities 

— Waters uses and other instrument vendors 

to create instrument control 


6

What is OIP Technology? 

� Open Interface Portal (OIP) technology is a 

software architecture that allows for a 

standardized specification of the interaction 

between the Data System and an instrument. 

� This allows for the development of an instrument 

―driver‖ that can be added to Empower Software 

without changing the core application. 

� OIP technology is separate from the physical 

connectivity (serial, ethernet, USB, IEEE-488) 

� OIP technology takes advantage of other software 

specifications: COM, ActiveX, XML 


7

Extended Instrument Control Using 

OIP with Empower Software 

� One software solution for all chromatographic systems 


— Reduced training, validation and support 

� 16 vendors with over 235+ instruments 

— Instrument control available from major LC Vendors including 

Waters, Agilent, Shimadzu, Hitachi and Dionex *) 

— Instrument Control Available from major GC Vendors including 

Agilent, Shimadzu, PerkinElmer and Varian 

� New instrument control 

— Waters ACQUITY H-Class 

— Waters Thar SFC 

— Beckman CE 

— WFC III 

*) some are still in testing 

8

Instrument control via OIP 

� Created by Waters 


— HPLC systems and module, ACQUITY UPLC, Single-quad & Triple-quad 

MS, A/D Converter, Agilent 6850 GC, Agilent 7694 Headspace Sampler, 

Agilent 1100, 1200 and 1260/1290 series LC modules 

� Created by Other Instrument Vendors 

— CTC PAL Autosamplers 

— Varian 3900 GC 

— Perkin-Elmer GC 

— Tekmar HT3 Headspace Sampler 

— Dissolution Baths 

o Hanson SR8-Plus, Distek (2100C, 

Evolution 6100 & 6300), Sotax and 

Erweka DT800 Online System 

— Selerity Polaratherm 9000 

— Shimadzu Prominence LC 20 System 

— Hitachi LaChrom Elite Systems 

— Dionex 

9

Complete list of all controlled systems 


10

Third Party Instrument Control in Empower 3 

Waters policy is to notify their software partners when a new informatics 

software product is under development. The Empower 3 team has notified all of 

our partners about Empower 3 and has offered beta software for use in testing 

/development of ICS software, for Empower 3. 

To date not all vendors have requested Empower 3 beta or released software. 

We have recently reminded our partners that the release of Empower 3 software 

and we would like to offer our mutual support of their products. We will contact 

our partners again. 


Please refer users who are requesting third party instrument control to the 

appropriate vendors to request support of these instruments in Empower 3. 

11

Instrument control 

� Consistent instrument interface assist in training new software 

users as new techniques such as Gas Chromatography (GC) or 

Ultra Performance Liquid Chromatography (UPLC) are introduce 

to the laboratory. 


12

Instrument Control 

� Once instrument parameters are entered into the Empower 

software they can be completely managed by the software to 

ensure that these same parameters are used for all future 

analysis. 

— If changes are required, all instrument parameters are 

completely documented in Empower's embedded relational 

database with complete audit trail including what changes were 

made, who made the changes, when the changes were made 

and why. 


13

Waters HPLC’s 

� Full control of Waters 

binary and quaternary 

pumps. 

� Full control of Multiple 

wavelength, Photodiode 

array, Fluorescence, and 

RI detectors. 

� Full Control of sample 

compartment and column 

oven temperatures 

� Full control of 

autosamplers. 


single quad mass 

detectors. 


14

Waters UPLC 


binary and quaternary 

pumps. 

� Full control of Multiple 

wavelength, Photodiode 

array, Fluorescence, and 

RI detectors. 

� Full Control of sample 

compartment and 

column oven 

temperatures 


autosamplers. 


Mass Spec detectors. 


15

Waters Mass Detectors 

� Data acquisition and 

instrument control of Mass 

Detectors. 

� Greater specificity of 

analysis. 

� Easily use MS and MS/MS 

in QC and Development 

lab environments. 

� 1st Chromatography 

Software to offer Tandem 

control and data 

processing in a network or 

regulated environment 


16

Mass Detection Waters SQD & TQD 

� Data acquisition and instrument control of Mass Detectors 

� Greater specificity of analysis 

� Easily use MS and MS/MS in QC and Development lab environments 

1 st Chromatography Software 

to offer Tandem control and 

data processing in a network 

or regulated environment. 


17

Supercritical Fluid Chromatography 

(SFC) 

� Thar Method Station & SFC-MS Resolution Systems 

— Analytical to semi-preparative purification solutions 

� Control includes: 

— Fluid Delivery Module and co-solvent selection 

— Photodiode Array, UV & ELSD detectors 

— Column oven and column selection 

— Automated Back Pressure Regulator 

— Thar Autosampler 

— Waters 3100 MS detectors 

— Waters Fraction Collector III 


18

ACQUITY UPSFC System 


19

Dissolution Baths 

� Integrity of your HPLC 

dissolution testing 

methods and results, 

helping increase lab 

productivity. 

� Combined software and 

hardware solution. 

— Hanson SR8-Plus 

— Distek 2100C, Evolution 6100 

& 6300 

— Sotax 

— Erweka DT800 Online 

Dissolution System 

— Vankel VK 7000 

— Vankel VK 7010 


20

Agilent 1100/1200/1260/1290 LC 

� Full control of Isocratic, 

Binary and Quatenary 

pumps. 


Autosampler. 

� Full control of UV, 

MWV, RI, FLD and DAD 

detectors 

� Full control of column 

oven. 


21

Agilent 5890 Series II GC 

� Control with either 7673 or 

G1512 Controller 

� Dual Tower capability (With 

serial card only) 

� Detector Supported 

FID,NPD,TCD,ECD 

� Sampling Rates of 1.25, 2.5, 

5, 10, 20 points per second. 

� Fully Programmable 

temperatures: 


— limits, ramps, and hold 

times. 

� Injector inlet zone 

temperature setting. 

22

Agilent 6890 / 6890N GC 

� 6890 supported in both Single 

and Dual Tower mode. 

� Sampling Rates of 0.1, 0.2, 

0.5, 1, 2, 5, 10, 20, 50, 100, 

and 200 points per second. 

� Fully Programmable 

temperatures: 

— limits, ramps, and hold times 

� Detector options: 

— Unknown (Other detectors) 

— FID (Flame Ionization) 

— TCD (Thermal Conductivity) 

— NPD (Nitrogen Phosphorous) 

— ECD (Electron Capture) 

— uECD (Micro Electron Capture) 

— FPD ( Flame Photometric) 


23

Agilent 6850 GC 

� Inlet: Split/Splitless & 

Purged Pack 


— limits, ramps, and hold 

times 

� Cool On-Column inlet 

project in progress 

� Detector options: 

— FID (Flame Ionization) 

— TCD (Thermal 

Conductivity) 

24

Agilent HS7694 Headspace Sampler 

� Introduced July, 2003 

� The first 

Headspace/GC system 

control option in a 

compliance-friendly 

CDS 

� G1289B and G1290B 


25

Agilent G1888 Headspace Sampler 

� Headspace Control Option 


— Will continue support for the 7694 

— Will add support for the G1888 

— Will allow remote operation through a 

LAC/E module 

26

Tekmar HT3 GC Headspace 

� Tekmar HT3 Static and Dynamic Headspace System driver available 

from Teledyne Tekmar 

� Static Headspace analysis: robust technique for volatile compounds 

analysis of in almost any matrix. 

� Dramatic improvements in sensitivity by new Dynamic Headspace 

option, while maintaining ruggedness and reliability of traditional 

Static Headspace. 


27

Varian 39XL GC 

� Drivers available from Varian Product Sales 

� Single 1177 split/splitless or 1041 injector equipped with Injector 

Electronic Flow Control, FID or TCD detector with Electronic Flow 

Control 

� Option: keypad and 

Ethernet communications 


28

CTC PAL Injection Systems 

� LC PAL, GC PAL and Combi PAL drivers available from CTC Analytics 

� Automated GC and LC injection systems 

� Outstanding performance and maximum flexibility in every LC sample 

processing system 

� Provides powerful working capabilities and maximum flexibility in 

every GC sample processing system 

� Combi PAL, the only GC sample injection system combining liquid, 

large volume, headspace, in tube extraction in a single instrument. 


29

Beckman CE Systems 

� Beckman P/ACE MDQ & PA 800 Capillary Electrophoresis Systems 

� Control includes photo diode array and selectable wavelength UV/Vis 

(with 200, 214, 254 and 280 nm filters) detector, UV source optics, 

temperature-controlled sample storage module and LIF Detector 

� Beckman CE Control License includes instrument control software, 

license, documentation, and an IEEE-to-Ethernet converter to connect 

Beckman CE (IEEE-488) via Ethernet 

� Support for the LIF (Laser-Induced Fluorescence) detector 


30

Selerity Polaratherm 9000 Total 

Temperature Controller 

� Selerity Polaratherm 

9000 Total Temperature 

Controller 


o Temperature 

programmed HPLC is 

taken to extremes with 

the Polaratherm Series 

9000 Total Temperature 

Controller with mobile 

phase preheating, and 

optional cryo cooling. 

31

Shimadzu Prominence LC 20 System 

� Prominence LC 20 drivers available from Shimadzu 

� Availability expected 3Q, 2007 

� Supported Modules 


— System Controller - CBM-20A, CBM-20A lite 

— Pump - LC-20AD, LC-20AT, LC-20AB 

— Autosampler - SIL-20A, SIL-20AC, Rack Changer, Rack Changer/C 

— Column Oven - CTO-20A, CTO-20AC 

— Detector - SPD-20A, SPD-20AV, SPD-M20A (PDA) 

— Solenoid valve - LPGE unit built in LC-20AD/20AT 

— Rotary valve - FCV-12AH installed in CTO-20A/20AC 

— Rotary valve - FCV-14AH installed in CTO-20A/20AC 

— Analog input - PC-55N 

32

Shimadzu GC 

� GC System Shimadzu GC-2010 

� GC System Shimadzu GC-2010 Plus 

� GC System Shimadzu GC-2014 

� GC Autosampler Shimadzu AOC-20i 

� GC Autosampler Shimadzu AOC-20i/s 


33

PerkinElmer Clarus GC 

� PerkinElmer Clarus 400 GC 




34

Perkin Elmer GC and HS 

•TurboMatrix Headspace samplers 


35

Hitachi LaChrom Elite Systems 

� LaChrom Elite System drivers available from Hitachi 

� Availability expected 4Q, 2007 

� Supported Modules 


— L-2100 and L-2130 - Pump 

— L-2200 - Autosampler 

— L-2300 and L-2350 - Column Oven 

— L-2400 - UV Detector 

— L-2420 - UV / Vis Detector 

— L-2450 and L-2455 - Diode Array Detector 

— L-2480 and L-2485 - Fluorescence Detector 

— L-2490 - Refractive Index Detector 

— AID - Analog Input Device (Single Channel) 

36

Hitachi LaChromUltra 

� Hitachi LaChromUltra L-2160U Pump 

� Hitachi LaChromUltra L-2200U Autosampler 

� Hitachi LaChromUltra L-2400U UV Detector 

� Hitachi LaChromUltra L-2420U UV-Vis Detector 

� Hitachi LaChrom L-2455U Diode Array Detector 

� Hitachi LaChromUltra L-2485U Fluorescence Detector 


37

ESA Biosciences 

� ESA pump, 

� ESA Coulochem III electrochemical detector, 

� ESA Corona, Corona Plus, Corona Ultra CAD detectors, 

� CAD v1.23 Detector 

� Corona Plus V1.23 

� Corona Ultra V1.05 


38

Dionex UltiMate 3000/ 

� UltiMate 3000/3000 RSLC LPG-3400SD Quaternary Analytical pump 

� UltiMate 3000/3000 RSLC LPG-3400BM Quaternary Biocompatible Micro pump 

� UltiMate 3000/3000 RSLC DGP-3600 pumps 

� UltiMate 3000/3000 RSLC DGP-3600RS rapid separation dual low-pressure gradient pump 

� UltiMate 3000/3000 RSLC DGP-3600SD analytical dual low-pressure gradient pump 

� UltiMate 3000/3000 RSLC DGP-3600BM biocompatible dual low-pressure gradient pump 

� UltiMate 3000/3000 RSLC HPG-3x00 pumps 

� UltiMate 3000/3000 RSLC HPG-3x00RS rapid separation high-pressure gradient pump 

� UltiMate 3000/3000 RSLC HPG-3x00SD analytical high-pressure gradient pump 

� UltiMate 3000/3000 RSLC ISO-3100 pumps 

� UltiMate 3000/3000 RSLC ISO-3100SD analytical isocratic pump 

� UltiMate 3000/3000 RSLC ISO-3100BM biocompatible isocratic micro pump 

� UltiMate 3000/3000 RSLC FLM-3x00 flow managers and termostatted column compartments 

� UltiMate 3000/3000 RSLC TCC-3X00(RS) thermostatted column compartments 

� UltiMate 3000/3000 RSLC ACC-3000 autosampler column compartment 

� UltiMate 3000/3000 RSLC WPS-3000(RS) autosamplers 

� UltiMate 3000/3000 RSLC DAD-3000(RS) diode-array detector 

� UltiMate 3000/3000 RSLC FLD-3x00(RS) fluorescence detector 

� UltiMate 3000/3000 RSLC MWD-3000(RS) multi-wavelength detector 

� UltiMate 3000/3000 RSLC VWD-3x00(RS) variable-wavelength detectors 


39

Dionex IC systems 

� Control of Dionex range of IC systems under development 


— ICS-5000 Reagent-Free IC System 

— ICS-2100 Integrated Reagent-Free IC System 

— ICS-1600 Standard Integrated IC System 

— ICS-1100 Basic Integrated IC System 

— ICS-900 Starter Line IC System 

40

Extended Instrument Control with 

Empower Software 

� Benefit to the Users: One Software solution for all 

chromatographic systems 


— Reduced Training, Validation and Support 

� Instrument Control Available Today 

— 16 Vendors with 235+ Instrument modules 

— Major LC and GC Vendors 

� New Techniques 

— Supercritical Fluid Chromatography (SFC) 

— Capillary Electrophoresis (CE) 

41


42

Chromatography Data Software 2008 Product Plan - Waters

Create successful ePaper yourself

Delete template?

Save as template?